SMT201600182B - Ligandi sigma per l'uso nella prevenzione e/o nel trattamento del dolore post-operatorio - Google Patents

Ligandi sigma per l'uso nella prevenzione e/o nel trattamento del dolore post-operatorio

Info

Publication number
SMT201600182B
SMT201600182B SM201600182T SM201600182T SMT201600182B SM T201600182 B SMT201600182 B SM T201600182B SM 201600182 T SM201600182 T SM 201600182T SM 201600182 T SM201600182 T SM 201600182T SM T201600182 B SMT201600182 B SM T201600182B
Authority
SM
San Marino
Prior art keywords
ligandi
sigma
prevention
post
treatment
Prior art date
Application number
SM201600182T
Other languages
English (en)
Inventor
Daniel Zamanillo-Castanedo
José Miguel Vela Hernández
Margarita Puig Riera De Conias
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of SMT201600182B publication Critical patent/SMT201600182B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SM201600182T 2010-02-04 2016-06-16 Ligandi sigma per l'uso nella prevenzione e/o nel trattamento del dolore post-operatorio SMT201600182B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10382024A EP2353598A1 (en) 2010-02-04 2010-02-04 Sigma ligands for use in the prevention and/or treatment of postoperative pain
PCT/EP2011/051643 WO2011095584A1 (en) 2010-02-04 2011-02-04 Sigma ligands for use in the prevention and/or treatment of postoperative pain
EP11702057.8A EP2531191B1 (en) 2010-02-04 2011-02-04 Sigma ligands for use in the prevention and/or treatment of postoperative pain

Publications (1)

Publication Number Publication Date
SMT201600182B true SMT201600182B (it) 2016-08-31

Family

ID=42091519

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201600182T SMT201600182B (it) 2010-02-04 2016-06-16 Ligandi sigma per l'uso nella prevenzione e/o nel trattamento del dolore post-operatorio

Country Status (34)

Country Link
US (1) US9844516B2 (it)
EP (2) EP2353598A1 (it)
JP (1) JP5926691B2 (it)
KR (1) KR101708447B1 (it)
CN (2) CN106924264A (it)
AR (1) AR080134A1 (it)
AU (1) AU2011212389B2 (it)
BR (1) BR112012018960A2 (it)
CA (1) CA2788029C (it)
CO (1) CO6602137A2 (it)
CY (1) CY1117651T1 (it)
DK (1) DK2531191T3 (it)
EC (1) ECSP12012038A (it)
ES (1) ES2576844T3 (it)
HK (1) HK1179511A1 (it)
HR (1) HRP20160695T1 (it)
HU (1) HUE027562T2 (it)
IL (1) IL221275A (it)
MA (1) MA34045B1 (it)
ME (1) ME02486B (it)
MX (1) MX2012008193A (it)
MY (1) MY162905A (it)
NZ (1) NZ601131A (it)
PL (1) PL2531191T3 (it)
PT (1) PT2531191E (it)
RS (1) RS55036B1 (it)
RU (1) RU2569055C2 (it)
SG (2) SG10201500868WA (it)
SI (1) SI2531191T1 (it)
SM (1) SMT201600182B (it)
TN (1) TN2012000349A1 (it)
TW (1) TWI585083B (it)
UA (1) UA111148C2 (it)
WO (1) WO2011095584A1 (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2116539A1 (en) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
EP2353591A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
EP2353598A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for use in the prevention and/or treatment of postoperative pain
EP2388005A1 (en) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2415471A1 (en) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
EP2426111A1 (en) * 2010-08-09 2012-03-07 Laboratorios Del. Dr. Esteve, S.A. 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms
RU2469712C2 (ru) * 2010-12-16 2012-12-20 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО "МОНИКИ им. М.Ф. Владимирского") Способ профилактики и лечения послеоперационного болевого синдрома при торакоскопических операциях
EP2524694A1 (en) 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
EP2818166A1 (en) * 2013-06-26 2014-12-31 Laboratorios del Dr. Esteve S.A. Use of sigma receptor ligands for the prevention and treatment of pain associated to interstitial cystitis/bladder pain syndrome (IC/BPS)
TW201605433A (zh) * 2013-09-12 2016-02-16 以斯提夫博士實驗室股份有限公司 ＮＳＡＩＤ與西克馬（ｓｉｇｍａ）受體配位體之組合
MA39147B1 (fr) 2013-12-17 2019-12-31 Esteve Labor Dr Combinaisons d'inhibiteurs de la recapture de sérotonine-norépinéphrine (snri) et de ligands des récepteurs sigma
SI3104847T1 (sl) 2014-02-07 2021-07-30 Tamogatott Kutatoscoportok Irodaja Nova uporaba spojin SIGMA-1 receptor agonista
MA41177A (fr) * 2014-12-15 2017-10-24 Esteve Labor Dr Utilisation de ligands des récepteurs sigma dans l'arthrose
US10189828B2 (en) 2014-12-15 2019-01-29 Laboratorios Del Dr. Esteve S.A. 1-methylpyrazole-piperazine compounds having multimodal activity against pain
CN107868033B (zh) * 2016-09-27 2021-05-18 深圳微芯生物科技股份有限公司 一种苯丙氨酸类化合物的制备方法
US10195192B2 (en) * 2016-11-01 2019-02-05 Anavex Life Sciences Corp. Analgesic therapeutic and method, 1-(3-4(((1R,3S,5S)-adamantan-1-yl)(phenyl)methyl)propyl)-4-methylpiperazine and salts thereof
CA3044746A1 (en) 2016-11-24 2018-05-31 Sigmadrugs Kutato Korlatolt Felelossegu Tarsasag Compositions for organ preservation
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU11248A1 (ru) 1927-03-29 1929-09-30 В.С. Григорьев Способ очистки антрацена
US3428634A (en) 1965-03-13 1969-02-18 Acraf 3-tertiary amino alkoxy-1-hydrocarbon indazoles
IT1005472B (it) 1974-02-15 1976-08-20 Montedison Spa Procedimento per la preparazione del 2,5, dimetil 3,2h, furanone
FR2301250A1 (fr) 1975-02-21 1976-09-17 Bellon Labor Sa Roger Nouveaux diaryl-1, 4o-aminoalcoxy-3 pyrazoles et leurs sels
CA1121651A (en) 1978-07-27 1982-04-13 Chi-Kuen Shu 2,5-dialkyl dihydrofuranones and 2,4,5-trialkyl dihydrofuranones, mixtures of same and organoleptic uses thereof
FR2472564A1 (fr) 1979-12-31 1981-07-03 Bellon Labor Sa Roger Nouveaux aryl-1 arylsulfonyl-4 1h-pyrazolols-3, et procede pour les preparer
US4826868A (en) 1986-05-29 1989-05-02 Ortho Pharmaceutical Corporation 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use
GB8917069D0 (en) 1989-07-26 1989-09-13 Merck Sharp & Dohme Therapeutic agents
IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
JPH05503517A (ja) 1989-12-18 1993-06-10 バージニア・コモンウェルス・ユニバーシティ シグマレセプターリガンド及びその用途
JPH03232817A (ja) 1990-02-07 1991-10-16 Showa Yakuhin Kako Kk 貼付剤
EP0445974A3 (en) 1990-03-05 1992-04-29 Merck Sharp & Dohme Ltd. Spirocyclic antipsychotic agents
JPH04364129A (ja) 1990-10-26 1992-12-16 Asahi Chem Ind Co Ltd ６−置換アルコキシキノキサリン誘導体含有医薬組成物およびその製造法
AU9137091A (en) 1990-11-27 1992-06-25 Northwestern University Gaba and l-glutamic acid analogs for antiseizure treatment
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
US5240925A (en) 1991-08-26 1993-08-31 Rohm And Haas Company Fungicidal 2-aryl-2-cyano-2-(heterocyclylalkyl)ethyl-1,2,4-triazoles
AU677008B2 (en) 1992-05-20 1997-04-10 Northwestern University Gaba and L-glutamic acid analogs for antiseizure treatment
GB9423542D0 (en) 1994-11-22 1995-01-11 Marples Brian A Pharmaceutical compounds
JPH1036259A (ja) 1996-04-11 1998-02-10 Kikkoman Corp 白内障の予防または治療薬剤
JPH1055048A (ja) 1996-08-08 1998-02-24 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
DE69815336T2 (de) 1997-04-14 2004-05-06 Ufc Ltd. Morphin-derivate
SK285644B6 (sk) 1997-07-02 2007-05-03 Merck & Co., Inc. Polymorfná forma zlúčeniny 2-(R)-(1-(R)-(3,5-bis(trifluórmetyl)- fenyl)etoxy)-3-(S)-(4-fluór)fenyl-4-(3-(5-oxo-1H,4H-1,2,4- triazolo)metyl)morfolínu,spôsob jej prípravy, farmaceutický prostriedok s jej obsahom a jej použitie
NZ503651A (en) 1997-10-27 2002-09-27 Warner Lambert Co Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
BR9813656A (pt) 1997-12-16 2000-10-10 Warner Lambert Co Aminas como agentes farmacêuticos
US6545022B1 (en) 1997-12-16 2003-04-08 Pfizer Inc. 4(3)substituted-4(3)-aminomethyl-(thio)pyran or piperidine derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
CN1495160A (zh) 1997-12-16 2004-05-12 ��ʲ 1-取代-1-氨基甲基-环烷衍生物（＝加巴喷丁类似物）、其制备及其在治疗神经病方面的用途
AU4198299A (en) 1998-05-21 1999-12-06 Rae R. Matsumoto Compounds and uses thereof
KR20010043831A (ko) 1998-05-26 2001-05-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 칼슘 채널의 알파2델타 서브유닛에 대한 친화력이 있는구조적으로 한정된 아미노산 화합물
WO2000020005A1 (en) 1998-10-01 2000-04-13 EGIS Gyógyszergyár Rt. Pharmaceutical compositions containing an opiate analgesic and a synergizing substance
GB9824310D0 (en) 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
DE69934902T2 (de) 1998-11-09 2007-10-18 Santen Pharmaceutical Co., Ltd Medikament gegen drogenabhängigkeit
US6627771B1 (en) 1998-11-25 2003-09-30 Pfizer Inc Gamma amino butyric and acid analogs
NO310544B1 (no) 1999-01-04 2001-07-23 Algeta As Opparbeidelse og anvendelse av radium-223 til fremstilling av preparat samt kit til behandling av kalsifisert vev for palliasjon, benkreft-terapi og/eller overflatebehandling av ben
JP2003500466A (ja) 1999-05-26 2003-01-07 ワーナー−ランバート・カンパニー 医薬としての融合多環式アミノ酸
US6436974B1 (en) 1999-06-02 2002-08-20 Warner-Lambert Company Amino heterocycles useful as pharmaceutical agents
NZ528151A (en) 2001-04-19 2005-04-29 Warner Lambert Co Fused bicyclic or tricyclic amino acids
CA2446864C (en) 2001-05-16 2011-02-15 Vertex Pharmaceuticals Incorporated Inhibitors of src and other protein kinases
WO2002102387A1 (en) 2001-06-18 2002-12-27 H. Lundbeck A/S Treatment of neuropathic pain
RU2218187C2 (ru) 2002-02-11 2003-12-10 Ростовский научно-исследовательский онкологический институт Способ лечения болевого синдрома у онкологических больных
GB0206505D0 (en) 2002-03-19 2002-05-01 Euro Celtique Sa Pharmaceutical combination
AU2003265395A1 (en) 2002-08-14 2004-03-03 Ppd Discovery, Inc. Prenylation inhibitors and methods of their synthesis and use
TW200413351A (en) 2002-08-21 2004-08-01 Astrazeneca Ab Chemical compounds
CN100486975C (zh) 2002-11-15 2009-05-13 杜邦公司 新的邻氨基苯甲酰胺杀虫剂
JP2004196678A (ja) 2002-12-17 2004-07-15 Dainippon Pharmaceut Co Ltd ピラゾール系誘導体
WO2005061462A2 (en) 2003-12-19 2005-07-07 Neurogen Corporation Diaryl pyrazole derivatives and their use as neurokinin-3 receptor modulators
WO2006010587A1 (en) 2004-07-24 2006-02-02 Laboratorios Del Dr. Esteve, S.A. Use of compounds active on the sigma receptor for the treatment of mechanical allodynia
ES2251316B1 (es) 2004-10-14 2007-03-16 Laboratorios Del Dr. Esteve, S.A. Inhibidores del receptor sigma.
ES2251317B1 (es) * 2004-10-14 2007-03-16 Laboratorios Del Dr. Esteve, S.A. Inhibidores del receptor sigma.
EP1781618B1 (en) * 2004-08-27 2012-10-03 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
EP1634873A1 (en) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
MX2007002340A (es) * 2004-08-27 2007-10-10 Esteve Labor Dr Inhibidores del receptor sigma.
EP1634872A1 (en) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Pyrazole derivatives as sigma receptor inhibitors
EP1632227A1 (en) 2004-09-07 2006-03-08 Laboratorios del Dr. Esteve S.A. Derivatives of aryl (or heteroaryl) azolylcarbinols (in particular cizolirtin citrate) for the treatment of opioid addiction
JP2008179541A (ja) * 2005-05-02 2008-08-07 Mochida Pharmaceut Co Ltd 神経因性疼痛治療薬
CA2613522A1 (en) 2005-06-27 2007-01-04 Exelixis, Inc. Imidazole based lxr modulators
WO2007025613A2 (en) 2005-07-15 2007-03-08 Laboratorios Del Dr. Esteve, S.A. Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain
EP1787679A1 (en) * 2005-07-29 2007-05-23 Laboratorios Del Dr. Esteve, S.A. Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain
EP1951678A1 (en) 2005-10-21 2008-08-06 Mitsubishi Tanabe Pharma Corporation Pyrazole compounds having cannabinoid receptor (cb1) antagonizing activity
WO2007079086A1 (en) 2005-12-28 2007-07-12 Coley Pharmaceutical Group, Inc. Pyrazoloalkyl substituted imidazo ring compounds and methods
EP1820502A1 (en) 2006-02-10 2007-08-22 Laboratorios Del Dr. Esteve, S.A. Active substance combination comprising azolylcarbinol compounds
US20090181976A1 (en) 2006-02-28 2009-07-16 Buschmann Helmut H Use of Compounds Binding to the Sigma Receptor for the Treatment of Metabolic Syndrome
EP1829875A1 (en) 2006-03-01 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Pyrazole derivatives as sigma receptor inhibitors
EP1829873A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Pyrrazole derivatives as sigma receptors antagonists
EP1829866A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
EP1997434B1 (en) 2006-03-22 2013-05-15 Panasonic Corporation Blood inspection device
ES2691411T3 (es) 2006-03-27 2018-11-27 Wex Medical Limited Uso de bloqueadores de los canales de sodio para el tratamiento del dolor neuropático que se desarrolla como consecuencia de la quimioterapia
EP1847542A1 (en) 2006-04-21 2007-10-24 Laboratorios del Dr. Esteve S.A. Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor
EA200802412A1 (ru) 2006-06-08 2009-06-30 Шварц Фарма Аг Терапевтические комбинации для сопровождающихся болью медицинских состояний
RU2322977C1 (ru) * 2006-08-01 2008-04-27 Закрытое акционерное общество "Физиофарм" Синтетическое анальгетическое средство и способ лечения на основе этого средства
CN101563332A (zh) * 2006-08-04 2009-10-21 埃斯蒂文博士实验室股份有限公司 取代的二甲基环丁基化合物、其制备及在药物中的用途
EP1921073A1 (en) 2006-11-10 2008-05-14 Laboratorios del Dr. Esteve S.A. 1,2,4-Triazole derivatives as sigma receptor inhibitors
KR100868353B1 (ko) 2007-03-08 2008-11-12 한국화학연구원 도파민 ｄ4 수용체 길항제인 신규 피페라지닐프로필피라졸유도체, 이의 제조방법 및 이를 포함하는 약학적 조성물
GB0710981D0 (en) 2007-06-07 2007-07-18 Acacia Pharma Ltd New Therapeutic use
EP2191830A4 (en) 2007-09-21 2011-11-23 Shionogi & Co SOLID PREPARATION COMPRISING A NPYY5 RECEPTOR ANTAGONIST
EP2070933A1 (en) 2007-12-07 2009-06-17 Laboratorios del Dr. Esteve S.A. Tricyclic triazolic compounds
EP2090311A1 (en) 2008-02-18 2009-08-19 Laboratorios Del. Dr. Esteve, S.A. Use of compounds binding to the sigma receptor ligands for the treatment of neuropathic pain developing as a consequence of chemotherapy
RU2537226C2 (ru) * 2008-02-18 2014-12-27 Лабораторьос Дель Др. Эстеве, С.А. Применение соединений, связывающихся с лигандами сигма-рецептора, для лечения развития невропатической боли вследствие химиотерапии
EP2113501A1 (en) 2008-04-25 2009-11-04 Laboratorios Del. Dr. Esteve, S.A. 5-Methyl-1-(naphthalen-2-YL)-1H-Pyrazoles useful as sigma receptor inhibitors
EP2116539A1 (en) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
EP2112139A1 (en) 2008-04-25 2009-10-28 Laboratorios Del. Dr. Esteve, S.A. Process for the preparation of naphthalen-2-yl-pyrazol-3-one intermediates useful in the synthesis of sigma receptor inhibitors
RU2382646C1 (ru) 2008-11-20 2010-02-27 Федеральное государственное учреждение "Московский научно-исследовательский онкологический институт им. П.А. Герцена Федерального агентства по высокотехнологичной медицинской помощи" Способ профилактики и лечения послеоперационного болевого синдрома при обширных торакоабдоминальных операциях
EP2292236A1 (en) 2009-08-14 2011-03-09 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention or treatment of pain induced by chemotherapy
EP2503993B1 (en) 2009-11-25 2016-07-13 Laboratorios Del. Dr. Esteve, S.A. Hydrochloride salt of 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine
EP2361904A1 (en) 2010-02-04 2011-08-31 Laboratorios Del. Dr. Esteve, S.A. 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride and crystalline forms thereof
EP2335688A1 (en) 2009-11-25 2011-06-22 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compositions comprising sigma receptor ligands
PT2531177T (pt) 2010-02-04 2016-08-17 Esteve Labor Dr Polimorfos e solvatos de cloridrato de 4-[-2-[[5-metil-1-(2-naftalenil)-1h-pirazol-3-il]oxi]etil]morfolina
EP2353598A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for use in the prevention and/or treatment of postoperative pain
EP2353591A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
EP2426112A1 (en) 2010-08-09 2012-03-07 Laboratorios Del. Dr. Esteve, S.A. 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride polymorphs and solvates
EP2388005A1 (en) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2395003A1 (en) 2010-05-27 2011-12-14 Laboratorios Del. Dr. Esteve, S.A. Pyrazole compounds as sigma receptor inhibitors
EP2415471A1 (en) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
EP2426111A1 (en) 2010-08-09 2012-03-07 Laboratorios Del. Dr. Esteve, S.A. 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms
EP2460804A1 (en) 2010-12-03 2012-06-06 Laboratorios Del Dr. Esteve, S.A. 5-methyl-1-(naphthalen-2-yl)-1h-pyrazole derivatives and their use in potentiating the effect of opioid analgesics
EP2460519A1 (en) 2010-12-03 2012-06-06 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in bone cancer pain
CN103649076B (zh) 2011-05-13 2015-09-09 阵列生物制药公司 作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物
EP2524694A1 (en) 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
EP2792352A1 (en) 2013-04-16 2014-10-22 Laboratorios Del. Dr. Esteve, S.A. Alpha-2 adrenoreceptor and sigma receptor ligand combinations
FR3005127B1 (fr) 2013-04-29 2015-04-17 Chassis Brakes Int Bv "frein a disque a patin de freins stabilises, et procedes associes d'assemblage et de remplacement d'un patin"
EP2818166A1 (en) 2013-06-26 2014-12-31 Laboratorios del Dr. Esteve S.A. Use of sigma receptor ligands for the prevention and treatment of pain associated to interstitial cystitis/bladder pain syndrome (IC/BPS)
TW201605433A (zh) 2013-09-12 2016-02-16 以斯提夫博士實驗室股份有限公司 ＮＳＡＩＤ與西克馬（ｓｉｇｍａ）受體配位體之組合
MA39147B1 (fr) 2013-12-17 2019-12-31 Esteve Labor Dr Combinaisons d'inhibiteurs de la recapture de sérotonine-norépinéphrine (snri) et de ligands des récepteurs sigma
MA39146A1 (fr) 2013-12-17 2017-11-30 Esteve Labor Dr Combinaisons de gabapentanoïdes et de ligands des récepteurs sigma

Also Published As

Publication number Publication date
CA2788029C (en) 2017-06-27
MA34045B1 (fr) 2013-03-05
HK1179511A1 (zh) 2013-10-04
CA2788029A1 (en) 2011-08-11
ECSP12012038A (es) 2012-08-31
CY1117651T1 (el) 2017-05-17
TWI585083B (zh) 2017-06-01
TW201202227A (en) 2012-01-16
EP2531191B1 (en) 2016-03-30
IL221275A0 (en) 2012-10-31
RS55036B1 (sr) 2016-12-30
CN106924264A (zh) 2017-07-07
ES2576844T3 (es) 2016-07-11
IL221275A (en) 2017-02-28
AU2011212389B2 (en) 2016-05-12
CO6602137A2 (es) 2013-01-18
EP2353598A1 (en) 2011-08-10
AU2011212389A1 (en) 2012-07-26
JP5926691B2 (ja) 2016-05-25
SG182627A1 (en) 2012-08-30
RU2012137501A (ru) 2014-03-10
CN102781445A (zh) 2012-11-14
KR101708447B1 (ko) 2017-02-20
MX2012008193A (es) 2012-08-08
DK2531191T3 (en) 2016-06-13
EP2531191A1 (en) 2012-12-12
SG10201500868WA (en) 2015-04-29
US9844516B2 (en) 2017-12-19
KR20130033351A (ko) 2013-04-03
JP2013518858A (ja) 2013-05-23
HRP20160695T1 (hr) 2016-08-12
HUE027562T2 (en) 2016-10-28
MY162905A (en) 2017-07-31
RU2569055C2 (ru) 2015-11-20
AR080134A1 (es) 2012-03-14
TN2012000349A1 (en) 2014-01-30
SI2531191T1 (sl) 2016-08-31
US20120302568A1 (en) 2012-11-29
BR112012018960A2 (pt) 2016-04-12
PT2531191E (pt) 2016-06-15
UA111148C2 (uk) 2016-04-11
PL2531191T3 (pl) 2017-04-28
NZ601131A (en) 2014-06-27
WO2011095584A1 (en) 2011-08-11
ME02486B (me) 2017-02-20

Similar Documents

Publication Publication Date Title
SMT201600182B (it) Ligandi sigma per l'uso nella prevenzione e/o nel trattamento del dolore post-operatorio
HRP20181364T1 (hr) Aminotriazolopiridin, namijenjen upotrebi u liječenju upale, te njegovi farmacetski pripravci
ZA201304638B (en) Composition for use in the prevention and /or treatment of skin condition and skin diseases.
HK1216251A1 (zh) 吡唑並吡咯烷衍生物及其治病作用
BR112012031194A2 (pt) derivados de cisteamina e seu uso no tratamento de ehna
CA2871774C (en) Use of n-acetylcysteine amide in the treatment of disease and injury
EP2651439A4 (en) COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HUMAN ADENOVIRUS 36 INFECTION
EP2854910A4 (en) CERAMID MIRRORS IN THE TREATMENT AND PREVENTION OF INFECTIONS
GB201222455D0 (en) Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
HRP20170198T1 (hr) Pripravci koji sadrže kondroitin-sulfat, natokinazu i sulfhidrilne spojeve za upotrebu u liječenju upale
GB201115992D0 (en) Inhibitors of Nox4 expression and/or Nox4 function and their use in the prevention and treatment of nerve injury and/or neuropathic pain
BR112015006272A2 (pt) ''uso cosmético, composto, composição cosmética e método de tratamento cosmético''
EP2744786A4 (en) SUBSTITUTED 2-IMIDAZOLIDINONE AND 2-IMIDAZOLONE AND THEIR USE IN THE TREATMENT OF CANCER
HK1206598A1 (en) Eprotirome for use in the prevention and or treatment of hair disorders and compositions thereof
EP3065548A4 (en) Fibrosis inhibiting compounds and methods of use thereof in the prevention or treatment of fibrosing diseases
PT2862576T (pt) Microrganismos e composições que os compreendem para utilização no tratamento ou prevenção de mastite
IT1400389B1 (it) Aminaftone per uso nel trattamento e/o nella prevenzione dell'emicrania
BR112012025829A2 (pt) ''composição de tratamento, composição líquido e utilização''
GB201104720D0 (en) Carncin - The use of L-carnosine and cinnamon in the treatment of alzheimer's disease
AP2015008849A0 (en) Pyrazolopyrrolidine derivatives and their use in the treatment of disease