TNSN05087A1 - Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates - Google Patents
Nouveau procede de synthese industriel du ranelate de strontium et de ses hydratesInfo
- Publication number
- TNSN05087A1 TNSN05087A1 TNP2005000087A TNSN05087A TNSN05087A1 TN SN05087 A1 TNSN05087 A1 TN SN05087A1 TN P2005000087 A TNP2005000087 A TN P2005000087A TN SN05087 A TNSN05087 A TN SN05087A TN SN05087 A1 TNSN05087 A1 TN SN05087A1
- Authority
- TN
- Tunisia
- Prior art keywords
- hydrates
- new process
- industrial synthesis
- strontium ranelate
- ranelate
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- ZHEZAQJNZMLYBA-UHFFFAOYSA-J distrontium;5-[bis(carboxylatomethyl)amino]-3-(carboxylatomethyl)-4-cyanothiophene-2-carboxylate;octahydrate Chemical compound O.O.O.O.O.O.O.O.[Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N ZHEZAQJNZMLYBA-UHFFFAOYSA-J 0.000 title abstract 2
- 150000004677 hydrates Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229940079488 strontium ranelate Drugs 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Inorganic Insulating Materials (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0211763A FR2844795B1 (fr) | 2002-09-24 | 2002-09-24 | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
| PCT/FR2003/002777 WO2004029036A1 (fr) | 2002-09-24 | 2003-09-22 | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN05087A1 true TNSN05087A1 (fr) | 2007-05-14 |
Family
ID=29415189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2005000087A TNSN05087A1 (fr) | 2002-09-24 | 2005-03-23 | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
Country Status (37)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1622630E (pt) * | 2003-05-07 | 2012-10-11 | Osteologix As | Combinações de estrôncio para a profilaxia/tratamento de patologias da cartilagem e/ou do osso |
| PT1534305E (pt) * | 2003-05-07 | 2007-02-28 | Osteologix As | Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis |
| US20080167513A1 (en) * | 2004-02-26 | 2008-07-10 | Osteologlx A/S | Strontium-Containing Compounds for Use in the Prevention or Treatment of Necrotic Bone Conditions |
| JP4954867B2 (ja) * | 2004-05-06 | 2012-06-20 | オステオロジックス エイ／エス | 有機金属塩類を製造するための高収率で迅速な合成法 |
| DK1768748T4 (da) | 2004-06-25 | 2019-06-11 | Mokwalo Spf S A | Sammensætninger omfattende strontium og vitamin D og anvendelser deraf |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| CN100538672C (zh) * | 2005-04-18 | 2009-09-09 | 索尼株式会社 | 控制设备和方法 |
| CN100391955C (zh) * | 2005-04-30 | 2008-06-04 | 河北医科大学 | 一种雷尼酸锶中间体的合成方法 |
| WO2007020527A2 (en) * | 2005-08-19 | 2007-02-22 | Glenmark Pharmaceuticals Limited | Process for the preparation of strontium ranelate |
| US20070292535A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating arthritic and or osteoporitic conditions |
| US20070292529A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating osteoporotic conditions |
| FR2921367B1 (fr) * | 2007-09-26 | 2009-10-30 | Servier Lab | Nouveau procede de synthese du ranelate de strontium et de ses hydrates |
| US20120123131A1 (en) * | 2008-08-22 | 2012-05-17 | Koilpillai Joseph Prabahar | Process for the preparation of strontium ranelate |
| HU228820B1 (en) | 2010-01-14 | 2013-05-28 | Richter Gedeon Nyrt | Process for the preparation of distrontium ranelate |
| WO2011110597A1 (de) | 2010-03-11 | 2011-09-15 | Azad Pharmaceutical Ingredients Ag | Verfahren zur herstellung von strontiumranelat |
| WO2011124992A1 (en) * | 2010-03-24 | 2011-10-13 | Actavis Group Ptc Ehf | Substantially pure strontium ranelate |
| US9301945B2 (en) | 2011-07-21 | 2016-04-05 | Emory University | Methods for treating inflammatory conditions and states, and cancers by antagonizing NF-κB activation |
| CN102321068B (zh) * | 2011-08-01 | 2013-01-23 | 山东铂源药业有限公司 | 一种雷奈酸锶的制备方法 |
| WO2013175270A1 (en) * | 2012-05-25 | 2013-11-28 | Fleming Laboratories Limited | Improved process for the preparation of strontium ranelate hydrates and new polymorphic form of monohydrate |
| EP2756841B1 (en) | 2013-01-21 | 2015-05-13 | Galenicum Health S.L. | Pharmaceutical compositions comprising an acid salt |
| CN103319454B (zh) * | 2013-06-14 | 2014-06-18 | 广东众生药业股份有限公司 | 一种高纯度雷尼酸四乙酯及其中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2651497B1 (fr) * | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| FR2749759B1 (fr) * | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR2844797B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
-
2002
- 2002-09-24 FR FR0211763A patent/FR2844795B1/fr not_active Expired - Fee Related
-
2003
- 2003-09-17 MY MYPI20033542A patent/MY134921A/en unknown
- 2003-09-22 GE GEAP20048761A patent/GEP20074215B/en unknown
- 2003-09-22 PT PT3292319T patent/PT1403266E/pt unknown
- 2003-09-22 HR HRP20050359AA patent/HRP20050359B1/hr not_active IP Right Cessation
- 2003-09-22 AU AU2003248281A patent/AU2003248281B2/en not_active Ceased
- 2003-09-22 DK DK03292319.5T patent/DK1403266T3/da active
- 2003-09-22 ES ES03292319.5T patent/ES2478620T3/es not_active Expired - Lifetime
- 2003-09-22 EP EP03292319.5A patent/EP1403266B1/fr not_active Expired - Lifetime
- 2003-09-22 ME MEP-2008-689A patent/ME00455B/me unknown
- 2003-09-22 JP JP2003330440A patent/JP4136867B2/ja not_active Expired - Fee Related
- 2003-09-22 UA UAA200503858A patent/UA79156C2/uk unknown
- 2003-09-22 OA OA1200500083A patent/OA12934A/en unknown
- 2003-09-22 RS YUP-2005/0240A patent/RS20050240A/sr unknown
- 2003-09-22 SI SI200332352T patent/SI1403266T1/sl unknown
- 2003-09-22 WO PCT/FR2003/002777 patent/WO2004029036A1/fr not_active Ceased
- 2003-09-22 RS RSP20050240 patent/RS53509B1/sr unknown
- 2003-09-22 AP AP2005003256A patent/AP1910A/xx active
- 2003-09-22 AU AU2003282179A patent/AU2003282179A1/en not_active Abandoned
- 2003-09-23 MX MXPA03008643A patent/MXPA03008643A/es active IP Right Grant
- 2003-09-23 ZA ZA200307409A patent/ZA200307409B/xx unknown
- 2003-09-23 PL PL362365A patent/PL214400B1/pl unknown
- 2003-09-23 NZ NZ528402A patent/NZ528402A/en not_active IP Right Cessation
- 2003-09-23 CA CA002442878A patent/CA2442878C/fr not_active Expired - Fee Related
- 2003-09-23 KR KR1020030065783A patent/KR100551501B1/ko not_active Expired - Fee Related
- 2003-09-23 AR ARP030103453A patent/AR041355A1/es not_active Application Discontinuation
- 2003-09-23 NO NO20034235A patent/NO328638B1/no not_active IP Right Cessation
- 2003-09-23 BR BR0304213-8A patent/BR0304213A/pt not_active Application Discontinuation
- 2003-09-23 EA EA200300925A patent/EA007489B1/ru not_active IP Right Cessation
- 2003-09-24 CN CNB031348130A patent/CN1212321C/zh not_active Expired - Fee Related
- 2003-09-24 US US10/669,301 patent/US7214805B2/en not_active Expired - Fee Related
- 2003-09-24 MA MA27321A patent/MA26102A1/fr unknown
- 2003-09-24 SG SG200305555A patent/SG110071A1/en unknown
-
2005
- 2005-03-08 IL IL167316A patent/IL167316A/en not_active IP Right Cessation
- 2005-03-18 CR CR7764A patent/CR7764A/es unknown
- 2005-03-23 TN TNP2005000087A patent/TNSN05087A1/fr unknown
- 2005-04-19 IS IS7807A patent/IS7807A/is unknown
- 2005-04-22 EC EC2005005741A patent/ECSP055741A/es unknown
-
2014
- 2014-06-05 CY CY20141100397T patent/CY1115162T1/el unknown
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