TR201808280T4 - Pirazolo[1,5-a]pirimidin-bazlı bileşikler, bunları içeren bileşimler, ve bunların kullanım usulleri. - Google Patents

Pirazolo[1,5-a]pirimidin-bazlı bileşikler, bunları içeren bileşimler, ve bunların kullanım usulleri. Download PDF

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Publication number
TR201808280T4
TR201808280T4 TR2018/08280T TR201808280T TR201808280T4 TR 201808280 T4 TR201808280 T4 TR 201808280T4 TR 2018/08280 T TR2018/08280 T TR 2018/08280T TR 201808280 T TR201808280 T TR 201808280T TR 201808280 T4 TR201808280 T4 TR 201808280T4
Authority
TR
Turkey
Prior art keywords
pyrazolo
pyrimidin
carboxylate
piperazine
pyrimidine
Prior art date
Application number
TR2018/08280T
Other languages
English (en)
Turkish (tr)
Inventor
Bi Yingzhi
Gordon Carson Kenneth
Cianchetta Giovanni
Alan Green Michael
Kumi Godwin
Main Alan
Zhang Yulian
Gregory Zipp Glenn
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of TR201808280T4 publication Critical patent/TR201808280T4/tr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
TR2018/08280T 2012-03-09 2013-03-05 Pirazolo[1,5-a]pirimidin-bazlı bileşikler, bunları içeren bileşimler, ve bunların kullanım usulleri. TR201808280T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261608765P 2012-03-09 2012-03-09

Publications (1)

Publication Number Publication Date
TR201808280T4 true TR201808280T4 (tr) 2018-07-23

Family

ID=47892052

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/08280T TR201808280T4 (tr) 2012-03-09 2013-03-05 Pirazolo[1,5-a]pirimidin-bazlı bileşikler, bunları içeren bileşimler, ve bunların kullanım usulleri.

Country Status (25)

Country Link
US (3) US8946415B2 (instruction)
EP (1) EP2834243B1 (instruction)
JP (1) JP6418950B2 (instruction)
KR (1) KR101965025B1 (instruction)
CN (1) CN104302649B (instruction)
AR (1) AR090292A1 (instruction)
AU (1) AU2013230128B2 (instruction)
BR (1) BR112014022000A8 (instruction)
CA (1) CA2866143C (instruction)
DK (1) DK2834243T3 (instruction)
ES (1) ES2676224T3 (instruction)
HU (1) HUE038786T2 (instruction)
IL (1) IL234486A (instruction)
IN (1) IN2014DN07384A (instruction)
MX (2) MX345830B (instruction)
NZ (1) NZ630721A (instruction)
PL (1) PL2834243T3 (instruction)
PT (1) PT2834243T (instruction)
RU (1) RU2014140735A (instruction)
SG (1) SG11201405561RA (instruction)
TR (1) TR201808280T4 (instruction)
TW (1) TW201341386A (instruction)
UY (1) UY34668A (instruction)
WO (1) WO2013134228A1 (instruction)
ZA (1) ZA201406149B (instruction)

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US9737542B2 (en) 2013-10-11 2017-08-22 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
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US20170239249A1 (en) * 2014-09-30 2017-08-24 Bristol-Myers Squibb Company Quinazoline-based kinase inhibitors
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US10174044B2 (en) 2015-04-10 2019-01-08 Bristol-Myers Squibb Company Fused pyridines as kinase inhibitors
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EA039788B1 (ru) * 2016-11-02 2022-03-14 Янссен Фармацевтика Нв Производные [1,2,4]триазоло[1,5-a]пиримидина в качестве ингибиторов pde2
ES2912264T3 (es) 2016-11-02 2022-05-25 Janssen Pharmaceutica Nv Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2
ES2855032T3 (es) 2016-11-02 2021-09-23 Janssen Pharmaceutica Nv Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2
TWI808958B (zh) 2017-01-25 2023-07-21 美商特普醫葯公司 涉及二芳基巨環化合物之組合療法
JP7224334B2 (ja) 2017-07-28 2023-02-17 ターニング・ポイント・セラピューティクス・インコーポレイテッド 大環式化合物およびその使用
MY205416A (en) 2017-07-28 2024-10-21 Takeda Pharmaceuticals Co Tyk2 inhibitors and uses thereof
TWI848925B (zh) * 2017-12-15 2024-07-21 美商金字塔生技公司 肌旋蛋白激酶抑制劑
SI3728271T1 (sl) 2017-12-19 2023-01-31 Turning Point Therapeutics, Inc. Makrociklične spojine za zdravljenje bolezni
EP3730492A4 (en) * 2017-12-22 2021-08-11 Shenzhen TargetRx, Inc. COMPOUND PYRAZOLO [1,5-A] PYRIMIDINE SUBSTITUTE, PHARMACEUTICAL COMPOSITION AND ASSOCIATED USE
JP7162915B2 (ja) 2018-01-23 2022-10-31 深▲チェン▼市塔吉瑞生物医薬有限公司 置換ピラゾロ[1,5-a]ピリミジン系大環状化合物
EP3856743A4 (en) * 2018-09-27 2022-06-15 Fochon Pharmaceuticals, Ltd. SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE AND [1,2,4]TRIAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
CN113271940A (zh) * 2018-10-15 2021-08-17 林伯士拉克许米公司 Tyk2抑制剂和其用途
CA3175973A1 (en) * 2020-04-21 2021-10-28 Lexicon Pharmaceuticals, Inc. 4-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine for use in the the treatment of cov-229e or cov-oc43 coronaviruses infections
US11730723B2 (en) 2020-04-21 2023-08-22 Lexicon Pharmaceuticals, Inc. Compounds and methods for treating viral infections
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US20250122207A1 (en) * 2023-09-08 2025-04-17 Satellos Bioscience Inc. Ap2 associated kinase 1 inhibitors and uses thereof

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MX345830B (es) 2012-03-09 2017-02-17 Lexicon Pharmaceuticals Inc Compuestos a base de pirazol[1,5-a]pirimidina, composiciones que los comprenden, y metodos para su uso.
TW201620911A (zh) * 2014-03-17 2016-06-16 雷西肯製藥股份有限公司 銜接子關聯激酶1之抑制劑、包含其之組成物、及其使用方法

Also Published As

Publication number Publication date
AR090292A1 (es) 2014-11-05
KR20140138864A (ko) 2014-12-04
BR112014022000A2 (pt) 2017-06-20
IN2014DN07384A (instruction) 2015-04-24
CA2866143A1 (en) 2013-09-12
DK2834243T3 (en) 2018-07-23
UY34668A (es) 2013-10-31
US20130253194A1 (en) 2013-09-26
CN104302649B (zh) 2017-06-23
ZA201406149B (en) 2016-06-29
US9403832B2 (en) 2016-08-02
US8946415B2 (en) 2015-02-03
BR112014022000A8 (pt) 2021-06-15
CN104302649A (zh) 2015-01-21
KR101965025B1 (ko) 2019-04-02
MX345830B (es) 2017-02-17
TW201341386A (zh) 2013-10-16
EP2834243B1 (en) 2018-04-25
JP6418950B2 (ja) 2018-11-07
EP2834243A1 (en) 2015-02-11
PT2834243T (pt) 2018-08-01
WO2013134228A1 (en) 2013-09-12
NZ630721A (en) 2016-12-23
AU2013230128B2 (en) 2017-08-17
ES2676224T3 (es) 2018-07-17
MX2014010589A (es) 2014-09-18
AU2013230128A1 (en) 2014-09-25
PL2834243T3 (pl) 2018-09-28
MX381849B (es) 2025-03-13
HUE038786T2 (hu) 2018-11-28
RU2014140735A (ru) 2016-04-27
US20170129896A1 (en) 2017-05-11
CA2866143C (en) 2020-08-04
SG11201405561RA (en) 2014-10-30
US20150183792A1 (en) 2015-07-02
JP2015509535A (ja) 2015-03-30
IL234486A (en) 2016-10-31
HK1201257A1 (en) 2015-08-28

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