TR199801432A2 - Rasemizasyona karsi stabilize edilmis farmakolojik silansetron karisimlari. - Google Patents
Rasemizasyona karsi stabilize edilmis farmakolojik silansetron karisimlari.Info
- Publication number
- TR199801432A2 TR199801432A2 TR1998/01432A TR9801432A TR199801432A2 TR 199801432 A2 TR199801432 A2 TR 199801432A2 TR 1998/01432 A TR1998/01432 A TR 1998/01432A TR 9801432 A TR9801432 A TR 9801432A TR 199801432 A2 TR199801432 A2 TR 199801432A2
- Authority
- TR
- Turkey
- Prior art keywords
- silansetron
- minus
- salts
- pharmacological
- cilansetron
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Silansetron veya onun asit katki tuzlari, etken madde içeren kati veya sivi farmakolojik karisim olarak tanimlanmaktadir, ki bunlar rasemizasyona karsi silansetronun strabilizasyonu için, 2 ila 12'ye kadar karbon atomlu ve 1,1 ile 4,8 arasinda bir birinci pKs degerli, belirtilen çok bazli organik asitlerin eksi tuzlari ve 1,5 ile 7,5 arasinda hazir bir birinci pKs - degerli çok bazli maden asitlerin eksi tuzlari ile bir veya çok bazli organik asitlerden seçilmis fizyolojik olarak uyumlu suda çözünür eksi bir katki maddesinin yeter miktarini içermektedir. Bunun disinda,rasemizasyona karsi silansetronun stabilizasyonu için eksi katki maddelerinin farmakolojik karisimlarda kullanimi tarif edilmektedir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19733271 | 1997-08-01 | ||
DE19813661A DE19813661A1 (de) | 1997-08-01 | 1998-03-27 | Gegen Racemisierung stabilisierte pharmazeutische Zubereitungen von Cilansetron |
Publications (2)
Publication Number | Publication Date |
---|---|
TR199801432A2 true TR199801432A2 (tr) | 1999-02-22 |
TR199801432A3 TR199801432A3 (tr) | 1999-02-22 |
Family
ID=7837672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1998/01432A TR199801432A3 (tr) | 1997-08-01 | 1998-07-23 | Rasemizasyona karsi stabilize edilmis farmakolojik silansetron karisimlari. |
Country Status (29)
Country | Link |
---|---|
US (1) | US5977127A (tr) |
EP (1) | EP0895782B1 (tr) |
JP (1) | JP4324260B2 (tr) |
KR (1) | KR100515201B1 (tr) |
CN (1) | CN1117565C (tr) |
AR (1) | AR010178A1 (tr) |
AT (1) | ATE283706T1 (tr) |
AU (1) | AU743043B2 (tr) |
BR (1) | BR9803730A (tr) |
CA (1) | CA2244389C (tr) |
CZ (1) | CZ295072B6 (tr) |
DE (2) | DE19813661A1 (tr) |
DK (1) | DK0895782T3 (tr) |
DZ (1) | DZ2560A1 (tr) |
ES (1) | ES2234051T3 (tr) |
HK (1) | HK1017611A1 (tr) |
HU (1) | HUP9801712A3 (tr) |
ID (1) | ID20685A (tr) |
IL (1) | IL125403A (tr) |
NO (1) | NO323229B1 (tr) |
NZ (1) | NZ331083A (tr) |
PL (1) | PL191767B1 (tr) |
PT (1) | PT895782E (tr) |
RU (1) | RU2199318C2 (tr) |
SK (1) | SK284916B6 (tr) |
TR (1) | TR199801432A3 (tr) |
TW (1) | TW509570B (tr) |
UA (1) | UA62924C2 (tr) |
ZA (1) | ZA986715B (tr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7452545B2 (en) * | 2001-11-13 | 2008-11-18 | Yu Ruey J | Oligosaccharide aldonic acids and their topical use |
CA2439097C (en) * | 2001-03-26 | 2010-10-12 | Novartis Ag | Pharmaceutical compositions |
US20040048874A1 (en) * | 2001-05-22 | 2004-03-11 | Bardsley Hazel Judith | New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine |
GB0216027D0 (en) * | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
EP1558081A4 (en) * | 2003-01-13 | 2006-06-14 | Dynogen Pharmaceuticals Inc | METHOD OF TREATING FUNCTIONAL INTESTINAL DISORDERS |
MXPA05007379A (es) * | 2003-01-13 | 2006-02-10 | Dynogen Pharmaceuticals Inc | Metodo para tratar nauseas, vomito, esfuerzo por vomitar o cualquier combinacion de los mismos. |
DE602004007225T2 (de) * | 2003-04-04 | 2008-03-06 | Dynogen Pharmaceuticals Inc., Waltham | Methode zur behandlung von erkrankungen der unteren harnwege |
US7820690B2 (en) * | 2004-03-19 | 2010-10-26 | Solvay Pharmaceuticals Gmbh | Method of treating or inhibiting a non-digestive tract derived abdominal disorder associated with pain using a 5-HT, receptor antagonist |
WO2006105117A2 (en) * | 2005-03-28 | 2006-10-05 | Dynogen Pharmaceuticals, Inc. | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors |
RU2011108420A (ru) | 2008-08-14 | 2012-09-20 | Киорин Фармасьютикал Ко., Лтд. (Jp) | Стабилизированный фармацевтический состав |
JPWO2021100728A1 (tr) | 2019-11-20 | 2021-05-27 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0297651B1 (en) * | 1987-06-29 | 1993-11-03 | Duphar International Research B.V | Anellated indole derivatives |
DE4238553A1 (de) * | 1992-11-14 | 1994-05-19 | Kali Chemie Pharma Gmbh | Neue Imidazol-1-yl-Verbindungen enthaltende Arzneimittel |
AU702594B2 (en) * | 1995-10-13 | 1999-02-25 | Duphar International Research B.V. | Process for the preparation of enantiomerically pure imidazolyl compounds |
-
1998
- 1998-03-27 DE DE19813661A patent/DE19813661A1/de not_active Withdrawn
- 1998-06-05 CN CN98109652A patent/CN1117565C/zh not_active Expired - Fee Related
- 1998-06-17 TW TW087109651A patent/TW509570B/zh not_active IP Right Cessation
- 1998-06-18 AR ARP980102904A patent/AR010178A1/es active IP Right Grant
- 1998-07-11 KR KR10-1998-0028014A patent/KR100515201B1/ko not_active IP Right Cessation
- 1998-07-15 DZ DZ980170A patent/DZ2560A1/xx active
- 1998-07-20 IL IL12540398A patent/IL125403A/en not_active IP Right Cessation
- 1998-07-22 EP EP98113643A patent/EP0895782B1/de not_active Expired - Lifetime
- 1998-07-22 PT PT98113643T patent/PT895782E/pt unknown
- 1998-07-22 AT AT98113643T patent/ATE283706T1/de active
- 1998-07-22 DK DK98113643T patent/DK0895782T3/da active
- 1998-07-22 DE DE59812317T patent/DE59812317D1/de not_active Expired - Lifetime
- 1998-07-22 ES ES98113643T patent/ES2234051T3/es not_active Expired - Lifetime
- 1998-07-23 TR TR1998/01432A patent/TR199801432A3/tr unknown
- 1998-07-24 SK SK1009-98A patent/SK284916B6/sk not_active IP Right Cessation
- 1998-07-24 NZ NZ331083A patent/NZ331083A/xx not_active IP Right Cessation
- 1998-07-27 CZ CZ19982367A patent/CZ295072B6/cs not_active IP Right Cessation
- 1998-07-28 ZA ZA986715A patent/ZA986715B/xx unknown
- 1998-07-29 RU RU98114668/14A patent/RU2199318C2/ru not_active IP Right Cessation
- 1998-07-29 HU HU9801712A patent/HUP9801712A3/hu unknown
- 1998-07-31 CA CA002244389A patent/CA2244389C/en not_active Expired - Fee Related
- 1998-07-31 NO NO19983540A patent/NO323229B1/no not_active IP Right Cessation
- 1998-07-31 JP JP21707598A patent/JP4324260B2/ja not_active Expired - Fee Related
- 1998-07-31 PL PL327786A patent/PL191767B1/pl not_active IP Right Cessation
- 1998-07-31 UA UA98074202A patent/UA62924C2/uk unknown
- 1998-07-31 BR BR9803730-7A patent/BR9803730A/pt not_active Application Discontinuation
- 1998-07-31 AU AU78630/98A patent/AU743043B2/en not_active Ceased
- 1998-07-31 US US09/126,751 patent/US5977127A/en not_active Expired - Lifetime
- 1998-08-03 ID IDP981075A patent/ID20685A/id unknown
-
1999
- 1999-06-30 HK HK99102775A patent/HK1017611A1/xx not_active IP Right Cessation
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