SI1403266T1 - Postopek za industrijsko sintezo stroncijevega ranelata in njegovih hidratov - Google Patents
Postopek za industrijsko sintezo stroncijevega ranelata in njegovih hidratovInfo
- Publication number
- SI1403266T1 SI1403266T1 SI200332352T SI200332352T SI1403266T1 SI 1403266 T1 SI1403266 T1 SI 1403266T1 SI 200332352 T SI200332352 T SI 200332352T SI 200332352 T SI200332352 T SI 200332352T SI 1403266 T1 SI1403266 T1 SI 1403266T1
- Authority
- SI
- Slovenia
- Prior art keywords
- hydrates
- industrial synthesis
- strontium ranelate
- ranelate
- strontium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Inorganic Insulating Materials (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0211763A FR2844795B1 (fr) | 2002-09-24 | 2002-09-24 | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
| EP03292319.5A EP1403266B1 (fr) | 2002-09-24 | 2003-09-22 | Nouveau procédé de synthèse industriel du ranélate de strontium et de ses hydrates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1403266T1 true SI1403266T1 (sl) | 2014-06-30 |
Family
ID=29415189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200332352T SI1403266T1 (sl) | 2002-09-24 | 2003-09-22 | Postopek za industrijsko sintezo stroncijevega ranelata in njegovih hidratov |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US7214805B2 (sl) |
| EP (1) | EP1403266B1 (sl) |
| JP (1) | JP4136867B2 (sl) |
| KR (1) | KR100551501B1 (sl) |
| CN (1) | CN1212321C (sl) |
| AP (1) | AP1910A (sl) |
| AR (1) | AR041355A1 (sl) |
| AU (2) | AU2003282179A1 (sl) |
| BR (1) | BR0304213A (sl) |
| CA (1) | CA2442878C (sl) |
| CR (1) | CR7764A (sl) |
| CY (1) | CY1115162T1 (sl) |
| DK (1) | DK1403266T3 (sl) |
| EA (1) | EA007489B1 (sl) |
| EC (1) | ECSP055741A (sl) |
| ES (1) | ES2478620T3 (sl) |
| FR (1) | FR2844795B1 (sl) |
| GE (1) | GEP20074215B (sl) |
| HK (1) | HK1065791A1 (sl) |
| HR (1) | HRP20050359B1 (sl) |
| IL (1) | IL167316A (sl) |
| IS (1) | IS7807A (sl) |
| MA (1) | MA26102A1 (sl) |
| ME (1) | ME00455B (sl) |
| MX (1) | MXPA03008643A (sl) |
| MY (1) | MY134921A (sl) |
| NO (1) | NO328638B1 (sl) |
| NZ (1) | NZ528402A (sl) |
| OA (1) | OA12934A (sl) |
| PL (1) | PL214400B1 (sl) |
| PT (1) | PT1403266E (sl) |
| RS (2) | RS20050240A (sl) |
| SG (1) | SG110071A1 (sl) |
| SI (1) | SI1403266T1 (sl) |
| TN (1) | TNSN05087A1 (sl) |
| UA (1) | UA79156C2 (sl) |
| WO (1) | WO2004029036A1 (sl) |
| ZA (1) | ZA200307409B (sl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2266584T1 (sl) * | 2003-05-07 | 2012-12-31 | Osteologix A/S, Symbion | Sestavek s stroncijem in vitaminom D za profilakso in/ali zdravljenje patologij hrustanca in/ali kosti |
| PT1534305E (pt) * | 2003-05-07 | 2007-02-28 | Osteologix As | Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis |
| KR101165614B1 (ko) | 2004-02-26 | 2012-07-18 | 오스테올로지스 에이에스 | 괴사성 골 질환의 예방 또는 치료에 사용하기 위한스트론튬 함유 화합물 |
| EP1744770A2 (en) * | 2004-05-06 | 2007-01-24 | Osteologix A/S | High yield and rapid syntheses methods for producing metallo-organic salts |
| BRPI0512357A (pt) | 2004-06-25 | 2008-03-04 | Strontin Aps | composições compreendendo estrÈncio e vitamina d e usos destas |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| CN100538672C (zh) * | 2005-04-18 | 2009-09-09 | 索尼株式会社 | 控制设备和方法 |
| CN100391955C (zh) * | 2005-04-30 | 2008-06-04 | 河北医科大学 | 一种雷尼酸锶中间体的合成方法 |
| CA2619720A1 (en) * | 2005-08-19 | 2007-02-22 | Glenmark Pharmaceuticals Limited | Process for the preparation of strontium ranelate |
| US20070292529A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating osteoporotic conditions |
| US20070292535A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating arthritic and or osteoporitic conditions |
| FR2921367B1 (fr) * | 2007-09-26 | 2009-10-30 | Servier Lab | Nouveau procede de synthese du ranelate de strontium et de ses hydrates |
| US20120123131A1 (en) * | 2008-08-22 | 2012-05-17 | Koilpillai Joseph Prabahar | Process for the preparation of strontium ranelate |
| HU228820B1 (en) | 2010-01-14 | 2013-05-28 | Richter Gedeon Nyrt | Process for the preparation of distrontium ranelate |
| WO2011110597A1 (de) | 2010-03-11 | 2011-09-15 | Azad Pharmaceutical Ingredients Ag | Verfahren zur herstellung von strontiumranelat |
| WO2011124992A1 (en) * | 2010-03-24 | 2011-10-13 | Actavis Group Ptc Ehf | Substantially pure strontium ranelate |
| US9301945B2 (en) | 2011-07-21 | 2016-04-05 | Emory University | Methods for treating inflammatory conditions and states, and cancers by antagonizing NF-κB activation |
| CN102321068B (zh) * | 2011-08-01 | 2013-01-23 | 山东铂源药业有限公司 | 一种雷奈酸锶的制备方法 |
| WO2013175270A1 (en) * | 2012-05-25 | 2013-11-28 | Fleming Laboratories Limited | Improved process for the preparation of strontium ranelate hydrates and new polymorphic form of monohydrate |
| EP2756841B1 (en) | 2013-01-21 | 2015-05-13 | Galenicum Health S.L. | Pharmaceutical compositions comprising an acid salt |
| CN103319454B (zh) * | 2013-06-14 | 2014-06-18 | 广东众生药业股份有限公司 | 一种高纯度雷尼酸四乙酯及其中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2651497B1 (fr) * | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| FR2749759B1 (fr) * | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
| FR2844797B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
-
2002
- 2002-09-24 FR FR0211763A patent/FR2844795B1/fr not_active Expired - Fee Related
-
2003
- 2003-09-17 MY MYPI20033542A patent/MY134921A/en unknown
- 2003-09-22 AP AP2005003256A patent/AP1910A/xx active
- 2003-09-22 AU AU2003282179A patent/AU2003282179A1/en not_active Abandoned
- 2003-09-22 WO PCT/FR2003/002777 patent/WO2004029036A1/fr not_active Application Discontinuation
- 2003-09-22 OA OA1200500083A patent/OA12934A/en unknown
- 2003-09-22 ES ES03292319.5T patent/ES2478620T3/es not_active Expired - Lifetime
- 2003-09-22 SI SI200332352T patent/SI1403266T1/sl unknown
- 2003-09-22 EP EP03292319.5A patent/EP1403266B1/fr not_active Expired - Lifetime
- 2003-09-22 ME MEP-2008-689A patent/ME00455B/me unknown
- 2003-09-22 RS YUP-2005/0240A patent/RS20050240A/sr unknown
- 2003-09-22 AU AU2003248281A patent/AU2003248281B2/en not_active Ceased
- 2003-09-22 GE GEAP20048761A patent/GEP20074215B/en unknown
- 2003-09-22 RS RSP20050240 patent/RS53509B1/en unknown
- 2003-09-22 JP JP2003330440A patent/JP4136867B2/ja not_active Expired - Fee Related
- 2003-09-22 UA UAA200503858A patent/UA79156C2/uk unknown
- 2003-09-22 PT PT3292319T patent/PT1403266E/pt unknown
- 2003-09-22 DK DK03292319.5T patent/DK1403266T3/da active
- 2003-09-23 BR BR0304213-8A patent/BR0304213A/pt not_active Application Discontinuation
- 2003-09-23 EA EA200300925A patent/EA007489B1/ru not_active IP Right Cessation
- 2003-09-23 NZ NZ528402A patent/NZ528402A/en not_active IP Right Cessation
- 2003-09-23 KR KR1020030065783A patent/KR100551501B1/ko not_active IP Right Cessation
- 2003-09-23 CA CA002442878A patent/CA2442878C/fr not_active Expired - Fee Related
- 2003-09-23 PL PL362365A patent/PL214400B1/pl unknown
- 2003-09-23 MX MXPA03008643A patent/MXPA03008643A/es active IP Right Grant
- 2003-09-23 AR ARP030103453A patent/AR041355A1/es not_active Application Discontinuation
- 2003-09-23 ZA ZA200307409A patent/ZA200307409B/xx unknown
- 2003-09-23 NO NO20034235A patent/NO328638B1/no not_active IP Right Cessation
- 2003-09-24 MA MA27321A patent/MA26102A1/fr unknown
- 2003-09-24 SG SG200305555A patent/SG110071A1/en unknown
- 2003-09-24 US US10/669,301 patent/US7214805B2/en not_active Expired - Fee Related
- 2003-09-24 CN CNB031348130A patent/CN1212321C/zh not_active Expired - Fee Related
-
2004
- 2004-11-01 HK HK04108552A patent/HK1065791A1/xx not_active IP Right Cessation
-
2005
- 2005-03-08 IL IL167316A patent/IL167316A/en not_active IP Right Cessation
- 2005-03-18 CR CR7764A patent/CR7764A/es unknown
- 2005-03-23 TN TNP2005000087A patent/TNSN05087A1/fr unknown
- 2005-04-19 IS IS7807A patent/IS7807A/is unknown
- 2005-04-21 HR HRP20050359AA patent/HRP20050359B1/hr not_active IP Right Cessation
- 2005-04-22 EC EC2005005741A patent/ECSP055741A/es unknown
-
2014
- 2014-06-05 CY CY20141100397T patent/CY1115162T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20050359A2 (en) | Novel method for the industrial synthesis of strontium ranelate and the hydrates thereof | |
| AU2003225551A8 (en) | Synthesis of 2h- and 13c- substituted dithianes | |
| ZA200501913B (en) | New compounds for the inhibition of rotamases and use thereof | |
| GB0316367D0 (en) | Production of agglomerates from gas phase | |
| ZA200405256B (en) | Process for the production of hydrocarbons | |
| GB0229742D0 (en) | Novel compounds and uses thereof | |
| AU2003236991A8 (en) | Representations of processes | |
| HRP20050360A2 (en) | Novel method for the industrial synthesis of the m | |
| IL163921A0 (en) | A method for the identification and synthesis of chemical compounds | |
| HK1061846A1 (en) | New process for the industrial synthesis of substituted thiophenecarboxylates, and application of such compounds | |
| PL374862A1 (en) | Process for the manufacture of valsartan | |
| AU2003262992A8 (en) | Amorphous hydrates of esomeprazole magnesium and process for the preparation thereof | |
| AU2003275056A8 (en) | Novel lapacho compounds and methods of use thereof | |
| AU2003286395A1 (en) | Process for the preparation of cabr2 hydrates and uses thereof | |
| GB0202544D0 (en) | The synthesis of naturally occuring ecteinascidins and related compounds | |
| PL373163A1 (en) | Salt of (s)-pantoprazole and its hydrates | |
| PL375101A1 (en) | Process for the production of 3-methylthiopropanal | |
| AU2003242867A8 (en) | Process for the synthesis of mosapride | |
| EP1541548A4 (en) | PROCESS FOR OXAMIDINATION OF CARBONYL COMPOUNDS | |
| GB0229243D0 (en) | Compounds and process | |
| GB0226457D0 (en) | Process for the production of gaskets | |
| GB0228898D0 (en) | Process for the production of gaskets | |
| GB0211751D0 (en) | Compound and process | |
| AU2003267944A8 (en) | Novel trifluoromethylepinephrine compounds and methods of making and using thereof | |
| GB0326463D0 (en) | Process for the production of gaskets |