SU719507A3 - Способ получени винкаменина или его солей, или его четвертичных солей, или его молекул рных соединений - Google Patents
Способ получени винкаменина или его солей, или его четвертичных солей, или его молекул рных соединенийInfo
- Publication number
- SU719507A3 SU719507A3 SU772504514A SU2504514A SU719507A3 SU 719507 A3 SU719507 A3 SU 719507A3 SU 772504514 A SU772504514 A SU 772504514A SU 2504514 A SU2504514 A SU 2504514A SU 719507 A3 SU719507 A3 SU 719507A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- salts
- vincamenine
- molecular compounds
- quaternary
- preparing
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims description 12
- 150000001875 compounds Chemical class 0.000 title claims description 10
- 238000000034 method Methods 0.000 title claims description 6
- VKTOXAGUZWAECL-MOPGFXCFSA-N (-)-eburnamenine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C=CN5C2=C1 VKTOXAGUZWAECL-MOPGFXCFSA-N 0.000 title description 3
- 238000002474 experimental method Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 10
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000012299 nitrogen atmosphere Substances 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- -1 vincamenine Chemical class 0.000 description 2
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical class C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 description 2
- OVFUUSPKWADLNJ-UHFFFAOYSA-N 5-methyl-4-nitro-2-(4-nitrophenyl)-4h-pyrazol-3-one Chemical compound O=C1C([N+]([O-])=O)C(C)=NN1C1=CC=C([N+]([O-])=O)C=C1 OVFUUSPKWADLNJ-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000006114 decarboxylation reaction Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940075930 picrate Drugs 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU76RI593A HU173511B (hu) | 1976-07-21 | 1976-07-21 | Sposob poluchenija vinkamenina, ego solejj i molekuljarnykh soedinenijj |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU719507A3 true SU719507A3 (ru) | 1980-02-29 |
Family
ID=11000999
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU772504514A SU719507A3 (ru) | 1976-07-21 | 1977-07-20 | Способ получени винкаменина или его солей, или его четвертичных солей, или его молекул рных соединений |
| SU792729451A SU862827A3 (ru) | 1976-07-21 | 1979-02-19 | Способ получени винкаменина или его солей |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU792729451A SU862827A3 (ru) | 1976-07-21 | 1979-02-19 | Способ получени винкаменина или его солей |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5331700A (enExample) |
| AT (1) | AT354646B (enExample) |
| BE (1) | BE856990A (enExample) |
| BG (1) | BG29875A3 (enExample) |
| CH (2) | CH629803A5 (enExample) |
| CS (1) | CS196378B2 (enExample) |
| DD (1) | DD131024A5 (enExample) |
| DE (1) | DE2733056C2 (enExample) |
| FR (1) | FR2359149A1 (enExample) |
| HU (1) | HU173511B (enExample) |
| NL (1) | NL7708056A (enExample) |
| SE (1) | SE7708250L (enExample) |
| SU (2) | SU719507A3 (enExample) |
| YU (1) | YU180177A (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2514357A1 (fr) * | 1981-10-08 | 1983-04-15 | Roussel Uclaf | Nouveaux derives de 20,21-dinoreburnamenine eventuellement substitues sur le cycle e, procede de preparation et application comme medicaments |
| LU84664A1 (fr) * | 1983-02-25 | 1984-11-08 | Onmichem S A | Alkyl-4-indolonaphtyridines et leur application therapeutique |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE772005A (fr) * | 1971-08-31 | 1971-12-31 | Omnium Chimique Sa | Procede de preparation du vincanol levogyre du vincanol dextrogyre, du vincanol racemique et derives indoliques nouveaux. |
| DE2538095A1 (de) * | 1974-09-06 | 1976-03-25 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
-
1976
- 1976-07-21 HU HU76RI593A patent/HU173511B/hu unknown
-
1977
- 1977-07-04 AT AT474177A patent/AT354646B/de not_active IP Right Cessation
- 1977-07-05 CH CH828577A patent/CH629803A5/de not_active IP Right Cessation
- 1977-07-07 BG BG036837A patent/BG29875A3/xx unknown
- 1977-07-15 SE SE7708250A patent/SE7708250L/xx unknown
- 1977-07-19 DD DD7700200166A patent/DD131024A5/xx unknown
- 1977-07-19 YU YU01801/77A patent/YU180177A/xx unknown
- 1977-07-20 CS CS774844A patent/CS196378B2/cs unknown
- 1977-07-20 FR FR7722309A patent/FR2359149A1/fr active Granted
- 1977-07-20 SU SU772504514A patent/SU719507A3/ru active
- 1977-07-20 JP JP8615677A patent/JPS5331700A/ja active Granted
- 1977-07-20 NL NL7708056A patent/NL7708056A/xx not_active Application Discontinuation
- 1977-07-20 BE BE179498A patent/BE856990A/xx not_active IP Right Cessation
- 1977-07-21 DE DE2733056A patent/DE2733056C2/de not_active Expired
-
1979
- 1979-02-19 SU SU792729451A patent/SU862827A3/ru active
-
1981
- 1981-08-31 CH CH558981A patent/CH631175A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| YU180177A (en) | 1982-08-31 |
| CS196378B2 (en) | 1980-03-31 |
| AT354646B (de) | 1979-01-25 |
| FR2359149B1 (enExample) | 1982-06-11 |
| CH629803A5 (en) | 1982-05-14 |
| CH631175A5 (en) | 1982-07-30 |
| NL7708056A (nl) | 1978-01-24 |
| JPS5526142B2 (enExample) | 1980-07-11 |
| DE2733056C2 (de) | 1982-08-12 |
| DD131024A5 (de) | 1978-05-24 |
| ATA474177A (de) | 1979-06-15 |
| DE2733056A1 (de) | 1978-01-26 |
| BG29875A3 (en) | 1981-02-16 |
| FR2359149A1 (fr) | 1978-02-17 |
| HU173511B (hu) | 1979-05-28 |
| BE856990A (fr) | 1977-11-14 |
| JPS5331700A (en) | 1978-03-25 |
| SE7708250L (sv) | 1978-01-22 |
| SU862827A3 (ru) | 1981-09-07 |
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