SK287318B6 - Spôsob výroby tiotropiumbromidu a použitie tropenolu a tropenolesteru - Google Patents

Spôsob výroby tiotropiumbromidu a použitie tropenolu a tropenolesteru Download PDF

Info

Publication number
SK287318B6
SK287318B6 SK935-2003A SK9352003A SK287318B6 SK 287318 B6 SK287318 B6 SK 287318B6 SK 9352003 A SK9352003 A SK 9352003A SK 287318 B6 SK287318 B6 SK 287318B6
Authority
SK
Slovakia
Prior art keywords
formula
compound
vii
tropenol
ester
Prior art date
Application number
SK935-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK9352003A3 (en
Inventor
Rolf Banholzer
Wolfgang Broeder
Manfred Graulich
Sven Luettke
Andreas Mathes
Helmut Meissner
Peter Specht
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7668836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK287318(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of SK9352003A3 publication Critical patent/SK9352003A3/sk
Publication of SK287318B6 publication Critical patent/SK287318B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK935-2003A 2000-12-22 2001-12-12 Spôsob výroby tiotropiumbromidu a použitie tropenolu a tropenolesteru SK287318B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064816A DE10064816A1 (de) 2000-12-22 2000-12-22 Verfahren zur Herstellung eines Anticholinergikums
PCT/EP2001/014566 WO2002051840A1 (de) 2000-12-22 2001-12-12 Verfahren zur herstellung des anticholinergikums tiotropiumbromid

Publications (2)

Publication Number Publication Date
SK9352003A3 SK9352003A3 (en) 2003-10-07
SK287318B6 true SK287318B6 (sk) 2010-07-07

Family

ID=7668836

Family Applications (1)

Application Number Title Priority Date Filing Date
SK935-2003A SK287318B6 (sk) 2000-12-22 2001-12-12 Spôsob výroby tiotropiumbromidu a použitie tropenolu a tropenolesteru

Country Status (42)

Country Link
US (1) US6486321B2 (xx)
EP (2) EP1345936B1 (xx)
JP (1) JP4198991B2 (xx)
KR (1) KR100853109B1 (xx)
CN (2) CN1244581C (xx)
AR (1) AR033599A1 (xx)
AT (2) ATE337314T1 (xx)
AU (1) AU2002229650B2 (xx)
BG (1) BG66373B1 (xx)
BR (1) BRPI0116444B8 (xx)
CA (1) CA2433518C (xx)
CY (1) CY1105210T1 (xx)
CZ (1) CZ294958B6 (xx)
DE (3) DE10064816A1 (xx)
DK (2) DK1345936T3 (xx)
EA (1) EA005533B1 (xx)
EC (1) ECSP034652A (xx)
EE (1) EE04495B1 (xx)
EG (1) EG23914A (xx)
ES (2) ES2221658T3 (xx)
HK (2) HK1060570A1 (xx)
HR (1) HRP20030502B1 (xx)
HU (1) HU230320B1 (xx)
IL (2) IL156351A0 (xx)
ME (1) MEP40608A (xx)
MX (1) MXPA03005426A (xx)
MY (1) MY129525A (xx)
NO (1) NO327739B1 (xx)
NZ (1) NZ527066A (xx)
PE (1) PE20020755A1 (xx)
PL (1) PL202478B1 (xx)
PT (2) PT1426373E (xx)
RS (1) RS50271B (xx)
SA (1) SA01220589B1 (xx)
SI (1) SI1345936T1 (xx)
SK (1) SK287318B6 (xx)
TR (1) TR200401127T4 (xx)
TW (1) TWI234564B (xx)
UA (1) UA74409C2 (xx)
UY (1) UY27079A1 (xx)
WO (1) WO2002051840A1 (xx)
ZA (1) ZA200304707B (xx)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1430887A1 (de) * 2000-10-12 2004-06-23 Boehringer Ingelheim Pharma GmbH & Co.KG Tiotropium-haltige Inhalationspulver
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
US6852728B2 (en) 2000-10-14 2005-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20020137764A1 (en) 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020151541A1 (en) * 2000-10-31 2002-10-17 Michel Pairet Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
US20030013675A1 (en) * 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
RS50441B (sr) * 2001-06-22 2010-03-02 Boehringer Ingelheim Pharma Gmbh. & Co.Kg. Kristalni antiholinergik, postupak za njegovo pripremanje i njegova primena u proizvodnji leka
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US7405224B2 (en) * 2002-01-31 2008-07-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
US6790856B2 (en) * 2002-01-31 2004-09-14 Boehringer Ingelheim Pharma Kg Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7311894B2 (en) * 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
ES2272968T3 (es) * 2002-04-04 2007-05-01 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO.KG Formulaciones en polvo, adecuadas para inhalacion.
US20030235538A1 (en) 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
SG149876A1 (en) * 2003-11-03 2009-02-27 Boehringer Ingelheim Int Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
SG137859A1 (en) * 2003-11-03 2007-12-28 Boehringer Ingelheim Int Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
CN101166738B (zh) * 2005-05-02 2011-06-01 贝林格尔·英格海姆国际有限公司 噻托溴铵的新晶型
MX2007013691A (es) * 2005-05-02 2008-01-21 Boehringer Ingelheim Int Nuevas formas cristalinas de bromuro de tiotropio.
NZ583872A (en) * 2005-06-15 2011-10-28 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
CN1316245C (zh) * 2005-07-28 2007-05-16 山东齐都药业有限公司 托烷司琼合成中残留中间体托品醇的检测方法
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
ES2396978T5 (es) * 2005-12-19 2015-12-04 Sicor, Inc. Forma cristalina novedosa de bromuro de tiotropio y procedimiento para la preparación de la misma
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
WO2007075838A2 (en) * 2005-12-19 2007-07-05 Sicor Inc. Pure and stable tiotropium bromide
RU2453547C2 (ru) * 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
CN100410254C (zh) * 2006-03-07 2008-08-13 南昌弘益科技有限公司 噻托溴铵无水物制备方法
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1882691A1 (en) * 2006-07-26 2008-01-30 CHIESI FARMACEUTICI S.p.A. Quinuclidine derivatives as M3 antagonists
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
EP2036898A2 (de) * 2007-09-13 2009-03-18 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von 1,3-Dioxolan-2Onen sowie von Carbonsäureestern durch Transacylierung unter Basischen Reaktionsbedingungen
EP2240477B8 (en) * 2008-01-10 2014-12-10 Generics [UK] Limited Novel process for the preparation of scopine esters
NZ624602A (en) 2009-08-07 2015-11-27 Generics Uk Ltd Anhydrate of tiotropium bromide
WO2011015884A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
CN101768158B (zh) * 2010-01-04 2013-05-29 南昌弘益科技有限公司 噻托溴铵无水物及其制备方法
CN101863885B (zh) * 2010-06-03 2012-05-30 南京金丹呈医药技术有限公司 一种噻托溴铵的制备方法
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
DK2607351T3 (en) * 2011-12-22 2017-06-06 Cerbios-Pharma S A CONTINUOUS PROCEDURE FOR ALKYLICATION OF CYCLIC TERTIARY AMINES
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
CZ305012B6 (cs) * 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
JP6473738B2 (ja) 2013-04-01 2019-02-20 パルマトリックス，インコーポレイテッド チオトロピウム乾燥粉末
WO2018055642A1 (en) * 2016-09-23 2018-03-29 Gbr Laboratories Pvt. Ltd. A process for preparing tiotropium bromide and intermediates thereof
WO2019129801A1 (en) 2017-12-28 2019-07-04 Linnea S.A. Process for the purification of methyl-2,2-dithienylglycolate
CN113264929B (zh) * 2021-05-02 2023-10-10 润生药业有限公司 一种噻托溴铵的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions

Also Published As

Publication number Publication date
MY129525A (en) 2007-04-30
BG66373B1 (bg) 2013-10-31
KR100853109B1 (ko) 2008-08-21
RS50271B (sr) 2009-07-15
US20020133010A1 (en) 2002-09-19
IL156351A (en) 2011-09-27
NO327739B1 (no) 2009-09-14
EE200300309A (et) 2003-10-15
DE50102299D1 (de) 2004-06-17
EE04495B1 (et) 2005-06-15
DE10064816A1 (de) 2002-06-27
BG107910A (bg) 2004-02-27
UY27079A1 (es) 2002-07-31
CY1105210T1 (el) 2010-03-03
CA2433518C (en) 2007-03-20
PL202478B1 (pl) 2009-06-30
EP1345936B1 (de) 2004-05-12
HRP20030502B1 (en) 2011-09-30
BRPI0116444B8 (pt) 2021-05-25
NO20032827L (no) 2003-06-20
KR20030062439A (ko) 2003-07-25
MEP40608A (en) 2011-02-10
CN100393719C (zh) 2008-06-11
PT1426373E (pt) 2006-11-30
EA200300666A1 (ru) 2003-12-25
HUP0301457A2 (hu) 2003-10-28
CN1840529A (zh) 2006-10-04
HUP0301457A3 (en) 2006-05-29
HRP20030502A2 (en) 2005-04-30
CN1244581C (zh) 2006-03-08
CA2433518A1 (en) 2002-07-04
NZ527066A (en) 2004-12-24
ATE266661T1 (de) 2004-05-15
AU2002229650B2 (en) 2006-12-21
YU50903A (sh) 2006-05-25
IL156351A0 (en) 2004-01-04
SA01220589B1 (ar) 2006-10-31
CZ20031685A3 (cs) 2003-10-15
WO2002051840A1 (de) 2002-07-04
PL361837A1 (en) 2004-10-04
SI1345936T1 (en) 2004-08-31
EP1345936A1 (de) 2003-09-24
EP1426373B1 (de) 2006-08-23
CN1481383A (zh) 2004-03-10
UA74409C2 (uk) 2005-12-15
JP4198991B2 (ja) 2008-12-17
DK1345936T3 (da) 2004-07-19
AR033599A1 (es) 2003-12-26
HK1096683A1 (en) 2007-06-08
TR200401127T4 (tr) 2004-07-21
ZA200304707B (en) 2004-04-20
EP1426373A1 (de) 2004-06-09
JP2004525099A (ja) 2004-08-19
TWI234564B (en) 2005-06-21
BRPI0116444B1 (pt) 2015-09-01
PT1345936E (pt) 2004-09-30
EA005533B1 (ru) 2005-04-28
BR0116444A (pt) 2003-12-23
ES2221658T3 (es) 2005-01-01
CZ294958B6 (cs) 2005-04-13
ECSP034652A (es) 2003-07-25
ATE337314T1 (de) 2006-09-15
NO20032827D0 (no) 2003-06-20
MXPA03005426A (es) 2005-04-20
ES2271722T3 (es) 2007-04-16
US6486321B2 (en) 2002-11-26
HK1060570A1 (en) 2004-08-13
PE20020755A1 (es) 2002-09-24
DK1426373T3 (da) 2006-12-18
SK9352003A3 (en) 2003-10-07
EG23914A (en) 2007-12-30
HU230320B1 (hu) 2016-01-28
DE50110835D1 (de) 2006-10-05

Similar Documents

Publication Publication Date Title
SK287318B6 (sk) Spôsob výroby tiotropiumbromidu a použitie tropenolu a tropenolesteru
US6506900B1 (en) Process for preparing a scopine ester intermediate
JP5048408B2 (ja) 臭化チオトロピウムの調製方法
HRP940723A2 (en) New thienylcarboxylic acid esters of aminoalcohols, their quarternary products, their preparation and use of the compounds
HU224210B1 (hu) Eljárás bi- és triciklikus amino-alkoholok észterei és ezeket hatóanyagként tartalmazó gyógyszerkészítmények előállítására
WO2011015884A1 (en) Process to prepare scopine esters
EP2552911B1 (en) Tiotropium bromide preparation process
US8957209B2 (en) Methods for the synthesis of tiotropium bromide
JP4610333B2 (ja) トロペノールの工業的製法
US8101763B2 (en) Method for producing scopine esters

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20141212