ECSP055741A - Nuevo método para la síntesis industrial de ranelato de estroncio y los hidratos del mismo - Google Patents

Nuevo método para la síntesis industrial de ranelato de estroncio y los hidratos del mismo

Info

Publication number
ECSP055741A
ECSP055741A EC2005005741A ECSP055741A ECSP055741A EC SP055741 A ECSP055741 A EC SP055741A EC 2005005741 A EC2005005741 A EC 2005005741A EC SP055741 A ECSP055741 A EC SP055741A EC SP055741 A ECSP055741 A EC SP055741A
Authority
EC
Ecuador
Prior art keywords
ranelato
estroncio
hydrats
same
new method
Prior art date
Application number
EC2005005741A
Other languages
English (en)
Inventor
Jean-Pierre Lecouve
Lucile Vaysse-Ludot
Pascal Langlois
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of ECSP055741A publication Critical patent/ECSP055741A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Inorganic Insulating Materials (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se relaciona con un método para la síntesis industrial de ranelato de estroncio de fórmula (I) y los hidratos del mismo.
EC2005005741A 2002-09-24 2005-04-22 Nuevo método para la síntesis industrial de ranelato de estroncio y los hidratos del mismo ECSP055741A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0211763A FR2844795B1 (fr) 2002-09-24 2002-09-24 Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates

Publications (1)

Publication Number Publication Date
ECSP055741A true ECSP055741A (es) 2005-07-06

Family

ID=29415189

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005741A ECSP055741A (es) 2002-09-24 2005-04-22 Nuevo método para la síntesis industrial de ranelato de estroncio y los hidratos del mismo

Country Status (38)

Country Link
US (1) US7214805B2 (es)
EP (1) EP1403266B1 (es)
JP (1) JP4136867B2 (es)
KR (1) KR100551501B1 (es)
CN (1) CN1212321C (es)
AP (1) AP1910A (es)
AR (1) AR041355A1 (es)
AU (2) AU2003248281B2 (es)
BR (1) BR0304213A (es)
CA (1) CA2442878C (es)
CR (1) CR7764A (es)
CY (1) CY1115162T1 (es)
DK (1) DK1403266T3 (es)
EA (1) EA007489B1 (es)
EC (1) ECSP055741A (es)
ES (1) ES2478620T3 (es)
FR (1) FR2844795B1 (es)
GE (1) GEP20074215B (es)
HK (1) HK1065791A1 (es)
HR (1) HRP20050359B1 (es)
IL (1) IL167316A (es)
IS (1) IS7807A (es)
MA (1) MA26102A1 (es)
ME (1) ME00455B (es)
MX (1) MXPA03008643A (es)
MY (1) MY134921A (es)
NO (1) NO328638B1 (es)
NZ (1) NZ528402A (es)
OA (1) OA12934A (es)
PL (1) PL214400B1 (es)
PT (1) PT1403266E (es)
RS (2) RS53509B1 (es)
SG (1) SG110071A1 (es)
SI (1) SI1403266T1 (es)
TN (1) TNSN05087A1 (es)
UA (1) UA79156C2 (es)
WO (1) WO2004029036A1 (es)
ZA (1) ZA200307409B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2524610C (en) * 2003-05-07 2014-03-25 Osteologix A/S Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions
AU2004237439B2 (en) * 2003-05-07 2009-09-10 Osteologix A/S Treating cartilage/bone conditions with water-soluble strontium salts
AU2005216596B2 (en) * 2004-02-26 2011-03-24 Osteologix A/S Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
AU2005240257B2 (en) * 2004-05-06 2011-11-24 Osteologix A/S High yield and rapid syntheses methods for producing metallo-organic salts
ATE443541T1 (de) 2004-06-25 2009-10-15 Strontin Aps Zusammensetzungen mit strontium und vitamin d und ihre verwendungen
FR2875807B1 (fr) * 2004-09-30 2006-11-17 Servier Lab Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN100538672C (zh) * 2005-04-18 2009-09-09 索尼株式会社 控制设备和方法
CN100391955C (zh) * 2005-04-30 2008-06-04 河北医科大学 一种雷尼酸锶中间体的合成方法
EP1928855A2 (en) * 2005-08-19 2008-06-11 Glenmark Pharmaceuticals Limited Process for the preparation of strontium ranelate
US20070292529A1 (en) * 2006-06-19 2007-12-20 Tabbiner Philip S Strontium compositions and methods of treating osteoporotic conditions
US20070292535A1 (en) * 2006-06-19 2007-12-20 Tabbiner Philip S Strontium compositions and methods of treating arthritic and or osteoporitic conditions
FR2921367B1 (fr) * 2007-09-26 2009-10-30 Servier Lab Nouveau procede de synthese du ranelate de strontium et de ses hydrates
US20120123131A1 (en) * 2008-08-22 2012-05-17 Koilpillai Joseph Prabahar Process for the preparation of strontium ranelate
HU228820B1 (en) 2010-01-14 2013-05-28 Richter Gedeon Nyrt Process for the preparation of distrontium ranelate
WO2011110597A1 (de) 2010-03-11 2011-09-15 Azad Pharmaceutical Ingredients Ag Verfahren zur herstellung von strontiumranelat
WO2011124992A1 (en) * 2010-03-24 2011-10-13 Actavis Group Ptc Ehf Substantially pure strontium ranelate
WO2013013003A1 (en) 2011-07-21 2013-01-24 Emory University Methods for treating inflamatory conditions and states, and cancers by antagonizing nf-kb activation
CN102321068B (zh) * 2011-08-01 2013-01-23 山东铂源药业有限公司 一种雷奈酸锶的制备方法
WO2013175270A1 (en) * 2012-05-25 2013-11-28 Fleming Laboratories Limited Improved process for the preparation of strontium ranelate hydrates and new polymorphic form of monohydrate
ES2505716T3 (es) 2013-01-21 2015-09-04 Galenicum Health S.L. Composiciones farmacéuticas que comprenden una sal de ácido
CN103319454B (zh) * 2013-06-14 2014-06-18 广东众生药业股份有限公司 一种高纯度雷尼酸四乙酯及其中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2651497B1 (fr) * 1989-09-01 1991-10-25 Adir Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2749759B1 (fr) * 1996-06-17 1999-11-26 Adir Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
FR2844796A1 (fr) * 2002-09-24 2004-03-26 Servier Lab Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844797B1 (fr) * 2002-09-24 2004-10-22 Servier Lab Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Also Published As

Publication number Publication date
MXPA03008643A (es) 2005-04-19
MA26102A1 (fr) 2004-04-01
PT1403266E (pt) 2014-05-06
HK1065791A1 (en) 2005-03-04
DK1403266T3 (da) 2014-07-07
US20040063972A1 (en) 2004-04-01
EP1403266B1 (fr) 2014-04-09
CR7764A (es) 2005-10-06
NO20034235L (no) 2004-03-25
EP1403266A1 (fr) 2004-03-31
CA2442878A1 (fr) 2004-03-24
AU2003248281B2 (en) 2009-08-06
AP1910A (en) 2008-10-30
IL167316A (en) 2008-08-07
US7214805B2 (en) 2007-05-08
KR20040026625A (ko) 2004-03-31
PL362365A1 (en) 2004-04-05
JP4136867B2 (ja) 2008-08-20
ES2478620T3 (es) 2014-07-22
NO20034235D0 (no) 2003-09-23
IS7807A (is) 2005-04-19
AU2003248281A1 (en) 2004-04-08
MY134921A (en) 2008-01-31
FR2844795B1 (fr) 2004-10-22
GEP20074215B (en) 2007-10-10
KR100551501B1 (ko) 2006-02-13
OA12934A (en) 2006-10-13
NZ528402A (en) 2004-07-30
FR2844795A1 (fr) 2004-03-26
HRP20050359B1 (hr) 2014-09-26
BR0304213A (pt) 2004-08-31
SG110071A1 (en) 2005-04-28
RS20050240A (en) 2007-06-04
SI1403266T1 (sl) 2014-06-30
EA007489B1 (ru) 2006-10-27
WO2004029036A1 (fr) 2004-04-08
CA2442878C (fr) 2009-03-03
CN1212321C (zh) 2005-07-27
AU2003282179A1 (en) 2004-04-19
JP2004149516A (ja) 2004-05-27
RS53509B1 (en) 2015-02-27
CN1496986A (zh) 2004-05-19
PL214400B1 (pl) 2013-07-31
EA200300925A1 (ru) 2004-04-29
ME00455B (me) 2011-10-10
CY1115162T1 (el) 2016-12-14
AP2005003256A0 (en) 2005-03-31
NO328638B1 (no) 2010-04-12
AR041355A1 (es) 2005-05-11
HRP20050359A2 (en) 2005-06-30
UA79156C2 (en) 2007-05-25
ZA200307409B (en) 2004-07-07
TNSN05087A1 (fr) 2007-05-14

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