TR199802091T2 - Alfa-17 ikame/ katkilama maddesi içermeyen yeni pregnan türevleri. - Google Patents

Alfa-17 ikame/ katkilama maddesi içermeyen yeni pregnan türevleri.

Info

Publication number
TR199802091T2
TR199802091T2 TR1998/02091T TR9802091T TR199802091T2 TR 199802091 T2 TR199802091 T2 TR 199802091T2 TR 1998/02091 T TR1998/02091 T TR 1998/02091T TR 9802091 T TR9802091 T TR 9802091T TR 199802091 T2 TR199802091 T2 TR 199802091T2
Authority
TR
Turkey
Prior art keywords
pregnan
substituents
alpha
additives
new derivatives
Prior art date
Application number
TR1998/02091T
Other languages
English (en)
Inventor
Bhatnagar Neerja
Claussner Andr
Marchandeau Christian
Resche Rigon Mich�Le
Georges Teutsch Jean-
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Publication of TR199802091T2 publication Critical patent/TR199802091T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Bu bulusun konusu formül (I)' i havi bilesikler, burada ya R1 halojen, hidroksil, (C1-C8) alkiloksi veya (C1-C12) asiloksiyi temsil eder, ve R2 de halojen veya hidrojeni temsil eder; yahut da R1 ve R2 birlikte bir çift bag meydana getirir, Z opsiyonel olarak ikame edilen/ katkilanan (C1-C8) alkiltio, opsiyonel olarak ikame edilen/ katkilanan ariltio, (C1-C8) alkiloksi, halojen, siyano, merkapto, tiosiyanato ve (CH2)0-1- CO2H' i temsil eder ve bunlar da opsiyonel olarak ikame edilebilir/ katkilanabilir, Y hidrojeni veya metili temsil eder, 1-2 veya 5-6 pozisyonundaki noktali çizgiler opsiyonel olarak bir ikinci bagi temsil eder, ve de bunlarin hazirlanmasina yönelik proses, bu prosesin ara maddeleri ve bunlari ihtiva eden farmasötik kompozisyonlardir.
TR1998/02091T 1996-04-18 1997-04-17 Alfa-17 ikame/ katkilama maddesi içermeyen yeni pregnan türevleri. TR199802091T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9604845A FR2747680B1 (fr) 1996-04-18 1996-04-18 Nouveaux steroides, leur application a titre de medicaments, leur procede de preparation, les intermediaires de ce procede et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
TR199802091T2 true TR199802091T2 (tr) 2000-09-21

Family

ID=9491327

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/02091T TR199802091T2 (tr) 1996-04-18 1997-04-17 Alfa-17 ikame/ katkilama maddesi içermeyen yeni pregnan türevleri.

Country Status (24)

Country Link
US (2) US6274572B1 (tr)
EP (1) EP0898579B1 (tr)
JP (1) JP2000508333A (tr)
KR (1) KR100450854B1 (tr)
CN (1) CN1144813C (tr)
AR (1) AR006706A1 (tr)
AT (1) ATE189896T1 (tr)
AU (1) AU721347B2 (tr)
BR (1) BR9708696A (tr)
CA (1) CA2251642A1 (tr)
CZ (1) CZ293156B6 (tr)
DE (1) DE69701328T2 (tr)
ES (1) ES2143306T3 (tr)
FR (1) FR2747680B1 (tr)
GR (1) GR3033249T3 (tr)
IL (1) IL126539A (tr)
NO (1) NO312035B1 (tr)
PL (1) PL186414B1 (tr)
PT (1) PT898579E (tr)
RU (1) RU2177951C2 (tr)
TR (1) TR199802091T2 (tr)
TW (1) TW386085B (tr)
WO (1) WO1997039018A1 (tr)
ZA (1) ZA973289B (tr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0984782A2 (en) * 1997-06-04 2000-03-15 Akzo Nobel N.V. Use of anti-inflammatory steroids for the treatment of chronic inflammatory intestinal diseases
US20030069215A1 (en) * 2001-03-30 2003-04-10 The Government Of The United States Of America, Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate
DE60121928T2 (de) * 2000-03-31 2007-03-01 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Verfahren zur herstellung von den trans-4-n-butylcyclohexanoicsaüre- und undecanoicsaüreestern von (7-alpha,11-beta)-dimethyl-17 beta -hydroxy-4-estren-3-one und deren medizynische anwendung
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
KR101591482B1 (ko) * 2008-05-28 2016-02-03 레베라겐 바이오파마 인코포레이티드 질환의 치료를 위한 ＮＦ-κＢ 의 비호르몬성 스테로이드 조절제
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
CN107365342B (zh) * 2017-07-17 2019-08-06 苏州博源医疗科技有限公司 醛固酮衍生物、免疫原、及合成方法、特异性抗体和检测试剂及制备方法、试剂盒
CN107973836B (zh) * 2017-10-19 2020-05-12 苏州博源医疗科技有限公司 醛固酮衍生物及其制备方法、醛固酮均相酶免疫检测试剂
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2837544A (en) * 1957-03-25 1958-06-03 Olin Mathieson Synthesis of steroids
DE1169444B (de) * 1961-02-22 1964-05-06 Schering Ag Verfahren zur Herstellung von ?-16ª‡-Methylsteroiden
FR7605M (tr) * 1968-04-23 1970-01-19
JPS615093A (ja) * 1984-06-15 1986-01-10 Mitsubishi Chem Ind Ltd 新規な２１位シアノ化コルチコイド誘導体およびその製法
US5223493A (en) * 1984-12-28 1993-06-29 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
WO1987001706A2 (en) * 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
JPS63303994A (ja) * 1987-06-04 1988-12-12 Taisho Pharmaceut Co Ltd ２１−置換チオステロイド化合物
US4968822A (en) * 1987-12-11 1990-11-06 Taisho Pharmaceutical Co., Ltd. 21-alkoxysteroid compounds
US5420120A (en) * 1993-12-17 1995-05-30 Alcon Laboratories, Inc. Anti-inflammatory glucocorticoid compounds for topical ophthalmic use

Also Published As

Publication number Publication date
FR2747680A1 (fr) 1997-10-24
WO1997039018A1 (fr) 1997-10-23
PL329387A1 (en) 1999-03-29
NO312035B1 (no) 2002-03-04
CZ332398A3 (cs) 1999-11-17
JP2000508333A (ja) 2000-07-04
IL126539A (en) 2003-07-06
AR006706A1 (es) 1999-09-08
AU721347B2 (en) 2000-06-29
TW386085B (en) 2000-04-01
ATE189896T1 (de) 2000-03-15
CN1222160A (zh) 1999-07-07
DE69701328D1 (de) 2000-03-30
CA2251642A1 (fr) 1997-10-23
EP0898579A1 (fr) 1999-03-03
US6274572B1 (en) 2001-08-14
US6492536B2 (en) 2002-12-10
KR100450854B1 (ko) 2004-12-16
DE69701328T2 (de) 2000-08-24
RU2177951C2 (ru) 2002-01-10
CN1144813C (zh) 2004-04-07
NO984858L (no) 1998-10-16
BR9708696A (pt) 1999-08-03
IL126539A0 (en) 1999-08-17
AU2703297A (en) 1997-11-07
CZ293156B6 (cs) 2004-02-18
KR20000005546A (ko) 2000-01-25
PL186414B1 (pl) 2004-01-30
PT898579E (pt) 2000-07-31
FR2747680B1 (fr) 1998-07-03
NO984858D0 (no) 1998-10-16
EP0898579B1 (fr) 2000-02-23
GR3033249T3 (en) 2000-09-29
ZA973289B (en) 1998-04-17
US20020002155A1 (en) 2002-01-03
ES2143306T3 (es) 2000-05-01

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