PE66998A1 - Composiciones para el tratamiento con una dosis diaria para enfermedades producidas por la ciclooxigenasa-2 - Google Patents

Composiciones para el tratamiento con una dosis diaria para enfermedades producidas por la ciclooxigenasa-2

Info

Publication number
PE66998A1
PE66998A1 PE1997000379A PE00037997A PE66998A1 PE 66998 A1 PE66998 A1 PE 66998A1 PE 1997000379 A PE1997000379 A PE 1997000379A PE 00037997 A PE00037997 A PE 00037997A PE 66998 A1 PE66998 A1 PE 66998A1
Authority
PE
Peru
Prior art keywords
formulation
excipients
phenyl
cyclooxygenase
daily dose
Prior art date
Application number
PE1997000379A
Other languages
English (en)
Inventor
Bruno Hancock
Barry Gertz
Elliot Ehrich
Conrad Winters
Original Assignee
Merck & Co Inc
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26309472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE66998(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9612063.9A external-priority patent/GB9612063D0/en
Application filed by Merck & Co Inc, Merck Frosst Canada Inc filed Critical Merck & Co Inc
Publication of PE66998A1 publication Critical patent/PE66998A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

CARACTERIZADAS PORQUE COMPRENDEN DE 5 mg A 125 mg DEL COMPUESTO 3-FENIL-4-(4-METILSULFONIL)FENIL)-2-(5H)-FURANONA; EN LA FORMULACION DE TABLETAS DE GRANULADO HUMEDO ADEMAS DE DICHO PRINCIPIO ACTIVO COMPRENDE: (A) CELULOSA MICROCRISTALINA, (B) MONOHIDRATO DE LACTOSA, (C) HIDROXIPROPILCELULOSA, (D) CROSCARMELOSA DE SODIO, (E) OXIDO DE HIERRO Y (F) ESTEARATO DE MAGNESIO; EN LA FORMULACION DE TABLETAS DE COMPRESION DIRECTA COMPRENDEN COMO EXCIPIENTES: (A), (D), (F) Y (G) ANHIDRATO DE LACTOSA; EN LA FORMULACION DE SUSPENSIONES ORALES COMPRENDEN COMO EXCIPIENTES: (H) SOLUCION DE SORBITOL, (I) POLIVINILPIRROLIDONA, (J) MONOLAURATO DE POLIOXIETILENO SORBITAN Y (K) ACIDO BENZOICO; EN LA FORMULACION DE UNA SOLUCION ORAL COMPRENDE COMO EXCIPIENTE: (L) OXIDO DE POLIETILENO 400. ESTAS COMPOSICIONES PRESENTAN POTENCIA, SEGURIDAD Y EFECTIVIDAD EN PEQUENAS DOSIS PARA INHIBIR LA CICLOXIGENASA-2, ADEMAS, PRESENTA UNA VIDA MEDIA PROLONGADA DE 15 HORAS O MAS, SIENDO UTILES EN EL TRATAMIENTO DE DOLENCIAS CRONICAS TALES COMO ARTRITIS O ENFERMEDAD DE ALZHEIMER, ENTRE OTROS
PE1997000379A 1996-05-17 1997-05-15 Composiciones para el tratamiento con una dosis diaria para enfermedades producidas por la ciclooxigenasa-2 PE66998A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1787896P 1996-05-17 1996-05-17
GBGB9612063.9A GB9612063D0 (en) 1996-06-10 1996-06-10 Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases

Publications (1)

Publication Number Publication Date
PE66998A1 true PE66998A1 (es) 1998-10-24

Family

ID=26309472

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000379A PE66998A1 (es) 1996-05-17 1997-05-15 Composiciones para el tratamiento con una dosis diaria para enfermedades producidas por la ciclooxigenasa-2

Country Status (29)

Country Link
US (1) US6063811A (es)
EP (1) EP0910368A1 (es)
JP (1) JPH11512754A (es)
KR (1) KR100373622B1 (es)
CN (1) CN1140267C (es)
AR (1) AR012014A1 (es)
AU (1) AU3004997A (es)
BG (1) BG103000A (es)
BR (1) BR9709097A (es)
CA (1) CA2254061C (es)
CO (1) CO5050370A1 (es)
CZ (1) CZ291463B6 (es)
DZ (1) DZ2200A1 (es)
EA (1) EA001596B1 (es)
EE (1) EE03746B1 (es)
HK (1) HK1021623A1 (es)
HR (1) HRP970262A2 (es)
HU (1) HUP9902889A3 (es)
ID (1) ID16921A (es)
IL (1) IL126899A (es)
IS (1) IS4891A (es)
MY (1) MY116201A (es)
NO (1) NO985342L (es)
NZ (1) NZ332670A (es)
PE (1) PE66998A1 (es)
PL (1) PL188649B1 (es)
SK (1) SK284330B6 (es)
TR (1) TR199802345T2 (es)
WO (1) WO1997044028A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136804A (en) * 1998-03-13 2000-10-24 Merck & Co., Inc. Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
CA2322824A1 (en) * 1998-03-13 1999-09-16 Merck & Co., Inc. Combination therapy and composition for acute coronary ischemic syndrome and related conditions
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
CO5190664A1 (es) 1999-06-30 2002-08-29 Pfizer Prod Inc Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
AU2731401A (en) * 1999-12-22 2001-07-03 Pharmacia Corporation Sustained-release formulation of a cyclooxygenase-2 inhibitor
US6924303B2 (en) 2000-06-13 2005-08-02 Wyeth Analgesic and anti-inflammatory compositions containing COX-2 inhibitors
CN1638739A (zh) * 2000-08-18 2005-07-13 法玛西雅厄普约翰美国公司 治疗成瘾性障碍的化合物
ES2265439T3 (es) * 2000-08-18 2007-02-16 Pharmacia Corporation Formulacion oral de valdecoxib que se desintegra rapidamente.
US8680081B2 (en) * 2000-08-29 2014-03-25 Peter Van Patten Prophylactic treatment of migraine
PE20020351A1 (es) * 2000-09-11 2002-06-14 Novartis Ag Composiciones farmaceuticas que comprenden acido 5-metil-2-(2'-cloro-6'-fluoroanilino)fenilacetico como inhibidor de la ciclooxigenasa-2
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
US20040132780A1 (en) * 2001-05-04 2004-07-08 Allen Christopher P. Method and compositions for treating migraines
AR036312A1 (es) * 2001-08-31 2004-08-25 Novartis Ag Composicion farmaceutica
KR20040058189A (ko) * 2001-09-26 2004-07-03 파마시아 코포레이션 관능상 허용가능한 경구내 붕해 조성물
MXPA04003404A (es) * 2001-10-10 2004-06-18 Pharmacia Corp Composiciones de valdecoxib de disgregacion intraoral preparadas mediante un procedimiento de desecacion por pulverizacion.
CN1330300C (zh) * 2002-03-07 2007-08-08 诺瓦提斯公司 药物组合物
ES2213485B1 (es) 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
ES2214129B1 (es) * 2003-02-13 2005-12-01 Almirall Prodesfarma, S.A. 3-fenilfuran-2-onas.
DE602004002832T2 (de) 2003-05-07 2007-06-06 Osteologix A/S Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
TR200301552A1 (tr) * 2003-09-18 2005-10-21 Nobel İlaç Sanayi̇ Ve Ti̇caret A. Ş. Rofekoksib' in yeni oral farmakolojik formülasyonları.
WO2008091530A2 (en) * 2007-01-19 2008-07-31 Mallinckrodt Inc. Diagnostic and therapeutic cyclooxygenase-2 binding ligands
KR20210124188A (ko) 2018-11-21 2021-10-14 트루모 파마슈티칼스, 인크. 정제된 형태의 로페콕시브, 제조 및 사용 방법
US20200323830A1 (en) * 2019-04-09 2020-10-15 Tremeau Pharmaceuticals, Inc. Treatment of viral hemorrhagic fevers with etoricoxib
US10945992B1 (en) 2019-11-13 2021-03-16 Tremeau Pharmaceuticals, Inc. Dosage forms of rofecoxib and related methods
US11161833B1 (en) 2021-04-09 2021-11-02 Tremeau Pharmaceuticals, Inc. Deuterated etoricoxib, methods of manufacture, and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
SG43841A1 (en) * 1994-01-10 1997-11-14 Merck Frosst Canada Inc Phenyl heterocycles as cox-2 inhibitors

Also Published As

Publication number Publication date
NO985342D0 (no) 1998-11-16
KR20000011082A (ko) 2000-02-25
CZ291463B6 (cs) 2003-03-12
AU3004997A (en) 1997-12-09
BR9709097A (pt) 1999-08-03
CA2254061C (en) 2003-12-02
DZ2200A1 (fr) 2004-06-20
TR199802345T2 (xx) 1999-03-22
EE9800393A (et) 1999-06-15
SK156798A3 (en) 2000-01-18
IL126899A0 (en) 1999-09-22
WO1997044028A1 (en) 1997-11-27
EE03746B1 (et) 2002-06-17
NZ332670A (en) 2000-07-28
AR012014A1 (es) 2000-09-27
CO5050370A1 (es) 2001-06-27
IL126899A (en) 2004-03-28
EA001596B1 (ru) 2001-06-25
SK284330B6 (sk) 2005-01-03
CZ373898A3 (cs) 1999-06-16
MY116201A (en) 2003-11-28
KR100373622B1 (ko) 2003-07-12
BG103000A (en) 1999-09-30
EA199801017A1 (ru) 1999-04-29
EP0910368A1 (en) 1999-04-28
CN1140267C (zh) 2004-03-03
HUP9902889A3 (en) 2002-04-29
CN1225010A (zh) 1999-08-04
US6063811A (en) 2000-05-16
HRP970262A2 (en) 1998-06-30
HUP9902889A2 (hu) 2002-01-28
HK1021623A1 (en) 2000-06-23
PL329940A1 (en) 1999-04-26
JPH11512754A (ja) 1999-11-02
NO985342L (no) 1998-11-16
IS4891A (is) 1998-11-10
CA2254061A1 (en) 1997-11-27
PL188649B1 (pl) 2005-03-31
ID16921A (id) 1997-11-20

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