SU1241989A3 - Способ получени (-)-2- @ 1-(2,6-дихлорфенокси)этил @ -1,3-диазациклопентена-2 или его гидрохлорида - Google Patents

Способ получени (-)-2- @ 1-(2,6-дихлорфенокси)этил @ -1,3-диазациклопентена-2 или его гидрохлорида Download PDF

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Publication number
SU1241989A3
SU1241989A3 SU823521885A SU3521885A SU1241989A3 SU 1241989 A3 SU1241989 A3 SU 1241989A3 SU 823521885 A SU823521885 A SU 823521885A SU 3521885 A SU3521885 A SU 3521885A SU 1241989 A3 SU1241989 A3 SU 1241989A3
Authority
SU
USSR - Soviet Union
Prior art keywords
dichlorophenoxy
ethyl
hydrochloride
diazacyclopentene
propionic acid
Prior art date
Application number
SU823521885A
Other languages
English (en)
Russian (ru)
Inventor
Бидерманн Юрген
Проп Геррит
Доппельфельд Илле-Штефание
Original Assignee
А.Наттерманн Унд Ко,Гмбх (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by А.Наттерманн Унд Ко,Гмбх (Фирма) filed Critical А.Наттерманн Унд Ко,Гмбх (Фирма)
Application granted granted Critical
Publication of SU1241989A3 publication Critical patent/SU1241989A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
SU823521885A 1981-12-10 1982-12-09 Способ получени (-)-2- @ 1-(2,6-дихлорфенокси)этил @ -1,3-диазациклопентена-2 или его гидрохлорида SU1241989A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813149009 DE3149009A1 (de) 1981-12-10 1981-12-10 (-)-2-(1-(2,6-dichlorphenoxy)-ethyl)-1,3-diazacyclopent-2-en, dessen herstellung und seine verwendung in pharmazeutischen praeparaten

Publications (1)

Publication Number Publication Date
SU1241989A3 true SU1241989A3 (ru) 1986-06-30

Family

ID=6148418

Family Applications (1)

Application Number Title Priority Date Filing Date
SU823521885A SU1241989A3 (ru) 1981-12-10 1982-12-09 Способ получени (-)-2- @ 1-(2,6-дихлорфенокси)этил @ -1,3-диазациклопентена-2 или его гидрохлорида

Country Status (19)

Country Link
US (1) US4518783A (enExample)
EP (1) EP0081748B1 (enExample)
JP (1) JPS58105968A (enExample)
AR (1) AR242192A1 (enExample)
AT (1) ATE25520T1 (enExample)
AU (1) AU553892B2 (enExample)
CA (1) CA1176641A (enExample)
DD (1) DD205682A5 (enExample)
DE (2) DE3149009A1 (enExample)
DK (1) DK548182A (enExample)
ES (1) ES8401947A1 (enExample)
FI (1) FI73980C (enExample)
GR (1) GR77767B (enExample)
IE (1) IE54222B1 (enExample)
NO (1) NO158016C (enExample)
PT (1) PT75961B (enExample)
SU (1) SU1241989A3 (enExample)
YU (1) YU273682A (enExample)
ZA (1) ZA828743B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3407509A1 (de) 1984-03-01 1985-09-05 A. Nattermann & Cie GmbH, 5000 Köln Neue arzneimittelkombination zur behandlung von bluthochdruck und thromboembolischen erkrankungen
US4801617A (en) * 1987-04-06 1989-01-31 Leclerc Gerard Iminoimidazolidines useful in lowering intraocular pressure
FR2642422A1 (fr) * 1988-12-22 1990-08-03 Roussel Uclaf Nouvelles polyamines acylees, leur procede de preparation et leur application comme fongicides
JP2011530504A (ja) * 2008-08-08 2011-12-22 アジーン リミテッド ライアビリティー カンパニー Ｃｎｓ疾患及び病理の治療に用いるロフェキシジンエナンチオマー、並びにそのキラル合成法
US8101779B2 (en) * 2008-10-06 2012-01-24 University Of Kentucky Research Foundation Enantioselective synthesis of (+) and (–)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene
IT201900009777A1 (it) 2019-06-21 2020-12-21 Procos Spa Processo per la sintesi di lofexidina
ES2993182T3 (en) 2020-04-17 2024-12-23 Medichem Sa Process for the synthesis of lofexidine
CN111393369B (zh) * 2020-05-13 2022-12-16 宁夏大学 一种2-己基咪唑的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966757A (en) * 1967-02-23 1976-06-29 A. Nattermann & Cie Gmbh Imidazoline derivatives and processes for the production thereof
DE1695555A1 (de) * 1967-02-23 1970-07-16 Nordmark Werke Gmbh Neue Aryloxy-isoalkyl-delta2-imidazoline und deren Saeureadditionssalze sowie Verfahren zu ihrer Herstellung
US4025639A (en) * 1967-02-23 1977-05-24 A. Nattermann & Cie Gmbh Blood pressure lowering in human mammals
AU3546478A (en) * 1977-04-29 1979-11-01 Ciba Geigy Ag Ectoparasiticides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент DE № 1795843, кл. С 07 D 233/22, опублик. 1977. *

Also Published As

Publication number Publication date
IE54222B1 (en) 1989-07-19
ES518033A0 (es) 1984-01-01
FI73980B (fi) 1987-08-31
EP0081748A3 (en) 1984-03-07
IE822812L (en) 1983-06-10
ZA828743B (en) 1983-09-28
FI73980C (fi) 1987-12-10
ATE25520T1 (de) 1987-03-15
NO158016B (no) 1988-03-21
FI824216A0 (fi) 1982-12-08
NO158016C (no) 1988-06-29
DE3275466D1 (en) 1987-04-02
NO824148L (no) 1983-06-13
DK548182A (da) 1983-06-11
AU9105982A (en) 1983-06-16
GR77767B (enExample) 1984-09-25
US4518783A (en) 1985-05-21
PT75961B (en) 1985-10-04
CA1176641A (en) 1984-10-23
ES8401947A1 (es) 1984-01-01
YU273682A (en) 1985-04-30
EP0081748B1 (de) 1987-02-25
AR242192A1 (es) 1993-03-31
AU553892B2 (en) 1986-07-31
FI824216L (fi) 1983-06-11
PT75961A (en) 1983-01-01
JPS58105968A (ja) 1983-06-24
DD205682A5 (de) 1984-01-04
EP0081748A2 (de) 1983-06-22
DE3149009A1 (de) 1983-06-23

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