CA2431080A1 - Amelioration de l'immunite contre le cancer par l'intermediaire de l'inhibition de l'arginase - Google Patents

Amelioration de l'immunite contre le cancer par l'intermediaire de l'inhibition de l'arginase Download PDF

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Publication number
CA2431080A1
CA2431080A1 CA002431080A CA2431080A CA2431080A1 CA 2431080 A1 CA2431080 A1 CA 2431080A1 CA 002431080 A CA002431080 A CA 002431080A CA 2431080 A CA2431080 A CA 2431080A CA 2431080 A1 CA2431080 A1 CA 2431080A1
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Prior art keywords
arginase
tumor
dendritic cell
cells
inhibition
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Abandoned
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CA002431080A
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Catherine Adele O'brien
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001169Tumor associated carbohydrates
    • A61K39/00117Mucins, e.g. MUC-1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/001154Enzymes
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    • A61K39/00118Cancer antigens from embryonic or fetal origin
    • A61K39/001182Carcinoembryonic antigen [CEA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • A61K39/0011Cancer antigens
    • A61K39/001184Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001184Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001186MAGE
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • A61K39/0011Cancer antigens
    • A61K39/001193Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
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    • A61K39/0011Cancer antigens
    • A61K39/001193Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A61K39/001194Prostate specific antigen [PSA]
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4615Dendritic cells
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/462Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622Antigen presenting cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/464493Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
    • A61K39/464494Prostate specific antigen [PSA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0639Dendritic cells, e.g. Langherhans cells in the epidermis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/26Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/55Lung
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/58Prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/22Colony stimulating factors (G-CSF, GM-CSF)
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    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
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    • C12N2533/50Proteins
CA002431080A 2003-06-02 2003-06-02 Amelioration de l'immunite contre le cancer par l'intermediaire de l'inhibition de l'arginase Abandoned CA2431080A1 (fr)

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CA002431080A CA2431080A1 (fr) 2003-06-02 2003-06-02 Amelioration de l'immunite contre le cancer par l'intermediaire de l'inhibition de l'arginase

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Application Number Priority Date Filing Date Title
CA002431080A CA2431080A1 (fr) 2003-06-02 2003-06-02 Amelioration de l'immunite contre le cancer par l'intermediaire de l'inhibition de l'arginase

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006058486A1 (fr) * 2004-12-03 2006-06-08 Bio-Cancer Treatment International Limited Emploi de l’arginase combinée au 5fu et à d'autres composés dans le traitement de tumeurs malignes humaines
WO2006133561A1 (fr) * 2005-06-15 2006-12-21 London Health Sciences Centre Research Inc. Methode de traitement du cancer par extinction genique au moyen de arnsi
WO2018089490A1 (fr) * 2016-11-08 2018-05-17 Calithera Biosciences, Inc. Polythérapies faisant appel à un inhibiteur d'arginase
US10065974B2 (en) 2015-10-30 2018-09-04 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US10143699B2 (en) 2015-06-23 2018-12-04 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US10287303B2 (en) 2016-12-22 2019-05-14 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
WO2019145453A1 (fr) * 2018-01-28 2019-08-01 Universite De Geneve Suppression de l'arginase pour le traitement du cancer
US10494339B2 (en) 2017-05-12 2019-12-03 Calithera Biosciences, Inc. Method of preparing (3R,4S)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carboxamide
US10538537B2 (en) 2010-04-22 2020-01-21 Mars, Incorporated Inhibitors of arginase and their therapeutic applications
US10603330B2 (en) 2010-10-26 2020-03-31 Mars, Incorporated Arginase inhibitors as therapeutics

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006058486A1 (fr) * 2004-12-03 2006-06-08 Bio-Cancer Treatment International Limited Emploi de l’arginase combinée au 5fu et à d'autres composés dans le traitement de tumeurs malignes humaines
WO2006133561A1 (fr) * 2005-06-15 2006-12-21 London Health Sciences Centre Research Inc. Methode de traitement du cancer par extinction genique au moyen de arnsi
EP1898936A1 (fr) * 2005-06-15 2008-03-19 London Health Sciences Centre Research Inc. Methode de traitement du cancer par extinction genique au moyen de arnsi
EP1898936A4 (fr) * 2005-06-15 2009-05-06 London Health Sci Ct Res Inc Methode de traitement du cancer par extinction genique au moyen de arnsi
US8389708B2 (en) 2005-06-15 2013-03-05 Weiping Min Method of cancer treatment using siRNA silencing
US10538537B2 (en) 2010-04-22 2020-01-21 Mars, Incorporated Inhibitors of arginase and their therapeutic applications
US11389464B2 (en) 2010-10-26 2022-07-19 Mars, Incorporated Arginase inhibitors as therapeutics
US10603330B2 (en) 2010-10-26 2020-03-31 Mars, Incorporated Arginase inhibitors as therapeutics
US10905701B2 (en) 2015-06-23 2021-02-02 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US10143699B2 (en) 2015-06-23 2018-12-04 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US10398714B2 (en) 2015-06-23 2019-09-03 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US10844080B2 (en) 2015-10-30 2020-11-24 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US10851118B2 (en) 2015-10-30 2020-12-01 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US10065974B2 (en) 2015-10-30 2018-09-04 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US11291674B2 (en) 2016-11-08 2022-04-05 Calithera Biosciences, Inc. Arginase inhibitor combination therapies
WO2018089490A1 (fr) * 2016-11-08 2018-05-17 Calithera Biosciences, Inc. Polythérapies faisant appel à un inhibiteur d'arginase
US10287303B2 (en) 2016-12-22 2019-05-14 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US11021495B2 (en) 2016-12-22 2021-06-01 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US10494339B2 (en) 2017-05-12 2019-12-03 Calithera Biosciences, Inc. Method of preparing (3R,4S)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carboxamide
US10906872B2 (en) 2017-05-12 2021-02-02 Calithera Biosciences, Inc. Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide
US11370754B2 (en) 2017-05-12 2022-06-28 Calithera Biosciences, Inc. Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide
WO2019145453A1 (fr) * 2018-01-28 2019-08-01 Universite De Geneve Suppression de l'arginase pour le traitement du cancer
CN111902532A (zh) * 2018-01-28 2020-11-06 日内瓦大学 用于癌症治疗的精氨酸酶抑制

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