IN2014DN07384A - - Google Patents
Info
- Publication number
- IN2014DN07384A IN2014DN07384A IN7384DEN2014A IN2014DN07384A IN 2014DN07384 A IN2014DN07384 A IN 2014DN07384A IN 7384DEN2014 A IN7384DEN2014 A IN 7384DEN2014A IN 2014DN07384 A IN2014DN07384 A IN 2014DN07384A
- Authority
- IN
- India
- Prior art keywords
- compounds
- disclosed
- mediated
- pyrimidinebased
- pyrazolo
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Pyrazolo[l,5-a]pyrimidinebased compounds of the formula: are disclosed, wherein Ri, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261608765P | 2012-03-09 | 2012-03-09 | |
| PCT/US2013/029056 WO2013134228A1 (en) | 2012-03-09 | 2013-03-05 | PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN07384A true IN2014DN07384A (en) | 2015-04-24 |
Family
ID=47892052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN7384DEN2014 IN2014DN07384A (en) | 2012-03-09 | 2013-03-05 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US8946415B2 (en) |
| EP (1) | EP2834243B1 (en) |
| JP (1) | JP6418950B2 (en) |
| KR (1) | KR101965025B1 (en) |
| CN (1) | CN104302649B (en) |
| AR (1) | AR090292A1 (en) |
| AU (1) | AU2013230128B2 (en) |
| BR (1) | BR112014022000A8 (en) |
| CA (1) | CA2866143C (en) |
| DK (1) | DK2834243T3 (en) |
| ES (1) | ES2676224T3 (en) |
| HU (1) | HUE038786T2 (en) |
| IL (1) | IL234486A (en) |
| IN (1) | IN2014DN07384A (en) |
| MX (2) | MX381849B (en) |
| NZ (1) | NZ630721A (en) |
| PL (1) | PL2834243T3 (en) |
| PT (1) | PT2834243T (en) |
| RU (1) | RU2014140735A (en) |
| SG (1) | SG11201405561RA (en) |
| TR (1) | TR201808280T4 (en) |
| TW (1) | TW201341386A (en) |
| UY (1) | UY34668A (en) |
| WO (1) | WO2013134228A1 (en) |
| ZA (1) | ZA201406149B (en) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014022000A8 (en) | 2012-03-09 | 2021-06-15 | Lexicon Pharmaceuticals Inc | pyrazol[1,5-a]pyrimidine-based compounds, their use and compositions comprising them |
| NZ630719A (en) | 2012-03-09 | 2017-01-27 | Lexicon Pharmaceuticals Inc | Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof |
| US8901305B2 (en) | 2012-07-31 | 2014-12-02 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| CN105121445A (en) | 2013-02-22 | 2015-12-02 | 百时美施贵宝公司 | 5H-chromeno[3,4-c]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) |
| TW201542550A (en) | 2013-09-06 | 2015-11-16 | Lexicon Pharmaceuticals Inc | Pyrazolo[1,5-a]pyrimidinyl compound, composition comprising the same, and method of using the same |
| US9737542B2 (en) | 2013-10-11 | 2017-08-22 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| AP2016009383A0 (en) | 2014-01-24 | 2016-08-31 | Tp Therapeutics Inc | Diaryl macrocycles as modulators of protein kinases |
| EP3099673B1 (en) * | 2014-01-31 | 2018-09-26 | Bristol-Myers Squibb Company | Quinoline-based kinase inhibitors |
| TW201620911A (en) * | 2014-03-17 | 2016-06-16 | 雷西肯製藥股份有限公司 | Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use |
| WO2016053794A1 (en) * | 2014-09-30 | 2016-04-07 | Bristol-Myers Squibb Company | Quinazoline-based kinase inhibitors |
| HRP20240937T1 (en) * | 2014-12-15 | 2024-10-25 | Cmg Pharmaceutical Co., Ltd. | Fused ring heteroaryl compounds and their use as trk inhibitors |
| US10174044B2 (en) | 2015-04-10 | 2019-01-08 | Bristol-Myers Squibb Company | Fused pyridines as kinase inhibitors |
| WO2017004342A1 (en) | 2015-07-02 | 2017-01-05 | Tp Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
| ES2979111T3 (en) | 2015-07-06 | 2024-09-24 | Turning Point Therapeutics Inc | Diaryl macrocycle polymorph |
| MX383823B (en) | 2015-07-21 | 2025-03-14 | Turning Point Therapeutics Inc | CHIRAL DIARYL MACROCYCLES AND THEIR USES. |
| CN108349979B (en) * | 2015-11-02 | 2021-04-09 | 詹森药业有限公司 | [1,2,4]Triazolo[1,5-a]pyrimidin-7-yl compounds |
| RU2019105587A (en) | 2016-07-28 | 2020-08-28 | Тёрнинг Поинт Терапьютикс, Инк. | MACROCYCLIC KINASE INHIBITORS |
| ES2855032T3 (en) | 2016-11-02 | 2021-09-23 | Janssen Pharmaceutica Nv | [1,2,4] triazolo [1,5-a] pyrimidine compounds as PDE2 inhibitors |
| BR112019008404A2 (en) * | 2016-11-02 | 2019-09-17 | Janssen Pharmaceutica Nv | [1,2,4] triazolo [1,5-a] pyrimidine derivatives as pde2 inhibitors |
| CN109890824B (en) | 2016-11-02 | 2022-05-24 | 詹森药业有限公司 | [1,2,4]Triazolo[1,5-A]pyrimidine compounds as PDE2 inhibitors |
| TWI808958B (en) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | Combination therapy involving diaryl macrocyclic compounds |
| DK3658557T3 (en) | 2017-07-28 | 2024-07-29 | Takeda Pharmaceuticals Co | TYK2 INHIBITORS AND USES THEREOF |
| RS65884B1 (en) | 2017-07-28 | 2024-09-30 | Turning Point Therapeutics Inc | Macrocyclic compounds and uses thereof |
| JP7321183B2 (en) * | 2017-12-15 | 2023-08-04 | ピラミッド バイオサイエンシズ インコーポレイテッド | 5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(1H-pyrazol-1-yl)pyrazolo[1,5] as TRK kinase inhibitors for treating cancer -A] pyrimidine derivatives and related compounds |
| CN111511746B (en) | 2017-12-19 | 2024-01-09 | 特普医药公司 | Macrocyclic compounds for the treatment of diseases |
| EP3730492A4 (en) * | 2017-12-22 | 2021-08-11 | Shenzhen TargetRx, Inc. | Substituted pyrazolo[1,5-a]pyrimidine compound and pharmaceutical composition and use thereof |
| JP7162915B2 (en) | 2018-01-23 | 2022-10-31 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | Substituted pyrazolo[1,5-a]pyrimidine macrocycles |
| JP2022503932A (en) * | 2018-09-27 | 2022-01-12 | フォチョン・ファーマシューティカルズ・リミテッド | Substituted imidazole [1,2-A] pyridine and [1,2,4] triazolo [1,5-A] pyridine compounds as RET kinase inhibitors |
| WO2020081508A1 (en) * | 2018-10-15 | 2020-04-23 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| WO2021216441A1 (en) | 2020-04-21 | 2021-10-28 | Lexicon Pharmaceuticals, Inc. | Aak1 inhibitors for use in treating viral infections |
| WO2021216454A1 (en) * | 2020-04-21 | 2021-10-28 | Lexicon Pharmaceuticals, Inc. | 4-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine for use in the the treatment of cov-229e or cov-oc43 coronaviruses infections |
| US11478733B2 (en) | 2020-11-24 | 2022-10-25 | Caterpillar Inc. | Filter interlock with tabs mating with a pedestal or a housing |
| WO2025054448A1 (en) * | 2023-09-08 | 2025-03-13 | Satellos Bioscience Inc. | Ap2 associated kinase 1 inhibitors and uses thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US6194410B1 (en) * | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
| JP4847275B2 (en) * | 2005-10-21 | 2011-12-28 | 田辺三菱製薬株式会社 | Pyrazolo [1,5-a] pyrimidine compounds |
| KR20090073121A (en) | 2006-09-29 | 2009-07-02 | 노파르티스 아게 | Pyrazolopyrimidines as PI3 'Lipid Kinase Inhibitors |
| US20120058997A1 (en) * | 2006-11-06 | 2012-03-08 | Supergen, Inc. | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
| KR101324804B1 (en) * | 2008-05-13 | 2013-11-01 | 아이알엠 엘엘씨 | Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors |
| SI2350071T1 (en) * | 2008-10-22 | 2014-05-30 | Array Biopharma, Inc. | SUBSTITUTED PYRAZOLOŠ1,5-aĆPYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS |
| AR077468A1 (en) * | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS |
| WO2011029027A1 (en) | 2009-09-03 | 2011-03-10 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS |
| WO2011087999A1 (en) | 2010-01-14 | 2011-07-21 | Merck Sharp & Dohme Corp. | Pyrazolo[1,5-a]pyrimidines as mark inhibitors |
| US9416132B2 (en) * | 2011-07-21 | 2016-08-16 | Tolero Pharmaceuticals, Inc. | Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors |
| BR112014022000A8 (en) | 2012-03-09 | 2021-06-15 | Lexicon Pharmaceuticals Inc | pyrazol[1,5-a]pyrimidine-based compounds, their use and compositions comprising them |
| EP2822555B1 (en) * | 2012-03-09 | 2017-11-08 | Lexicon Pharmaceuticals, Inc. | Inhibition of adaptor associated kinase 1 for the treatment of pain |
| NZ630719A (en) | 2012-03-09 | 2017-01-27 | Lexicon Pharmaceuticals Inc | Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof |
| TW201620911A (en) * | 2014-03-17 | 2016-06-16 | 雷西肯製藥股份有限公司 | Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use |
-
2013
- 2013-03-05 BR BR112014022000A patent/BR112014022000A8/en not_active Application Discontinuation
- 2013-03-05 IN IN7384DEN2014 patent/IN2014DN07384A/en unknown
- 2013-03-05 TR TR2018/08280T patent/TR201808280T4/en unknown
- 2013-03-05 ES ES13710250.5T patent/ES2676224T3/en active Active
- 2013-03-05 DK DK13710250.5T patent/DK2834243T3/en active
- 2013-03-05 US US13/785,355 patent/US8946415B2/en active Active
- 2013-03-05 PT PT137102505T patent/PT2834243T/en unknown
- 2013-03-05 JP JP2014561024A patent/JP6418950B2/en active Active
- 2013-03-05 AU AU2013230128A patent/AU2013230128B2/en active Active
- 2013-03-05 CA CA2866143A patent/CA2866143C/en active Active
- 2013-03-05 CN CN201380012483.0A patent/CN104302649B/en active Active
- 2013-03-05 HU HUE13710250A patent/HUE038786T2/en unknown
- 2013-03-05 EP EP13710250.5A patent/EP2834243B1/en active Active
- 2013-03-05 KR KR1020147028071A patent/KR101965025B1/en active Active
- 2013-03-05 WO PCT/US2013/029056 patent/WO2013134228A1/en active Application Filing
- 2013-03-05 MX MX2017002117A patent/MX381849B/en unknown
- 2013-03-05 NZ NZ630721A patent/NZ630721A/en unknown
- 2013-03-05 PL PL13710250T patent/PL2834243T3/en unknown
- 2013-03-05 MX MX2014010589A patent/MX345830B/en active IP Right Grant
- 2013-03-05 SG SG11201405561RA patent/SG11201405561RA/en unknown
- 2013-03-05 RU RU2014140735A patent/RU2014140735A/en not_active Application Discontinuation
- 2013-03-08 TW TW102108283A patent/TW201341386A/en unknown
- 2013-03-11 AR ARP130100765A patent/AR090292A1/en unknown
- 2013-03-11 UY UY0001034668A patent/UY34668A/en not_active Application Discontinuation
-
2014
- 2014-08-21 ZA ZA2014/06149A patent/ZA201406149B/en unknown
- 2014-09-07 IL IL234486A patent/IL234486A/en active IP Right Grant
- 2014-09-11 US US14/483,898 patent/US9403832B2/en active Active
-
2016
- 2016-07-12 US US15/207,677 patent/US20170129896A1/en not_active Abandoned
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