SU1238732A3 - Способ получени 6-хлор-3-метил-2,3,4,5-тетрагидро-1 @ -3-бензазепина или его гидрохлорида - Google Patents

Способ получени 6-хлор-3-метил-2,3,4,5-тетрагидро-1 @ -3-бензазепина или его гидрохлорида Download PDF

Info

Publication number
SU1238732A3
SU1238732A3 SU823513948A SU3513948A SU1238732A3 SU 1238732 A3 SU1238732 A3 SU 1238732A3 SU 823513948 A SU823513948 A SU 823513948A SU 3513948 A SU3513948 A SU 3513948A SU 1238732 A3 SU1238732 A3 SU 1238732A3
Authority
SU
USSR - Soviet Union
Prior art keywords
chloro
hydrochloride
benzazepine
rats
solution
Prior art date
Application number
SU823513948A
Other languages
English (en)
Russian (ru)
Inventor
Майкл Демаринис Роберт
Пол Хибл Джэкоб
Дэвид Мэтьюс Вильям
Original Assignee
Смитклайн Бекмэн Корпорейшн (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бекмэн Корпорейшн (Фирма) filed Critical Смитклайн Бекмэн Корпорейшн (Фирма)
Application granted granted Critical
Publication of SU1238732A3 publication Critical patent/SU1238732A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
SU823513948A 1981-11-27 1982-11-25 Способ получени 6-хлор-3-метил-2,3,4,5-тетрагидро-1 @ -3-бензазепина или его гидрохлорида SU1238732A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32524981A 1981-11-27 1981-11-27

Publications (1)

Publication Number Publication Date
SU1238732A3 true SU1238732A3 (ru) 1986-06-15

Family

ID=23267072

Family Applications (1)

Application Number Title Priority Date Filing Date
SU823513948A SU1238732A3 (ru) 1981-11-27 1982-11-25 Способ получени 6-хлор-3-метил-2,3,4,5-тетрагидро-1 @ -3-бензазепина или его гидрохлорида

Country Status (6)

Country Link
JP (1) JPS5892616A (ko)
KR (1) KR840002358A (ko)
CS (1) CS233740B2 (ko)
HU (1) HU190648B (ko)
SU (1) SU1238732A3 (ko)
ZA (1) ZA827887B (ko)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7704993B2 (en) 2003-06-17 2010-04-27 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
US8153621B2 (en) 2004-12-23 2012-04-10 Arena Pharmaceuticals, Inc. 5ht2C receptor modulator compositions
US8168782B2 (en) 2006-04-03 2012-05-01 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates related thereto
US8299241B2 (en) 2006-12-05 2012-10-30 Arena Pharmaceuticals, Inc. Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
US8367657B2 (en) 2003-06-17 2013-02-05 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
US8999970B2 (en) 2010-09-01 2015-04-07 Arena Pharmaceuticals, Inc. Administration of an anti-obesity compound to individuals with renal impairment
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
US9169213B2 (en) 2012-10-09 2015-10-27 Arena Pharmaceuticals, Inc. Method of weight management
US9248133B2 (en) 2010-09-01 2016-02-02 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
US9365521B2 (en) 2010-09-01 2016-06-14 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-HT2C agonists

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4541954A (en) * 1984-09-05 1985-09-17 Smithkline Beckman Corporation Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4265890A (en) * 1978-07-07 1981-05-05 Smithkline Corporation 6-Phenyl thio- and 6-cyclohexyl thio-2,3,4,5-tetrahydro-1H-3-benzazepines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент US №.3752892, кл. 424-2444 1973. *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9102627B2 (en) 2003-06-17 2015-08-11 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
US8946207B2 (en) 2003-06-17 2015-02-03 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
US8367657B2 (en) 2003-06-17 2013-02-05 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
US8404675B2 (en) 2003-06-17 2013-03-26 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5HT2C receptor associated diseases
US7704993B2 (en) 2003-06-17 2010-04-27 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
US8546378B2 (en) 2004-12-23 2013-10-01 Arena Pharmaceuticals, Inc. 5HT2C receptor modulator compositions and methods of use
US8153621B2 (en) 2004-12-23 2012-04-10 Arena Pharmaceuticals, Inc. 5ht2C receptor modulator compositions
US8802845B2 (en) 2006-04-03 2014-08-12 Arena Phamaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates related thereto
US8501935B2 (en) 2006-04-03 2013-08-06 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates related thereto
US8168782B2 (en) 2006-04-03 2012-05-01 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates related thereto
US8299241B2 (en) 2006-12-05 2012-10-30 Arena Pharmaceuticals, Inc. Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
US8999970B2 (en) 2010-09-01 2015-04-07 Arena Pharmaceuticals, Inc. Administration of an anti-obesity compound to individuals with renal impairment
US9248133B2 (en) 2010-09-01 2016-02-02 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
US9365521B2 (en) 2010-09-01 2016-06-14 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-HT2C agonists
US9770455B2 (en) 2010-09-01 2017-09-26 Arena Pharmaceuticals, Inc. Administration of an anti-obesity compound to individuals with renal impairment
US9169213B2 (en) 2012-10-09 2015-10-27 Arena Pharmaceuticals, Inc. Method of weight management

Also Published As

Publication number Publication date
JPS5892616A (ja) 1983-06-02
KR840002358A (ko) 1984-06-25
HU190648B (en) 1986-09-29
ZA827887B (en) 1983-11-30
CS233740B2 (en) 1985-03-14

Similar Documents

Publication Publication Date Title
AT390257B (de) Verfahren zur herstellung neuer imidazo(4,5-b)chinolin-derivate
SU820659A3 (ru) Способ получени производных 4-амино- 5-АлКилСульфОНилОАНизАМидОВ, иХ СОлЕй,ОКиСЕй, лЕВО- и пРАВОВРАщАющиХизОМЕРОВ /иХ ВАРиАНТы/
SU1238732A3 (ru) Способ получени 6-хлор-3-метил-2,3,4,5-тетрагидро-1 @ -3-бензазепина или его гидрохлорида
SU1349700A3 (ru) Способ получени (2-оксо-1,2,3,5-тетрагидроимидазо-/2,1- @ /хиназолинил)оксиалкиламидов,их оптических изомеров или фармакологически приемлемых солей с кислотами
JPH05208957A (ja) 新規ｒ−及びｓ−カルバゾール誘導体
PL169415B1 (pl) metylo-6-okso-3-pirydazynylo)fenylo]hydrazono]propanodinitrylu PL PL PL PL PL PL PL PL
US4244961A (en) 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents
CS262690B2 (en) Process for preparing 1-/hydroxystyryl/-5h-2,3-benzodiazepines
PL108111B1 (pl) Method of producing optically active antipodes of sposob wytwarzania optycznie czynnych antypodow n-n-/2-benzhydryloethylo/-n-/1-phenyloethylo/amines /2-benzhydryloetylo/-n-/1-fenyloetylo-/amin,i ich soli and salts thereof
KR920005827B1 (ko) 벤조티아디아제핀 유도체
US4465677A (en) Pharmaceutical compositions and method of producing alpha2 antagonism
US5096900A (en) (4-piperidyl)methyl-2,3-dihydro-1h-isoindole and -2,3,4,5-tetrahydro-1h-benzazepine derivatives, their preparation and their application in therapy
US4298609A (en) 4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol and salts, their preparation and use as blood pressure lowering agents
US4598093A (en) 4-amino-tetrahydro-2-naphthoic acid derivatives
HU196408B (en) Process for producing tetrahydro-imidazo-quinazolines and stimulators of cardiac action containing them
EP0136736B1 (en) 1-(4'-alkylthiophenyl)-2-amino-1,3-propanediol n-substituted derivatives
US3086972A (en) Aza-thiaxanthene derivatives
US4421754A (en) Syndonimine derivatives, process for production thereof, and use thereof
US3496183A (en) Beta-guanidino-ethyl-piperazine derivatives
US5081128A (en) 2,3-dihydro-1h-isoindole derivatives and their application in therapy
SU1551245A3 (ru) Способ получени производных 3-(гидроксиметил)-изохинолина или их фармацевтически активных кислотно-аддитивных солей
US4849420A (en) 2,3,11,12-substituted-5,6,8,9,14,14a-hexahydroisoquino-[1,2-b][3]benzazepines
JPS59155315A (ja) イミダゾ−ル誘導体
US4416882A (en) Di(alkylamino) derivatives of chloronitropyrazines useful as adjuncts to radiation therapy
JP3269658B2 (ja) フェノール誘導体