SU1197566A3 - Способ получени производных имидазолина - Google Patents
Способ получени производных имидазолина Download PDFInfo
- Publication number
- SU1197566A3 SU1197566A3 SU823385605A SU3385605A SU1197566A3 SU 1197566 A3 SU1197566 A3 SU 1197566A3 SU 823385605 A SU823385605 A SU 823385605A SU 3385605 A SU3385605 A SU 3385605A SU 1197566 A3 SU1197566 A3 SU 1197566A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- compound
- methyl
- imidazoline
- formula
- mixture
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract description 5
- 150000002462 imidazolines Chemical class 0.000 title abstract description 3
- 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 title abstract description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 24
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims description 6
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000003054 catalyst Substances 0.000 claims 1
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 abstract description 8
- 231100000252 nontoxic Toxicity 0.000 abstract description 7
- 230000003000 nontoxic effect Effects 0.000 abstract description 7
- 230000008485 antagonism Effects 0.000 abstract description 6
- 230000003518 presynaptic effect Effects 0.000 abstract description 6
- 238000002360 preparation method Methods 0.000 abstract description 5
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- 239000008194 pharmaceutical composition Substances 0.000 abstract description 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 21
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- -1 Hydrochloride (2-methyl-1,4-benzodioxanyl) 2-imidazoline Chemical compound 0.000 description 13
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- 238000005406 washing Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- BLGXFZZNTVWLAY-SCYLSFHTSA-N yohimbine Chemical compound C1=CC=C2C(CCN3C[C@@H]4CC[C@H](O)[C@@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 0.000 description 1
- 229960000317 yohimbine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8102906 | 1981-01-30 | ||
| GB8123277 | 1981-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1197566A3 true SU1197566A3 (ru) | 1985-12-07 |
Family
ID=26278285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU823385605A SU1197566A3 (ru) | 1981-01-30 | 1982-01-28 | Способ получени производных имидазолина |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4397860A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0058006B1 (cg-RX-API-DMAC10.html) |
| AR (1) | AR229957A1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU545344B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA1176638A (cg-RX-API-DMAC10.html) |
| CS (1) | CS245766B2 (cg-RX-API-DMAC10.html) |
| DE (1) | DE3262919D1 (cg-RX-API-DMAC10.html) |
| DK (1) | DK40482A (cg-RX-API-DMAC10.html) |
| ES (1) | ES8302694A1 (cg-RX-API-DMAC10.html) |
| FI (1) | FI67544C (cg-RX-API-DMAC10.html) |
| GB (1) | GB2092139B (cg-RX-API-DMAC10.html) |
| GR (1) | GR75168B (cg-RX-API-DMAC10.html) |
| HU (1) | HU190983B (cg-RX-API-DMAC10.html) |
| IE (1) | IE52310B1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL64880A (cg-RX-API-DMAC10.html) |
| NO (1) | NO156865C (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ199469A (cg-RX-API-DMAC10.html) |
| PH (1) | PH17747A (cg-RX-API-DMAC10.html) |
| PL (1) | PL137716B1 (cg-RX-API-DMAC10.html) |
| PT (1) | PT74354B (cg-RX-API-DMAC10.html) |
| SU (1) | SU1197566A3 (cg-RX-API-DMAC10.html) |
| ZW (1) | ZW1882A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ203680A (en) * | 1982-04-17 | 1985-08-16 | Reckitt & Colmann Prod Ltd | Imidazolines and pharmaceutical compositions |
| US4634714A (en) * | 1983-12-01 | 1987-01-06 | American Home Products Corporation | Inhibition of prolactin release by a benzodioxinylimidazoline derivative |
| FR2698789B1 (fr) * | 1992-12-07 | 1995-03-03 | Pf Medicament | Utilisation de l'idazoxan et ses dérivés pour la préparation d'un médicament destiné au traitement de la maladie de Parkinson et de son évolution. |
| FR2700113B1 (fr) * | 1993-01-07 | 1995-03-24 | Pf Medicament | Utilisation de l'Idazoxan et ses dérivés pour la fabrication de médicaments destinés au traitement des maladies neurodégénératives et en particulier l'évolution de la maladie d'Alzheimer. |
| US6162455A (en) * | 1997-01-22 | 2000-12-19 | American Cyanamid Company | Method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals |
| FR2766824B1 (fr) * | 1997-07-30 | 1999-09-10 | Adir | Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6650943B1 (en) | 2000-04-07 | 2003-11-18 | Advanced Bionics Corporation | Fully implantable neurostimulator for cavernous nerve stimulation as a therapy for erectile dysfunction and other sexual dysfunction |
| US6885895B1 (en) * | 2001-04-26 | 2005-04-26 | Advanced Bionics Corporation | Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction |
| US20050240229A1 (en) * | 2001-04-26 | 2005-10-27 | Whitehurst Tood K | Methods and systems for stimulation as a therapy for erectile dysfunction |
| RU2223450C1 (ru) * | 2002-06-25 | 2004-02-10 | Долотовский Владимир Васильевич | Водонагреватель емкостной газовый |
| CN103030646B (zh) * | 2011-09-29 | 2016-08-24 | 上海恒瑞医药有限公司 | 苯并二氧六环类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2979511A (en) * | 1959-03-25 | 1961-04-11 | Olin Mathieson | Certain 1, 4-benzodioxanyl imidazolines and corresponding pyrimidines and process |
| PH16249A (en) * | 1980-02-04 | 1983-08-16 | Reckitt & Colmann Prod Ltd | Imidazoline derivatives,its pharmaceutical composition and method of use |
-
1982
- 1982-01-12 NZ NZ199469A patent/NZ199469A/en unknown
- 1982-01-13 CA CA000394056A patent/CA1176638A/en not_active Expired
- 1982-01-18 US US06/340,461 patent/US4397860A/en not_active Expired - Fee Related
- 1982-01-22 GB GB8201828A patent/GB2092139B/en not_active Expired
- 1982-01-25 DE DE8282300365T patent/DE3262919D1/de not_active Expired
- 1982-01-25 EP EP82300365A patent/EP0058006B1/en not_active Expired
- 1982-01-26 AR AR288247A patent/AR229957A1/es active
- 1982-01-26 PH PH26794A patent/PH17747A/en unknown
- 1982-01-27 FI FI820262A patent/FI67544C/fi not_active IP Right Cessation
- 1982-01-28 AU AU79926/82A patent/AU545344B2/en not_active Ceased
- 1982-01-28 GR GR67143A patent/GR75168B/el unknown
- 1982-01-28 SU SU823385605A patent/SU1197566A3/ru active
- 1982-01-28 IL IL64880A patent/IL64880A/xx unknown
- 1982-01-28 ES ES509131A patent/ES8302694A1/es not_active Expired
- 1982-01-28 NO NO820258A patent/NO156865C/no unknown
- 1982-01-29 ZW ZW18/82A patent/ZW1882A1/xx unknown
- 1982-01-29 PT PT74354A patent/PT74354B/pt unknown
- 1982-01-29 CS CS82631A patent/CS245766B2/cs unknown
- 1982-01-29 DK DK40482A patent/DK40482A/da not_active Application Discontinuation
- 1982-01-29 HU HU82273A patent/HU190983B/hu not_active IP Right Cessation
- 1982-01-29 IE IE209/82A patent/IE52310B1/en unknown
- 1982-02-19 PL PL1982235152A patent/PL137716B1/pl unknown
Non-Patent Citations (1)
| Title |
|---|
| Эльдерфильд Р. Гетероциклические соединени , т. 5.-М., 196 с. 224. * |
Also Published As
| Publication number | Publication date |
|---|---|
| DK40482A (da) | 1982-07-31 |
| US4397860A (en) | 1983-08-09 |
| CA1176638A (en) | 1984-10-23 |
| IE820209L (en) | 1982-07-30 |
| IL64880A (en) | 1985-04-30 |
| AU545344B2 (en) | 1985-07-11 |
| FI67544B (fi) | 1984-12-31 |
| IE52310B1 (en) | 1987-09-02 |
| GB2092139A (en) | 1982-08-11 |
| ES509131A0 (es) | 1983-01-16 |
| EP0058006A1 (en) | 1982-08-18 |
| AR229957A1 (es) | 1984-01-31 |
| PT74354B (en) | 1983-07-04 |
| PH17747A (en) | 1984-11-27 |
| PL137716B1 (en) | 1986-07-31 |
| DE3262919D1 (en) | 1985-05-15 |
| FI67544C (fi) | 1985-04-10 |
| FI820262L (fi) | 1982-07-31 |
| PL235152A1 (en) | 1983-07-18 |
| AU7992682A (en) | 1982-08-05 |
| GR75168B (cg-RX-API-DMAC10.html) | 1984-07-13 |
| NO156865B (no) | 1987-08-31 |
| NZ199469A (en) | 1984-03-16 |
| HU190983B (en) | 1986-12-28 |
| GB2092139B (en) | 1984-10-31 |
| ES8302694A1 (es) | 1983-01-16 |
| PT74354A (en) | 1982-02-01 |
| IL64880A0 (en) | 1982-03-31 |
| NO156865C (no) | 1987-12-09 |
| EP0058006B1 (en) | 1985-04-10 |
| NO820258L (no) | 1982-08-02 |
| CS245766B2 (en) | 1986-10-16 |
| ZW1882A1 (en) | 1982-06-23 |
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