SK283820B6 - Tricyklická amidová zlúčenina, farmaceutický prostriedok s jej obsahom a jej použitie - Google Patents
Tricyklická amidová zlúčenina, farmaceutický prostriedok s jej obsahom a jej použitie Download PDFInfo
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- SK283820B6 SK283820B6 SK1824-99A SK182499A SK283820B6 SK 283820 B6 SK283820 B6 SK 283820B6 SK 182499 A SK182499 A SK 182499A SK 283820 B6 SK283820 B6 SK 283820B6
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- DDKMFOUTRRODRE-UHFFFAOYSA-N chloromethanone Chemical compound Cl[C]=O DDKMFOUTRRODRE-UHFFFAOYSA-N 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
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- 230000001419 dependent effect Effects 0.000 description 1
- AQEFLFZSWDEAIP-UHFFFAOYSA-N di-tert-butyl ether Chemical compound CC(C)(C)OC(C)(C)C AQEFLFZSWDEAIP-UHFFFAOYSA-N 0.000 description 1
- WGLUMOCWFMKWIL-UHFFFAOYSA-N dichloromethane;methanol Chemical compound OC.ClCCl WGLUMOCWFMKWIL-UHFFFAOYSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
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- 239000003480 eluent Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 150000002085 enols Chemical group 0.000 description 1
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- QVLJLWHOILVHJJ-UHFFFAOYSA-N ethyl 2-pyridin-4-ylacetate Chemical compound CCOC(=O)CC1=CC=NC=C1 QVLJLWHOILVHJJ-UHFFFAOYSA-N 0.000 description 1
- NHLYOAHHECPKBH-UHFFFAOYSA-N ethyl 4-(8-chloro-11h-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCC1C1C2=NC=CC=C2C=CC2=CC(Cl)=CC=C21 NHLYOAHHECPKBH-UHFFFAOYSA-N 0.000 description 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000006126 farnesylation Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
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- 239000006260 foam Substances 0.000 description 1
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- 230000014509 gene expression Effects 0.000 description 1
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- 238000010438 heat treatment Methods 0.000 description 1
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- 239000008240 homogeneous mixture Substances 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
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- 238000002347 injection Methods 0.000 description 1
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- 230000003834 intracellular effect Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 230000006122 isoprenylation Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- PQSCCWFMTRVFDA-UHFFFAOYSA-N n-[[3-fluoro-4-ethoxy-pyrid-2-yl]ethyl]-n'-[5-nitrilomethyl-pyridyl]-thiourea Chemical compound CCOC1=CC=NC(CCNC(=S)NC=2N=CC(=CC=2)C#N)=C1F PQSCCWFMTRVFDA-UHFFFAOYSA-N 0.000 description 1
- 201000004931 neurofibromatosis Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 150000004885 piperazines Chemical class 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- 239000004540 pour-on Substances 0.000 description 1
- 238000012746 preparative thin layer chromatography Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- ALDITMKAAPLVJK-UHFFFAOYSA-N prop-1-ene;hydrate Chemical group O.CC=C ALDITMKAAPLVJK-UHFFFAOYSA-N 0.000 description 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- 230000004853 protein function Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000008844 regulatory mechanism Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
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- 239000007858 starting material Substances 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
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- 239000013076 target substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 231100000588 tumorigenic Toxicity 0.000 description 1
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- 241000701447 unidentified baculovirus Species 0.000 description 1
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- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87705797A | 1997-06-17 | 1997-06-17 | |
| PCT/US1998/011500 WO1998057959A1 (en) | 1997-06-17 | 1998-06-15 | Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives for the inhibition of farnesyl protein transferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK182499A3 SK182499A3 (en) | 2000-09-12 |
| SK283820B6 true SK283820B6 (sk) | 2004-02-03 |
Family
ID=25369159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1824-99A SK283820B6 (sk) | 1997-06-17 | 1998-06-15 | Tricyklická amidová zlúčenina, farmaceutický prostriedok s jej obsahom a jej použitie |
Country Status (29)
| Country | Link |
|---|---|
| EP (2) | EP0988300B1 (cs) |
| JP (1) | JP2002504148A (cs) |
| KR (1) | KR100588799B1 (cs) |
| CN (1) | CN1131228C (cs) |
| AR (1) | AR016074A1 (cs) |
| AT (1) | ATE222905T1 (cs) |
| AU (1) | AU753863B2 (cs) |
| BR (1) | BR9811470A (cs) |
| CA (1) | CA2294347C (cs) |
| CO (1) | CO4940455A1 (cs) |
| CZ (1) | CZ297450B6 (cs) |
| DE (1) | DE69807477T2 (cs) |
| DK (1) | DK0988300T3 (cs) |
| ES (1) | ES2178224T3 (cs) |
| HU (1) | HUP0003046A3 (cs) |
| ID (1) | ID30349A (cs) |
| IL (2) | IL133449A0 (cs) |
| MY (1) | MY117925A (cs) |
| NO (1) | NO318938B1 (cs) |
| NZ (1) | NZ501618A (cs) |
| PE (1) | PE83799A1 (cs) |
| PL (1) | PL191866B1 (cs) |
| PT (1) | PT988300E (cs) |
| RU (1) | RU2220139C2 (cs) |
| SK (1) | SK283820B6 (cs) |
| TR (2) | TR200003580T2 (cs) |
| TW (1) | TW544451B (cs) |
| WO (1) | WO1998057959A1 (cs) |
| ZA (1) | ZA985210B (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20000904A2 (en) | 1998-07-06 | 2001-12-31 | Janssen Pharmaceutica Nv | Farnesyl protein transferase inhibitors for treating arthropathies |
| US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| PE20020635A1 (es) * | 2000-11-29 | 2002-07-11 | Schering Corp | Compuestos triciclicos como inhibidores de la farnesil transferasa |
| WO2007002254A2 (en) * | 2005-06-23 | 2007-01-04 | Merck & Co., Inc. | Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
-
1998
- 1998-06-15 ZA ZA985210A patent/ZA985210B/xx unknown
- 1998-06-15 BR BR9811470-0A patent/BR9811470A/pt not_active Application Discontinuation
- 1998-06-15 WO PCT/US1998/011500 patent/WO1998057959A1/en not_active Ceased
- 1998-06-15 CZ CZ0447199A patent/CZ297450B6/cs not_active IP Right Cessation
- 1998-06-15 DK DK98928888T patent/DK0988300T3/da active
- 1998-06-15 PT PT98928888T patent/PT988300E/pt unknown
- 1998-06-15 PE PE1998000509A patent/PE83799A1/es not_active Application Discontinuation
- 1998-06-15 CN CN98808210A patent/CN1131228C/zh not_active Expired - Fee Related
- 1998-06-15 TR TR2000/03580T patent/TR200003580T2/xx unknown
- 1998-06-15 AT AT98928888T patent/ATE222905T1/de not_active IP Right Cessation
- 1998-06-15 MY MYPI98002657A patent/MY117925A/en unknown
- 1998-06-15 EP EP98928888A patent/EP0988300B1/en not_active Expired - Lifetime
- 1998-06-15 ID IDW991624A patent/ID30349A/id unknown
- 1998-06-15 RU RU2000101293/04A patent/RU2220139C2/ru not_active IP Right Cessation
- 1998-06-15 HU HU0003046A patent/HUP0003046A3/hu unknown
- 1998-06-15 ES ES98928888T patent/ES2178224T3/es not_active Expired - Lifetime
- 1998-06-15 SK SK1824-99A patent/SK283820B6/sk not_active IP Right Cessation
- 1998-06-15 IL IL13344998A patent/IL133449A0/xx active IP Right Grant
- 1998-06-15 NZ NZ501618A patent/NZ501618A/en unknown
- 1998-06-15 PL PL337481A patent/PL191866B1/pl not_active IP Right Cessation
- 1998-06-15 CA CA002294347A patent/CA2294347C/en not_active Expired - Fee Related
- 1998-06-15 KR KR1019997011974A patent/KR100588799B1/ko not_active Expired - Fee Related
- 1998-06-15 TR TR2000/00114T patent/TR200000114T2/xx unknown
- 1998-06-15 EP EP01120740A patent/EP1156046A1/en not_active Withdrawn
- 1998-06-15 DE DE69807477T patent/DE69807477T2/de not_active Expired - Lifetime
- 1998-06-15 JP JP50449599A patent/JP2002504148A/ja not_active Ceased
- 1998-06-15 AU AU80582/98A patent/AU753863B2/en not_active Ceased
- 1998-06-16 AR ARP980102864A patent/AR016074A1/es active IP Right Grant
- 1998-06-16 CO CO98034141A patent/CO4940455A1/es unknown
- 1998-06-22 TW TW087109502A patent/TW544451B/zh active
-
1999
- 1999-12-09 IL IL133449A patent/IL133449A/en not_active IP Right Cessation
- 1999-12-16 NO NO19996236A patent/NO318938B1/no not_active IP Right Cessation
Also Published As
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| Date | Code | Title | Description |
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| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20110615 |