FI824216A0 - Foerfarande foer framstaellning av (-)-2-/1-(2,6-diklorfenoxi)-etyl-/1,3-diazacyklopent-2-en - Google Patents
Foerfarande foer framstaellning av (-)-2-/1-(2,6-diklorfenoxi)-etyl-/1,3-diazacyklopent-2-enInfo
- Publication number
- FI824216A0 FI824216A0 FI824216A FI824216A FI824216A0 FI 824216 A0 FI824216 A0 FI 824216A0 FI 824216 A FI824216 A FI 824216A FI 824216 A FI824216 A FI 824216A FI 824216 A0 FI824216 A0 FI 824216A0
- Authority
- FI
- Finland
- Prior art keywords
- diazacyclopent
- framstation
- dichlorophenoxy
- ethyl
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813149009 DE3149009A1 (de) | 1981-12-10 | 1981-12-10 | (-)-2-(1-(2,6-dichlorphenoxy)-ethyl)-1,3-diazacyclopent-2-en, dessen herstellung und seine verwendung in pharmazeutischen praeparaten |
| DE3149009 | 1981-12-10 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI824216A0 true FI824216A0 (fi) | 1982-12-08 |
| FI824216L FI824216L (fi) | 1983-06-11 |
| FI73980B FI73980B (fi) | 1987-08-31 |
| FI73980C FI73980C (fi) | 1987-12-10 |
Family
ID=6148418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI824216A FI73980C (fi) | 1981-12-10 | 1982-12-08 | Foerfarande foer framstaellning av (-)-2-/1-(2,6-diklorfenoxi)-etyl-/1,3-diazacyklopent-2-en. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4518783A (fi) |
| EP (1) | EP0081748B1 (fi) |
| JP (1) | JPS58105968A (fi) |
| AR (1) | AR242192A1 (fi) |
| AT (1) | ATE25520T1 (fi) |
| AU (1) | AU553892B2 (fi) |
| CA (1) | CA1176641A (fi) |
| DD (1) | DD205682A5 (fi) |
| DE (2) | DE3149009A1 (fi) |
| DK (1) | DK548182A (fi) |
| ES (1) | ES8401947A1 (fi) |
| FI (1) | FI73980C (fi) |
| GR (1) | GR77767B (fi) |
| IE (1) | IE54222B1 (fi) |
| NO (1) | NO158016C (fi) |
| PT (1) | PT75961B (fi) |
| SU (1) | SU1241989A3 (fi) |
| YU (1) | YU273682A (fi) |
| ZA (1) | ZA828743B (fi) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3407509A1 (de) * | 1984-03-01 | 1985-09-05 | A. Nattermann & Cie GmbH, 5000 Köln | Neue arzneimittelkombination zur behandlung von bluthochdruck und thromboembolischen erkrankungen |
| US4801617A (en) * | 1987-04-06 | 1989-01-31 | Leclerc Gerard | Iminoimidazolidines useful in lowering intraocular pressure |
| FR2642422A1 (fr) * | 1988-12-22 | 1990-08-03 | Roussel Uclaf | Nouvelles polyamines acylees, leur procede de preparation et leur application comme fongicides |
| WO2010016844A1 (en) * | 2008-08-08 | 2010-02-11 | Agean Llc | Lofexidine enantiomers for use as a treatment for cns disease and pathologies and its chiral synthesis |
| US8101779B2 (en) * | 2008-10-06 | 2012-01-24 | University Of Kentucky Research Foundation | Enantioselective synthesis of (+) and (–)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene |
| IT201900009777A1 (it) | 2019-06-21 | 2020-12-21 | Procos Spa | Processo per la sintesi di lofexidina |
| US20230123335A1 (en) | 2020-04-17 | 2023-04-20 | Medichem, S.A. | Process for the synthesis of lofexidine |
| CN111393369B (zh) * | 2020-05-13 | 2022-12-16 | 宁夏大学 | 一种2-己基咪唑的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1695555A1 (de) * | 1967-02-23 | 1970-07-16 | Nordmark Werke Gmbh | Neue Aryloxy-isoalkyl-delta2-imidazoline und deren Saeureadditionssalze sowie Verfahren zu ihrer Herstellung |
| US4025639A (en) * | 1967-02-23 | 1977-05-24 | A. Nattermann & Cie Gmbh | Blood pressure lowering in human mammals |
| US3966757A (en) * | 1967-02-23 | 1976-06-29 | A. Nattermann & Cie Gmbh | Imidazoline derivatives and processes for the production thereof |
| NL7804482A (nl) * | 1977-04-29 | 1978-10-31 | Ciba Geigy | Preparaten ter bestrijding van ectoparasieten. |
-
1981
- 1981-12-10 DE DE19813149009 patent/DE3149009A1/de not_active Withdrawn
-
1982
- 1982-11-25 IE IE2812/82A patent/IE54222B1/en unknown
- 1982-11-26 ZA ZA828743A patent/ZA828743B/xx unknown
- 1982-12-01 DE DE8282111098T patent/DE3275466D1/de not_active Expired
- 1982-12-01 AT AT82111098T patent/ATE25520T1/de not_active IP Right Cessation
- 1982-12-01 EP EP82111098A patent/EP0081748B1/de not_active Expired
- 1982-12-02 GR GR69957A patent/GR77767B/el unknown
- 1982-12-02 AU AU91059/82A patent/AU553892B2/en not_active Ceased
- 1982-12-07 DD DD82245653A patent/DD205682A5/de unknown
- 1982-12-08 FI FI824216A patent/FI73980C/fi not_active IP Right Cessation
- 1982-12-09 DK DK548182A patent/DK548182A/da not_active Application Discontinuation
- 1982-12-09 SU SU823521885A patent/SU1241989A3/ru active
- 1982-12-09 CA CA000417366A patent/CA1176641A/en not_active Expired
- 1982-12-09 PT PT75961A patent/PT75961B/pt unknown
- 1982-12-09 ES ES518033A patent/ES8401947A1/es not_active Expired
- 1982-12-09 NO NO824148A patent/NO158016C/no unknown
- 1982-12-09 JP JP57214751A patent/JPS58105968A/ja active Pending
- 1982-12-09 AR AR82291532A patent/AR242192A1/es active
- 1982-12-10 YU YU02736/82A patent/YU273682A/xx unknown
-
1983
- 1983-05-27 US US06/498,786 patent/US4518783A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES518033A0 (es) | 1984-01-01 |
| FI73980C (fi) | 1987-12-10 |
| JPS58105968A (ja) | 1983-06-24 |
| NO158016B (no) | 1988-03-21 |
| DE3149009A1 (de) | 1983-06-23 |
| ES8401947A1 (es) | 1984-01-01 |
| EP0081748A2 (de) | 1983-06-22 |
| YU273682A (en) | 1985-04-30 |
| NO824148L (no) | 1983-06-13 |
| EP0081748B1 (de) | 1987-02-25 |
| NO158016C (no) | 1988-06-29 |
| DD205682A5 (de) | 1984-01-04 |
| AU9105982A (en) | 1983-06-16 |
| SU1241989A3 (ru) | 1986-06-30 |
| IE54222B1 (en) | 1989-07-19 |
| DE3275466D1 (en) | 1987-04-02 |
| ZA828743B (en) | 1983-09-28 |
| IE822812L (en) | 1983-06-10 |
| ATE25520T1 (de) | 1987-03-15 |
| GR77767B (fi) | 1984-09-25 |
| AU553892B2 (en) | 1986-07-31 |
| CA1176641A (en) | 1984-10-23 |
| DK548182A (da) | 1983-06-11 |
| PT75961A (en) | 1983-01-01 |
| AR242192A1 (es) | 1993-03-31 |
| PT75961B (en) | 1985-10-04 |
| US4518783A (en) | 1985-05-21 |
| FI73980B (fi) | 1987-08-31 |
| FI824216L (fi) | 1983-06-11 |
| EP0081748A3 (en) | 1984-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: A. NATTERMANN & CIE. G.M.B.H |