TR199800444A2 - Hipolipidemik 1,4-benzotiazepin-1,1-diyoksitler. - Google Patents
Hipolipidemik 1,4-benzotiazepin-1,1-diyoksitler.Info
- Publication number
- TR199800444A2 TR199800444A2 TR1998/00444A TR9800444A TR199800444A2 TR 199800444 A2 TR199800444 A2 TR 199800444A2 TR 1998/00444 A TR1998/00444 A TR 1998/00444A TR 9800444 A TR9800444 A TR 9800444A TR 199800444 A2 TR199800444 A2 TR 199800444A2
- Authority
- TR
- Turkey
- Prior art keywords
- hypolipidemic
- dioxytler
- benzothiazepine
- new
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/007—Vector systems having a special element relevant for transcription cell cycle specific enhancer/promoter combination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Isbu bulus yeni hipolipidemik bilesimler, yeni islemler ve bunlarin hazirlanmasi için yeni ara bilesimler, bunlari içeren farmakolojik terkipler ve tiptaki kullanimlari, özellikle profilaksis ve aterosklerosis gibi hiperlipidemik durumlarin tedavisi ile ilgilidir. Formül (I)'in bilesimleri: (I) . Burada R1'den R10'a kadar ve X tanimlandiklari gibidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97104348 | 1997-03-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
TR199800444A2 true TR199800444A2 (tr) | 1998-10-21 |
TR199800444A3 TR199800444A3 (tr) | 1998-10-21 |
Family
ID=8226598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1998/00444A TR199800444A3 (tr) | 1997-03-14 | 1998-03-12 | Hipolipidemik 1,4-benzotiazepin-1,1-diyoksitler. |
Country Status (23)
Country | Link |
---|---|
US (2) | US6020330A (tr) |
EP (1) | EP0864582B1 (tr) |
JP (1) | JP3282998B2 (tr) |
KR (1) | KR19980080223A (tr) |
CN (1) | CN1070484C (tr) |
AR (1) | AR011189A1 (tr) |
AT (1) | ATE242258T1 (tr) |
AU (1) | AU731575B2 (tr) |
BR (1) | BR9801126A (tr) |
CA (1) | CA2231971C (tr) |
CZ (1) | CZ75998A3 (tr) |
DE (1) | DE69815180T2 (tr) |
DK (1) | DK0864582T3 (tr) |
ES (1) | ES2198613T3 (tr) |
HU (1) | HUP9800541A3 (tr) |
ID (1) | ID20053A (tr) |
IL (1) | IL123648A (tr) |
NZ (1) | NZ329932A (tr) |
PL (1) | PL325363A1 (tr) |
PT (1) | PT864582E (tr) |
RU (1) | RU2179977C2 (tr) |
TR (1) | TR199800444A3 (tr) |
ZA (1) | ZA982140B (tr) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6262277B1 (en) * | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
EP0864582B1 (en) * | 1997-03-14 | 2003-06-04 | Aventis Pharma Deutschland GmbH | Hypolipidemic 1,4-benzothiazepine-1,-dioxides |
DE69907960T2 (de) | 1998-12-23 | 2004-02-26 | G.D. Searle Llc, Chicago | Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
DK1140185T3 (da) | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer |
DK1140190T3 (da) * | 1998-12-23 | 2002-12-23 | Searle Llc | Kombinationer af ileumgaldesyretransport-inhibitorer og galdesyre-sekvestreringsmidler til cardiovaskulære indikatorer |
PT1140187E (pt) * | 1998-12-23 | 2004-01-30 | Searle Llc | Combinacoes de um inibidor de ibat e de um inibidor de mtp para indicacoes cardiovasculares |
JP2002533408A (ja) | 1998-12-23 | 2002-10-08 | ジー.ディー.サール エルエルシー | 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤およびニコチン酸誘導体の組み合わせ |
MXPA01006469A (es) | 1998-12-23 | 2004-03-10 | Searle & Co | Combinaciones de inhibidores de proteina de transferencia de ester colesterilico y derivados de acido fibrico para indicaciones cardiovasculares. |
ES2200587T3 (es) * | 1998-12-23 | 2004-03-01 | G.D. Searle Llc | Combinaciones de inhibidors del transporte de acidos biliares del ileon e inhibidores de la proteina de transferencia de colesteril ester para indicaciones cardiovasculares. |
AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
DE19916108C1 (de) * | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
GB9914745D0 (en) * | 1999-06-24 | 1999-08-25 | Knoll Ag | Therapeutic agents |
SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
AU2001240115A1 (en) | 2000-03-10 | 2001-09-24 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
US20020061888A1 (en) * | 2000-03-10 | 2002-05-23 | Keller Bradley T. | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
US20020183307A1 (en) * | 2000-07-26 | 2002-12-05 | Tremont Samuel J. | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake |
EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
US20040077625A1 (en) * | 2001-07-25 | 2004-04-22 | Tremont Samuel J. | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake |
GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
RU2305681C2 (ru) | 2001-09-08 | 2007-09-10 | Астразенека Аб | Производные бензотиадиазепина, способ их получения (варианты) |
MXPA04003524A (es) * | 2001-11-02 | 2004-07-23 | Searle Llc | Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato. |
CA2471639A1 (en) | 2002-01-17 | 2003-07-31 | Pharmacia Corporation | Novel alkyl/aryl hydroxy or keto thiepines. |
GB0201850D0 (en) * | 2002-01-26 | 2002-03-13 | Astrazeneca Ab | Therapeutic treatment |
GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
US7312208B2 (en) | 2002-08-28 | 2007-12-25 | Asahi Kasei Pharma Corporation | Quaternary ammonium compounds |
GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
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KR102560954B1 (ko) | 2014-06-25 | 2023-07-31 | 이에이 파마 가부시키가이샤 | 고형 제제 및 그의 착색 방지 또는 착색 감소 방법 |
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WO2023203248A1 (en) | 2022-04-22 | 2023-10-26 | Albireo Ab | Subcutaneous administration of an asbt inhibitor |
WO2023237728A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
WO2024008766A1 (en) | 2022-07-05 | 2024-01-11 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
US20240173333A1 (en) | 2022-11-03 | 2024-05-30 | Albireo Ab | Treating Alagille Syndrome (ALGS) |
WO2024121434A1 (en) | 2022-12-09 | 2024-06-13 | Albireo Ab | Asbt inhibitors in the treatment of renal diseases |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9203347D0 (en) * | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
ES2113081T3 (es) * | 1992-11-09 | 1998-04-16 | Knoll Ag | 1,4-benzotiazepinas utiles como agentes neurologicos. |
ZA941003B (en) * | 1993-02-15 | 1995-08-14 | Wellcome Found | Hypolipidaemic compounds |
IL108634A0 (en) * | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
ZA956647B (en) * | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
EP0864582B1 (en) * | 1997-03-14 | 2003-06-04 | Aventis Pharma Deutschland GmbH | Hypolipidemic 1,4-benzothiazepine-1,-dioxides |
-
1998
- 1998-03-03 EP EP98103702A patent/EP0864582B1/en not_active Expired - Lifetime
- 1998-03-03 DK DK98103702T patent/DK0864582T3/da active
- 1998-03-03 DE DE69815180T patent/DE69815180T2/de not_active Expired - Lifetime
- 1998-03-03 ES ES98103702T patent/ES2198613T3/es not_active Expired - Lifetime
- 1998-03-03 PT PT98103702T patent/PT864582E/pt unknown
- 1998-03-03 AT AT98103702T patent/ATE242258T1/de active
- 1998-03-11 AR ARP980101096A patent/AR011189A1/es unknown
- 1998-03-12 ID IDP980360A patent/ID20053A/id unknown
- 1998-03-12 RU RU98104950/04A patent/RU2179977C2/ru not_active IP Right Cessation
- 1998-03-12 HU HU9800541A patent/HUP9800541A3/hu unknown
- 1998-03-12 NZ NZ329932A patent/NZ329932A/xx unknown
- 1998-03-12 CZ CZ98759A patent/CZ75998A3/cs unknown
- 1998-03-12 IL IL12364898A patent/IL123648A/xx not_active IP Right Cessation
- 1998-03-12 AU AU58349/98A patent/AU731575B2/en not_active Ceased
- 1998-03-12 CA CA002231971A patent/CA2231971C/en not_active Expired - Fee Related
- 1998-03-12 TR TR1998/00444A patent/TR199800444A3/tr unknown
- 1998-03-13 CN CN98108046A patent/CN1070484C/zh not_active Expired - Fee Related
- 1998-03-13 JP JP06266598A patent/JP3282998B2/ja not_active Expired - Fee Related
- 1998-03-13 BR BR9801126A patent/BR9801126A/pt not_active IP Right Cessation
- 1998-03-13 KR KR1019980008440A patent/KR19980080223A/ko not_active Application Discontinuation
- 1998-03-13 ZA ZA982140A patent/ZA982140B/xx unknown
- 1998-03-13 US US09/041,953 patent/US6020330A/en not_active Expired - Lifetime
- 1998-03-14 PL PL98325363A patent/PL325363A1/xx not_active Application Discontinuation
-
1999
- 1999-07-27 US US09/361,530 patent/US6114322A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AR011189A1 (es) | 2000-08-02 |
JP3282998B2 (ja) | 2002-05-20 |
PT864582E (pt) | 2003-10-31 |
US6020330A (en) | 2000-02-01 |
PL325363A1 (en) | 1998-09-28 |
US6114322A (en) | 2000-09-05 |
ZA982140B (en) | 1998-09-14 |
TR199800444A3 (tr) | 1998-10-21 |
DE69815180D1 (de) | 2003-07-10 |
EP0864582A3 (en) | 1998-10-21 |
AU5834998A (en) | 1998-09-17 |
BR9801126A (pt) | 2000-03-21 |
IL123648A (en) | 2000-11-21 |
JPH10279568A (ja) | 1998-10-20 |
HUP9800541A1 (hu) | 1999-06-28 |
ATE242258T1 (de) | 2003-06-15 |
NZ329932A (en) | 1999-01-28 |
CZ75998A3 (cs) | 1998-09-16 |
CN1194979A (zh) | 1998-10-07 |
CA2231971A1 (en) | 1998-09-14 |
ID20053A (id) | 1998-09-17 |
RU2179977C2 (ru) | 2002-02-27 |
EP0864582B1 (en) | 2003-06-04 |
EP0864582A2 (en) | 1998-09-16 |
AU731575B2 (en) | 2001-04-05 |
CN1070484C (zh) | 2001-09-05 |
KR19980080223A (ko) | 1998-11-25 |
HU9800541D0 (en) | 1998-05-28 |
IL123648A0 (en) | 1998-10-30 |
DK0864582T3 (da) | 2003-09-29 |
ES2198613T3 (es) | 2004-02-01 |
HUP9800541A3 (en) | 2000-08-28 |
CA2231971C (en) | 2008-05-20 |
DE69815180T2 (de) | 2004-04-29 |
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