TN2010000100A1 - Pyridin -2-yl-amino -i,2,4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus - Google Patents
Pyridin -2-yl-amino -i,2,4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitusInfo
- Publication number
- TN2010000100A1 TN2010000100A1 TNP2010000100A TN2010000100A TN2010000100A1 TN 2010000100 A1 TN2010000100 A1 TN 2010000100A1 TN P2010000100 A TNP2010000100 A TN P2010000100A TN 2010000100 A TN2010000100 A TN 2010000100A TN 2010000100 A1 TN2010000100 A1 TN 2010000100A1
- Authority
- TN
- Tunisia
- Prior art keywords
- treatment
- diabetes mellitus
- pyridin
- amino
- glucokinase activators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97422507P | 2007-09-21 | 2007-09-21 | |
PCT/US2008/076401 WO2009042435A1 (fr) | 2007-09-21 | 2008-09-15 | Activateurs de glucokinase |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2010000100A1 true TN2010000100A1 (en) | 2011-09-26 |
Family
ID=40250949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2010000100A TN2010000100A1 (en) | 2007-09-21 | 2010-03-04 | Pyridin -2-yl-amino -i,2,4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus |
Country Status (29)
Country | Link |
---|---|
US (3) | US8212045B2 (fr) |
EP (4) | EP2573087A1 (fr) |
JP (1) | JP5722037B2 (fr) |
KR (1) | KR101566042B1 (fr) |
CN (1) | CN101868459B (fr) |
AR (1) | AR068628A1 (fr) |
AU (1) | AU2008305294B2 (fr) |
BR (1) | BRPI0816881A2 (fr) |
CA (1) | CA2699718C (fr) |
CO (1) | CO6270223A2 (fr) |
CR (2) | CR11383A (fr) |
DK (1) | DK2209778T3 (fr) |
EA (1) | EA019104B1 (fr) |
ES (2) | ES2569734T3 (fr) |
HK (2) | HK1145498A1 (fr) |
HR (1) | HRP20120814T1 (fr) |
IL (1) | IL204264A (fr) |
MA (1) | MA31779B1 (fr) |
MX (1) | MX2010002772A (fr) |
MY (1) | MY180558A (fr) |
NZ (1) | NZ583538A (fr) |
PL (1) | PL2209778T3 (fr) |
PT (1) | PT2209778E (fr) |
SI (1) | SI2209778T1 (fr) |
TN (1) | TN2010000100A1 (fr) |
TW (1) | TWI423799B (fr) |
UA (1) | UA101166C2 (fr) |
WO (1) | WO2009042435A1 (fr) |
ZA (2) | ZA201002206B (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2131656A4 (fr) * | 2006-11-15 | 2011-12-07 | Forest Lab Holdings Ltd | Dérivés de phtalazine |
MX2010002772A (es) | 2007-09-21 | 2010-03-31 | Array Biopharma Inc | Derivados de piridin-2-il-amino-1,2,4-tiadiazol como activadores de glucocinasa para el tratamiento de diabetes mellitus. |
WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
CA2800498C (fr) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Nouvelle programmation de cellules |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
CA2808590A1 (fr) | 2010-08-23 | 2012-03-01 | Amgen Inc. | Derives de sulfonylpiperazine qui interagissent avec la proteine regulatrice de la glucokinase pour le traitement du diabete |
JPWO2012121314A1 (ja) | 2011-03-09 | 2014-07-17 | 第一三共株式会社 | ジピリジルアミン誘導体 |
CN103717586A (zh) | 2011-04-05 | 2014-04-09 | 安姆根有限公司 | 用于治疗糖尿病的与葡糖激酶调节蛋白相互作用的苯并二氧杂*和苯并二氧杂环己烯化合物 |
WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
WO2013045413A1 (fr) | 2011-09-27 | 2013-04-04 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
WO2013123444A1 (fr) | 2012-02-17 | 2013-08-22 | Amgen Inc. | Composés de sulfonyle qui interagissent avec la protéine régulatrice de la glucokinase |
WO2013173382A1 (fr) | 2012-05-15 | 2013-11-21 | Amgen Inc. | Benzothiophène sulfonamides et autres composés qui interagissent avec une protéine régulatrice de la glucokinase |
WO2013173672A1 (fr) * | 2012-05-18 | 2013-11-21 | Array Biopharma Inc. | Procédé pour la préparation de thiadiazoles |
CN105164123A (zh) * | 2012-11-09 | 2015-12-16 | 安进股份有限公司 | (1s)-1-[5-({3-[(2-甲基吡啶-3-基)氧基]-5-(吡啶-2-基硫基)吡啶-2-基}氨基)-1,2,4-噻二唑-3-基]乙烷-1,2-二醇的结晶形式 |
WO2016059647A2 (fr) * | 2014-10-13 | 2016-04-21 | SHRI CHHATRAPTI SHIVAJI COLLEGE Maharashtra, India) | Dérivés de triaminotriazine et de picolinonitrile utilisables en tant qu'inhibiteurs efficaces de la transcriptase inverse du vih-1 |
GB201714777D0 (en) | 2017-09-14 | 2017-11-01 | Univ London Queen Mary | Agent |
CN111372579B (zh) | 2017-10-30 | 2023-08-22 | 神经孔疗法股份有限公司 | 取代的苯基磺酰基苯基三唑硫酮和其用途 |
MX2020012965A (es) | 2018-05-31 | 2021-02-16 | Hua Medicine Shanghai Ltd | Combinacion, composicion y preparacion de compuesto farmaceutico que comprende activador de glucocinasa e inhibidor de dpp-iv, metodo de preparacion y uso del mismo. |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3983246A (en) | 1974-04-04 | 1976-09-28 | Fmc Corporation | N-(sulfonyloxy) benzimidoyl halides as bactericidal or fungicidal agents |
DE2949913A1 (de) * | 1979-12-12 | 1981-06-25 | Basf Ag, 6700 Ludwigshafen | Azofarbstoffe |
EP0300688A1 (fr) | 1987-07-21 | 1989-01-25 | FISONS plc | Dérivés de pyrrole, procédé de préparation et compositions pharmaceutiques les contenant |
JPH0228168A (ja) * | 1988-04-14 | 1990-01-30 | Sankyo Co Ltd | チアゾール誘導体 |
WO1993017681A1 (fr) | 1992-03-02 | 1993-09-16 | Abbott Laboratories | Antagonistes du recepteur d'angiotensine ii |
AU4090093A (en) | 1992-05-29 | 1993-12-30 | Yamanouchi Pharmaceutical Co., Ltd. | Medicine containing benzoic acid derivative and novel benzoic acid derivative |
MX9700068A (es) | 1994-06-24 | 1997-12-31 | Euro Celtique Sa | Compuestos y metodo para inhibir a la fosfodiesterasa iv. |
GB9908410D0 (en) * | 1999-04-13 | 1999-06-09 | Pfizer Ltd | Pyridines |
RU2312860C2 (ru) * | 1999-04-15 | 2007-12-20 | Бристол-Маерс Сквибб Компани | Циклические ингибиторы протеинтирозинкиназ |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
EE200100556A (et) | 1999-04-28 | 2003-02-17 | Aventis Pharma Deutschland Gmbh | Diarüülhappe derivaat, seda sisaldav farmatseutiline kompositsioon ja ühendi kasutamine ravimite valmistamiseks |
DE60024986T2 (de) | 1999-05-21 | 2006-07-27 | Biovitrum Ab | Pyrazinyl-piperazin-verbindungen, ihre anwendung und herstellung |
US6465467B1 (en) | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
JP4144978B2 (ja) | 1999-09-09 | 2008-09-03 | 富士フイルム株式会社 | 1,2,4−チアジアゾール誘導体の合成法 |
BR0013899A (pt) | 1999-09-10 | 2003-07-08 | Merck & Co Inc | Composto, composição farmacêutica, processos de tratamento ou prevenção de câncer, de uma doença em que a angiogênese esteja implicada, da vascularização retinal, da retinopatia diabética, da degeneração macular relacionada a idade, de doenças inflamatórias, de uma doença ou condições dependentes da tirosina quinase, de patologias associadas com ossos, e, processos para produzir uma composição farmacêutica, e de reduzir ou prevenir dano tecidual em seguida a um evento isquêmico cerebral |
US20020065270A1 (en) | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
EP1246823A1 (fr) | 1999-12-28 | 2002-10-09 | Pharmacopeia, Inc. | Composes de pyrimidine et de triazine presentant une activite inhibant la kinase |
US6906067B2 (en) | 1999-12-28 | 2005-06-14 | Bristol-Myers Squibb Company | N-heterocyclic inhibitors of TNF-α expression |
US7345051B2 (en) | 2000-01-31 | 2008-03-18 | Genaera Corporation | Mucin synthesis inhibitors |
CN1518543A (zh) | 2000-08-31 | 2004-08-04 | �Ʒ� | 吡唑衍生物和它们作为蛋白激酶抑制剂的用途 |
US20050209297A1 (en) | 2000-08-31 | 2005-09-22 | Pfizer Inc | Pyrazole derivatives |
WO2002030358A2 (fr) | 2000-10-11 | 2002-04-18 | Tularik Inc. | Modulation de fonction de ccr4 |
WO2002030357A2 (fr) | 2000-10-11 | 2002-04-18 | Chemocentryx, Inc. | Composes et procedes servant a moduler la fonction de ccr4 |
AU3950802A (en) | 2000-12-07 | 2002-06-18 | Cv Therapeutics Inc | Abca-1 elevating compounds |
BR0116411A (pt) | 2000-12-21 | 2003-11-11 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
AU2002258400A1 (en) | 2001-02-16 | 2002-08-28 | Tularik Inc. | Methods of using pyrimidine-based antiviral agents |
US7144903B2 (en) | 2001-05-23 | 2006-12-05 | Amgen Inc. | CCR4 antagonists |
PE20030008A1 (es) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
JP2005500294A (ja) | 2001-06-19 | 2005-01-06 | ブリストル−マイヤーズ スクイブ カンパニー | ホスホジエステラーゼ7に対するピリミジン阻害剤 |
JP2004535437A (ja) * | 2001-06-22 | 2004-11-25 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼ阻害剤 |
AU2003202263A1 (en) | 2002-01-10 | 2003-07-30 | Bayer Healthcare Ag | Roh-kinase inhibitors |
KR100875362B1 (ko) | 2002-02-05 | 2008-12-22 | 아스텔라스세이야쿠 가부시키가이샤 | 2,4,6-트리아미노-1,3,5-트리아진 유도체 |
EP1485381B8 (fr) | 2002-03-15 | 2010-05-12 | Vertex Pharmaceuticals Incorporated | Azolylaminoazines en tant qu'inhibiteurs de proteines kinases |
WO2003078423A1 (fr) | 2002-03-15 | 2003-09-25 | Vertex Pharmaceuticals, Inc. | Compositions s'utilisant comme inhibiteurs de proteine kinases |
DE60332433D1 (de) | 2002-03-15 | 2010-06-17 | Vertex Pharma | Azolylaminoazine als proteinkinasehemmer |
AU2003218215A1 (en) | 2002-03-15 | 2003-09-29 | Vertex Pharmaceuticals, Inc. | Azolylaminoazines as inhibitors of protein kinases |
DE60329910D1 (de) | 2002-03-29 | 2009-12-17 | Novartis Vaccines & Diagnostic | Substituierte benzazole und ihre verwendung als raf-kinase-hemmer |
US8299108B2 (en) | 2002-03-29 | 2012-10-30 | Novartis Ag | Substituted benzazoles and methods of their use as inhibitors of raf kinase |
WO2003091213A1 (fr) * | 2002-04-25 | 2003-11-06 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'amide ou sels de ces derives |
US7015227B2 (en) | 2002-06-21 | 2006-03-21 | Cgi Pharmaceuticals, Inc. | Certain amino-substituted monocycles as kinase modulators |
KR20050039846A (ko) | 2002-08-09 | 2005-04-29 | 아스트라제네카 에이비이 | 메타보트로픽 글루타메이트 수용체-5의 조절제로서의옥사디아졸 |
AU2003272324A1 (en) | 2002-09-10 | 2004-04-30 | Scios Inc. | INHIBITORS OF TFGBeta |
CA2498089A1 (fr) | 2002-10-03 | 2004-06-17 | Novartis Ag | Sulfamide ou amide a substitution (thiazol-2-yl) utile en tant qu'activateur de glycokinase dans le traitement du diabete de type 2 |
AU2003285007A1 (en) | 2002-10-30 | 2004-06-07 | Merck & Co., Inc. | Kinase inhibitors |
CA2755297A1 (fr) | 2003-02-10 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Procedes de preparation de n-heteroaryl-n-aryl-amines par mise en reaction d'un ester d'acide n-aryl-carbamique avec un halo-heteroaryle, et procedess analogues |
CA2515544A1 (fr) | 2003-02-11 | 2004-08-26 | Kemia Inc. | Composes destines au traitement d'une infection virale |
AU2004220234C1 (en) | 2003-02-13 | 2013-01-17 | Msd K.K. | Novel 2-pyridinecarboxamide derivatives |
CA2523126A1 (fr) | 2003-03-25 | 2004-10-14 | Vertex Pharmaceuticals Incorporated | Thiazoles utiles en tant qu'inhibiteurs des proteines kinases |
US7244763B2 (en) | 2003-04-17 | 2007-07-17 | Warner Lambert Company Llc | Compounds that modulate PPAR activity and methods of preparation |
US20070027321A1 (en) | 2003-09-02 | 2007-02-01 | Kamenecka Theodore M | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 |
US7470712B2 (en) | 2004-01-21 | 2008-12-30 | Bristol-Myers Squibb Company | Amino-benzazoles as P2Y1 receptor inhibitors |
WO2005077373A2 (fr) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Nouveau traitement du reflux gastro-oesophagien pathologique ii |
AR049418A1 (es) | 2004-02-27 | 2006-08-02 | Bayer Pharmaceuticals Corp | Derivados de heteroarilaminopirazol y composiciones farmaceuticas para el tratamiento de la diabetes. |
KR20050091462A (ko) | 2004-03-12 | 2005-09-15 | 한국과학기술연구원 | 푸로피리미딘 화합물 및 이를 포함하는 ddr2 티로신키나아제 활성 저해제 |
US7687502B2 (en) | 2004-03-23 | 2010-03-30 | Banyu Pharmaceutical Co., Ltd. | Substituted quinazoline or pyridopyrimidine derivative |
CA2561157A1 (fr) | 2004-04-02 | 2005-10-13 | Novartis Ag | Derives thiazolopyridine, compositions pharmaceutiques les contenant et procedes de traitement de troubles a mediation par glucokinase |
MXPA06011807A (es) | 2004-04-13 | 2007-02-21 | Icagen Inc | Piridinas policiclicas como moduladores del canal del ion de potasio. |
WO2005121126A1 (fr) | 2004-04-13 | 2005-12-22 | Icagen, Inc. | Pyrazines polycycliques tenant lieu de modulateurs du canal ionique du potassium |
TW200606129A (en) * | 2004-07-26 | 2006-02-16 | Chugai Pharmaceutical Co Ltd | Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same |
KR20060079121A (ko) | 2004-12-31 | 2006-07-05 | 에스케이케미칼주식회사 | 당뇨 및 비만 치료예방에 유효한 퀴나졸린 유도체 |
WO2006078621A2 (fr) | 2005-01-19 | 2006-07-27 | Bristol-Myers Squibb Company | Composes heteroaryle tenant lieu d'inhibiteurs du recepteur p2y1 |
DE102005025161A1 (de) | 2005-06-01 | 2006-12-07 | Phenion Gmbh & Co. Kg | Derivate des Pyrimidins und Triazins und deren Verwendung |
US7737151B2 (en) | 2005-08-18 | 2010-06-15 | Vertex Pharmaceuticals Incorporated | Pyrazine kinase inhibitors |
AU2006285834A1 (en) * | 2005-08-31 | 2007-03-08 | Astellas Pharma Inc. | Thiazole derivative |
WO2007038387A2 (fr) | 2005-09-23 | 2007-04-05 | Yale University | Composes et methodes de traitement des virus et du cancer |
ES2372540T3 (es) | 2005-11-01 | 2012-01-23 | Array Biopharma, Inc. | Activadores de glucocinasa. |
CN101316843B (zh) | 2005-11-03 | 2013-01-02 | 顶点医药品公司 | 用作激酶抑制剂的氨基嘧啶 |
CA2629781A1 (fr) | 2005-11-16 | 2007-05-24 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines utiles en tant qu'inhibiteurs de la kinase |
WO2007058482A1 (fr) | 2005-11-16 | 2007-05-24 | Lg Life Sciences, Ltd. | Inhibiteurs de la proteine kinase |
JP5236499B2 (ja) * | 2006-01-27 | 2013-07-17 | アレイ バイオファーマ、インコーポレイテッド | グルコキナーゼ活性化剤 |
CN101437816B (zh) * | 2006-03-24 | 2013-08-14 | 阿雷生物药品公司 | 作为葡萄糖激酶活性剂的2-氨基吡啶类似物 |
WO2007131953A1 (fr) | 2006-05-12 | 2007-11-22 | Ab Science | Un nouveau procédé pour la synthèse de composés de 2-aminoxazole |
WO2008024963A1 (fr) | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Dérivés de benzène, de pyridine et de pyridazine |
SA07280576B1 (ar) | 2006-10-26 | 2011-06-22 | استرازينيكا ايه بي | مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز |
AU2007333394C1 (en) | 2006-12-08 | 2011-08-18 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
US8431713B2 (en) | 2007-01-24 | 2013-04-30 | Array Biopharma, Inc. | 2-aminopyridine derivatives as glucokinase activators |
US8362037B2 (en) | 2007-03-23 | 2013-01-29 | Array Biopharma, Inc. | 2-aminopyridine analogs as glucokinase activators |
CA2682504C (fr) | 2007-04-05 | 2012-10-30 | Amgen Inc. | Modulateurs de la kinase aurora et methode d'utilisation |
US20090012091A1 (en) | 2007-07-02 | 2009-01-08 | Kinagen, Inc. | Oximide derivatives and their therapeutical application |
WO2009022171A1 (fr) | 2007-08-13 | 2009-02-19 | Astrazeneca Ab | Composés chimiques 1 - 821 |
MX2010002772A (es) | 2007-09-21 | 2010-03-31 | Array Biopharma Inc | Derivados de piridin-2-il-amino-1,2,4-tiadiazol como activadores de glucocinasa para el tratamiento de diabetes mellitus. |
SI2195312T1 (sl) | 2007-10-09 | 2013-01-31 | Merck Patent Gmbh | Derivati piridina, uporabni kot aktivatorji glukokinaze |
-
2008
- 2008-09-15 MX MX2010002772A patent/MX2010002772A/es active IP Right Grant
- 2008-09-15 CA CA2699718A patent/CA2699718C/fr not_active Expired - Fee Related
- 2008-09-15 SI SI200830746T patent/SI2209778T1/sl unknown
- 2008-09-15 EP EP12181665A patent/EP2573087A1/fr not_active Withdrawn
- 2008-09-15 CN CN2008801169950A patent/CN101868459B/zh not_active Expired - Fee Related
- 2008-09-15 WO PCT/US2008/076401 patent/WO2009042435A1/fr active Application Filing
- 2008-09-15 JP JP2010525902A patent/JP5722037B2/ja not_active Expired - Fee Related
- 2008-09-15 US US12/678,995 patent/US8212045B2/en not_active Expired - Fee Related
- 2008-09-15 EP EP16160414.5A patent/EP3078662A1/fr not_active Withdrawn
- 2008-09-15 UA UAA201004782A patent/UA101166C2/ru unknown
- 2008-09-15 NZ NZ583538A patent/NZ583538A/en not_active IP Right Cessation
- 2008-09-15 ES ES13186328.4T patent/ES2569734T3/es active Active
- 2008-09-15 KR KR1020107008594A patent/KR101566042B1/ko not_active IP Right Cessation
- 2008-09-15 ES ES08834504T patent/ES2393824T3/es active Active
- 2008-09-15 EP EP08834504A patent/EP2209778B1/fr not_active Not-in-force
- 2008-09-15 EA EA201000515A patent/EA019104B1/ru not_active IP Right Cessation
- 2008-09-15 AU AU2008305294A patent/AU2008305294B2/en not_active Ceased
- 2008-09-15 PT PT88345046T patent/PT2209778E/pt unknown
- 2008-09-15 MY MYPI2010001186A patent/MY180558A/en unknown
- 2008-09-15 BR BRPI0816881 patent/BRPI0816881A2/pt not_active IP Right Cessation
- 2008-09-15 PL PL08834504T patent/PL2209778T3/pl unknown
- 2008-09-15 EP EP13186328.4A patent/EP2727910B1/fr not_active Not-in-force
- 2008-09-15 DK DK08834504.6T patent/DK2209778T3/da active
- 2008-09-19 AR ARP080104095A patent/AR068628A1/es not_active Application Discontinuation
- 2008-09-19 TW TW097136197A patent/TWI423799B/zh not_active IP Right Cessation
-
2010
- 2010-03-02 IL IL204264A patent/IL204264A/en not_active IP Right Cessation
- 2010-03-04 TN TNP2010000100A patent/TN2010000100A1/fr unknown
- 2010-03-29 ZA ZA2010/02206A patent/ZA201002206B/en unknown
- 2010-04-14 MA MA32775A patent/MA31779B1/fr unknown
- 2010-04-21 CO CO10046631A patent/CO6270223A2/es not_active Application Discontinuation
- 2010-04-21 CR CR11383A patent/CR11383A/es unknown
- 2010-12-24 HK HK10112096.6A patent/HK1145498A1/xx not_active IP Right Cessation
-
2011
- 2011-03-29 ZA ZA2011/02350A patent/ZA201102350B/en unknown
-
2012
- 2012-06-11 US US13/493,616 patent/US8853409B2/en not_active Expired - Fee Related
- 2012-10-11 HR HRP20120814AT patent/HRP20120814T1/hr unknown
-
2014
- 2014-09-23 US US14/494,430 patent/US9079890B2/en not_active Expired - Fee Related
- 2014-11-06 HK HK14111244.5A patent/HK1197821A1/zh not_active IP Right Cessation
-
2015
- 2015-03-12 CR CR20150131A patent/CR20150131A/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TN2010000100A1 (en) | Pyridin -2-yl-amino -i,2,4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus | |
ATE539748T1 (de) | Glucokinaseaktivatoren | |
PH12018500767A1 (en) | Pharmaceutical composition, methods for treating and uses thereof | |
NO20064929L (no) | Sulfonamid-tiazolpyrldinderivater som glukokinaseaktivatorer anvendelige i behandlingen av type 2 diabetes | |
MY160123A (en) | Pharmaceutical composition comprising a sglt2 inhibitor, a dpp-iv inhibitor and optionally a further antidiabetic agent and uses thereof | |
SG170775A1 (en) | 2 -aminopyridine analogs as glucokinase activators | |
PH12016501607A1 (en) | Sglt-2 inhibitor for treating type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance or hyperglycemia | |
MX2010001560A (es) | Composicion farmaceutica que comprende un inhibidor de sglt2 en combinacion con un inhibidor de dpp-iv. | |
WO2008118718A3 (fr) | Analogues de la 2-aminopyridine comme activateurs de la glucokinase | |
NO20090064L (no) | Pyrasoler som glucokinase aktivatorer | |
TW200745037A (en) | Organic compounds | |
UA100384C2 (en) | Pharmaceutical composition comprising a glucopyranosyl-substituted benzene derivative | |
TW200633992A (en) | Biaryloxymethylarenecarboxylic acids | |
EP2217596B8 (fr) | Dérivés hétérocycliques bicycliques et leur utilisation en tant que modulateurs de l'activite du gpr 119 | |
NO20055887L (no) | Pyrido'2, 1-A-isokinoliderivater som DPP-IV-inhibitorer | |
MX2007005590A (es) | Compuestos del inhibidor glicogeno fosforilasa y sus composiciones farmaceuticas. | |
TW200631580A (en) | Substituted benzoquinolizine derivatives | |
MX2007007174A (es) | Derivados de cicloalquilamina. | |
ATE521608T1 (de) | Glucokinaseaktivatoren | |
MX2009009416A (es) | Derivados de bencimidazol y sus metodos de uso. | |
IL186566A0 (en) | Substituted 2-amin0alkylth10-benzimidaz0les and use thereof for reducing blood sugar levels | |
MX2009009417A (es) | Piperidinil-piperidina y piperazinil-piperidina para uso en el tratamiento de diabetes o dolor. | |
UY31352A1 (es) | Activadores de glucocinasa | |
CY1116557T1 (el) | Παραγωγα πυριδιν-2-υλ-αμινο-1,2,4-θειαδιαζολιου ως αναστολεις γλυκοκινασης για τη θεραπεια σακχαρωδους διαβητη |