SK3372000A3 - A compound having structure of aromatic substituted prostaglandins and its use for the treatment of bone disorders - Google Patents
A compound having structure of aromatic substituted prostaglandins and its use for the treatment of bone disorders Download PDFInfo
- Publication number
- SK3372000A3 SK3372000A3 SK337-2000A SK3372000A SK3372000A3 SK 3372000 A3 SK3372000 A3 SK 3372000A3 SK 3372000 A SK3372000 A SK 3372000A SK 3372000 A3 SK3372000 A3 SK 3372000A3
- Authority
- SK
- Slovakia
- Prior art keywords
- ring
- preferred
- dihydro
- prostaglandin
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 50
- 208000020084 Bone disease Diseases 0.000 title claims abstract description 14
- 125000003118 aryl group Chemical group 0.000 title claims description 27
- 150000003180 prostaglandins Chemical class 0.000 title description 50
- 229940094443 oxytocics prostaglandins Drugs 0.000 title description 20
- 150000002148 esters Chemical class 0.000 claims abstract description 5
- 150000001408 amides Chemical class 0.000 claims abstract description 4
- 230000003287 optical effect Effects 0.000 claims abstract description 4
- 150000003949 imides Chemical class 0.000 claims abstract description 3
- 150000003839 salts Chemical class 0.000 claims abstract description 3
- -1 alkyl R 10 Chemical compound 0.000 claims description 70
- 125000000217 alkyl group Chemical group 0.000 claims description 25
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 25
- 125000001424 substituent group Chemical group 0.000 claims description 21
- 125000001072 heteroaryl group Chemical group 0.000 claims description 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 18
- 125000001188 haloalkyl group Chemical group 0.000 claims description 14
- 229910052799 carbon Inorganic materials 0.000 claims description 9
- 229910052717 sulfur Inorganic materials 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 7
- 125000002252 acyl group Chemical group 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 5
- 125000001544 thienyl group Chemical group 0.000 claims description 5
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- 238000000034 method Methods 0.000 abstract description 32
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 abstract description 3
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 30
- 239000002904 solvent Substances 0.000 description 27
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 24
- DZUXGQBLFALXCR-UHFFFAOYSA-N (+)-(9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprost-13-en-1-oic acid Natural products CCCCCC(O)C=CC1C(O)CC(O)C1CCCCCCC(O)=O DZUXGQBLFALXCR-UHFFFAOYSA-N 0.000 description 23
- 238000006243 chemical reaction Methods 0.000 description 23
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 9
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- DZUXGQBLFALXCR-CDIPTNKSSA-N prostaglandin F1alpha Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(O)=O DZUXGQBLFALXCR-CDIPTNKSSA-N 0.000 description 7
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- RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 6
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- 238000004821 distillation Methods 0.000 description 5
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- 229910002027 silica gel Inorganic materials 0.000 description 5
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 239000007818 Grignard reagent Substances 0.000 description 4
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 125000002619 bicyclic group Chemical group 0.000 description 4
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- MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 4
- 230000004410 intraocular pressure Effects 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
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- LEHBURLTIWGHEM-UHFFFAOYSA-N pyridinium chlorochromate Chemical compound [O-][Cr](Cl)(=O)=O.C1=CC=[NH+]C=C1 LEHBURLTIWGHEM-UHFFFAOYSA-N 0.000 description 4
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- MPCRDALPQLDDFX-UHFFFAOYSA-L Magnesium perchlorate Chemical compound [Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O MPCRDALPQLDDFX-UHFFFAOYSA-L 0.000 description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5821797P | 1997-09-09 | 1997-09-09 | |
| PCT/US1998/018339 WO1999012895A1 (en) | 1997-09-09 | 1998-09-04 | Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK3372000A3 true SK3372000A3 (en) | 2000-10-09 |
Family
ID=22015427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK337-2000A SK3372000A3 (en) | 1997-09-09 | 1998-09-04 | A compound having structure of aromatic substituted prostaglandins and its use for the treatment of bone disorders |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5977173A (xx) |
| EP (1) | EP1012136B1 (xx) |
| JP (1) | JP2001515882A (xx) |
| KR (1) | KR20010023839A (xx) |
| CN (1) | CN1269786A (xx) |
| AR (1) | AR013477A1 (xx) |
| AT (1) | ATE270660T1 (xx) |
| AU (1) | AU731153B2 (xx) |
| BR (1) | BR9811774A (xx) |
| CA (1) | CA2303764C (xx) |
| CO (1) | CO4970731A1 (xx) |
| DE (1) | DE69824966T2 (xx) |
| ES (1) | ES2223141T3 (xx) |
| HU (1) | HUP0100638A3 (xx) |
| ID (1) | ID23971A (xx) |
| IL (1) | IL134839A0 (xx) |
| NO (1) | NO20001141L (xx) |
| NZ (1) | NZ503735A (xx) |
| PE (1) | PE115499A1 (xx) |
| PL (1) | PL339212A1 (xx) |
| SK (1) | SK3372000A3 (xx) |
| TR (1) | TR200000671T2 (xx) |
| WO (1) | WO1999012895A1 (xx) |
| ZA (1) | ZA988230B (xx) |
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| US20020013294A1 (en) * | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US20020172693A1 (en) * | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| KR100437873B1 (ko) * | 2001-05-08 | 2004-06-26 | 연성정밀화학(주) | 프로스타글란딘 유도체의 제조방법 및 그의 입체특이적출발물질 |
| US9216183B2 (en) | 2002-02-04 | 2015-12-22 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US7351404B2 (en) | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| US8758733B2 (en) | 2002-02-04 | 2014-06-24 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US20060135609A1 (en) | 2004-10-21 | 2006-06-22 | Duke University | Ophthamological drugs |
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| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
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| WO2010039535A1 (en) * | 2008-09-23 | 2010-04-08 | Meta Cosmetics, Llc | Compositions and methods to treat epithelial-related conditions |
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| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| EP3053913B1 (en) | 2009-05-01 | 2018-03-07 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| US9149484B2 (en) | 2009-11-09 | 2015-10-06 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| JP5982287B2 (ja) | 2009-11-09 | 2016-08-31 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 発毛を刺激する組成物および方法 |
| US8859616B2 (en) | 2011-01-21 | 2014-10-14 | Allergan, Inc. | Compounds and methods for enhancing hair growth |
| CN109528721B (zh) | 2013-03-15 | 2021-10-01 | 爱瑞制药公司 | 联合治疗 |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| CA3035566A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| CN110506037A (zh) | 2017-03-31 | 2019-11-26 | 爱瑞制药公司 | 芳基环丙基-氨基-异喹啉酰胺化合物 |
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-
1998
- 1998-09-04 ID IDW20000639A patent/ID23971A/id unknown
- 1998-09-04 WO PCT/US1998/018339 patent/WO1999012895A1/en not_active Application Discontinuation
- 1998-09-04 NZ NZ503735A patent/NZ503735A/en unknown
- 1998-09-04 CA CA002303764A patent/CA2303764C/en not_active Expired - Lifetime
- 1998-09-04 PL PL98339212A patent/PL339212A1/xx unknown
- 1998-09-04 AU AU92193/98A patent/AU731153B2/en not_active Expired
- 1998-09-04 CN CN98808990A patent/CN1269786A/zh active Pending
- 1998-09-04 HU HU0100638A patent/HUP0100638A3/hu unknown
- 1998-09-04 US US09/148,006 patent/US5977173A/en not_active Expired - Lifetime
- 1998-09-04 ES ES98944719T patent/ES2223141T3/es not_active Expired - Lifetime
- 1998-09-04 DE DE69824966T patent/DE69824966T2/de not_active Expired - Lifetime
- 1998-09-04 KR KR1020007002515A patent/KR20010023839A/ko not_active Application Discontinuation
- 1998-09-04 BR BR9811774-2A patent/BR9811774A/pt not_active IP Right Cessation
- 1998-09-04 EP EP98944719A patent/EP1012136B1/en not_active Expired - Lifetime
- 1998-09-04 IL IL13483998A patent/IL134839A0/xx unknown
- 1998-09-04 JP JP2000510707A patent/JP2001515882A/ja not_active Withdrawn
- 1998-09-04 TR TR2000/00671T patent/TR200000671T2/xx unknown
- 1998-09-04 AT AT98944719T patent/ATE270660T1/de not_active IP Right Cessation
- 1998-09-04 SK SK337-2000A patent/SK3372000A3/sk unknown
- 1998-09-08 PE PE1998000843A patent/PE115499A1/es not_active Application Discontinuation
- 1998-09-08 AR ARP980104479A patent/AR013477A1/es unknown
- 1998-09-09 CO CO98051818A patent/CO4970731A1/es unknown
- 1998-09-09 ZA ZA988230A patent/ZA988230B/xx unknown
-
2000
- 2000-03-06 NO NO20001141A patent/NO20001141L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TR200000671T2 (tr) | 2000-07-21 |
| AU731153B2 (en) | 2001-03-22 |
| CN1269786A (zh) | 2000-10-11 |
| BR9811774A (pt) | 2000-08-29 |
| CA2303764C (en) | 2005-02-15 |
| CO4970731A1 (es) | 2000-11-07 |
| JP2001515882A (ja) | 2001-09-25 |
| HUP0100638A2 (hu) | 2001-07-30 |
| WO1999012895A1 (en) | 1999-03-18 |
| NO20001141D0 (no) | 2000-03-06 |
| PE115499A1 (es) | 2000-02-03 |
| AU9219398A (en) | 1999-03-29 |
| ID23971A (id) | 2000-06-14 |
| ATE270660T1 (de) | 2004-07-15 |
| DE69824966D1 (de) | 2004-08-12 |
| IL134839A0 (en) | 2001-05-20 |
| ES2223141T3 (es) | 2005-02-16 |
| HUP0100638A3 (en) | 2002-12-28 |
| NZ503735A (en) | 2001-05-25 |
| CA2303764A1 (en) | 1999-03-18 |
| AR013477A1 (es) | 2000-12-27 |
| PL339212A1 (en) | 2000-12-04 |
| DE69824966T2 (de) | 2005-04-07 |
| EP1012136A1 (en) | 2000-06-28 |
| NO20001141L (no) | 2000-05-04 |
| ZA988230B (en) | 1999-03-09 |
| US5977173A (en) | 1999-11-02 |
| KR20010023839A (ko) | 2001-03-26 |
| EP1012136B1 (en) | 2004-07-07 |
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