SU1604159A3 - Способ получени макролидных соединений - Google Patents

Способ получени макролидных соединений Download PDF

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Publication number
SU1604159A3
SU1604159A3 SU4613316A SU4613316A SU1604159A3 SU 1604159 A3 SU1604159 A3 SU 1604159A3 SU 4613316 A SU4613316 A SU 4613316A SU 4613316 A SU4613316 A SU 4613316A SU 1604159 A3 SU1604159 A3 SU 1604159A3
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SU
USSR - Soviet Union
Prior art keywords
group
hydrogen atom
doublet
formula
methyl
Prior art date
Application number
SU4613316A
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English (en)
Russian (ru)
Inventor
Оказаки Такао
Original Assignee
Санкио Компани Лимитед (Фирма)
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Publication of SU1604159A3 publication Critical patent/SU1604159A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/898—Streptomyces hygroscopicus

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pest Control & Pesticides (AREA)
  • Insects & Arthropods (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SU4613316A 1986-12-11 1989-01-23 Способ получени макролидных соединений SU1604159A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61295452 1986-12-11

Publications (1)

Publication Number Publication Date
SU1604159A3 true SU1604159A3 (ru) 1990-10-30

Family

ID=17820769

Family Applications (1)

Application Number Title Priority Date Filing Date
SU4613316A SU1604159A3 (ru) 1986-12-11 1989-01-23 Способ получени макролидных соединений

Country Status (23)

Country Link
US (1) US5008191A (enExample)
EP (1) EP0274871B1 (enExample)
KR (1) KR960013079B1 (enExample)
CN (2) CN1020114C (enExample)
AR (1) AR243528A1 (enExample)
AT (1) ATE73805T1 (enExample)
AU (1) AU605218B2 (enExample)
BR (1) BR8706745A (enExample)
CA (1) CA1338050C (enExample)
DE (1) DE3777604D1 (enExample)
DK (2) DK168488B1 (enExample)
EG (1) EG18720A (enExample)
ES (1) ES2033325T3 (enExample)
GR (1) GR3004882T3 (enExample)
HU (1) HU198723B (enExample)
IL (1) IL84801A (enExample)
NZ (1) NZ222884A (enExample)
OA (1) OA08698A (enExample)
PH (1) PH26780A (enExample)
PT (1) PT86350B (enExample)
RU (1) RU1836426C (enExample)
SU (1) SU1604159A3 (enExample)
ZA (1) ZA879279B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2133753C1 (ru) * 1993-08-19 1999-07-27 Мерк Энд Ко., Инк. Кристаллический полугидрат типа b соли бензойной кислоты 4''-деокси-4''-эпи- метиламиноавермектина bia/bib, способ ее получения, инсектицидная композиция и способ борьбы с сельскохозяйственными насекомыми-вредителями

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3750495T2 (de) * 1986-07-24 1995-02-23 Beecham Group Plc Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen.
AR243528A1 (es) * 1986-12-11 1993-08-31 Sankyo Co Procedimiento para preparar compuestos de macrolida y un procedimiento para producir con los mismos una composicion parasiticida.
US5212322A (en) * 1986-12-11 1993-05-18 Sankyo Company, Limited Macrolide compounds, their preparation and their use
AU615921B2 (en) * 1987-07-07 1991-10-17 Kumiai Chemical Industry Co., Ltd. Antibiotic ksb-1939 compounds and production process thereof as well as pesticidal agents containing same
NZ233680A (en) * 1989-05-17 1995-02-24 Beecham Group Plc Avermectins and milbemycins and compositions thereof
IT1255135B (it) * 1992-05-05 1995-10-20 Principio attivo a base di avermectine, ceppo e procedimento per la sua preparazione e composizione veterinaria che lo contiene.
US5364623A (en) * 1993-04-30 1994-11-15 Bristol-Myers Squibb Company Antibiotic produced by Bacillus subtilis ATCC 55422 capable of inhibiting bacteria
US5362863A (en) * 1993-09-29 1994-11-08 Merck & Co., Inc. Process for the preparation of 4"-amino avermectin compounds
GB9402916D0 (en) * 1994-02-16 1994-04-06 Pfizer Ltd Antiparasitic agents
JP2003501358A (ja) * 1999-05-26 2003-01-14 ノバルティス アクチエンゲゼルシャフト ４置換ミルベマイシン誘導体
JP4373080B2 (ja) * 2002-12-24 2009-11-25 三井化学アグロ株式会社 ミルベマイシン類の精製法
EP2886640A1 (en) 2013-12-18 2015-06-24 Riga Technical University Process for isolation of milbemycins A3 and A4
CN103833811A (zh) * 2014-03-25 2014-06-04 武汉大学 一种阿维菌素衍生物及其制备方法
CN106148215B (zh) * 2015-03-27 2019-06-14 浙江海正药业股份有限公司 一种链霉菌及其生产米尔贝霉素a4的方法
CN106148216B (zh) 2015-03-27 2019-06-04 浙江海正药业股份有限公司 一种链霉菌及其生产米尔贝霉素a3的方法
CN104860961B (zh) * 2015-04-10 2017-08-04 新宇药业股份有限公司 一种制备5‑氧（对‑硝基苯甲酰）‑尼莫克汀的方法
CN109516996B (zh) * 2018-11-26 2021-12-17 山东农业大学 一种大环内酯类衍生物、其合成及应用
CN117568205B (zh) * 2023-10-12 2024-08-16 湖北宏中药业股份有限公司 一株米尔贝霉素高产菌株及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984564A (en) * 1972-06-08 1976-10-05 Sankyo Company Limited Antibiotic substances B-41, their production and their use as insecticides and acaricides
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
US4378353A (en) * 1981-02-17 1983-03-29 Merck & Co., Inc. Novel C-076 compounds
US4412991A (en) * 1981-08-28 1983-11-01 Merck & Co., Inc. 22-Hydroxy derivatives of C-076 compounds, pharmaceutical compositions and method of use
NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions
US4415669A (en) * 1981-12-07 1983-11-15 Merck & Co., Inc. Substance and process for its production
US4582852A (en) * 1983-11-02 1986-04-15 Ciba-Geigy Corporation 14- and 15-hydroxy milbemycin derivatives for controlling plant and animal parasites
US4547491A (en) * 1984-07-18 1985-10-15 Merck & Co., Inc. C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical compositions and method of use
HUT39739A (en) * 1984-12-04 1986-10-29 Ciba Geigy Ag Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
NZ215917A (en) * 1985-05-02 1989-10-27 Merck & Co Inc 22-oh milbemycin derivatives and parasiticidal compositions
GB8606123D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
GB8606116D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process
GB8606120D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process
DE3750495T2 (de) * 1986-07-24 1995-02-23 Beecham Group Plc Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen.
AR243528A1 (es) * 1986-12-11 1993-08-31 Sankyo Co Procedimiento para preparar compuestos de macrolida y un procedimiento para producir con los mismos una composicion parasiticida.
DE3889676D1 (de) * 1987-02-04 1994-06-30 Ciba Geigy Mikrobielles Verfahren zur Herstellung von Milbemycin-Derivaten.
AU615921B2 (en) * 1987-07-07 1991-10-17 Kumiai Chemical Industry Co., Ltd. Antibiotic ksb-1939 compounds and production process thereof as well as pesticidal agents containing same
JPH01197488A (ja) * 1988-02-02 1989-08-09 Kumiai Chem Ind Co Ltd 生理活性物質ｋｓｂ−１９３９化合物及びその製造法
JPS6429378A (en) * 1987-07-23 1989-01-31 Kumiai Chemical Industry Co Physiologically active substance and production thereof
JPH01272587A (ja) * 1987-10-09 1989-10-31 Microbial Chem Res Found マクロライド抗生物質ｍｉ１９８物質及びその製造法、並びに線形動物又は節足動物の殺滅剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ЕР № 74758, кл. С 07 D 493/22, опублик. 1982. ЕР N 1237341, кл. С 07 D 493/22, опублик. 1987. Патент JP К 29742-84, 25 (243) опублик. 1984. Патент US № 3950360, кл. 260-343.2, R, опублик;. 1975. Патент US № 4346771, кл. 260- 343, 41, опублик. 1985. Патент GB № 2056986 А, кл. С 07 D 493/22, спублик. 1981. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2133753C1 (ru) * 1993-08-19 1999-07-27 Мерк Энд Ко., Инк. Кристаллический полугидрат типа b соли бензойной кислоты 4''-деокси-4''-эпи- метиламиноавермектина bia/bib, способ ее получения, инсектицидная композиция и способ борьбы с сельскохозяйственными насекомыми-вредителями

Also Published As

Publication number Publication date
US5008191A (en) 1991-04-16
AR243528A1 (es) 1993-08-31
EP0274871A1 (en) 1988-07-20
EG18720A (en) 1993-12-30
PT86350B (pt) 1990-11-07
IL84801A (en) 1992-02-16
KR880007740A (ko) 1988-08-29
ATE73805T1 (de) 1992-04-15
OA08698A (en) 1989-03-31
CA1338050C (en) 1996-02-13
EP0274871B1 (en) 1992-03-18
CN87108339A (zh) 1988-07-13
ES2033325T3 (es) 1993-03-16
PT86350A (en) 1988-01-01
DK653287A (da) 1988-06-12
DK168994B1 (da) 1994-07-25
AU605218B2 (en) 1991-01-10
ZA879279B (en) 1989-08-30
HUT45982A (en) 1988-09-28
CN1028530C (zh) 1995-05-24
DK168488B1 (da) 1994-04-05
IL84801A0 (en) 1988-06-30
HU198723B (en) 1989-11-28
RU1836426C (ru) 1993-08-23
PH26780A (en) 1992-10-13
DK90393D0 (da) 1993-08-04
CN1064866A (zh) 1992-09-30
AU8247987A (en) 1988-06-23
NZ222884A (en) 1992-02-25
DK90393A (da) 1993-08-04
DK653287D0 (da) 1987-12-11
BR8706745A (pt) 1988-07-19
CN1020114C (zh) 1993-03-17
KR960013079B1 (ko) 1996-09-30
GR3004882T3 (enExample) 1993-04-28
DE3777604D1 (de) 1992-04-23

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