SK285231B6 - Použitie 6-[(imidazol-5-yl)metyl]chinolínovej zlúčeniny na prípravu farmaceutickej kompozície na liečbu artropatie - Google Patents
Použitie 6-[(imidazol-5-yl)metyl]chinolínovej zlúčeniny na prípravu farmaceutickej kompozície na liečbu artropatie Download PDFInfo
- Publication number
- SK285231B6 SK285231B6 SK1987-2000A SK19872000A SK285231B6 SK 285231 B6 SK285231 B6 SK 285231B6 SK 19872000 A SK19872000 A SK 19872000A SK 285231 B6 SK285231 B6 SK 285231B6
- Authority
- SK
- Slovakia
- Prior art keywords
- alkyl
- group
- methyl
- alkyloxy
- formula
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98202258 | 1998-07-06 | ||
| PCT/EP1999/004546 WO2000001386A1 (en) | 1998-07-06 | 1999-06-30 | Farnesyl protein transferase inhibitors for treating arthropathies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK19872000A3 SK19872000A3 (sk) | 2001-08-06 |
| SK285231B6 true SK285231B6 (sk) | 2006-09-07 |
Family
ID=8233891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1987-2000A SK285231B6 (sk) | 1998-07-06 | 1999-06-30 | Použitie 6-[(imidazol-5-yl)metyl]chinolínovej zlúčeniny na prípravu farmaceutickej kompozície na liečbu artropatie |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6451812B1 (de) |
| EP (1) | EP1094815B1 (de) |
| JP (1) | JP4491136B2 (de) |
| KR (1) | KR100674122B1 (de) |
| CN (1) | CN1170538C (de) |
| AP (1) | AP1597A (de) |
| AT (1) | ATE253914T1 (de) |
| AU (1) | AU762470B2 (de) |
| BG (1) | BG64939B1 (de) |
| BR (1) | BR9911869A (de) |
| CA (1) | CA2337800C (de) |
| CZ (1) | CZ302269B6 (de) |
| DE (1) | DE69912790T2 (de) |
| DK (1) | DK1094815T3 (de) |
| EA (1) | EA003510B1 (de) |
| EE (1) | EE04579B1 (de) |
| ES (1) | ES2212580T3 (de) |
| HK (1) | HK1034450A1 (de) |
| HR (1) | HRP20000904A2 (de) |
| HU (1) | HU229358B1 (de) |
| ID (1) | ID27199A (de) |
| IL (2) | IL140720A0 (de) |
| MY (1) | MY122189A (de) |
| NO (1) | NO318338B1 (de) |
| NZ (1) | NZ509647A (de) |
| PL (1) | PL193296B1 (de) |
| PT (1) | PT1094815E (de) |
| SI (1) | SI1094815T1 (de) |
| SK (1) | SK285231B6 (de) |
| TR (1) | TR200003882T2 (de) |
| TW (1) | TW557212B (de) |
| UA (1) | UA64797C2 (de) |
| WO (1) | WO2000001386A1 (de) |
| ZA (1) | ZA200100152B (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69912790T2 (de) | 1998-07-06 | 2004-09-23 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitoren zur behandlung von arthropathien |
| EP1106612B1 (de) | 1999-11-30 | 2004-02-11 | Pfizer Products Inc. | Chinolinderivate verwendbar zur Hemmung der Farnesyl-Protein Transferase |
| JO2361B1 (en) | 2000-06-22 | 2006-12-12 | جانسين فارماسيوتيكا ان. في | Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl |
| DE60118225T2 (de) | 2000-09-25 | 2007-05-03 | Janssen Pharmaceutica N.V. | Chinolin- und chinazolinderivate und deren verwendung als farnesyl transferase inhibitoren |
| EP1322644A1 (de) | 2000-09-25 | 2003-07-02 | Janssen Pharmaceutica N.V. | 6-heterocyclylmethyl chinolon derivate und deren verwendung als farnesyl transferase inhibitoren |
| EP1322636A1 (de) | 2000-09-25 | 2003-07-02 | Janssen Pharmaceutica N.V. | 6-(substituierte phenyl)methyl)chinolin- und chinazolinderivate und deren verwendung als farneyl transferase inhibitoren |
| WO2002024686A2 (en) | 2000-09-25 | 2002-03-28 | Janssen Pharmaceutica N.V. | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives |
| ATE434615T1 (de) | 2000-11-21 | 2009-07-15 | Janssen Pharmaceutica Nv | Farnesyltransferase hemmende benzoheterocyclische derivate |
| ES2263684T3 (es) * | 2000-12-27 | 2006-12-16 | Janssen Pharmaceutica N.V. | Derivados de 4-heterociclil-quinolina y -quinazolina que inhiben la farnesil transferasa. |
| ES2260316T3 (es) | 2000-12-27 | 2006-11-01 | Janssen Pharmaceutica N.V. | Derivados de quinazolina y quinolina 4-sustituidos que inhiben la farnesil transferasa. |
| AU2002250236A1 (en) * | 2001-03-02 | 2002-09-19 | Medimmune, Inc. | Cd2 antagonists for treatment of autoimmune or inflammatory disease |
| EP1408971A4 (de) | 2001-06-21 | 2006-01-25 | Ariad Pharma Inc | Neue chinoline und ihre verwendungszwecke |
| EP1412367A4 (de) * | 2001-06-21 | 2006-05-03 | Ariad Pharma Inc | Neue chinoline und deren verwendung |
| US7408063B2 (en) | 2001-12-19 | 2008-08-05 | Janssen Pharmaceutica, N.V. | 1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors |
| ATE364384T1 (de) | 2002-03-22 | 2007-07-15 | Janssen Pharmaceutica Nv | Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren |
| ATE336496T1 (de) | 2002-04-15 | 2006-09-15 | Janssen Pharmaceutica Nv | Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| ES2391087T3 (es) | 2003-04-11 | 2012-11-21 | Medimmune, Llc | Anticuerpos de IL-9 recombinantes y usos de los mismos |
| WO2005042743A2 (en) | 2003-08-18 | 2005-05-12 | Medimmune, Inc. | Humanization of antibodies |
| EP1691812A4 (de) | 2003-11-20 | 2010-01-13 | Childrens Hosp Medical Center | Gtpase-hemmer und anwendungsverfahren |
| CA2559221A1 (en) * | 2004-03-18 | 2005-09-29 | Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| US20050272068A1 (en) * | 2004-03-18 | 2005-12-08 | The Brigham And Women's Hospital, Inc. | UCH-L1 expression and cancer therapy |
| EP2422811A2 (de) | 2004-10-27 | 2012-02-29 | MedImmune, LLC | Modulation von Antikörperspezifität mittels Anpassung der Affinität zu verwandten Antigenen |
| RS52741B (en) | 2004-11-05 | 2013-08-30 | Janssen Pharmaceutica N.V. | THERAPEUTIC USE OF FARNEZILTRANSPHERASE INHIBITORS AND PROCEDURES FOR MONITORING THEIR EFFICIENCY |
| US20060194821A1 (en) * | 2005-02-18 | 2006-08-31 | The Brigham And Women's Hospital, Inc. | Compounds inhibiting the aggregation of superoxide dismutase-1 |
| AU2006227377B2 (en) | 2005-03-18 | 2013-01-31 | Medimmune, Llc | Framework-shuffling of antibodies |
| JP2008546805A (ja) | 2005-06-23 | 2008-12-25 | メディミューン，エルエルシー | 最適な凝集および断片化プロフィールを有する抗体製剤 |
| AU2006275528B2 (en) | 2005-07-29 | 2012-03-08 | Children's Hospital Medical Center | GTPase inhibitors and methods of use and crystal structure of Rac-1 GTPase |
| EP2545919A1 (de) | 2005-12-23 | 2013-01-16 | Link Medicine Corporation | Behandlung von Synucleinopathien |
| TW201343676A (zh) | 2006-08-28 | 2013-11-01 | Kyowa Hakko Kirin Co Ltd | 具拮抗性之人類ｌｉｇｈｔ專一性人類單株抗體 |
| EP2077859A4 (de) | 2007-03-30 | 2010-11-24 | Medimmune Llc | Antikörper-formulierung |
| DK2160386T3 (da) * | 2007-05-23 | 2012-08-27 | Allergan Inc | Terapeutiske ((phenyl)imidazolyl)methylquinolinylforbindelser |
| US8232402B2 (en) | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| BRPI0920927A2 (pt) | 2008-11-13 | 2019-09-24 | Link Medicine Corp | derivados de azaquinolinona e usos dos mesmos |
| FR2967353B1 (fr) * | 2010-11-16 | 2013-08-16 | Centre Nat Rech Scient | Derives de quinolinone |
| US9540443B2 (en) | 2011-01-26 | 2017-01-10 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies |
| US9980942B2 (en) | 2012-05-02 | 2018-05-29 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
| WO2014018625A1 (en) | 2012-07-25 | 2014-01-30 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
| EP2906598A1 (de) | 2012-10-09 | 2015-08-19 | Igenica Biotherapeutics, Inc. | Anti-c16orf54-antikörper und verfahren zur verwendung davon |
| RS56283B1 (sr) | 2012-10-16 | 2017-12-29 | Janssen Pharmaceutica Nv | Metilen vezani hinolinil modulatori ror-gama-t |
| CA2888485C (en) * | 2012-10-16 | 2021-01-26 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of ror.gamma.t |
| EP2909189B8 (de) * | 2012-10-16 | 2017-04-19 | Janssen Pharmaceutica NV | Heteroarylverknüpfte chinolinyl-modulatoren von ror-gamma-t |
| SG11201509982UA (de) | 2013-06-06 | 2016-04-28 | Igenica Biotherapeutics Inc | |
| RS62189B1 (sr) | 2013-08-26 | 2021-08-31 | Biontech Research And Development Inc | Nukleinske kiseline koje kodiraju humana antitela na sijalil-luis a |
| AU2014334619A1 (en) | 2013-10-15 | 2016-04-21 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORyt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| ES2742843T3 (es) | 2013-10-15 | 2020-02-17 | Janssen Pharmaceutica Nv | Moduladores de quinolinilo de ROR(gamma)t |
| US9403816B2 (en) * | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US9284308B2 (en) * | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| CA2927152C (en) * | 2013-10-15 | 2021-09-14 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of ror-gamma-t |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9221804B2 (en) * | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| WO2015187811A2 (en) | 2014-06-04 | 2015-12-10 | MabVax Therapeutics, Inc. | Human monoclonal antibodies to ganglioside gd2 |
| US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
| DK3229838T3 (da) | 2014-12-11 | 2020-10-19 | Pf Medicament | Anti-C10orf54-antistoffer og anvendelser deraf |
| HUE061070T2 (hu) | 2015-03-03 | 2023-05-28 | Kymab Ltd | Ellenanyagok, alkalmazások és eljárások |
| PT3277842T (pt) | 2015-08-17 | 2019-09-05 | Kura Oncology Inc | Métodos de tratamento de doentes com cancro usando inibidores da farnesiltransferase |
| US11253590B2 (en) | 2015-12-02 | 2022-02-22 | Stsciences, Inc. | Antibodies specific to glycosylated BTLA (B- and T- lymphocyte attenuator) |
| US10875920B2 (en) | 2015-12-02 | 2020-12-29 | Stcube & Co., Inc. | Antibodies and molecules that immunospecifically bind to BTN1A1 and the therapeutic uses thereof |
| LT3534885T (lt) | 2016-11-03 | 2021-07-12 | Kura Oncology, Inc. | Farneziltransferazės inhibitoriai, skirti naudoti vėžio gydymui |
| WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| CN111148762A (zh) | 2017-05-31 | 2020-05-12 | 斯特库伯株式会社 | 免疫特异性结合至btn1a1的抗体和分子及其治疗性用途 |
| CA3065300A1 (en) | 2017-05-31 | 2018-12-06 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that immunospecifically bind to btn1a1 |
| CN110997724A (zh) | 2017-06-06 | 2020-04-10 | 斯特库伯株式会社 | 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法 |
| EP3694889A1 (de) | 2017-10-13 | 2020-08-19 | Boehringer Ingelheim International GmbH | Humane antikörper gegen thomsen-nouvelle (tn)-antigen |
| CN112740043A (zh) | 2018-07-20 | 2021-04-30 | 皮埃尔法布雷医药公司 | Vista受体 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602184A (en) | 1993-03-03 | 1997-02-11 | The United States Of America As Represented By Department Of Health And Human Services | Monoterpenes, sesquiterpenes and diterpenes as cancer therapy |
| US5574025A (en) * | 1994-10-26 | 1996-11-12 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferases |
| US5831004A (en) * | 1994-10-27 | 1998-11-03 | Affymax Technologies N.V. | Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use |
| FR2729390A1 (fr) * | 1995-01-18 | 1996-07-19 | Rhone Poulenc Rorer Sa | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
| TW349948B (en) | 1995-10-31 | 1999-01-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 2-quinolone derivatives |
| ES2175137T3 (es) * | 1995-12-08 | 2002-11-16 | Janssen Pharmaceutica Nv | Derivados de (imidazol-5-il)metil-2-quinolinona como inhibidores de laproteina farnesil-transferasa. |
| US20020034725A1 (en) | 1996-04-15 | 2002-03-21 | W. Gillies Mckenna | Sensitization of cells to radiation and and chemotherapy |
| AU709409B2 (en) * | 1996-07-15 | 1999-08-26 | Bristol-Myers Squibb Company | Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase |
| TW591030B (en) | 1997-03-10 | 2004-06-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles |
| GB2323783A (en) * | 1997-04-02 | 1998-10-07 | Ferring Bv Group Holdings | Inhibitors of farnesyl protein transferase |
| CZ296959B6 (cs) | 1997-04-25 | 2006-08-16 | Janssen Pharmaceutica N. V. | Chinazolon, zpusob a meziprodukt pro jeho výrobu a farmaceutický prostredek s jeho obsahem |
| DE69807222T2 (de) | 1997-06-02 | 2003-04-17 | Janssen Pharmaceutica Nv | (imidazol-5-yl)methyl-2-quinolinone derivativen als inhibitoren von proliferation der glatten muskelzellen |
| IL133449A0 (en) | 1997-06-17 | 2001-04-30 | Schering Corp | Benzo (5, 6) cyclohepta (1, 2-b) pyridine derivatives as farnesyl protein transferase inhibitors |
| DE69912790T2 (de) | 1998-07-06 | 2004-09-23 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitoren zur behandlung von arthropathien |
| CN1152716C (zh) | 1998-07-06 | 2004-06-09 | 詹森药业有限公司 | 具体内射线感受性的法呢基蛋白质转移酶抑制剂 |
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| JP5574025B1 (ja) * | 2013-06-25 | 2014-08-20 | 大日本印刷株式会社 | 飲料供給系配管の殺菌方法及び装置 |
-
1999
- 1999-06-30 DE DE69912790T patent/DE69912790T2/de not_active Expired - Lifetime
- 1999-06-30 EP EP99931230A patent/EP1094815B1/de not_active Expired - Lifetime
- 1999-06-30 ID IDW20010018A patent/ID27199A/id unknown
- 1999-06-30 DK DK99931230T patent/DK1094815T3/da active
- 1999-06-30 SI SI9930475T patent/SI1094815T1/xx unknown
- 1999-06-30 NZ NZ509647A patent/NZ509647A/en not_active IP Right Cessation
- 1999-06-30 AU AU47806/99A patent/AU762470B2/en not_active Expired
- 1999-06-30 JP JP2000557832A patent/JP4491136B2/ja not_active Expired - Lifetime
- 1999-06-30 CZ CZ20004778A patent/CZ302269B6/cs not_active IP Right Cessation
- 1999-06-30 EA EA200100112A patent/EA003510B1/ru not_active IP Right Cessation
- 1999-06-30 CA CA002337800A patent/CA2337800C/en not_active Expired - Lifetime
- 1999-06-30 KR KR1020007014067A patent/KR100674122B1/ko not_active IP Right Cessation
- 1999-06-30 CN CNB998083119A patent/CN1170538C/zh not_active Expired - Lifetime
- 1999-06-30 ES ES99931230T patent/ES2212580T3/es not_active Expired - Lifetime
- 1999-06-30 TR TR2000/03882T patent/TR200003882T2/xx unknown
- 1999-06-30 WO PCT/EP1999/004546 patent/WO2000001386A1/en not_active Application Discontinuation
- 1999-06-30 IL IL14072099A patent/IL140720A0/xx active IP Right Grant
- 1999-06-30 UA UA2000127574A patent/UA64797C2/uk unknown
- 1999-06-30 PT PT99931230T patent/PT1094815E/pt unknown
- 1999-06-30 AP APAP/P/2001/002058A patent/AP1597A/en active
- 1999-06-30 HU HU0103670A patent/HU229358B1/hu unknown
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- 1999-06-30 BR BR9911869-6A patent/BR9911869A/pt not_active Application Discontinuation
- 1999-06-30 AT AT99931230T patent/ATE253914T1/de active
- 1999-06-30 US US09/743,077 patent/US6451812B1/en not_active Expired - Lifetime
- 1999-06-30 SK SK1987-2000A patent/SK285231B6/sk not_active IP Right Cessation
- 1999-06-30 PL PL345352A patent/PL193296B1/pl unknown
- 1999-07-01 MY MYPI99002787A patent/MY122189A/en unknown
- 1999-07-05 TW TW088111347A patent/TW557212B/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
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| MK4A | Expiry of patent |
Expiry date: 20190630 |