SK285670B6 - Deriváty piperazinylalkyltiopyrimidínu, spôsob ich prípravy, ich použitie a farmaceutické kompozície s ich obsahom - Google Patents

Deriváty piperazinylalkyltiopyrimidínu, spôsob ich prípravy, ich použitie a farmaceutické kompozície s ich obsahom Download PDF

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Publication number
SK285670B6
SK285670B6 SK1927-2001A SK19272001A SK285670B6 SK 285670 B6 SK285670 B6 SK 285670B6 SK 19272001 A SK19272001 A SK 19272001A SK 285670 B6 SK285670 B6 SK 285670B6
Authority
SK
Slovakia
Prior art keywords
group
mmol
alkyl
acid addition
pharmaceutically acceptable
Prior art date
Application number
SK1927-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK19272001A3 (sk
Inventor
Simonek Ildik� R�Tzn�
D�Niel B�Zsing
G�Bor N�Meth
Gyula Simig
L�Szl� Posz�V�Cz
Iv�N Jak�Czi
Gyrgy Lvay
Istvn Gacslyi
K�Roly Tihanyi
J�Nos Wellman
Andr�S Egyed
Original Assignee
Egis Gy�Gyszergy�R Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9902214A external-priority patent/HU9902214D0/hu
Priority claimed from HU0002156A external-priority patent/HU227402B1/hu
Application filed by Egis Gy�Gyszergy�R Rt. filed Critical Egis Gy�Gyszergy�R Rt.
Publication of SK19272001A3 publication Critical patent/SK19272001A3/sk
Publication of SK285670B6 publication Critical patent/SK285670B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK1927-2001A 1999-06-29 2000-06-29 Deriváty piperazinylalkyltiopyrimidínu, spôsob ich prípravy, ich použitie a farmaceutické kompozície s ich obsahom SK285670B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU9902214A HU9902214D0 (en) 1999-06-29 1999-06-29 Novel piperazinyl-alkyl-thio-pyrimidine-derivatives, process for producing them and medicaments containing the same
HU0002156A HU227402B1 (en) 2000-06-06 2000-06-06 Novel piperazinyl alkylthio pyrimidinyl derivatives, pharmaceutical compositions containing such active ingredients and process for producing the active ingredients
PCT/HU2000/000064 WO2001000617A2 (en) 1999-06-29 2000-06-29 Novel piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same, and a process for the preparation of the same

Publications (2)

Publication Number Publication Date
SK19272001A3 SK19272001A3 (sk) 2002-05-09
SK285670B6 true SK285670B6 (sk) 2007-06-07

Family

ID=89998587

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1927-2001A SK285670B6 (sk) 1999-06-29 2000-06-29 Deriváty piperazinylalkyltiopyrimidínu, spôsob ich prípravy, ich použitie a farmaceutické kompozície s ich obsahom

Country Status (19)

Country Link
US (1) US6469168B1 (cs)
EP (1) EP1194415B1 (cs)
JP (1) JP2003503404A (cs)
KR (1) KR20020016872A (cs)
CN (1) CN1173956C (cs)
AT (1) ATE247645T1 (cs)
AU (1) AU5835400A (cs)
CA (1) CA2376307A1 (cs)
CZ (1) CZ20014575A3 (cs)
DE (1) DE60004671T2 (cs)
DK (1) DK1194415T3 (cs)
ES (1) ES2204643T3 (cs)
HK (1) HK1046902A1 (cs)
HR (1) HRP20010969B1 (cs)
PL (1) PL352476A1 (cs)
PT (1) PT1194415E (cs)
RU (1) RU2245334C2 (cs)
SK (1) SK285670B6 (cs)
WO (1) WO2001000617A2 (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003246587A1 (en) 2002-07-02 2004-01-23 F. Hoffmann-La Roche Ag 2, 5-substituted pyrimidine derivatives as ccr-3 receptor antagonists ix
AU2009262068C1 (en) 2008-06-27 2015-07-02 Celgene Car Llc Heteroaryl compounds and uses thereof
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
RU2013109393A (ru) * 2010-08-10 2014-09-20 Сэлджин Авиаломикс Ресеарч, Инк. Безилатная соль ингибитора втк
CA2815858C (en) 2010-11-01 2018-10-16 Celgene Avilomics Research, Inc. Heterocyclic compounds and uses thereof
WO2012061303A1 (en) 2010-11-01 2012-05-10 Avila Therapeutics, Inc. Heteroaryl compounds and uses thereof
JP5957003B2 (ja) 2010-11-10 2016-07-27 セルジーン アヴィロミクス リサーチ， インコーポレイテッド 変異体選択的ｅｇｆｒ阻害剤およびその使用
TW201325593A (zh) 2011-10-28 2013-07-01 Celgene Avilomics Res Inc 治療布魯頓（ｂｒｕｔｏｎ’ｓ）酪胺酸激酶疾病或病症之方法
KR102081042B1 (ko) 2012-03-15 2020-02-26 셀젠 카르 엘엘씨 상피 성장 인자 수용체 키나제 억제제의 고체 형태
EP2825042B1 (en) 2012-03-15 2018-08-01 Celgene CAR LLC Salts of an epidermal growth factor receptor kinase inhibitor
WO2014100748A1 (en) 2012-12-21 2014-06-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EP2953457B1 (en) 2013-02-08 2020-04-08 Celgene CAR LLC Erk inhibitors and uses thereof
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
WO2016025561A1 (en) 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Forms and compositions of an erk inhibitor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79933B (cs) * 1983-06-23 1984-10-31 Nissan Chemical Ind Ltd
HUT76266A (en) * 1995-10-31 1997-07-28 Egyt Gyogyszervegyeszeti Gyar New piperazinyl-alkylthio-pyrimidine derivatives, pharmaceutical compositions containing them, and process for producing the active components

Also Published As

Publication number Publication date
AU5835400A (en) 2001-01-31
CA2376307A1 (en) 2001-01-04
CN1173956C (zh) 2004-11-03
ES2204643T3 (es) 2004-05-01
HRP20010969A2 (en) 2003-04-30
HK1046902A1 (zh) 2003-01-30
RU2245334C2 (ru) 2005-01-27
CZ20014575A3 (cs) 2002-04-17
ATE247645T1 (de) 2003-09-15
EP1194415B1 (en) 2003-08-20
WO2001000617A3 (en) 2001-03-01
EP1194415A2 (en) 2002-04-10
DE60004671D1 (de) 2003-09-25
HRP20010969B1 (en) 2005-04-30
DE60004671T2 (de) 2004-07-29
CN1359375A (zh) 2002-07-17
PT1194415E (pt) 2004-01-30
SK19272001A3 (sk) 2002-05-09
KR20020016872A (ko) 2002-03-06
US6469168B1 (en) 2002-10-22
PL352476A1 (en) 2003-08-25
JP2003503404A (ja) 2003-01-28
WO2001000617A2 (en) 2001-01-04
DK1194415T3 (da) 2003-12-08

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