RU1836426C - Способ получени смеси милбемицинов @ , @ , @ , @ и @ - Google Patents

Способ получени смеси милбемицинов @ , @ , @ , @ и @

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Publication number
RU1836426C
RU1836426C SU4203955A SU4203955A RU1836426C RU 1836426 C RU1836426 C RU 1836426C SU 4203955 A SU4203955 A SU 4203955A SU 4203955 A SU4203955 A SU 4203955A RU 1836426 C RU1836426 C RU 1836426C
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SU4203955A
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English (en)
Inventor
Оказаки Такао
Танахаси Судзи
Ивадо Сейго
Танака Кейдзи
Янаи Тосиаки
Кадзино Хисаки
Original Assignee
Санкио Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Санкио Компани Лимитед filed Critical Санкио Компани Лимитед
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Publication of RU1836426C publication Critical patent/RU1836426C/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/898—Streptomyces hygroscopicus

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Insects & Arthropods (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Использование: фармацевтическа  промышленность , ветеринари  и медицина. Сущность способа заключаетс  в том, что штамм Streptomyces hygroscopicus subsp. aureolacrimpsus.. SANK 6028 PERM BP- 1190 культивируют в аэробных услови х в питательной среде, содержащей источники углерода, азота, в течение 5-15 дней при 22-30°С и выдел ют целевой продукт из фильтрата культуральной жидкости. 3 табл.

Description

Среда
Свойство
Характеристики
Сахарно - нитратный агар
рост
аэриальный мицелий обратна  поверхность растворимый пигмент
Глюкозо - аспарагиновый агар
рост аэриальный мицелий
обратна  поверхность растворимый пигмент
Неорганическа  соль-крахмальный arap(SP4)
аэриальный мицелий
обратна  поверхность
растворимый пигмент
агар
рост аэриальный мицелий
обратна  поверхность растворимый пигмент
рост
аэриальный мицелий обратна  поверхность растворимый пигмент
рост аэриальный мицелий
обратна  поверхность растворимый пигмент
хороший, серовато-белый
(№-9)
хороший, белый
желтозато - сера 
нет
очень хороший, желтовато - серый
(2-9-11)
хороший, серовато-белый (Мг-9)
с ветло - жел та  (3-9-10)
нет
Хороший, желтовато-коричневый (2-9-11) хороший, белый - желтовато-серый (2-9-11) светло-желта  (8-9-11) нет
очень хороший, светло оливковый (6-8-11) обильный, от белого до светло олй йково-серого
(4-8-11)
желтовато- коричнева 
(2-9-11)
нет
хороший, светлый оливковосерый (2-8-11) хороший, от белого до светл о-желтого (3-9-10) . светло-желта (6-8-10) нет
хороший, желтовато-серый
(2-9-12)
хороший, белый
желтовато-сера  (4-9-11)
нет
хороший, желтовато-серый
(1-9-10)
незначительное образование , серый () светло-желта  (3-9-Ю) нет
Среда
Агар дрожжевой экстракт- солодовый экстракт (ISP2)
обратна  поверхность
растворимый пигмент
Агар овс ной муки (ISP3)
Водный агар
Агар картофельный
экстракт- морковный
экстракт
3. Физиологические свойства Физиологические свойства штамма SANK 60286 показаны ниже,
Гидролиз крахмала
Ожижение желатина
Восстановление нитрата
Коагул ци  молока ( при 28° и 37°С)
Пептонизаци  молока (при 28 и 37°С)
Интервал температур роста (среда 1)
Образование меланоидного пигмента
Продолжение табл. 1
Свойство
Характеристики
очень хороший, желтовато- коричневый (2-9-11 ) обильный, серовато-белый
(№-9) красновато - желта 
(12-8-9) светло-желтый ( 8-9-12 )
очень хороший, светло- желтый (8-9-12 ) . обильный, серовато-белый (Мг-8) желтовато-коричнева 
(2-9-11)
светлый оливково-се- рый (4-7-11)
бедный, серовато-белый
(№-9)
незначительное образование , светлый коричнево-серый (2-8-9) серовато-бела  (№-9) нет
бедный, серовато-белый
(hfc-9)
хороший, светлый коричнево-серый (2-8-8) светложелто-оранжева  (2-9-9) нет
положительный положительное(слабое)
положительное
положительно  (слабо )
положительной(слабо )
13-37°С
Среда 1: агар дрожжевой экстракт-солодовый экстракт (ISP2) среда 2: триптон-дрожжевой экстракт-бульон (ISP 1) среда 3: агар пептон дрожжевой экстракт-железо (ISP 6) среда 4: тирозиновый агар (ISP 7)
ррт ч/млн
Продолжение табл. 1
Таблица 2
Таблица 3
ppm ч/млн.
Продолжение табл. 3
SU4203955A 1986-12-11 1987-12-10 Способ получени смеси милбемицинов @ , @ , @ , @ и @ RU1836426C (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61295452 1986-12-11

Publications (1)

Publication Number Publication Date
RU1836426C true RU1836426C (ru) 1993-08-23

Family

ID=17820769

Family Applications (1)

Application Number Title Priority Date Filing Date
SU4203955A RU1836426C (ru) 1986-12-11 1987-12-10 Способ получени смеси милбемицинов @ , @ , @ , @ и @

Country Status (23)

Country Link
US (1) US5008191A (ru)
EP (1) EP0274871B1 (ru)
KR (1) KR960013079B1 (ru)
CN (2) CN1020114C (ru)
AR (1) AR243528A1 (ru)
AT (1) ATE73805T1 (ru)
AU (1) AU605218B2 (ru)
BR (1) BR8706745A (ru)
CA (1) CA1338050C (ru)
DE (1) DE3777604D1 (ru)
DK (2) DK168488B1 (ru)
EG (1) EG18720A (ru)
ES (1) ES2033325T3 (ru)
GR (1) GR3004882T3 (ru)
HU (1) HU198723B (ru)
IL (1) IL84801A (ru)
NZ (1) NZ222884A (ru)
OA (1) OA08698A (ru)
PH (1) PH26780A (ru)
PT (1) PT86350B (ru)
RU (1) RU1836426C (ru)
SU (1) SU1604159A3 (ru)
ZA (1) ZA879279B (ru)

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JP2587241B2 (ja) * 1986-07-24 1997-03-05 ビ−チヤム・グル−プ・ピ−エルシ− 新規化合物、その製法及びそれを含む医薬組成物
AR243528A1 (es) * 1986-12-11 1993-08-31 Sankyo Co Procedimiento para preparar compuestos de macrolida y un procedimiento para producir con los mismos una composicion parasiticida.
US5212322A (en) * 1986-12-11 1993-05-18 Sankyo Company, Limited Macrolide compounds, their preparation and their use
EP0298423A3 (en) * 1987-07-07 1989-10-25 Kumiai Chemical Industry Co., Ltd. Antibiotic ksb-1939 compounds and production process thereof as well as pesticidal agents containing same
NZ233680A (en) * 1989-05-17 1995-02-24 Beecham Group Plc Avermectins and milbemycins and compositions thereof
IT1255135B (it) * 1992-05-05 1995-10-20 Principio attivo a base di avermectine, ceppo e procedimento per la sua preparazione e composizione veterinaria che lo contiene.
US5364623A (en) * 1993-04-30 1994-11-15 Bristol-Myers Squibb Company Antibiotic produced by Bacillus subtilis ATCC 55422 capable of inhibiting bacteria
US5362863A (en) * 1993-09-29 1994-11-08 Merck & Co., Inc. Process for the preparation of 4"-amino avermectin compounds
EP1180106A1 (en) * 1999-05-26 2002-02-20 Novartis AG 4-substituted milbemycin derivatives
JP4373080B2 (ja) * 2002-12-24 2009-11-25 三井化学アグロ株式会社 ミルベマイシン類の精製法
EP2886640A1 (en) 2013-12-18 2015-06-24 Riga Technical University Process for isolation of milbemycins A3 and A4
CN103833811A (zh) * 2014-03-25 2014-06-04 武汉大学 一种阿维菌素衍生物及其制备方法
CN106148216B (zh) * 2015-03-27 2019-06-04 浙江海正药业股份有限公司 一种链霉菌及其生产米尔贝霉素a3的方法
CN106148215B (zh) * 2015-03-27 2019-06-14 浙江海正药业股份有限公司 一种链霉菌及其生产米尔贝霉素a4的方法
CN104860961B (zh) * 2015-04-10 2017-08-04 新宇药业股份有限公司 一种制备5‑氧（对‑硝基苯甲酰）‑尼莫克汀的方法
CN109516996B (zh) * 2018-11-26 2021-12-17 山东农业大学 一种大环内酯类衍生物、其合成及应用
CN117568205B (zh) * 2023-10-12 2024-08-16 湖北宏中药业股份有限公司 一株米尔贝霉素高产菌株及其应用

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US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
US4378353A (en) * 1981-02-17 1983-03-29 Merck & Co., Inc. Novel C-076 compounds
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NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions
US4415669A (en) * 1981-12-07 1983-11-15 Merck & Co., Inc. Substance and process for its production
US4582852A (en) * 1983-11-02 1986-04-15 Ciba-Geigy Corporation 14- and 15-hydroxy milbemycin derivatives for controlling plant and animal parasites
US4547491A (en) * 1984-07-18 1985-10-15 Merck & Co., Inc. C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical compositions and method of use
HUT39739A (en) * 1984-12-04 1986-10-29 Ciba Geigy Ag Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
NZ215917A (en) * 1985-05-02 1989-10-27 Merck & Co Inc 22-oh milbemycin derivatives and parasiticidal compositions
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AR243528A1 (es) * 1986-12-11 1993-08-31 Sankyo Co Procedimiento para preparar compuestos de macrolida y un procedimiento para producir con los mismos una composicion parasiticida.
EP0277916B1 (de) * 1987-02-04 1994-05-25 Ciba-Geigy Ag Mikrobielles Verfahren zur Herstellung von Milbemycin-Derivaten
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Also Published As

Publication number Publication date
HU198723B (en) 1989-11-28
CN1064866A (zh) 1992-09-30
DK90393D0 (da) 1993-08-04
CN87108339A (zh) 1988-07-13
CN1028530C (zh) 1995-05-24
KR880007740A (ko) 1988-08-29
IL84801A0 (en) 1988-06-30
EG18720A (en) 1993-12-30
CN1020114C (zh) 1993-03-17
HUT45982A (en) 1988-09-28
ES2033325T3 (es) 1993-03-16
DK90393A (da) 1993-08-04
EP0274871B1 (en) 1992-03-18
AR243528A1 (es) 1993-08-31
PH26780A (en) 1992-10-13
OA08698A (en) 1989-03-31
SU1604159A3 (ru) 1990-10-30
DE3777604D1 (de) 1992-04-23
ZA879279B (en) 1989-08-30
DK168994B1 (da) 1994-07-25
US5008191A (en) 1991-04-16
DK653287D0 (da) 1987-12-11
PT86350A (en) 1988-01-01
PT86350B (pt) 1990-11-07
EP0274871A1 (en) 1988-07-20
DK168488B1 (da) 1994-04-05
GR3004882T3 (ru) 1993-04-28
CA1338050C (en) 1996-02-13
ATE73805T1 (de) 1992-04-15
IL84801A (en) 1992-02-16
KR960013079B1 (ko) 1996-09-30
AU605218B2 (en) 1991-01-10
DK653287A (da) 1988-06-12
BR8706745A (pt) 1988-07-19
AU8247987A (en) 1988-06-23
NZ222884A (en) 1992-02-25

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