GR970100409A - Βελτιωσεις στην προληψη του καρκινου του μαστου και σε σχεση με αυτην - Google Patents

Βελτιωσεις στην προληψη του καρκινου του μαστου και σε σχεση με αυτην

Info

Publication number
GR970100409A
GR970100409A GR970100409A GR970100409A GR970100409A GR 970100409 A GR970100409 A GR 970100409A GR 970100409 A GR970100409 A GR 970100409A GR 970100409 A GR970100409 A GR 970100409A GR 970100409 A GR970100409 A GR 970100409A
Authority
GR
Greece
Prior art keywords
prophylaxis
breast cancer
relating
woman
raloxifene
Prior art date
Application number
GR970100409A
Other languages
English (en)
Inventor
Ellen Joan Glusman
Jay Frederic Cohen
Thomas Nikolaus Nickelsen
Janine Teri Scott
Keith Ronald Knickerbocker
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR970100409(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9624800.0A external-priority patent/GB9624800D0/en
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of GR970100409A publication Critical patent/GR970100409A/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
GR970100409A 1996-10-30 1997-10-29 Βελτιωσεις στην προληψη του καρκινου του μαστου και σε σχεση με αυτην GR970100409A (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2985096P 1996-10-30 1996-10-30
GBGB9624800.0A GB9624800D0 (en) 1996-11-29 1996-11-29 Methods of preventing breast cancer
US4026097P 1997-03-10 1997-03-10

Publications (1)

Publication Number Publication Date
GR970100409A true GR970100409A (el) 1998-06-30

Family

ID=27268608

Family Applications (2)

Application Number Title Priority Date Filing Date
GR970100408A GR1003189B (el) 1996-10-30 1997-10-29 Μεθοδοι προληψεως του καρκινου του μαστου
GR970100409A GR970100409A (el) 1996-10-30 1997-10-29 Βελτιωσεις στην προληψη του καρκινου του μαστου και σε σχεση με αυτην

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GR970100408A GR1003189B (el) 1996-10-30 1997-10-29 Μεθοδοι προληψεως του καρκινου του μαστου

Country Status (44)

Country Link
US (2) US6303634B1 (el)
EP (3) EP0839532B1 (el)
JP (2) JPH10147530A (el)
CN (2) CN1182590A (el)
AP (1) AP971A (el)
AR (2) AR010538A1 (el)
AT (2) ATE239475T1 (el)
AU (3) AU5005197A (el)
BE (2) BE1011382A5 (el)
BG (1) BG63841B1 (el)
BR (1) BR9712703A (el)
CA (2) CA2219070C (el)
CH (2) CH693820A5 (el)
CZ (2) CZ300261B6 (el)
DE (2) DE69721692T2 (el)
DK (2) DK0839532T3 (el)
EA (2) EA006083B1 (el)
EE (1) EE03663B1 (el)
ES (4) ES2135342B1 (el)
FR (2) FR2755014B1 (el)
GB (3) GB2318734B (el)
GE (1) GEP20032910B (el)
GR (2) GR1003189B (el)
HK (1) HK1010495A1 (el)
HU (2) HUP9701777A3 (el)
IE (2) IE970773A1 (el)
IL (2) IL122025A (el)
IS (1) IS5035A (el)
IT (2) ITMI972434A1 (el)
LU (2) LU90157B1 (el)
LV (1) LV12353B (el)
MY (1) MY121623A (el)
NL (2) NL1007387C2 (el)
NO (2) NO322468B1 (el)
NZ (1) NZ329042A (el)
PT (2) PT1369115E (el)
RO (1) RO120813B1 (el)
SG (2) SG72765A1 (el)
SI (3) SI0839532T1 (el)
SK (1) SK287047B6 (el)
TR (1) TR199900951T2 (el)
UA (1) UA46762C2 (el)
WO (2) WO1998018325A1 (el)
YU (1) YU42397A (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458811B1 (en) * 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
GB9624800D0 (en) * 1996-11-29 1997-01-15 Lilly Co Eli Methods of preventing breast cancer
FI982733A (fi) 1998-12-17 2000-06-18 Orion Yhtymae Oyj Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia
FI109332B (fi) 1998-12-17 2002-07-15 Orion Yhtymae Oyj Toremifeenin liukoisia koostumuksia
ES2236536T3 (es) 2001-05-22 2005-07-16 Eli Lilly And Company Derivados tetrahidroquinolino para la inhibicion de enfermedades asociadas con la privacion de estrogenos o con una respuesta fisiologica aberrante a estrogenos endogenos.
ES2259376T3 (es) 2001-05-22 2006-10-01 Eli Lilly And Company 1,2,3,4-tetrahidroquinolinas 2-sustituidas y sus derivados, composiciones y procedimientos.
US20040225200A1 (en) * 2003-05-09 2004-11-11 Edmundson Catherine M. System and method of analyzing the health of a population
GR1005694B (el) * 2005-06-08 2007-10-22 Αλεξης Μιχαηλ Ιστοειδικα αντιοιστρογονα ειδικα για τον αλφα υποδοχεα των οιστρογονων
UA97813C2 (uk) * 2006-12-05 2012-03-26 Янссен Фармацевтика Н.В. Фумаратна сіль (альфа s, бета r)-6-бром-альфа-[2-(диметиламіно)етил]-2-метоксі-альфа-1-нафталеніл-бета-феніл-3-хінолінетанолу
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
CN102973573B (zh) * 2012-11-28 2015-04-08 玉林师范学院 一种人乳腺癌细胞抑制剂及制备方法
CN103830197A (zh) * 2014-03-14 2014-06-04 崔书豪 一种盐酸雷洛昔芬分散片及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
EP0652004A1 (en) * 1993-10-15 1995-05-10 Eli Lilly And Company Methods for treating resistant neoplasms
EP0674903A1 (en) * 1994-03-02 1995-10-04 Eli Lilly And Company Raloxifene for inhibiting bone loss and lowing serum cholesterol
EP0680758A1 (en) * 1994-05-05 1995-11-08 Eli Lilly And Company Pharmaceutical compositions containing tamoxifen or analogs and raloxifene or analogs
WO1996022771A1 (en) * 1995-01-25 1996-08-01 Eli Lilly And Company Methods of inhibiting environmental estrogens
WO1997035571A1 (en) * 1996-03-26 1997-10-02 Eli Lilly And Company Benzothiophenes, formulations containing same, and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656187A (en) * 1981-08-03 1987-04-07 Eli Lilly And Company Treatment of mammary cancer
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
IL112746A (en) * 1994-03-02 1999-12-31 Lilly Co Eli Orally administrable pharmaceutical formulation comprising raloxifene hydrochoride
US5821254A (en) 1995-02-17 1998-10-13 The United States Of America As Represented By The Department Of Health And Human Services Uses of 9-cis-retinoic acids and derivatives thereof alone or in combination with antineoplastic agents in the prevention or treatment of cancer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
EP0652004A1 (en) * 1993-10-15 1995-05-10 Eli Lilly And Company Methods for treating resistant neoplasms
EP0674903A1 (en) * 1994-03-02 1995-10-04 Eli Lilly And Company Raloxifene for inhibiting bone loss and lowing serum cholesterol
EP0680758A1 (en) * 1994-05-05 1995-11-08 Eli Lilly And Company Pharmaceutical compositions containing tamoxifen or analogs and raloxifene or analogs
WO1996022771A1 (en) * 1995-01-25 1996-08-01 Eli Lilly And Company Methods of inhibiting environmental estrogens
WO1997035571A1 (en) * 1996-03-26 1997-10-02 Eli Lilly And Company Benzothiophenes, formulations containing same, and methods

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"FIRST PHASE III RESULTS WITH RALOXIFENE", DATABASE FILE 129, PHIND; DIALOG INFORMATION SERVICES; AN=540210, 13 June 1997 (1997-06-13), pages 17, XP002054373 *
"MARKET ANALYSIS FROM DECISION RESOURCES: BREAST CANCER", DATABASE FILE 187, FDC REPORTS; DIALOG INFORMATION SERVICES, AN=1249, vol. 1, no. 4, 1 April 1996 (1996-04-01), XP002054375 *
M.A. ANZANO ET AL.: "CHEMOPREVENTION OF MAMMARY CARCINOGENESIS IN THE RAT: COMBINED USE OF RALOXIFENE AND 9-CIS-RETINOIC ACID", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 88, no. 2, January 1996 (1996-01-01), pages 123 - 125, XP002054376 *
V.C. JORDAN ET AL.: "ALTERNATE ANTIESTROGENS AND APPROACHES TO THE PREVENTION OF BREAST CANCER", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 58, no. S.22, 1995, pages 51 - 57, XP002054374 *

Also Published As

Publication number Publication date
NL1007386C2 (nl) 1998-05-14
SI1369115T1 (sl) 2006-12-31
HUP9701777A2 (hu) 1999-06-28
AU5005697A (en) 1998-05-22
SG72765A1 (en) 2000-05-23
TR199900951T2 (xx) 1999-07-21
IL122026A0 (en) 1998-03-10
IS5035A (is) 1999-04-27
CZ300261B6 (cs) 2009-04-01
GB9722796D0 (en) 1997-12-24
IE970772A1 (en) 2000-02-09
NO974972D0 (no) 1997-10-28
FR2756490A1 (fr) 1998-06-05
NO974973D0 (no) 1997-10-28
ITMI972433A1 (it) 1999-04-29
CZ341197A3 (cs) 1998-05-13
DK1369115T3 (da) 2007-01-02
LU90158B1 (fr) 1998-06-02
MX9708340A (es) 1998-08-30
GB9911557D0 (en) 1999-07-21
FR2756490B1 (fr) 2003-06-20
SK287047B6 (sk) 2009-10-07
PT839532E (pt) 2003-09-30
LV12353B (en) 2000-02-20
US6303634B1 (en) 2001-10-16
AR010538A1 (es) 2000-06-28
ES2135342A1 (es) 1999-10-16
EE9900162A (et) 1999-12-15
MX9708341A (es) 1998-08-30
WO1998018449A1 (en) 1998-05-07
BG63841B1 (bg) 2003-03-31
BG103369A (en) 2000-05-31
EE03663B1 (et) 2002-04-15
AR013864A1 (es) 2001-01-31
AU4364797A (en) 1998-05-07
CA2219377A1 (en) 1998-04-30
CA2219070C (en) 2007-12-18
EP0839532A1 (en) 1998-05-06
CA2219070A1 (en) 1998-04-30
YU42397A (sh) 2000-10-30
DE69721692T2 (de) 2004-03-25
CN1182590A (zh) 1998-05-27
CN1182591A (zh) 1998-05-27
AP971A (en) 2001-05-30
LV12353A (lv) 1999-10-20
AU731388B2 (en) 2001-03-29
EA199900431A1 (ru) 1999-10-28
CZ341297A3 (cs) 1998-05-13
CH693820A5 (fr) 2004-02-27
GB9722801D0 (en) 1997-12-24
NL1007387C2 (nl) 1998-05-14
DK0839532T3 (da) 2003-08-25
EP1369115A1 (en) 2003-12-10
SI0839532T1 (en) 2003-10-31
ES2135343A1 (es) 1999-10-16
GR970100408A (el) 1998-06-30
EA006083B1 (ru) 2005-08-25
ES2197312T3 (es) 2004-01-01
GB2318733A (en) 1998-05-06
EA200100716A1 (ru) 2002-06-27
HK1010495A1 (en) 1999-06-25
GR1003189B (el) 1999-09-01
MY121623A (en) 2006-02-28
UA46762C2 (uk) 2002-06-17
ES2135342B1 (es) 2000-05-16
HUP9701777A3 (en) 1999-07-28
HUP9701778A3 (en) 1999-06-28
DE69736644T2 (de) 2007-10-25
IT1298470B1 (it) 2000-01-10
LU90157B1 (fr) 1998-06-02
EP0839533A1 (en) 1998-05-06
BR9712703A (pt) 1999-10-26
ES2271476T3 (es) 2007-04-16
EA002054B1 (ru) 2001-12-24
IE970773A1 (en) 2000-02-09
SI20107A (sl) 2000-06-30
ATE338551T1 (de) 2006-09-15
DE69721692D1 (de) 2003-06-12
JPH10147529A (ja) 1998-06-02
FR2755014B1 (fr) 1999-02-05
IL122025A0 (en) 1998-03-10
EP0839532B1 (en) 2003-05-07
PT1369115E (pt) 2006-12-29
EP1369115B1 (en) 2006-09-06
AU5005197A (en) 1998-05-22
JPH10147530A (ja) 1998-06-02
SG83672A1 (en) 2001-10-16
WO1998018325A1 (en) 1998-05-07
AU4364897A (en) 1998-05-07
US20020019418A1 (en) 2002-02-14
ATE239475T1 (de) 2003-05-15
BE1011381A5 (fr) 1999-08-03
RO120813B1 (ro) 2006-08-30
IL122025A (en) 2003-01-12
GB2318734A (en) 1998-05-06
GB2318734B (en) 1999-12-01
FR2755014A1 (fr) 1998-04-30
NZ329042A (en) 1999-08-30
AP9901494A0 (en) 1999-03-31
ITMI972434A1 (it) 1999-04-29
SK55999A3 (en) 2000-06-12
GEP20032910B (en) 2003-03-25
NO974972L (no) 1998-05-04
HUP9701778A2 (hu) 1999-01-28
DE69736644D1 (de) 2006-10-19
HU9701777D0 (en) 1997-12-29
HU9701778D0 (en) 1997-12-29
BE1011382A5 (fr) 1999-08-03
NO322468B1 (no) 2006-10-09
CH691847A5 (fr) 2001-11-15

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