SMT201600141B - Boronati quali inibitori di arginasi - Google Patents
Boronati quali inibitori di arginasiInfo
- Publication number
- SMT201600141B SMT201600141B SM201600141T SM201600141T SMT201600141B SM T201600141 B SMT201600141 B SM T201600141B SM 201600141 T SM201600141 T SM 201600141T SM 201600141 T SM201600141 T SM 201600141T SM T201600141 B SMT201600141 B SM T201600141B
- Authority
- SM
- San Marino
- Prior art keywords
- boronati
- arginasi
- inhibitors
- arginasi inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40676010P | 2010-10-26 | 2010-10-26 | |
PCT/US2011/056844 WO2012058065A1 (fr) | 2010-10-26 | 2011-10-19 | Boronates en tant qu'inhibiteurs d'arginase |
Publications (1)
Publication Number | Publication Date |
---|---|
SMT201600141B true SMT201600141B (it) | 2016-07-01 |
Family
ID=44913403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SM201600141T SMT201600141B (it) | 2010-10-26 | 2016-05-19 | Boronati quali inibitori di arginasi |
Country Status (19)
Country | Link |
---|---|
US (5) | US9233985B2 (fr) |
EP (3) | EP2632927B1 (fr) |
JP (1) | JP5909239B2 (fr) |
CN (2) | CN106008569B9 (fr) |
AU (1) | AU2011320732B2 (fr) |
BR (1) | BR112013010099B1 (fr) |
CA (1) | CA2815536C (fr) |
DK (1) | DK2632927T3 (fr) |
ES (2) | ES2794006T3 (fr) |
HK (2) | HK1223104A1 (fr) |
HR (1) | HRP20160305T1 (fr) |
HU (1) | HUE027317T2 (fr) |
IL (1) | IL225926A (fr) |
MX (1) | MX336381B (fr) |
PL (1) | PL2632927T3 (fr) |
RS (1) | RS54750B1 (fr) |
SI (1) | SI2632927T1 (fr) |
SM (1) | SMT201600141B (fr) |
WO (1) | WO2012058065A1 (fr) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2729936T3 (es) | 2010-04-22 | 2019-11-07 | Mars Inc | Inhibidores de arginasa y sus aplicaciones terapéuticas |
ES2691468T3 (es) | 2010-08-10 | 2018-11-27 | Rempex Pharmaceuticals, Inc. | Derivados de éster del ácido borónico cíclicos y usos terapéuticos de los mismos |
ES2794006T3 (es) | 2010-10-26 | 2020-11-17 | Mars Inc | Inhibidores de arginasa como agentes terapéuticos |
WO2013158262A1 (fr) * | 2012-04-18 | 2013-10-24 | Mars, Incorporated | Analogues à cycle contraint en tant qu'inhibiteurs d'arginase |
JP2016509594A (ja) | 2013-01-04 | 2016-03-31 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | ボロン酸誘導体及びその治療的使用 |
EP3134546A4 (fr) | 2014-04-24 | 2017-12-06 | Dana-Farber Cancer Institute, Inc. | Suppresseur de tumeur et biomarqueurs oncogènes prédictifs de réponse à un inhibiteur de point de contrôle anti-immunitaire |
DK3140310T3 (da) | 2014-05-05 | 2019-10-21 | Rempex Pharmaceuticals Inc | Syntese af boronatsalte og brug deraf |
EP3139930A4 (fr) | 2014-05-05 | 2018-01-17 | Rempex Pharmaceuticals, Inc. | Sels et polymorphes de dérivés cycliques d'ester d'acide boronique, et leurs utilisations thérapeutiques |
EP3145936B1 (fr) | 2014-05-19 | 2020-09-30 | Qpex Biopharma, Inc. | Dérivés d'acide boronique et leurs utilisations thérapeutiques |
EP3164406A4 (fr) | 2014-07-01 | 2018-04-04 | Rempex Pharmaceuticals, Inc. | Dérivés d'acide boronique et leurs utilisations thérapeutiques |
WO2016081297A1 (fr) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Dérivés d'esters d'acide boronique cycliques et leurs utilisations thérapeutiques |
PL410665A1 (pl) | 2014-12-29 | 2016-07-04 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
WO2016149393A1 (fr) * | 2015-03-17 | 2016-09-22 | Rempex Pharmaceuticals, Inc. | Dérivés d'acide boronique et leurs utilisations thérapeutiques |
US10143699B2 (en) * | 2015-06-23 | 2018-12-04 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
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EP3368541B1 (fr) * | 2015-10-30 | 2020-05-27 | Calithera Biosciences, Inc. | Compositions et procédés d'inhibition de l'activité de l'arginase |
PL417066A1 (pl) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
ES2894251T3 (es) | 2016-06-30 | 2022-02-14 | Qpex Biopharma Inc | Derivados de ácido borónico y usos terapéuticos de los mismos |
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ES2970715T3 (es) | 2016-12-22 | 2024-05-30 | Prec Pharmaceuticals Inc | Composiciones y métodos para inhibir la actividad de la arginasa |
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JOP20190203A1 (ar) | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها |
JP2020519583A (ja) * | 2017-05-12 | 2020-07-02 | カリセラ バイオサイエンシズ,インコーポレイテッド | (3r,4s)−3−アセトアミド−4−アリル−n−(tert−ブチル)ピロリジン−3−カルボキサミドの製造方法 |
JP7377545B2 (ja) | 2017-10-11 | 2023-11-10 | キューペックス バイオファーマ, インコーポレイテッド | ボロン酸誘導体およびその合成 |
WO2019120296A1 (fr) * | 2017-12-22 | 2019-06-27 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Composés hétérocycliques utilisés en tant qu'inhibiteurs de l'arginase |
WO2019159120A1 (fr) | 2018-02-17 | 2019-08-22 | Astrazeneca Ab | Inhibiteurs de l'arginase et leurs procédés d'utilisation |
BR112020017604A2 (pt) * | 2018-03-05 | 2020-12-22 | Arcus Biosciences, Inc. | Inibidores de arginase |
EP3765006A4 (fr) * | 2018-03-13 | 2022-02-23 | Merck Sharp & Dohme Corp. | Inhibiteurs d'arginase et procédés d'utilisation |
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CN112424209A (zh) | 2018-04-20 | 2021-02-26 | Qpex生物制药有限公司 | 硼酸衍生物及其治疗用途 |
WO2019205979A1 (fr) * | 2018-04-27 | 2019-10-31 | 四川科伦博泰生物医药股份有限公司 | Dérivé d'acide aminé non naturel, composition pharmaceutique le contenant, son procédé de préparation et son utilisation |
WO2019218904A1 (fr) * | 2018-05-18 | 2019-11-21 | 四川科伦博泰生物医药股份有限公司 | Dérivé d'acide aminé non naturel, son procédé de préparation et son utilisation |
EP3810615A4 (fr) | 2018-06-20 | 2022-03-30 | Merck Sharp & Dohme Corp. | Inhibiteurs d'arginase et procédés d'utilisation |
TWI828800B (zh) | 2018-11-16 | 2024-01-11 | 美商阿克思生物科學有限公司 | Arg1及/或arg2之抑制劑 |
WO2020113094A1 (fr) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Composés pyrrole et pyrazole et leurs procédés d'utilisation |
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US20220251116A1 (en) * | 2019-02-06 | 2022-08-11 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Alkylboronic acids as arginase inhibitors |
CN113395996B (zh) * | 2019-02-08 | 2024-05-28 | 阿斯利康(瑞典)有限公司 | 精氨酸酶抑制剂及其使用方法 |
CN110734456A (zh) * | 2019-11-06 | 2020-01-31 | 南京谷睿生物科技有限公司 | 一种化合物及其制备方法和医药上的应用 |
US20230140132A1 (en) * | 2020-01-07 | 2023-05-04 | Merck Sharp & Dohme Llc | Arginase inhibitors and methods of use |
WO2021257863A1 (fr) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Composés de pyrrolotriazine utilisés en tant qu'inhibiteurs de v617f de jak2 |
US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
WO2022006456A1 (fr) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Composés de pyridone tricyclique en tant qu'inhibiteurs de v617f de jak2 |
TW202216713A (zh) | 2020-07-02 | 2022-05-01 | 美商英塞特公司 | 作為jak2 v617f抑制劑之三環脲化合物 |
WO2022046989A1 (fr) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Composés d'urée tricycliques en tant qu'inhibiteurs de v617f de jak2 |
WO2022140231A1 (fr) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Composés de déazaguanine utilisés en tant qu'inhibiteurs de v617f de jak2 |
TW202228720A (zh) | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | 精胺酸酶抑制劑及其使用方法 |
US11958861B2 (en) | 2021-02-25 | 2024-04-16 | Incyte Corporation | Spirocyclic lactams as JAK2 V617F inhibitors |
WO2023283332A1 (fr) * | 2021-07-07 | 2023-01-12 | Emory University | Utilisations d'inhibiteurs d'arginase pour la gestion d'une maladie rénale et de troubles cardiovasculaires |
WO2023191116A2 (fr) | 2022-01-21 | 2023-10-05 | Opiyo Sammy Oyoo | Procédés améliorés faisant appel à la suramine et compositions |
WO2023178285A1 (fr) | 2022-03-17 | 2023-09-21 | Incyte Corporation | Composés d'urée tricycliques en tant qu'inhibiteurs de jak2 v617f |
US20240190876A1 (en) | 2022-10-21 | 2024-06-13 | Incyte Corporation | Tricyclic Urea Compounds As JAK2 V617F Inhibitors |
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EP3368541B1 (fr) | 2015-10-30 | 2020-05-27 | Calithera Biosciences, Inc. | Compositions et procédés d'inhibition de l'activité de l'arginase |
PL417066A1 (pl) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
ES2970715T3 (es) | 2016-12-22 | 2024-05-30 | Prec Pharmaceuticals Inc | Composiciones y métodos para inhibir la actividad de la arginasa |
JP2020519583A (ja) | 2017-05-12 | 2020-07-02 | カリセラ バイオサイエンシズ,インコーポレイテッド | (3r,4s)−3−アセトアミド−4−アリル−n−(tert−ブチル)ピロリジン−3−カルボキサミドの製造方法 |
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2011
- 2011-10-19 ES ES16150285T patent/ES2794006T3/es active Active
- 2011-10-19 ES ES11779904.9T patent/ES2568680T3/es active Active
- 2011-10-19 EP EP11779904.9A patent/EP2632927B1/fr active Active
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