IL126539A - Pregnane derivatives with no alpha-17 substituent, their medicinal use and manufacturing method - Google Patents

Pregnane derivatives with no alpha-17 substituent, their medicinal use and manufacturing method

Info

Publication number
IL126539A
IL126539A IL12653997A IL12653997A IL126539A IL 126539 A IL126539 A IL 126539A IL 12653997 A IL12653997 A IL 12653997A IL 12653997 A IL12653997 A IL 12653997A IL 126539 A IL126539 A IL 126539A
Authority
IL
Israel
Prior art keywords
substituent
alpha
manufacturing
medicinal use
pregnane derivatives
Prior art date
Application number
IL12653997A
Other languages
English (en)
Other versions
IL126539A0 (en
Inventor
Neeria Bhatnagar
Andre Claussner
Christian Marchandeau
Michele Resche Rigon
Jean-Georges Teutsch
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Priority to IL15327097A priority Critical patent/IL153270A0/xx
Publication of IL126539A0 publication Critical patent/IL126539A0/xx
Publication of IL126539A publication Critical patent/IL126539A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL12653997A 1996-04-18 1997-04-17 Pregnane derivatives with no alpha-17 substituent, their medicinal use and manufacturing method IL126539A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL15327097A IL153270A0 (en) 1996-04-18 1997-04-17 Intermediates of a process for preparing new steroids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9604845A FR2747680B1 (fr) 1996-04-18 1996-04-18 Nouveaux steroides, leur application a titre de medicaments, leur procede de preparation, les intermediaires de ce procede et les compositions pharmaceutiques les renfermant
PCT/FR1997/000693 WO1997039018A1 (fr) 1996-04-18 1997-04-17 Nouveaux derives de pregnane sans substituent en position 17-alpha-, leur application a titre de medicament, leur procede de preparation, les intermediaires de ce procede et les compositions les contenant

Publications (2)

Publication Number Publication Date
IL126539A0 IL126539A0 (en) 1999-08-17
IL126539A true IL126539A (en) 2003-07-06

Family

ID=9491327

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12653997A IL126539A (en) 1996-04-18 1997-04-17 Pregnane derivatives with no alpha-17 substituent, their medicinal use and manufacturing method

Country Status (24)

Country Link
US (2) US6274572B1 (tr)
EP (1) EP0898579B1 (tr)
JP (1) JP2000508333A (tr)
KR (1) KR100450854B1 (tr)
CN (1) CN1144813C (tr)
AR (1) AR006706A1 (tr)
AT (1) ATE189896T1 (tr)
AU (1) AU721347B2 (tr)
BR (1) BR9708696A (tr)
CA (1) CA2251642A1 (tr)
CZ (1) CZ293156B6 (tr)
DE (1) DE69701328T2 (tr)
ES (1) ES2143306T3 (tr)
FR (1) FR2747680B1 (tr)
GR (1) GR3033249T3 (tr)
IL (1) IL126539A (tr)
NO (1) NO312035B1 (tr)
PL (1) PL186414B1 (tr)
PT (1) PT898579E (tr)
RU (1) RU2177951C2 (tr)
TR (1) TR199802091T2 (tr)
TW (1) TW386085B (tr)
WO (1) WO1997039018A1 (tr)
ZA (1) ZA973289B (tr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL337458A1 (en) * 1997-06-04 2000-08-14 Akzo Nobel Nv Application of anti-inflammatory steroids in treating chronic intestinal inflammatory diseases
AU4966101A (en) * 2000-03-31 2001-10-15 Us Gov Health & Human Serv Methods of making and using 7alpha,11beta-dimethyl-17beta-hydroxy-4-estren-3-one17beta-trans-4-m-butylcyclohexane carboxylate and 7alpha,11beta-dimethyl-17beta -hydroxyestr-4-en-3-one 17-undecanoate
US20030069215A1 (en) * 2001-03-30 2003-04-10 The Government Of The United States Of America, Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
KR101591482B1 (ko) 2008-05-28 2016-02-03 레베라겐 바이오파마 인코포레이티드 질환의 치료를 위한 ＮＦ-κＢ 의 비호르몬성 스테로이드 조절제
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
CN107365342B (zh) * 2017-07-17 2019-08-06 苏州博源医疗科技有限公司 醛固酮衍生物、免疫原、及合成方法、特异性抗体和检测试剂及制备方法、试剂盒
CN107973836B (zh) * 2017-10-19 2020-05-12 苏州博源医疗科技有限公司 醛固酮衍生物及其制备方法、醛固酮均相酶免疫检测试剂
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2837544A (en) * 1957-03-25 1958-06-03 Olin Mathieson Synthesis of steroids
DE1169444B (de) * 1961-02-22 1964-05-06 Schering Ag Verfahren zur Herstellung von ?-16ª‡-Methylsteroiden
FR7605M (tr) * 1968-04-23 1970-01-19
JPS615093A (ja) * 1984-06-15 1986-01-10 Mitsubishi Chem Ind Ltd 新規な２１位シアノ化コルチコイド誘導体およびその製法
US5223493A (en) * 1984-12-28 1993-06-29 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
WO1987001706A2 (en) * 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
JPS63303994A (ja) * 1987-06-04 1988-12-12 Taisho Pharmaceut Co Ltd ２１−置換チオステロイド化合物
US4968822A (en) * 1987-12-11 1990-11-06 Taisho Pharmaceutical Co., Ltd. 21-alkoxysteroid compounds
US5420120A (en) * 1993-12-17 1995-05-30 Alcon Laboratories, Inc. Anti-inflammatory glucocorticoid compounds for topical ophthalmic use

Also Published As

Publication number Publication date
CZ293156B6 (cs) 2004-02-18
CZ332398A3 (cs) 1999-11-17
AU721347B2 (en) 2000-06-29
PT898579E (pt) 2000-07-31
CN1144813C (zh) 2004-04-07
CN1222160A (zh) 1999-07-07
FR2747680B1 (fr) 1998-07-03
ES2143306T3 (es) 2000-05-01
KR100450854B1 (ko) 2004-12-16
RU2177951C2 (ru) 2002-01-10
BR9708696A (pt) 1999-08-03
JP2000508333A (ja) 2000-07-04
TR199802091T2 (tr) 2000-09-21
AU2703297A (en) 1997-11-07
WO1997039018A1 (fr) 1997-10-23
TW386085B (en) 2000-04-01
US6274572B1 (en) 2001-08-14
PL186414B1 (pl) 2004-01-30
CA2251642A1 (fr) 1997-10-23
KR20000005546A (ko) 2000-01-25
FR2747680A1 (fr) 1997-10-24
ZA973289B (en) 1998-04-17
EP0898579B1 (fr) 2000-02-23
GR3033249T3 (en) 2000-09-29
NO984858D0 (no) 1998-10-16
DE69701328D1 (de) 2000-03-30
AR006706A1 (es) 1999-09-08
NO312035B1 (no) 2002-03-04
NO984858L (no) 1998-10-16
DE69701328T2 (de) 2000-08-24
US20020002155A1 (en) 2002-01-03
ATE189896T1 (de) 2000-03-15
US6492536B2 (en) 2002-12-10
IL126539A0 (en) 1999-08-17
EP0898579A1 (fr) 1999-03-03
PL329387A1 (en) 1999-03-29

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees