SK285688B6 - Inhibítory retrovírusových proteáz na báze hydroxyetylaminosulfónamidu aminokyselín a ich použitie - Google Patents

Inhibítory retrovírusových proteáz na báze hydroxyetylaminosulfónamidu aminokyselín a ich použitie Download PDF

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Publication number
SK285688B6
SK285688B6 SK1224-97A SK122497A SK285688B6 SK 285688 B6 SK285688 B6 SK 285688B6 SK 122497 A SK122497 A SK 122497A SK 285688 B6 SK285688 B6 SK 285688B6
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SK
Slovakia
Prior art keywords
amino
phenylmethyl
hydroxy
methylpropyl
propyl
Prior art date
Application number
SK1224-97A
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English (en)
Slovak (sk)
Other versions
SK122497A3 (en
Inventor
Daniel P. Getman
Gary A. Decrescenzo
John N. Freskos
Michael L. Vazquez
James A. Sikorski
Balekudru Devadas
Srinivasan Nagarajan
David L. Brown
Joseph J. Mcdonald
Original Assignee
G. D. Searle & Co.
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Application filed by G. D. Searle & Co. filed Critical G. D. Searle & Co.
Publication of SK122497A3 publication Critical patent/SK122497A3/sk
Publication of SK285688B6 publication Critical patent/SK285688B6/sk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18Ethylenedioxybenzenes, not substituted on the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D339/00Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02Five-membered rings
    • C07D339/06Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069Ser-amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK1224-97A 1995-03-10 1996-03-07 Inhibítory retrovírusových proteáz na báze hydroxyetylaminosulfónamidu aminokyselín a ich použitie SK285688B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40228795A 1995-03-10 1995-03-10
US08/474,052 US5756533A (en) 1995-03-10 1995-06-07 Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002684 WO1996028463A1 (en) 1995-03-10 1996-03-07 Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (2)

Publication Number Publication Date
SK122497A3 SK122497A3 (en) 1998-03-04
SK285688B6 true SK285688B6 (sk) 2007-06-07

Family

ID=23591303

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1224-97A SK285688B6 (sk) 1995-03-10 1996-03-07 Inhibítory retrovírusových proteáz na báze hydroxyetylaminosulfónamidu aminokyselín a ich použitie

Country Status (23)

Country Link
US (3) US5756533A (de)
EP (2) EP1258491A1 (de)
JP (1) JP4091111B2 (de)
KR (1) KR100377855B1 (de)
CN (1) CN1204144C (de)
AT (1) ATE226213T1 (de)
AU (1) AU705268B2 (de)
BR (1) BR9607638A (de)
CA (1) CA2215061A1 (de)
CZ (1) CZ297719B6 (de)
DE (1) DE69624346T2 (de)
DK (1) DK0813542T3 (de)
EA (1) EA000470B1 (de)
EE (1) EE04349B1 (de)
ES (1) ES2187640T3 (de)
HU (1) HUP9801562A3 (de)
NO (1) NO974148L (de)
NZ (1) NZ303861A (de)
PL (1) PL184748B1 (de)
PT (1) PT813542E (de)
SK (1) SK285688B6 (de)
UA (1) UA56130C2 (de)
WO (1) WO1996028463A1 (de)

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WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
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JP2007528423A (ja) 2004-03-11 2007-10-11 セコイア、ファーマシューティカルズ、インコーポレイテッド 耐性防止レトロウイルスプロテアーゼ阻害薬
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Also Published As

Publication number Publication date
NO974148D0 (no) 1997-09-09
KR19980702905A (ko) 1998-09-05
NO974148L (no) 1997-10-27
EE9700201A (et) 1998-02-16
EA199700221A1 (ru) 1998-04-30
NZ303861A (en) 1999-02-25
EP0813542B1 (de) 2002-10-16
BR9607638A (pt) 1998-05-26
CA2215061A1 (en) 1996-09-19
AU705268B2 (en) 1999-05-20
PL184748B1 (pl) 2002-12-31
WO1996028463A1 (en) 1996-09-19
AU5029496A (en) 1996-10-02
JP2001513746A (ja) 2001-09-04
ATE226213T1 (de) 2002-11-15
JP4091111B2 (ja) 2008-05-28
CN1186499A (zh) 1998-07-01
DE69624346T2 (de) 2003-06-26
CZ282497A3 (cs) 1998-02-18
HUP9801562A3 (en) 2001-02-28
SK122497A3 (en) 1998-03-04
KR100377855B1 (ko) 2003-07-23
PL322784A1 (en) 1998-02-16
PT813542E (pt) 2003-01-31
EP0813542A1 (de) 1997-12-29
US5756533A (en) 1998-05-26
ES2187640T3 (es) 2003-06-16
US5965601A (en) 1999-10-12
CN1204144C (zh) 2005-06-01
CZ297719B6 (cs) 2007-03-14
US5968970A (en) 1999-10-19
EA000470B1 (ru) 1999-08-26
DE69624346D1 (de) 2002-11-21
EE04349B1 (et) 2004-08-16
DK0813542T3 (da) 2003-02-17
HUP9801562A2 (hu) 1998-11-30
EP1258491A1 (de) 2002-11-20
UA56130C2 (uk) 2003-05-15

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