SMT201300063B - Procedimento per preparazione di composti piperazinici e loro sali idrocloruri - Google Patents

Procedimento per preparazione di composti piperazinici e loro sali idrocloruri

Info

Publication number
SMT201300063B
SMT201300063B SM201300063T SM201300063T SMT201300063B SM T201300063 B SMT201300063 B SM T201300063B SM 201300063 T SM201300063 T SM 201300063T SM 201300063 T SM201300063 T SM 201300063T SM T201300063 B SMT201300063 B SM T201300063B
Authority
SM
San Marino
Prior art keywords
preparation
hydrochloride salts
piperazine compounds
piperazine
compounds
Prior art date
Application number
SM201300063T
Other languages
English (en)
Italian (it)
Inventor
Laszlo Czibula
Balint Juhasz
Csongor Eva Againe
Ferenc Sebok
Janos Galambos
Katalin Nogradi
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of SMT201300063B publication Critical patent/SMT201300063B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SM201300063T 2008-12-18 2013-06-11 Procedimento per preparazione di composti piperazinici e loro sali idrocloruri SMT201300063B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0800765A HUP0800765A2 (en) 2008-12-18 2008-12-18 A new process for the preparation of piperazine derivatives and their hydrochloric salts
PCT/HU2009/000109 WO2010070370A1 (en) 2008-12-18 2009-12-18 Process for the preparation of piperazine compounds and hydrochloride salts thereof

Publications (1)

Publication Number Publication Date
SMT201300063B true SMT201300063B (it) 2013-07-09

Family

ID=89988674

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201300063T SMT201300063B (it) 2008-12-18 2013-06-11 Procedimento per preparazione di composti piperazinici e loro sali idrocloruri

Country Status (28)

Country Link
US (1) US8569498B2 (es)
EP (1) EP2358691B8 (es)
JP (1) JP5744751B2 (es)
CN (1) CN102256954B (es)
AU (1) AU2009329295B2 (es)
BR (1) BRPI0923380B8 (es)
CA (1) CA2744073C (es)
CY (1) CY1113923T1 (es)
DK (1) DK2358691T3 (es)
EA (1) EA019329B1 (es)
ES (1) ES2407182T3 (es)
GE (1) GEP20125712B (es)
HK (1) HK1160849A1 (es)
HR (1) HRP20130394T1 (es)
HU (1) HUP0800765A2 (es)
IL (1) IL212640A (es)
IN (1) IN2011KN02904A (es)
MX (1) MX2011006590A (es)
NZ (1) NZ592906A (es)
PL (1) PL2358691T3 (es)
PT (1) PT2358691E (es)
RS (1) RS52738B (es)
SG (1) SG171716A1 (es)
SI (1) SI2358691T1 (es)
SM (1) SMT201300063B (es)
TW (1) TWI460164B (es)
UA (1) UA102422C2 (es)
WO (1) WO2010070370A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
EA023972B1 (ru) * 2008-02-21 2016-08-31 Рихтер Гедеон Нирт. Стабильный твёрдый препарат карипразина для перорального введения и способ его получения
SI2317852T1 (sl) 2008-07-16 2015-04-30 Richter Gedeon Nyrt. Farmacevtske formulacije, ki vsebujejo ligande dopaminskega receptorja
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0900790A2 (en) * 2009-12-17 2011-09-28 Richter Gedeon Nyrt A new process for the preparation of piperazine and their hydrochloric salts
EP2508525A1 (en) 2011-04-05 2012-10-10 Bayer Pharma Aktiengesellschaft Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
CN104140421B (zh) 2013-05-08 2017-04-05 上海医药工业研究院 苯并异噻唑类化合物及在制备抗精神分裂症药物中的应用
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
CN110317182B (zh) * 2018-03-29 2021-10-15 上虞京新药业有限公司 一种卡利拉嗪的制备方法
CN108586389B (zh) * 2018-06-29 2020-06-12 成都福柯斯医药技术有限公司 一种合成卡利拉嗪的方法
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
CN111892556A (zh) * 2019-05-06 2020-11-06 北京万全德众医药生物技术有限公司 新的卡利拉嗪制备方法
CN110372557B (zh) * 2019-08-06 2021-05-18 上海勋和医药科技有限公司 环己烷胺类d3/d2受体部分激动剂
CN113912565A (zh) * 2020-07-11 2022-01-11 广东东阳光药业有限公司 一种卡利拉嗪的新晶型及其制备方法
KR20240112213A (ko) 2023-01-11 2024-07-18 리히터 게데온 닐트. 도파민 d3/d2 수용체 조절 화합물

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US4957921A (en) 1989-12-06 1990-09-18 Warner-Lambert Company Substituted cyclohexanols as central nervous system agents
US5047406A (en) 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
AU707748B2 (en) 1994-03-25 1999-07-22 Isotechnika Inc. Enhancement of the efficacy of drugs by deuteration
AU6859096A (en) 1995-09-22 1997-04-09 Warner-Lambert Company Substituted cyclohexylamines as central nervous system agents
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
NZ525108A (en) 1998-03-31 2005-02-25 Acadia Pharm Inc Compounds with activity on muscarinic receptors
SE9802208D0 (sv) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
US6489341B1 (en) 1999-06-02 2002-12-03 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
AU2002242226B2 (en) 2001-02-27 2006-06-29 Ortho-Mcneil Pharmaceutical, Inc. Carbamate compounds for use in preventing or treating bipolar disorder
US6566550B2 (en) 2001-06-21 2003-05-20 Pfizer Inc Substituted aromatic ethers as inhibitors of glycine transport
HU227543B1 (en) 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
SE0200301D0 (sv) 2002-02-01 2002-02-01 Axon Biochemicals Bv Thio-carbostyril derivative
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
DE102004047517A1 (de) 2004-09-28 2006-03-30 Merck Patent Gmbh Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid
HUP0500170A3 (en) 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
GT200600414A (es) 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
JP2010526832A (ja) 2007-05-11 2010-08-05 リヒター ゲデオン エヌワイアールティー． カルバモイル−シクロヘキサン誘導体の溶媒和物および結晶形態
HU230748B1 (hu) 2007-05-11 2018-02-28 Richter Gedeon Nyrt Új piperazin só és előállítási eljárása
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
HUP0700370A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania
HUP0700369A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
MX2010001171A (es) 2007-08-01 2010-03-01 Lundbeck & Co As H Uso de abridores de canales de potasio kcnq para reducir los sintomas o tratar desordenes o afecciones en las cuales se encuentra anulado el sistema dopaminergico.
US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
EA023972B1 (ru) 2008-02-21 2016-08-31 Рихтер Гедеон Нирт. Стабильный твёрдый препарат карипразина для перорального введения и способ его получения
SI2317852T1 (sl) 2008-07-16 2015-04-30 Richter Gedeon Nyrt. Farmacevtske formulacije, ki vsebujejo ligande dopaminskega receptorja
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives

Also Published As

Publication number Publication date
CN102256954A (zh) 2011-11-23
IN2011KN02904A (es) 2015-07-10
CN102256954B (zh) 2016-09-28
PL2358691T3 (pl) 2013-08-30
WO2010070370A8 (en) 2011-04-28
TWI460164B (zh) 2014-11-11
RS52738B (en) 2013-08-30
EA201170808A1 (ru) 2011-12-30
WO2010070370A1 (en) 2010-06-24
ES2407182T3 (es) 2013-06-12
US20110275804A1 (en) 2011-11-10
HU0800765D0 (en) 2009-03-02
EP2358691B1 (en) 2013-03-20
CA2744073A1 (en) 2010-06-24
EP2358691A1 (en) 2011-08-24
NZ592906A (en) 2013-07-26
GEP20125712B (en) 2012-12-10
PT2358691E (pt) 2013-05-22
EP2358691B8 (en) 2013-05-01
EA019329B1 (ru) 2014-02-28
BRPI0923380B8 (pt) 2022-07-19
BRPI0923380B1 (pt) 2022-05-24
CA2744073C (en) 2016-07-12
HK1160849A1 (zh) 2012-08-17
AU2009329295A1 (en) 2010-06-24
DK2358691T3 (da) 2013-05-21
SI2358691T1 (sl) 2013-07-31
HUP0800765A2 (en) 2010-11-29
AU2009329295B2 (en) 2014-02-06
US8569498B2 (en) 2013-10-29
MX2011006590A (es) 2011-07-12
CY1113923T1 (el) 2016-07-27
JP2012512861A (ja) 2012-06-07
JP5744751B2 (ja) 2015-07-08
IL212640A0 (en) 2011-07-31
BRPI0923380A2 (pt) 2015-07-28
HRP20130394T1 (en) 2013-06-30
TW201033180A (en) 2010-09-16
UA102422C2 (ru) 2013-07-10
IL212640A (en) 2014-06-30
SG171716A1 (en) 2011-07-28

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