SK9292002A3 - Oral preparations for diabetes - Google Patents
Oral preparations for diabetes Download PDFInfo
- Publication number
- SK9292002A3 SK9292002A3 SK929-2002A SK9292002A SK9292002A3 SK 9292002 A3 SK9292002 A3 SK 9292002A3 SK 9292002 A SK9292002 A SK 9292002A SK 9292002 A3 SK9292002 A3 SK 9292002A3
- Authority
- SK
- Slovakia
- Prior art keywords
- copolymer
- blood glucose
- derivatives
- nateglinide
- active ingredient
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 110
- 239000008103 glucose Substances 0.000 claims abstract description 110
- 239000008280 blood Substances 0.000 claims abstract description 109
- 210000004369 blood Anatomy 0.000 claims abstract description 109
- OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 claims abstract description 93
- 229960000698 nateglinide Drugs 0.000 claims abstract description 93
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims abstract description 48
- 238000013270 controlled release Methods 0.000 claims abstract description 46
- 230000000291 postprandial effect Effects 0.000 claims abstract description 40
- 239000000203 mixture Substances 0.000 claims description 72
- 239000011159 matrix material Substances 0.000 claims description 62
- 239000004480 active ingredient Substances 0.000 claims description 54
- 238000004090 dissolution Methods 0.000 claims description 54
- 239000000463 material Substances 0.000 claims description 52
- 238000000576 coating method Methods 0.000 claims description 51
- 229920001577 copolymer Polymers 0.000 claims description 42
- -1 polyoxyethylene Polymers 0.000 claims description 41
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 35
- 239000011248 coating agent Substances 0.000 claims description 34
- 238000009472 formulation Methods 0.000 claims description 31
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 27
- 239000004626 polylactic acid Substances 0.000 claims description 27
- 239000003921 oil Substances 0.000 claims description 21
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 20
- 230000003178 anti-diabetic effect Effects 0.000 claims description 20
- 239000003472 antidiabetic agent Substances 0.000 claims description 20
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 20
- 239000000839 emulsion Substances 0.000 claims description 18
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 17
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 17
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 17
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims description 16
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims description 16
- 239000003094 microcapsule Substances 0.000 claims description 16
- 230000001419 dependent effect Effects 0.000 claims description 15
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 14
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 14
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 14
- 229920002125 Sokalan® Polymers 0.000 claims description 13
- 239000004584 polyacrylic acid Substances 0.000 claims description 13
- 239000001856 Ethyl cellulose Substances 0.000 claims description 11
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 11
- 238000007922 dissolution test Methods 0.000 claims description 11
- 229920001249 ethyl cellulose Polymers 0.000 claims description 11
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 11
- 150000004676 glycans Chemical class 0.000 claims description 11
- 229920001282 polysaccharide Polymers 0.000 claims description 11
- 239000005017 polysaccharide Substances 0.000 claims description 11
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- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 10
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 10
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 10
- 239000002736 nonionic surfactant Substances 0.000 claims description 10
- 150000003904 phospholipids Chemical class 0.000 claims description 10
- 150000001298 alcohols Chemical class 0.000 claims description 9
- 125000005456 glyceride group Chemical group 0.000 claims description 9
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 9
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 8
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims description 7
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- 239000011734 sodium Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 230000010030 glucose lowering effect Effects 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 3
- MUZDXNQOSGWMJJ-UHFFFAOYSA-N 2-methylprop-2-enoic acid;prop-2-enoic acid Chemical compound OC(=O)C=C.CC(=C)C(O)=O MUZDXNQOSGWMJJ-UHFFFAOYSA-N 0.000 claims description 2
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 2
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- RWHRFHQRVDUPIK-UHFFFAOYSA-N 50867-57-7 Chemical compound CC(=C)C(O)=O.CC(=C)C(O)=O RWHRFHQRVDUPIK-UHFFFAOYSA-N 0.000 claims 1
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- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229920006243 acrylic copolymer Polymers 0.000 claims 1
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- 238000002386 leaching Methods 0.000 description 18
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 15
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
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- 229940125708 antidiabetic agent Drugs 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 238000009506 drug dissolution testing Methods 0.000 description 3
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- 239000000454 talc Substances 0.000 description 3
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- 239000007864 aqueous solution Substances 0.000 description 2
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- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- XHIOOWRNEXFQFM-UHFFFAOYSA-N ethyl prop-2-enoate;prop-2-enoic acid Chemical compound OC(=O)C=C.CCOC(=O)C=C XHIOOWRNEXFQFM-UHFFFAOYSA-N 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000005414 inactive ingredient Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
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- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 description 1
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
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- JLRGJRBPOGGCBT-UHFFFAOYSA-N Tolbutamide Chemical compound CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 JLRGJRBPOGGCBT-UHFFFAOYSA-N 0.000 description 1
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- XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 description 1
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- 230000002378 acidificating effect Effects 0.000 description 1
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- 230000006399 behavior Effects 0.000 description 1
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- 235000005687 corn oil Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- VCMFGDACKBCWDX-UHFFFAOYSA-K dipotassium sodium hydrogen phosphate hydroxide Chemical compound [OH-].[Na+].P(=O)(O)([O-])[O-].[K+].[K+] VCMFGDACKBCWDX-UHFFFAOYSA-K 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
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- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
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- 229960004329 metformin hydrochloride Drugs 0.000 description 1
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 description 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- MYSWGNHLJGOCPT-UHFFFAOYSA-N methyl prop-2-enoate;prop-2-enoic acid Chemical compound OC(=O)C=C.COC(=O)C=C MYSWGNHLJGOCPT-UHFFFAOYSA-N 0.000 description 1
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- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
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- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- A61K9/2022—Organic macromolecular compounds
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- A61K9/5005—Wall or coating material
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
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-
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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-
- A—HUMAN NECESSITIES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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-
- A—HUMAN NECESSITIES
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP37495999 | 1999-12-28 | ||
| JP2000085159 | 2000-03-24 | ||
| PCT/JP2000/009281 WO2001047557A1 (fr) | 1999-12-28 | 2000-12-27 | Preparations orales pour diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK9292002A3 true SK9292002A3 (en) | 2002-10-08 |
Family
ID=26582645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK929-2002A SK9292002A3 (en) | 1999-12-28 | 2000-12-27 | Oral preparations for diabetes |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7022339B2 (no) |
| EP (2) | EP1616561B1 (no) |
| JP (2) | JP4822039B2 (no) |
| KR (1) | KR20020063282A (no) |
| CN (1) | CN1437483A (no) |
| AT (2) | ATE399000T1 (no) |
| AU (1) | AU2226901A (no) |
| BR (1) | BR0016801A (no) |
| CA (1) | CA2395993A1 (no) |
| CZ (1) | CZ20022294A3 (no) |
| DE (2) | DE60024320T2 (no) |
| ES (2) | ES2305977T3 (no) |
| HK (1) | HK1049622A1 (no) |
| HU (1) | HUP0204109A3 (no) |
| IL (1) | IL150294A0 (no) |
| MX (1) | MXPA02006443A (no) |
| NO (1) | NO20023035L (no) |
| PL (1) | PL356300A1 (no) |
| PT (1) | PT1616561E (no) |
| RU (1) | RU2002120498A (no) |
| SK (1) | SK9292002A3 (no) |
| WO (1) | WO2001047557A1 (no) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2305977T3 (es) | 1999-12-28 | 2008-11-01 | Ajinomoto Co., Inc. | Preparacion antidiabetica para administracion oral. |
| SK14922002A3 (sk) * | 2000-03-17 | 2003-04-01 | Ajinomoto Co., Inc. | Farmaceutický prostriedok na prevenciu, zlepšenie a/alebo liečenie diabetickej komplikácie a použitie postprandiálnej látky na zníženie hladiny krvného cukru |
| MXPA03003484A (es) * | 2000-10-18 | 2003-07-14 | Ajinomoto Kk | Procedimiento para producir cristales de nateglinida. |
| DK1334962T3 (da) * | 2000-10-18 | 2007-12-10 | Ajinomoto Kk | Fremgangsmåder til fremstilling af acylphenylalanin |
| SI1334721T1 (sl) * | 2000-10-24 | 2009-08-31 | Ajinomoto Kk | Hidrofilni farmacevtski pripravki, ki vsebujejo nateglinid |
| JP4225057B2 (ja) * | 2000-10-24 | 2009-02-18 | 味の素株式会社 | ナテグリニドｂ型結晶の製造方法 |
| EP1334720B1 (en) * | 2000-10-24 | 2008-09-03 | Ajinomoto Co., Inc. | Nateglinide-containing preparations |
| FR2816840B1 (fr) * | 2000-11-17 | 2004-04-09 | Flamel Tech Sa | Medicament a base de microcapsules d'anti-hyperclycemiant a liberation prolongee et son procede de preparation |
| US6830759B2 (en) | 2002-06-28 | 2004-12-14 | Ajinomoto Co., Inc. | Antidiabetic preparation for oral administration |
| CN1247194C (zh) * | 2002-08-27 | 2006-03-29 | 石药集团中奇制药技术（石家庄）有限公司 | 一种那格列奈包合物 |
| AU2003262059A1 (en) * | 2002-09-11 | 2004-04-30 | Takeda Pharmaceutical Company Limited | Sustained release preparation |
| CA2504329C (en) | 2002-11-01 | 2013-08-20 | Biodelivery Sciences International, Inc. | Geodate delivery vehicles |
| JP4505859B2 (ja) * | 2003-08-08 | 2010-07-21 | 味の素株式会社 | ナテグリニド含有製剤 |
| WO2005016315A1 (en) * | 2003-08-14 | 2005-02-24 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of nateglinide and a high amount of a water-soluble filler |
| WO2005020979A1 (en) * | 2003-09-03 | 2005-03-10 | Ranbaxy Laboratories Limited | A process for the preparation of pharmaceutical compositions of nateglinide |
| CN1867363B (zh) * | 2003-09-17 | 2010-05-12 | 得克萨斯大学体系董事会 | 用于使胰腺显像的组合物及其用途 |
| US20070219250A1 (en) * | 2003-11-28 | 2007-09-20 | Romi Singh | Pharmaceutical Compositions of Nateglinide |
| KR20120064735A (ko) * | 2004-04-01 | 2012-06-19 | 아지노모토 가부시키가이샤 | 나테글리니드 함유 제제 |
| CN100455279C (zh) * | 2004-04-29 | 2009-01-28 | 美时化学制药股份有限公司 | 口服延迟释放锭剂组成物及其制法 |
| EP1802286B1 (en) * | 2004-08-04 | 2008-07-23 | ALZA Corporation | Sustained drug release composition demonstrating an ascending zero order release pattern, methods of manufacturing such a composition |
| KR20130018956A (ko) * | 2004-08-10 | 2013-02-25 | 아지노모토 가부시키가이샤 | 쓴맛이 감소된 나테글리니드 함유 제제 |
| CN1660064B (zh) * | 2004-12-28 | 2010-09-29 | 中山大学 | 那格列奈自乳化释药系统 |
| JP4974057B2 (ja) * | 2005-01-31 | 2012-07-11 | 味の素株式会社 | 血糖降下剤を含有する、耐糖能異常、境界型糖尿病、インスリン抵抗性及び高インスリン血症の改善ないし治療用医薬組成物 |
| TW200815045A (en) * | 2006-06-29 | 2008-04-01 | Jazz Pharmaceuticals Inc | Pharmaceutical compositions of ropinirole and methods of use thereof |
| CA2638240C (en) * | 2008-08-29 | 2010-02-02 | Alexander Macgregor | Method of treating dysglycemia and glucose excursions |
| RU2016125229A (ru) * | 2010-07-09 | 2018-12-04 | БиЭйчВи ФАРМА, ИНК. | Комбинированная система доставки с немедленным/замедленным высвобождением для лекарственных средств с коротким периодом полувыведения, в том числе для ремоглифлозина |
| WO2013077819A1 (en) * | 2011-11-23 | 2013-05-30 | Mahmut Bilgic | Pharmaceutical formulations comprising nateglinide |
| EP3256114A4 (en) * | 2015-02-09 | 2018-11-21 | Entera Bio Ltd. | Treatment of osteoporosis |
| CN107296954A (zh) * | 2017-06-09 | 2017-10-27 | 王丛飞 | 一种层粘连蛋白创面保护膜 |
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| US124191A (en) * | 1872-02-27 | Improvement in woven felted fabrics for bonnets | ||
| IT1226940B (it) * | 1988-09-16 | 1991-02-22 | Recordati Chem Pharm | Sistema terapeutico a rilascio controllato per formulazioni farmaceutiche liquide |
| US5296236A (en) * | 1988-09-16 | 1994-03-22 | Recordati S.A., Chemical And Pharmaceutical Company | Controlled release therapeutic system for a liquid pharmaceutical formulations |
| US5609884A (en) * | 1992-08-31 | 1997-03-11 | G. D. Searle & Co. | Controlled release naproxen sodium plus naproxen combination tablet |
| US6245351B1 (en) * | 1996-03-07 | 2001-06-12 | Takeda Chemical Industries, Ltd. | Controlled-release composition |
| AUPN969796A0 (en) * | 1996-05-07 | 1996-05-30 | F.H. Faulding & Co. Limited | Taste masked liquid suspensions |
| AU3662597A (en) * | 1996-07-17 | 1998-02-09 | Bramlet, Dale G. | Surgical fastener assembly |
| CA2271865C (en) * | 1996-11-15 | 2003-10-14 | Ajinomoto Co., Inc. | Tablet composition |
| JPH10231242A (ja) * | 1997-02-20 | 1998-09-02 | Taiyo Yakuhin Kogyo Kk | 持続性ジクロフェナクナトリウム組成物 |
| DE19710008A1 (de) * | 1997-03-12 | 1998-09-17 | Basf Ag | Feste, mindestens zweiphasige Zubereitungsformen eines Opioid-Analgeticums mit verzögerter Freisetzung |
| ES2203963T3 (es) * | 1997-05-30 | 2004-04-16 | Osmotica Corp. | Dispositivo osmotico multicapa. |
| DE69800806T2 (de) * | 1997-06-13 | 2001-09-13 | Novo Nordisk A/S, Bagsvaerd | Neue dosierung für diabetes type 2 |
| JPH11130696A (ja) * | 1997-08-27 | 1999-05-18 | Takeda Chem Ind Ltd | 経口徐放性製剤 |
| JP3677156B2 (ja) * | 1997-09-05 | 2005-07-27 | 武田薬品工業株式会社 | 医薬 |
| US6056977A (en) * | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
| DE19860698A1 (de) * | 1998-12-30 | 2000-07-06 | Hexal Ag | Neue pharmazeutische Zusammensetzung |
| US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
| JP3691685B2 (ja) * | 1999-06-22 | 2005-09-07 | 株式会社バイオックス | 血糖値上昇抑制剤 |
| US6559188B1 (en) * | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
| AR028299A1 (es) * | 1999-09-17 | 2003-05-07 | Novartis Ag | Una composicion farmaceutica que comprende nateglinida, un proceso para su preparacion y el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con diabetes. |
| PH12000002657B1 (en) * | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
| ES2305977T3 (es) | 1999-12-28 | 2008-11-01 | Ajinomoto Co., Inc. | Preparacion antidiabetica para administracion oral. |
| WO2001078725A2 (en) * | 2000-04-13 | 2001-10-25 | Synthon B.V. | Modified release formulations containing a hypnotic agent |
| SI1334721T1 (sl) * | 2000-10-24 | 2009-08-31 | Ajinomoto Kk | Hidrofilni farmacevtski pripravki, ki vsebujejo nateglinid |
| EP1334720B1 (en) * | 2000-10-24 | 2008-09-03 | Ajinomoto Co., Inc. | Nateglinide-containing preparations |
| FR2834212B1 (fr) | 2001-12-27 | 2004-07-09 | Besins Int Belgique | Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques |
| US6830759B2 (en) * | 2002-06-28 | 2004-12-14 | Ajinomoto Co., Inc. | Antidiabetic preparation for oral administration |
-
2000
- 2000-12-27 ES ES05020892T patent/ES2305977T3/es not_active Expired - Lifetime
- 2000-12-27 SK SK929-2002A patent/SK9292002A3/sk unknown
- 2000-12-27 WO PCT/JP2000/009281 patent/WO2001047557A1/ja active IP Right Grant
- 2000-12-27 RU RU2002120498/15A patent/RU2002120498A/ru not_active Application Discontinuation
- 2000-12-27 DE DE60024320T patent/DE60024320T2/de not_active Expired - Lifetime
- 2000-12-27 JP JP2001548145A patent/JP4822039B2/ja not_active Expired - Fee Related
- 2000-12-27 ES ES00985918T patent/ES2248159T3/es not_active Expired - Lifetime
- 2000-12-27 AT AT05020892T patent/ATE399000T1/de not_active IP Right Cessation
- 2000-12-27 PT PT05020892T patent/PT1616561E/pt unknown
- 2000-12-27 DE DE60039315T patent/DE60039315D1/de not_active Expired - Lifetime
- 2000-12-27 EP EP05020892A patent/EP1616561B1/en not_active Revoked
- 2000-12-27 AU AU22269/01A patent/AU2226901A/en not_active Abandoned
- 2000-12-27 HU HU0204109A patent/HUP0204109A3/hu unknown
- 2000-12-27 BR BR0016801-7A patent/BR0016801A/pt not_active IP Right Cessation
- 2000-12-27 KR KR1020027008506A patent/KR20020063282A/ko not_active Application Discontinuation
- 2000-12-27 CN CN00819230A patent/CN1437483A/zh active Pending
- 2000-12-27 CA CA002395993A patent/CA2395993A1/en not_active Abandoned
- 2000-12-27 MX MXPA02006443A patent/MXPA02006443A/es unknown
- 2000-12-27 EP EP00985918A patent/EP1258249B1/en not_active Expired - Lifetime
- 2000-12-27 CZ CZ20022294A patent/CZ20022294A3/cs unknown
- 2000-12-27 AT AT00985918T patent/ATE310507T1/de not_active IP Right Cessation
- 2000-12-27 IL IL15029400A patent/IL150294A0/xx unknown
- 2000-12-27 PL PL00356300A patent/PL356300A1/xx unknown
-
2002
- 2002-06-21 NO NO20023035A patent/NO20023035L/no not_active Application Discontinuation
- 2002-06-28 US US10/183,322 patent/US7022339B2/en not_active Expired - Fee Related
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2003
- 2003-03-11 HK HK03101753.2A patent/HK1049622A1/zh unknown
-
2005
- 2005-10-11 US US11/246,453 patent/US7488498B2/en not_active Expired - Fee Related
-
2011
- 2011-05-13 JP JP2011108428A patent/JP2011153157A/ja active Pending
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