SK284330B6 - Použitie 3-fenyl-4-(4-metylsulfonyl)fenyl)-2-(5H)-furanónu - Google Patents
Použitie 3-fenyl-4-(4-metylsulfonyl)fenyl)-2-(5H)-furanónu Download PDFInfo
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- SK284330B6 SK284330B6 SK1567-98A SK156798A SK284330B6 SK 284330 B6 SK284330 B6 SK 284330B6 SK 156798 A SK156798 A SK 156798A SK 284330 B6 SK284330 B6 SK 284330B6
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- Prior art keywords
- phenyl
- cyclooxygenase
- treatment
- pharmaceutical composition
- mediated diseases
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- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 201000004595 synovitis Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- PXNWAKXRIXUEKZ-UHFFFAOYSA-N trimethyl-[4-(4-methylsulfanylphenyl)oxolan-2-yl]oxysilane Chemical compound C1=CC(SC)=CC=C1C1CC(O[Si](C)(C)C)OC1 PXNWAKXRIXUEKZ-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1787896P | 1996-05-17 | 1996-05-17 | |
| GBGB9612063.9A GB9612063D0 (en) | 1996-06-10 | 1996-06-10 | Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases |
| PCT/US1997/008041 WO1997044028A1 (en) | 1996-05-17 | 1997-05-13 | Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK156798A3 SK156798A3 (en) | 2000-01-18 |
| SK284330B6 true SK284330B6 (sk) | 2005-01-03 |
Family
ID=26309472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1567-98A SK284330B6 (sk) | 1996-05-17 | 1997-05-13 | Použitie 3-fenyl-4-(4-metylsulfonyl)fenyl)-2-(5H)-furanónu |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6063811A (de) |
| EP (1) | EP0910368A1 (de) |
| JP (1) | JPH11512754A (de) |
| KR (1) | KR100373622B1 (de) |
| CN (1) | CN1140267C (de) |
| AR (1) | AR012014A1 (de) |
| AU (1) | AU3004997A (de) |
| BG (1) | BG103000A (de) |
| BR (1) | BR9709097A (de) |
| CA (1) | CA2254061C (de) |
| CO (1) | CO5050370A1 (de) |
| CZ (1) | CZ291463B6 (de) |
| DZ (1) | DZ2200A1 (de) |
| EA (1) | EA001596B1 (de) |
| EE (1) | EE03746B1 (de) |
| HK (1) | HK1021623A1 (de) |
| HR (1) | HRP970262A2 (de) |
| HU (1) | HUP9902889A3 (de) |
| ID (1) | ID16921A (de) |
| IL (1) | IL126899A (de) |
| IS (1) | IS4891A (de) |
| MY (1) | MY116201A (de) |
| NO (1) | NO985342L (de) |
| NZ (1) | NZ332670A (de) |
| PE (1) | PE66998A1 (de) |
| PL (1) | PL188649B1 (de) |
| SK (1) | SK284330B6 (de) |
| TR (1) | TR199802345T2 (de) |
| WO (1) | WO1997044028A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136804A (en) * | 1998-03-13 | 2000-10-24 | Merck & Co., Inc. | Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions |
| CA2322824A1 (en) * | 1998-03-13 | 1999-09-16 | Merck & Co., Inc. | Combination therapy and composition for acute coronary ischemic syndrome and related conditions |
| SA99191255B1 (ar) * | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
| CO5190664A1 (es) | 1999-06-30 | 2002-08-29 | Pfizer Prod Inc | Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2 |
| GB9920558D0 (en) * | 1999-08-31 | 1999-11-03 | Bradford Particle Design Ltd | Methods for particle formation and their products |
| KR20020082473A (ko) * | 1999-12-22 | 2002-10-31 | 파마시아 코포레이션 | 시클로옥시게나제-2 억제제의 지속-방출 조제물 |
| EA200802070A1 (ru) | 2000-06-13 | 2009-06-30 | Вайет | Болеутоляющее и противовоспалительные составы, содержащие ингибиторы циклооксигеназы-2 |
| US20020071857A1 (en) * | 2000-08-18 | 2002-06-13 | Kararli Tugrul T. | Rapidly disintegrating oral formulation of a cyclooxygenase-2 inhibitor |
| CN1638739A (zh) * | 2000-08-18 | 2005-07-13 | 法玛西雅厄普约翰美国公司 | 治疗成瘾性障碍的化合物 |
| AU2001285334A1 (en) * | 2000-08-29 | 2002-03-13 | Peter Van Patten | Combination for the treatment of migraine comprising a cyclooxygenase-2 inhibitor and acetylsalicylic acid |
| PE20020351A1 (es) * | 2000-09-11 | 2002-06-14 | Novartis Ag | Composiciones farmaceuticas que comprenden acido 5-metil-2-(2'-cloro-6'-fluoroanilino)fenilacetico como inhibidor de la ciclooxigenasa-2 |
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| EP1423114A4 (de) * | 2001-05-04 | 2006-05-17 | Merck & Co Inc | Verfahren und zusammensetzungen zur behandlung von migräne |
| PE20030323A1 (es) * | 2001-08-31 | 2003-05-12 | Novartis Ag | Composicion farmaceutica |
| YU34804A (sh) * | 2001-09-26 | 2006-08-17 | Pharmacia Corporation | Organoleptički prihvatljivi preparati sa oralnim razlaganjem |
| IL161253A0 (en) * | 2001-10-10 | 2004-09-27 | Pharmacia Corp | Intraorally disintegrating valdecoxib compositions prepared by spray drying process |
| TW200305443A (en) * | 2002-03-07 | 2003-11-01 | Novartis Ag | Pharmaceutical compositions |
| ES2214129B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 3-fenilfuran-2-onas. |
| ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
| PT1534305E (pt) | 2003-05-07 | 2007-02-28 | Osteologix As | Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis |
| TR200301552A1 (tr) * | 2003-09-18 | 2005-10-21 | Nobel İlaç Sanayi̇ Ve Ti̇caret A. Ş. | Rofekoksib' in yeni oral farmakolojik formülasyonları. |
| CA2676413A1 (en) * | 2007-01-19 | 2008-07-31 | Mallinckrodt Inc. | Diagnostic and therapeutic cyclooxygenase-2 binding ligands |
| WO2020106522A1 (en) | 2018-11-21 | 2020-05-28 | Tremeau Pharmaceuticals, Inc. | Purified forms of rofecoxib, methods of manufacture and use |
| WO2020210341A1 (en) * | 2019-04-09 | 2020-10-15 | Tremeau Pharmaceuticals, Inc. | Treatment of viral hemorrhagic fevers with cox-2 selective non-steroidal antiinflammatory drugs |
| US10945992B1 (en) | 2019-11-13 | 2021-03-16 | Tremeau Pharmaceuticals, Inc. | Dosage forms of rofecoxib and related methods |
| US11161833B1 (en) | 2021-04-09 | 2021-11-02 | Tremeau Pharmaceuticals, Inc. | Deuterated etoricoxib, methods of manufacture, and use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| CN1143365A (zh) * | 1994-01-10 | 1997-02-19 | 麦克弗罗斯特(加拿大)有限公司 | 作为cox-2抑制剂的苯基杂环类化合物 |
-
1997
- 1997-05-13 EE EE9800393A patent/EE03746B1/xx not_active IP Right Cessation
- 1997-05-13 CZ CZ19983738A patent/CZ291463B6/cs not_active IP Right Cessation
- 1997-05-13 CN CNB971963150A patent/CN1140267C/zh not_active Expired - Fee Related
- 1997-05-13 TR TR1998/02345T patent/TR199802345T2/xx unknown
- 1997-05-13 CA CA002254061A patent/CA2254061C/en not_active Expired - Fee Related
- 1997-05-13 NZ NZ332670A patent/NZ332670A/xx unknown
- 1997-05-13 AU AU30049/97A patent/AU3004997A/en not_active Abandoned
- 1997-05-13 US US09/180,647 patent/US6063811A/en not_active Expired - Lifetime
- 1997-05-13 KR KR10-1998-0709239A patent/KR100373622B1/ko not_active IP Right Cessation
- 1997-05-13 JP JP9542486A patent/JPH11512754A/ja active Pending
- 1997-05-13 HU HU9902889A patent/HUP9902889A3/hu unknown
- 1997-05-13 IL IL12689997A patent/IL126899A/en not_active IP Right Cessation
- 1997-05-13 SK SK1567-98A patent/SK284330B6/sk unknown
- 1997-05-13 EP EP97924688A patent/EP0910368A1/de not_active Withdrawn
- 1997-05-13 BR BR9709097A patent/BR9709097A/pt not_active IP Right Cessation
- 1997-05-13 EA EA199801017A patent/EA001596B1/ru not_active IP Right Cessation
- 1997-05-13 WO PCT/US1997/008041 patent/WO1997044028A1/en not_active Application Discontinuation
- 1997-05-14 AR ARP970102021A patent/AR012014A1/es unknown
- 1997-05-14 DZ DZ970087A patent/DZ2200A1/fr active
- 1997-05-15 PE PE1997000379A patent/PE66998A1/es not_active Application Discontinuation
- 1997-05-16 ID IDP971640A patent/ID16921A/id unknown
- 1997-05-16 HR HR9612063.9A patent/HRP970262A2/xx not_active Application Discontinuation
- 1997-05-16 MY MYPI97002138A patent/MY116201A/en unknown
- 1997-05-16 CO CO97026568A patent/CO5050370A1/es unknown
-
1998
- 1998-11-10 IS IS4891A patent/IS4891A/is unknown
- 1998-11-16 NO NO985342A patent/NO985342L/no not_active Application Discontinuation
- 1998-12-08 BG BG103000A patent/BG103000A/xx unknown
-
1999
- 1999-01-11 PL PL97329940A patent/PL188649B1/pl not_active IP Right Cessation
-
2000
- 2000-02-02 HK HK00100645A patent/HK1021623A1/xx not_active IP Right Cessation
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