SK287047B6 - Použitie raloxifénu hydrochloridu na prípravu lieku na prevenciu karcinómu prsníka - Google Patents

Použitie raloxifénu hydrochloridu na prípravu lieku na prevenciu karcinómu prsníka Download PDF

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Publication number
SK287047B6
SK287047B6 SK559-99A SK55999A SK287047B6 SK 287047 B6 SK287047 B6 SK 287047B6 SK 55999 A SK55999 A SK 55999A SK 287047 B6 SK287047 B6 SK 287047B6
Authority
SK
Slovakia
Prior art keywords
breast cancer
raloxifene
risk
estrogen
disease
Prior art date
Application number
SK559-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK55999A3 (en
Inventor
Fredric J. Cohen
Robert S. Eckert
Joan E. Glusman
Ronald K. Knickerbocker
Nikolaus T. Nickelsen
Teri J. Scott
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK287047(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9624800.0A external-priority patent/GB9624800D0/en
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of SK55999A3 publication Critical patent/SK55999A3/sk
Publication of SK287047B6 publication Critical patent/SK287047B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK559-99A 1996-10-30 1997-10-29 Použitie raloxifénu hydrochloridu na prípravu lieku na prevenciu karcinómu prsníka SK287047B6 (sk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2985096P 1996-10-30 1996-10-30
GBGB9624800.0A GB9624800D0 (en) 1996-11-29 1996-11-29 Methods of preventing breast cancer
US4026097P 1997-03-10 1997-03-10
PCT/US1997/019779 WO1998018449A1 (en) 1996-10-30 1997-10-29 Methods of preventing breast cancer

Publications (2)

Publication Number Publication Date
SK55999A3 SK55999A3 (en) 2000-06-12
SK287047B6 true SK287047B6 (sk) 2009-10-07

Family

ID=27268608

Family Applications (1)

Application Number Title Priority Date Filing Date
SK559-99A SK287047B6 (sk) 1996-10-30 1997-10-29 Použitie raloxifénu hydrochloridu na prípravu lieku na prevenciu karcinómu prsníka

Country Status (44)

Country Link
US (2) US6303634B1 (xx)
EP (3) EP1369115B1 (xx)
JP (2) JPH10147530A (xx)
CN (2) CN1182591A (xx)
AP (1) AP971A (xx)
AR (2) AR010538A1 (xx)
AT (2) ATE239475T1 (xx)
AU (3) AU5005197A (xx)
BE (2) BE1011381A5 (xx)
BG (1) BG63841B1 (xx)
BR (1) BR9712703A (xx)
CA (2) CA2219070C (xx)
CH (2) CH691847A5 (xx)
CZ (2) CZ300261B6 (xx)
DE (2) DE69721692T2 (xx)
DK (2) DK1369115T3 (xx)
EA (2) EA002054B1 (xx)
EE (1) EE03663B1 (xx)
ES (4) ES2135343A1 (xx)
FR (2) FR2756490B1 (xx)
GB (3) GB2318733A (xx)
GE (1) GEP20032910B (xx)
GR (2) GR1003189B (xx)
HK (1) HK1010495A1 (xx)
HU (2) HUP9701777A3 (xx)
IE (2) IE970773A1 (xx)
IL (2) IL122026A0 (xx)
IS (1) IS5035A (xx)
IT (2) ITMI972434A1 (xx)
LU (2) LU90158B1 (xx)
LV (1) LV12353B (xx)
MY (1) MY121623A (xx)
NL (2) NL1007386C2 (xx)
NO (2) NO974973D0 (xx)
NZ (1) NZ329042A (xx)
PT (2) PT839532E (xx)
RO (1) RO120813B1 (xx)
SG (2) SG83672A1 (xx)
SI (3) SI0839532T1 (xx)
SK (1) SK287047B6 (xx)
TR (1) TR199900951T2 (xx)
UA (1) UA46762C2 (xx)
WO (2) WO1998018325A1 (xx)
YU (1) YU42397A (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458811B1 (en) * 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
GB9624800D0 (en) * 1996-11-29 1997-01-15 Lilly Co Eli Methods of preventing breast cancer
FI109332B (fi) 1998-12-17 2002-07-15 Orion Yhtymae Oyj Toremifeenin liukoisia koostumuksia
FI982733A (fi) 1998-12-17 2000-06-18 Orion Yhtymae Oyj Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia
EP1401446B1 (en) 2001-05-22 2005-02-09 Eli Lilly And Company Tetrahydroquinolin derivatives for the inhibition of diseases associated with estrogen deprivation or with an aberrant physiological response to endogenous estrogen
JP2004531562A (ja) 2001-05-22 2004-10-14 イーライ・リリー・アンド・カンパニー ２−置換１，２，３，４−テトラヒドロキノリンおよびその誘導体、組成物ならびに方法
US20040225200A1 (en) * 2003-05-09 2004-11-11 Edmundson Catherine M. System and method of analyzing the health of a population
GR1005694B (el) * 2005-06-08 2007-10-22 Αλεξης Μιχαηλ Ιστοειδικα αντιοιστρογονα ειδικα για τον αλφα υποδοχεα των οιστρογονων
UA97813C2 (uk) * 2006-12-05 2012-03-26 Янссен Фармацевтика Н.В. Фумаратна сіль (альфа s, бета r)-6-бром-альфа-[2-(диметиламіно)етил]-2-метоксі-альфа-1-нафталеніл-бета-феніл-3-хінолінетанолу
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
CN102973573B (zh) * 2012-11-28 2015-04-08 玉林师范学院 一种人乳腺癌细胞抑制剂及制备方法
CN103830197A (zh) * 2014-03-14 2014-06-04 崔书豪 一种盐酸雷洛昔芬分散片及其制备方法
CN116650484A (zh) * 2023-05-11 2023-08-29 南通大学 一种乳腺癌相关蛋白的抑制剂及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4656187A (en) * 1981-08-03 1987-04-07 Eli Lilly And Company Treatment of mammary cancer
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
JPH07149638A (ja) * 1993-10-15 1995-06-13 Eli Lilly & Co 耐性新生物の治療法
ZA951497B (en) * 1994-03-02 1996-08-23 Lilly Co Eli Orally administerable pharmaceutical formulations
US5478847A (en) * 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
US5604248A (en) * 1994-05-05 1997-02-18 Eli Lilly And Company Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs
US5521214A (en) * 1995-01-25 1996-05-28 Eli Lilly And Company Methods of inhibiting environmental estrogens
US5821254A (en) 1995-02-17 1998-10-13 The United States Of America As Represented By The Department Of Health And Human Services Uses of 9-cis-retinoic acids and derivatives thereof alone or in combination with antineoplastic agents in the prevention or treatment of cancer
EA001257B1 (ru) * 1996-03-26 2000-12-25 Эли Лилли Энд Компани Бензотиофены, содержащие их фармацевтические композиции и способы лечения патологических состояний с их использованием

Also Published As

Publication number Publication date
NL1007386C2 (nl) 1998-05-14
MY121623A (en) 2006-02-28
AR010538A1 (es) 2000-06-28
FR2756490A1 (fr) 1998-06-05
GEP20032910B (en) 2003-03-25
AP9901494A0 (en) 1999-03-31
ITMI972434A1 (it) 1999-04-29
FR2755014A1 (fr) 1998-04-30
WO1998018325A1 (en) 1998-05-07
DE69736644D1 (de) 2006-10-19
WO1998018449A1 (en) 1998-05-07
HUP9701778A3 (en) 1999-06-28
DK1369115T3 (da) 2007-01-02
SG72765A1 (en) 2000-05-23
HUP9701778A2 (hu) 1999-01-28
EP0839532B1 (en) 2003-05-07
IL122025A0 (en) 1998-03-10
CZ341197A3 (cs) 1998-05-13
SI20107A (sl) 2000-06-30
CN1182591A (zh) 1998-05-27
DE69721692T2 (de) 2004-03-25
BG63841B1 (bg) 2003-03-31
GR970100408A (el) 1998-06-30
LU90157B1 (fr) 1998-06-02
IT1298470B1 (it) 2000-01-10
US6303634B1 (en) 2001-10-16
GR1003189B (el) 1999-09-01
CN1182590A (zh) 1998-05-27
NO974972L (no) 1998-05-04
EP0839533A1 (en) 1998-05-06
ES2197312T3 (es) 2004-01-01
ATE239475T1 (de) 2003-05-15
ES2271476T3 (es) 2007-04-16
NZ329042A (en) 1999-08-30
AR013864A1 (es) 2001-01-31
SK55999A3 (en) 2000-06-12
IL122026A0 (en) 1998-03-10
EA006083B1 (ru) 2005-08-25
AU731388B2 (en) 2001-03-29
BE1011381A5 (fr) 1999-08-03
GB9911557D0 (en) 1999-07-21
BR9712703A (pt) 1999-10-26
CA2219377A1 (en) 1998-04-30
HUP9701777A2 (hu) 1999-06-28
DK0839532T3 (da) 2003-08-25
AP971A (en) 2001-05-30
UA46762C2 (uk) 2002-06-17
US20020019418A1 (en) 2002-02-14
BE1011382A5 (fr) 1999-08-03
AU5005697A (en) 1998-05-22
LV12353A (lv) 1999-10-20
ES2135342A1 (es) 1999-10-16
GB2318734A (en) 1998-05-06
FR2755014B1 (fr) 1999-02-05
CZ341297A3 (cs) 1998-05-13
EP1369115B1 (en) 2006-09-06
EP0839532A1 (en) 1998-05-06
CA2219070C (en) 2007-12-18
ES2135342B1 (es) 2000-05-16
AU4364797A (en) 1998-05-07
EA200100716A1 (ru) 2002-06-27
ATE338551T1 (de) 2006-09-15
EE03663B1 (et) 2002-04-15
IE970772A1 (en) 2000-02-09
TR199900951T2 (xx) 1999-07-21
ITMI972433A1 (it) 1999-04-29
CH691847A5 (fr) 2001-11-15
BG103369A (en) 2000-05-31
GB9722801D0 (en) 1997-12-24
ES2135343A1 (es) 1999-10-16
HU9701777D0 (en) 1997-12-29
HU9701778D0 (en) 1997-12-29
GB9722796D0 (en) 1997-12-24
EA199900431A1 (ru) 1999-10-28
CZ300261B6 (cs) 2009-04-01
FR2756490B1 (fr) 2003-06-20
LV12353B (en) 2000-02-20
EP1369115A1 (en) 2003-12-10
RO120813B1 (ro) 2006-08-30
SG83672A1 (en) 2001-10-16
IL122025A (en) 2003-01-12
JPH10147530A (ja) 1998-06-02
EE9900162A (et) 1999-12-15
NO974972D0 (no) 1997-10-28
GR970100409A (el) 1998-06-30
NO322468B1 (no) 2006-10-09
EA002054B1 (ru) 2001-12-24
CA2219070A1 (en) 1998-04-30
NO974973D0 (no) 1997-10-28
HUP9701777A3 (en) 1999-07-28
NL1007387C2 (nl) 1998-05-14
DE69721692D1 (de) 2003-06-12
AU4364897A (en) 1998-05-07
PT839532E (pt) 2003-09-30
JPH10147529A (ja) 1998-06-02
SI0839532T1 (en) 2003-10-31
HK1010495A1 (en) 1999-06-25
IE970773A1 (en) 2000-02-09
MX9708341A (es) 1998-08-30
GB2318733A (en) 1998-05-06
PT1369115E (pt) 2006-12-29
YU42397A (sh) 2000-10-30
SI1369115T1 (sl) 2006-12-31
CH693820A5 (fr) 2004-02-27
GB2318734B (en) 1999-12-01
DE69736644T2 (de) 2007-10-25
AU5005197A (en) 1998-05-22
IS5035A (is) 1999-04-27
LU90158B1 (fr) 1998-06-02
MX9708340A (es) 1998-08-30

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Legal Events

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20131029