IN2014DN07384A - - Google Patents
Info
- Publication number
- IN2014DN07384A IN2014DN07384A IN7384DEN2014A IN2014DN07384A IN 2014DN07384 A IN2014DN07384 A IN 2014DN07384A IN 7384DEN2014 A IN7384DEN2014 A IN 7384DEN2014A IN 2014DN07384 A IN2014DN07384 A IN 2014DN07384A
- Authority
- IN
- India
- Prior art keywords
- compounds
- disclosed
- mediated
- pyrimidinebased
- pyrazolo
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Pyrazolo[l,5-a]pyrimidinebased compounds of the formula: are disclosed, wherein Ri, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261608765P | 2012-03-09 | 2012-03-09 | |
| PCT/US2013/029056 WO2013134228A1 (en) | 2012-03-09 | 2013-03-05 | PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN07384A true IN2014DN07384A (en) | 2015-04-24 |
Family
ID=47892052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN7384DEN2014 IN2014DN07384A (en) | 2012-03-09 | 2013-03-05 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US8946415B2 (en) |
| EP (1) | EP2834243B1 (en) |
| JP (1) | JP6418950B2 (en) |
| KR (1) | KR101965025B1 (en) |
| CN (1) | CN104302649B (en) |
| AR (1) | AR090292A1 (en) |
| AU (1) | AU2013230128B2 (en) |
| BR (1) | BR112014022000A8 (en) |
| CA (1) | CA2866143C (en) |
| DK (1) | DK2834243T3 (en) |
| ES (1) | ES2676224T3 (en) |
| HU (1) | HUE038786T2 (en) |
| IL (1) | IL234486A (en) |
| IN (1) | IN2014DN07384A (en) |
| MX (2) | MX345830B (en) |
| NZ (1) | NZ630721A (en) |
| PL (1) | PL2834243T3 (en) |
| PT (1) | PT2834243T (en) |
| RU (1) | RU2014140735A (en) |
| SG (1) | SG11201405561RA (en) |
| TR (1) | TR201808280T4 (en) |
| TW (1) | TW201341386A (en) |
| UY (1) | UY34668A (en) |
| WO (1) | WO2013134228A1 (en) |
| ZA (1) | ZA201406149B (en) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8969565B2 (en) | 2012-03-09 | 2015-03-03 | Lexicon Pharmaceuticals, Inc. | Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use |
| CN104302649B (en) | 2012-03-09 | 2017-06-23 | 莱西肯医药有限公司 | Compound based on pyrazolo [1,5 a] pyrimidine, comprising their compositions and its application method |
| US8901305B2 (en) | 2012-07-31 | 2014-12-02 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| WO2014130258A1 (en) | 2013-02-22 | 2014-08-28 | Bristol-Myers Squibb Company | 5h-chromeno[3,4-c]pyridines as inhibitors of adaptor associated kinase 1 (aak1) |
| TW201542550A (en) * | 2013-09-06 | 2015-11-16 | Lexicon Pharmaceuticals Inc | Pyrazolo[1,5-a]pyrimidinyl compound, composition comprising the same, and method of using the same |
| JP6473146B2 (en) | 2013-10-11 | 2019-02-20 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Pyrrolotriazine kinase inhibitor |
| HRP20191283T1 (en) | 2014-01-24 | 2019-10-18 | Turning Point Therapeutics, Inc. | DIARYL MACROCYCLES AS PROTEIN KINAZE MODULATORS |
| EA201691397A1 (en) * | 2014-01-31 | 2016-11-30 | Бристол-Майерс Сквибб Компани | QUINOLINE KINASE INHIBITORS |
| TW201620911A (en) * | 2014-03-17 | 2016-06-16 | 雷西肯製藥股份有限公司 | Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use |
| US20170239249A1 (en) * | 2014-09-30 | 2017-08-24 | Bristol-Myers Squibb Company | Quinazoline-based kinase inhibitors |
| CN107207514B (en) * | 2014-12-15 | 2020-01-24 | 康联制药有限公司 | Fused ring heteroaryl compounds and their use as TRK inhibitors |
| US10174044B2 (en) | 2015-04-10 | 2019-01-08 | Bristol-Myers Squibb Company | Fused pyridines as kinase inhibitors |
| AU2016287568B2 (en) | 2015-07-02 | 2020-08-20 | Turning Point Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
| EP4397665A3 (en) | 2015-07-06 | 2024-08-21 | Turning Point Therapeutics, Inc. | Diaryl macrocycle polymorph |
| DK3325488T3 (en) | 2015-07-21 | 2020-09-14 | Turning Point Therapeutics Inc | Chiral diaryl macrocycle and its use in the treatment of cancer |
| ES2765738T3 (en) * | 2015-11-02 | 2020-06-10 | Janssen Pharmaceutica Nv | [1,2,4] Triazolo [1,5-a] pyrimidin-7-yl compound |
| TW201815799A (en) | 2016-07-28 | 2018-05-01 | 美商Ｔｐ生物醫藥公司 | Macrocycle kinase inhibitors |
| EP3535269B1 (en) | 2016-11-02 | 2020-12-09 | Janssen Pharmaceutica NV | [1,2,4]triazolo[1,5-a]pyrimidine compounds as pde2 inhibitors |
| KR20190067788A (en) | 2016-11-02 | 2019-06-17 | 얀센 파마슈티카 엔.브이. | [1,2,4] triazolo [1,5-A] pyrimidine compound as a PDE2 inhibitor |
| UA125302C2 (en) | 2016-11-02 | 2022-02-16 | Янссен Фармацевтика Нв | DERIVATIVES [1,2,4] TRIAZOLO [1,5-A] PYRIMIDINE AS PDE2 INHIBITORS |
| TWI808958B (en) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | Combination therapy involving diaryl macrocyclic compounds |
| BR112020001695A2 (en) | 2017-07-28 | 2020-07-21 | Turning Point Therapeutics, Inc. | macrocyclic compounds and their uses |
| JP7216705B2 (en) | 2017-07-28 | 2023-02-02 | ニンバス ラクシュミ， インコーポレイテッド | TYK2 inhibitors and methods of use thereof |
| PL3724191T3 (en) * | 2017-12-15 | 2022-04-25 | Pyramid Biosciences, Inc. | 5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(1h-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer |
| CN111511746B (en) | 2017-12-19 | 2024-01-09 | 特普医药公司 | Macrocyclic compounds for the treatment of diseases |
| WO2019120194A1 (en) | 2017-12-22 | 2019-06-27 | 深圳市塔吉瑞生物医药有限公司 | Substituted pyrazolo[1,5-a]pyrimidine compound and pharmaceutical composition and use thereof |
| EP3744723B1 (en) | 2018-01-23 | 2023-10-18 | Shenzhen TargetRx, Inc. | Substituted pyrazolo[1,5-a]pyrimidine macrocyclic compound |
| CN112771047A (en) * | 2018-09-27 | 2021-05-07 | 重庆复创医药研究有限公司 | Substituted imidazo [1,2-a ] pyridine and [1,2,4] triazolo [1,5-a ] pyridine compounds as RET kinase inhibitors |
| US11414431B2 (en) * | 2018-10-15 | 2022-08-16 | Nimbus Lakshmi, Inc. | Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors |
| US11730723B2 (en) | 2020-04-21 | 2023-08-22 | Lexicon Pharmaceuticals, Inc. | Compounds and methods for treating viral infections |
| CN115427045A (en) * | 2020-04-21 | 2022-12-02 | 莱西肯医药有限公司 | 4- (3- (pyridin-3-yl) pyrazolo [1,5-a ] pyrimidin-5-yl) piperazine for the treatment of COV-229E or COV-OC43 coronavirus infection |
| US11478733B2 (en) | 2020-11-24 | 2022-10-25 | Caterpillar Inc. | Filter interlock with tabs mating with a pedestal or a housing |
| US20250122207A1 (en) * | 2023-09-08 | 2025-04-17 | Satellos Bioscience Inc. | Ap2 associated kinase 1 inhibitors and uses thereof |
| WO2025230262A1 (en) * | 2024-04-29 | 2025-11-06 | 심플렉스 주식회사 | Novel heteroaryl derivatives and use thereof in inhibiting aak1 |
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| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US6194410B1 (en) * | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
| JP4847275B2 (en) * | 2005-10-21 | 2011-12-28 | 田辺三菱製薬株式会社 | Pyrazolo [1,5-a] pyrimidine compounds |
| RU2009115954A (en) | 2006-09-29 | 2010-11-10 | Новартис АГ (CH) | Pyrazolopyrimidines as P13K Lipid Kinase Inhibitors |
| US20120058997A1 (en) * | 2006-11-06 | 2012-03-08 | Supergen, Inc. | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
| EA019507B1 (en) * | 2008-05-13 | 2014-04-30 | Айрм Ллк | Fused nitrogen containing heterocycles and compounds thereof as kinase inhibitors |
| PT3106463T (en) * | 2008-10-22 | 2018-05-18 | Array Biopharma Inc | Substituted pyrazolo[1,5-]pyrimidine compounds as trk kinase inhibitors |
| AR077468A1 (en) * | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS |
| WO2011029027A1 (en) | 2009-09-03 | 2011-03-10 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS |
| WO2011087999A1 (en) * | 2010-01-14 | 2011-07-21 | Merck Sharp & Dohme Corp. | Pyrazolo[1,5-a]pyrimidines as mark inhibitors |
| PL3409278T3 (en) * | 2011-07-21 | 2021-02-22 | Sumitomo Pharma Oncology, Inc. | Heterocyclic protein kinase inhibitors |
| HUE036040T2 (en) * | 2012-03-09 | 2018-06-28 | Lexicon Pharmaceuticals Inc | Inhibition of adaptor associated kinase 1 for the treatment of pain |
| CN104302649B (en) | 2012-03-09 | 2017-06-23 | 莱西肯医药有限公司 | Compound based on pyrazolo [1,5 a] pyrimidine, comprising their compositions and its application method |
| US8969565B2 (en) | 2012-03-09 | 2015-03-03 | Lexicon Pharmaceuticals, Inc. | Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use |
| TW201620911A (en) * | 2014-03-17 | 2016-06-16 | 雷西肯製藥股份有限公司 | Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use |
-
2013
- 2013-03-05 CN CN201380012483.0A patent/CN104302649B/en active Active
- 2013-03-05 NZ NZ630721A patent/NZ630721A/en unknown
- 2013-03-05 MX MX2014010589A patent/MX345830B/en active IP Right Grant
- 2013-03-05 PL PL13710250T patent/PL2834243T3/en unknown
- 2013-03-05 TR TR2018/08280T patent/TR201808280T4/en unknown
- 2013-03-05 US US13/785,355 patent/US8946415B2/en active Active
- 2013-03-05 JP JP2014561024A patent/JP6418950B2/en active Active
- 2013-03-05 DK DK13710250.5T patent/DK2834243T3/en active
- 2013-03-05 PT PT137102505T patent/PT2834243T/en unknown
- 2013-03-05 MX MX2017002117A patent/MX381849B/en unknown
- 2013-03-05 KR KR1020147028071A patent/KR101965025B1/en active Active
- 2013-03-05 EP EP13710250.5A patent/EP2834243B1/en active Active
- 2013-03-05 IN IN7384DEN2014 patent/IN2014DN07384A/en unknown
- 2013-03-05 SG SG11201405561RA patent/SG11201405561RA/en unknown
- 2013-03-05 CA CA2866143A patent/CA2866143C/en active Active
- 2013-03-05 AU AU2013230128A patent/AU2013230128B2/en active Active
- 2013-03-05 BR BR112014022000A patent/BR112014022000A8/en not_active Application Discontinuation
- 2013-03-05 ES ES13710250.5T patent/ES2676224T3/en active Active
- 2013-03-05 WO PCT/US2013/029056 patent/WO2013134228A1/en not_active Ceased
- 2013-03-05 HU HUE13710250A patent/HUE038786T2/en unknown
- 2013-03-05 RU RU2014140735A patent/RU2014140735A/en not_active Application Discontinuation
- 2013-03-08 TW TW102108283A patent/TW201341386A/en unknown
- 2013-03-11 AR ARP130100765A patent/AR090292A1/en unknown
- 2013-03-11 UY UY0001034668A patent/UY34668A/en not_active Application Discontinuation
-
2014
- 2014-08-21 ZA ZA2014/06149A patent/ZA201406149B/en unknown
- 2014-09-07 IL IL234486A patent/IL234486A/en active IP Right Grant
- 2014-09-11 US US14/483,898 patent/US9403832B2/en active Active
-
2016
- 2016-07-12 US US15/207,677 patent/US20170129896A1/en not_active Abandoned
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