DK2358691T3 - Fremgangsmåde til fremstilling af piperazinforbindelser og hydrochloridsalte deraf - Google Patents

Fremgangsmåde til fremstilling af piperazinforbindelser og hydrochloridsalte deraf

Info

Publication number
DK2358691T3
DK2358691T3 DK09797146.9T DK09797146T DK2358691T3 DK 2358691 T3 DK2358691 T3 DK 2358691T3 DK 09797146 T DK09797146 T DK 09797146T DK 2358691 T3 DK2358691 T3 DK 2358691T3
Authority
DK
Denmark
Prior art keywords
preparation
hydrochloride salts
piperazine compounds
piperazine
compounds
Prior art date
Application number
DK09797146.9T
Other languages
English (en)
Inventor
Csongor Eva Againe
Katalin Nogradi
Laszlo Czibula
Balint Juhasz
Ferenc Seboek
Janos Galambos
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Application granted granted Critical
Publication of DK2358691T3 publication Critical patent/DK2358691T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
DK09797146.9T 2008-12-18 2009-12-18 Fremgangsmåde til fremstilling af piperazinforbindelser og hydrochloridsalte deraf DK2358691T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0800765A HUP0800765A2 (en) 2008-12-18 2008-12-18 A new process for the preparation of piperazine derivatives and their hydrochloric salts
PCT/HU2009/000109 WO2010070370A1 (en) 2008-12-18 2009-12-18 Process for the preparation of piperazine compounds and hydrochloride salts thereof

Publications (1)

Publication Number Publication Date
DK2358691T3 true DK2358691T3 (da) 2013-05-21

Family

ID=89988674

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09797146.9T DK2358691T3 (da) 2008-12-18 2009-12-18 Fremgangsmåde til fremstilling af piperazinforbindelser og hydrochloridsalte deraf

Country Status (28)

Country Link
US (1) US8569498B2 (da)
EP (1) EP2358691B8 (da)
JP (1) JP5744751B2 (da)
CN (1) CN102256954B (da)
AU (1) AU2009329295B2 (da)
BR (1) BRPI0923380B8 (da)
CA (1) CA2744073C (da)
CY (1) CY1113923T1 (da)
DK (1) DK2358691T3 (da)
EA (1) EA019329B1 (da)
ES (1) ES2407182T3 (da)
GE (1) GEP20125712B (da)
HK (1) HK1160849A1 (da)
HR (1) HRP20130394T1 (da)
HU (1) HUP0800765A2 (da)
IL (1) IL212640A (da)
IN (1) IN2011KN02904A (da)
MX (1) MX2011006590A (da)
NZ (1) NZ592906A (da)
PL (1) PL2358691T3 (da)
PT (1) PT2358691E (da)
RS (1) RS52738B (da)
SG (1) SG171716A1 (da)
SI (1) SI2358691T1 (da)
SM (1) SMT201300063B (da)
TW (1) TWI460164B (da)
UA (1) UA102422C2 (da)
WO (1) WO2010070370A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
WO2009104739A1 (ja) * 2008-02-21 2009-08-27 田辺三菱製薬株式会社 経口投与用固形製剤
CN104997743A (zh) 2008-07-16 2015-10-28 吉瑞工厂 包含多巴胺受体配体的药物制剂
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0900790A2 (en) * 2009-12-17 2011-09-28 Richter Gedeon Nyrt A new process for the preparation of piperazine and their hydrochloric salts
EP2508525A1 (en) 2011-04-05 2012-10-10 Bayer Pharma Aktiengesellschaft Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
CN104140421B (zh) 2013-05-08 2017-04-05 上海医药工业研究院 苯并异噻唑类化合物及在制备抗精神分裂症药物中的应用
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
CN110317182B (zh) * 2018-03-29 2021-10-15 上虞京新药业有限公司 一种卡利拉嗪的制备方法
CN108586389B (zh) * 2018-06-29 2020-06-12 成都福柯斯医药技术有限公司 一种合成卡利拉嗪的方法
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
CN111892556A (zh) * 2019-05-06 2020-11-06 北京万全德众医药生物技术有限公司 新的卡利拉嗪制备方法
CN110372557B (zh) * 2019-08-06 2021-05-18 上海勋和医药科技有限公司 环己烷胺类d3/d2受体部分激动剂

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WO1997011070A1 (en) 1995-09-22 1997-03-27 Warner-Lambert Company Substituted cyclohexylamines as central nervous system agents
JP2002509918A (ja) 1998-03-31 2002-04-02 アケイディア ファーマスーティカルズ インコーポレイテッド ムスカリン性レセプタに活性を有する化合物
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CN1250214C (zh) 2001-02-27 2006-04-12 奥索-麦克尼尔药品公司 用于预防或治疗双相性精神障碍的氨基甲酸酯化合物
US6566550B2 (en) 2001-06-21 2003-05-20 Pfizer Inc Substituted aromatic ethers as inhibitors of glycine transport
HU227543B1 (en) 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
SE0200301D0 (sv) 2002-02-01 2002-02-01 Axon Biochemicals Bv Thio-carbostyril derivative
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
HU227534B1 (en) 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
DE102004047517A1 (de) 2004-09-28 2006-03-30 Merck Patent Gmbh Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid
HUP0500170A3 (en) 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
GT200600414A (es) 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
HU230748B1 (hu) 2007-05-11 2018-02-28 Richter Gedeon Nyrt Új piperazin só és előállítási eljárása
DK2155200T3 (da) 2007-05-11 2017-03-13 Richter Gedeon Nyrt Krystallinsk form af et carbamoyl-cyclohexan-derivat
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
HUP0700370A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania
HUP0700369A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
CA2694887A1 (en) 2007-08-01 2009-02-05 Henriette Husum Bak-Jensen Use of kncq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted
US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
WO2009104739A1 (ja) 2008-02-21 2009-08-27 田辺三菱製薬株式会社 経口投与用固形製剤
CN104997743A (zh) 2008-07-16 2015-10-28 吉瑞工厂 包含多巴胺受体配体的药物制剂
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives

Also Published As

Publication number Publication date
CN102256954A (zh) 2011-11-23
HUP0800765A2 (en) 2010-11-29
WO2010070370A1 (en) 2010-06-24
HU0800765D0 (en) 2009-03-02
SI2358691T1 (sl) 2013-07-31
RS52738B (en) 2013-08-30
CY1113923T1 (el) 2016-07-27
AU2009329295A1 (en) 2010-06-24
US20110275804A1 (en) 2011-11-10
EA201170808A1 (ru) 2011-12-30
AU2009329295B2 (en) 2014-02-06
IL212640A (en) 2014-06-30
US8569498B2 (en) 2013-10-29
EP2358691B1 (en) 2013-03-20
ES2407182T3 (es) 2013-06-12
NZ592906A (en) 2013-07-26
PT2358691E (pt) 2013-05-22
BRPI0923380A2 (pt) 2015-07-28
CN102256954B (zh) 2016-09-28
SMT201300063B (it) 2013-07-09
CA2744073A1 (en) 2010-06-24
HK1160849A1 (zh) 2012-08-17
WO2010070370A8 (en) 2011-04-28
MX2011006590A (es) 2011-07-12
EA019329B1 (ru) 2014-02-28
TW201033180A (en) 2010-09-16
BRPI0923380B8 (pt) 2022-07-19
JP5744751B2 (ja) 2015-07-08
UA102422C2 (ru) 2013-07-10
PL2358691T3 (pl) 2013-08-30
EP2358691A1 (en) 2011-08-24
SG171716A1 (en) 2011-07-28
EP2358691B8 (en) 2013-05-01
TWI460164B (zh) 2014-11-11
BRPI0923380B1 (pt) 2022-05-24
CA2744073C (en) 2016-07-12
JP2012512861A (ja) 2012-06-07
IL212640A0 (en) 2011-07-31
HRP20130394T1 (en) 2013-06-30
IN2011KN02904A (da) 2015-07-10
GEP20125712B (en) 2012-12-10

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