SU593668A3 - Способ получени производных цефалоспорина или их солей - Google Patents
Способ получени производных цефалоспорина или их солейInfo
- Publication number
- SU593668A3 SU593668A3 SU762335245A SU2335245A SU593668A3 SU 593668 A3 SU593668 A3 SU 593668A3 SU 762335245 A SU762335245 A SU 762335245A SU 2335245 A SU2335245 A SU 2335245A SU 593668 A3 SU593668 A3 SU 593668A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- methyl
- product
- sodium bicarbonate
- carboxy
- water
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims 4
- 238000000034 method Methods 0.000 title claims 3
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 9
- 239000000047 product Substances 0.000 claims 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 3
- 238000002844 melting Methods 0.000 claims 3
- 230000008018 melting Effects 0.000 claims 3
- -1 1-imidazolyl Chemical group 0.000 claims 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 2
- 150000001340 alkali metals Chemical class 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 239000012153 distilled water Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- XOHZHMUQBFJTNH-UHFFFAOYSA-N 1-methyl-2h-tetrazole-5-thione Chemical compound CN1N=NN=C1S XOHZHMUQBFJTNH-UHFFFAOYSA-N 0.000 claims 1
- DPWOISJOHBVMNF-UHFFFAOYSA-N 2,3-dihydrothiadiazole Chemical compound N1NC=CS1 DPWOISJOHBVMNF-UHFFFAOYSA-N 0.000 claims 1
- FPVUWZFFEGYCGB-UHFFFAOYSA-N 5-methyl-3h-1,3,4-thiadiazole-2-thione Chemical compound CC1=NN=C(S)S1 FPVUWZFFEGYCGB-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims 1
- 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 claims 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000021523 carboxylation Effects 0.000 claims 1
- 238000006473 carboxylation reaction Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 239000002826 coolant Substances 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-N sodium;hydron;carbonate Chemical compound [Na+].OC(O)=O UIIMBOGNXHQVGW-UHFFFAOYSA-N 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7415226A FR2269348A1 (en) | 1974-05-02 | 1974-05-02 | 7-Acylamino cephalosporin derivs - antibacterials active against Gram positive and Gram negative bacteria |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU593668A3 true SU593668A3 (ru) | 1978-02-15 |
Family
ID=9138377
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU762335245A SU593668A3 (ru) | 1974-05-02 | 1976-03-25 | Способ получени производных цефалоспорина или их солей |
| SU7602335246A SU578890A3 (ru) | 1974-05-02 | 1976-03-25 | Способ получени производных цефалоспорина или их солей |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU7602335246A SU578890A3 (ru) | 1974-05-02 | 1976-03-25 | Способ получени производных цефалоспорина или их солей |
Country Status (9)
| Country | Link |
|---|---|
| AR (1) | AR207604A1 (enrdf_load_stackoverflow) |
| AT (1) | AT336791B (enrdf_load_stackoverflow) |
| BE (1) | BE828631A (enrdf_load_stackoverflow) |
| CH (1) | CH601318A5 (enrdf_load_stackoverflow) |
| CS (1) | CS188226B2 (enrdf_load_stackoverflow) |
| ES (1) | ES441745A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2269348A1 (enrdf_load_stackoverflow) |
| SU (2) | SU593668A3 (enrdf_load_stackoverflow) |
| ZA (1) | ZA752798B (enrdf_load_stackoverflow) |
-
1974
- 1974-05-02 FR FR7415226A patent/FR2269348A1/fr active Granted
-
1975
- 1975-01-01 AR AR261526A patent/AR207604A1/es active
- 1975-04-30 ZA ZA00752798A patent/ZA752798B/xx unknown
- 1975-04-30 CS CS753027A patent/CS188226B2/cs unknown
- 1975-04-30 BE BE155993A patent/BE828631A/xx unknown
- 1975-05-01 CH CH993677A patent/CH601318A5/xx not_active IP Right Cessation
- 1975-05-02 AT AT337575A patent/AT336791B/de not_active IP Right Cessation
- 1975-10-13 ES ES75441745A patent/ES441745A1/es not_active Expired
-
1976
- 1976-03-25 SU SU762335245A patent/SU593668A3/ru active
- 1976-03-25 SU SU7602335246A patent/SU578890A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| FR2269348A1 (en) | 1975-11-28 |
| CS188226B2 (en) | 1979-02-28 |
| AT336791B (de) | 1977-05-25 |
| BE828631A (fr) | 1975-10-30 |
| AR207604A1 (es) | 1976-10-15 |
| ZA752798B (en) | 1976-04-28 |
| CH601318A5 (enrdf_load_stackoverflow) | 1978-07-14 |
| ATA337575A (de) | 1976-09-15 |
| FR2269348B1 (enrdf_load_stackoverflow) | 1977-11-10 |
| SU578890A3 (ru) | 1977-10-30 |
| ES441745A1 (es) | 1977-03-16 |
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