ZA828743B - (2)-2-(1-(2,6-dichlorophenoxy)-ethyl)-1,3-diazacyclopent-2-ene,the production thereof and the uste thereof in pharmaceutical preparations - Google Patents

(2)-2-(1-(2,6-dichlorophenoxy)-ethyl)-1,3-diazacyclopent-2-ene,the production thereof and the uste thereof in pharmaceutical preparations

Info

Publication number
ZA828743B
ZA828743B ZA828743A ZA828743A ZA828743B ZA 828743 B ZA828743 B ZA 828743B ZA 828743 A ZA828743 A ZA 828743A ZA 828743 A ZA828743 A ZA 828743A ZA 828743 B ZA828743 B ZA 828743B
Authority
ZA
South Africa
Prior art keywords
diazacyclopent
uste
dichlorophenoxy
ene
ethyl
Prior art date
Application number
ZA828743A
Other languages
English (en)
Inventor
Juergen Dr Biedermann
Gerrit Dr Prop
Ille-Stephanie Doppelfeld
Original Assignee
Nattermann A & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nattermann A & Cie filed Critical Nattermann A & Cie
Publication of ZA828743B publication Critical patent/ZA828743B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
ZA828743A 1981-12-10 1982-11-26 (2)-2-(1-(2,6-dichlorophenoxy)-ethyl)-1,3-diazacyclopent-2-ene,the production thereof and the uste thereof in pharmaceutical preparations ZA828743B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813149009 DE3149009A1 (de) 1981-12-10 1981-12-10 (-)-2-(1-(2,6-dichlorphenoxy)-ethyl)-1,3-diazacyclopent-2-en, dessen herstellung und seine verwendung in pharmazeutischen praeparaten

Publications (1)

Publication Number Publication Date
ZA828743B true ZA828743B (en) 1983-09-28

Family

ID=6148418

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA828743A ZA828743B (en) 1981-12-10 1982-11-26 (2)-2-(1-(2,6-dichlorophenoxy)-ethyl)-1,3-diazacyclopent-2-ene,the production thereof and the uste thereof in pharmaceutical preparations

Country Status (19)

Country Link
US (1) US4518783A (xx)
EP (1) EP0081748B1 (xx)
JP (1) JPS58105968A (xx)
AR (1) AR242192A1 (xx)
AT (1) ATE25520T1 (xx)
AU (1) AU553892B2 (xx)
CA (1) CA1176641A (xx)
DD (1) DD205682A5 (xx)
DE (2) DE3149009A1 (xx)
DK (1) DK548182A (xx)
ES (1) ES518033A0 (xx)
FI (1) FI73980C (xx)
GR (1) GR77767B (xx)
IE (1) IE54222B1 (xx)
NO (1) NO158016C (xx)
PT (1) PT75961B (xx)
SU (1) SU1241989A3 (xx)
YU (1) YU273682A (xx)
ZA (1) ZA828743B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3407509A1 (de) 1984-03-01 1985-09-05 A. Nattermann & Cie GmbH, 5000 Köln Neue arzneimittelkombination zur behandlung von bluthochdruck und thromboembolischen erkrankungen
US4801617A (en) * 1987-04-06 1989-01-31 Leclerc Gerard Iminoimidazolidines useful in lowering intraocular pressure
FR2642422A1 (fr) * 1988-12-22 1990-08-03 Roussel Uclaf Nouvelles polyamines acylees, leur procede de preparation et leur application comme fongicides
EP2334297A1 (en) * 2008-08-08 2011-06-22 Agean Llc Lofexidine enantiomers for use as a treatment for cns disease and pathologies and its chiral synthesis
US8101779B2 (en) * 2008-10-06 2012-01-24 University Of Kentucky Research Foundation Enantioselective synthesis of (+) and (–)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene
IT201900009777A1 (it) 2019-06-21 2020-12-21 Procos Spa Processo per la sintesi di lofexidina
US20230123335A1 (en) 2020-04-17 2023-04-20 Medichem, S.A. Process for the synthesis of lofexidine
CN111393369B (zh) * 2020-05-13 2022-12-16 宁夏大学 一种2-己基咪唑的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4025639A (en) * 1967-02-23 1977-05-24 A. Nattermann & Cie Gmbh Blood pressure lowering in human mammals
DE1695555A1 (de) * 1967-02-23 1970-07-16 Nordmark Werke Gmbh Neue Aryloxy-isoalkyl-delta2-imidazoline und deren Saeureadditionssalze sowie Verfahren zu ihrer Herstellung
US3966757A (en) * 1967-02-23 1976-06-29 A. Nattermann & Cie Gmbh Imidazoline derivatives and processes for the production thereof
NL7804482A (nl) * 1977-04-29 1978-10-31 Ciba Geigy Preparaten ter bestrijding van ectoparasieten.

Also Published As

Publication number Publication date
NO158016C (no) 1988-06-29
NO824148L (no) 1983-06-13
EP0081748B1 (de) 1987-02-25
SU1241989A3 (ru) 1986-06-30
FI824216A0 (fi) 1982-12-08
DE3275466D1 (en) 1987-04-02
IE822812L (en) 1983-06-10
EP0081748A2 (de) 1983-06-22
US4518783A (en) 1985-05-21
AR242192A1 (es) 1993-03-31
DK548182A (da) 1983-06-11
YU273682A (en) 1985-04-30
AU9105982A (en) 1983-06-16
ES8401947A1 (es) 1984-01-01
PT75961B (en) 1985-10-04
ATE25520T1 (de) 1987-03-15
JPS58105968A (ja) 1983-06-24
GR77767B (xx) 1984-09-25
IE54222B1 (en) 1989-07-19
FI73980C (fi) 1987-12-10
EP0081748A3 (en) 1984-03-07
DE3149009A1 (de) 1983-06-23
AU553892B2 (en) 1986-07-31
PT75961A (en) 1983-01-01
CA1176641A (en) 1984-10-23
DD205682A5 (de) 1984-01-04
ES518033A0 (es) 1984-01-01
NO158016B (no) 1988-03-21
FI73980B (fi) 1987-08-31
FI824216L (fi) 1983-06-11

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