SK282824B6 - (R)-(Z)-1-Azabicyklo[2,2,1]heptan-3-ón-O-[3-(3-metoxyfenyl)-2- propinyl]oxím-maleát vo forme kryštálov ako liečivo, kompozícia obsahujúca túto soľ a použitie tejto soli na výrobu liečiva - Google Patents

(R)-(Z)-1-Azabicyklo[2,2,1]heptan-3-ón-O-[3-(3-metoxyfenyl)-2- propinyl]oxím-maleát vo forme kryštálov ako liečivo, kompozícia obsahujúca túto soľ a použitie tejto soli na výrobu liečiva Download PDF

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Publication number
SK282824B6
SK282824B6 SK1644-97A SK164497A SK282824B6 SK 282824 B6 SK282824 B6 SK 282824B6 SK 164497 A SK164497 A SK 164497A SK 282824 B6 SK282824 B6 SK 282824B6
Authority
SK
Slovakia
Prior art keywords
salt
maleate
heptan
azabicyclo
methoxyphenyl
Prior art date
Application number
SK1644-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK164497A3 (en
Inventor
Howard Yoshihisa Ando
Stephen Douglas Barrett
Juan Carlos Jaen
Steven Edward Rose
Haile Tecle
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of SK164497A3 publication Critical patent/SK164497A3/sk
Publication of SK282824B6 publication Critical patent/SK282824B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
SK1644-97A 1995-06-07 1996-05-13 (R)-(Z)-1-Azabicyklo[2,2,1]heptan-3-ón-O-[3-(3-metoxyfenyl)-2- propinyl]oxím-maleát vo forme kryštálov ako liečivo, kompozícia obsahujúca túto soľ a použitie tejto soli na výrobu liečiva SK282824B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/474,622 US5534522A (en) 1995-06-07 1995-06-07 (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
PCT/US1996/006814 WO1996040687A1 (en) 1995-06-07 1996-05-13 (r)-(z)-1-azabicyclo[2.2.1]heptan-3-one,o-[3-(3-methoxyphenyl)-2-propynyl]oxime maleate as a pharmaceutical agent

Publications (2)

Publication Number Publication Date
SK164497A3 SK164497A3 (en) 1998-06-03
SK282824B6 true SK282824B6 (sk) 2002-12-03

Family

ID=23884337

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1644-97A SK282824B6 (sk) 1995-06-07 1996-05-13 (R)-(Z)-1-Azabicyklo[2,2,1]heptan-3-ón-O-[3-(3-metoxyfenyl)-2- propinyl]oxím-maleát vo forme kryštálov ako liečivo, kompozícia obsahujúca túto soľ a použitie tejto soli na výrobu liečiva

Country Status (25)

Country Link
US (1) US5534522A (zh)
EP (1) EP0839148B1 (zh)
JP (1) JPH11506723A (zh)
KR (1) KR100383031B1 (zh)
CN (1) CN1063181C (zh)
AT (1) ATE187967T1 (zh)
BG (1) BG63571B1 (zh)
CA (1) CA2219753A1 (zh)
CZ (1) CZ286528B6 (zh)
DE (1) DE69605800T2 (zh)
DK (1) DK0839148T3 (zh)
EA (1) EA000381B1 (zh)
EE (1) EE03971B1 (zh)
ES (1) ES2142586T3 (zh)
GE (1) GEP19991874B (zh)
GR (1) GR3032772T3 (zh)
HK (1) HK1018055A1 (zh)
HU (1) HUP9802499A3 (zh)
NO (1) NO308901B1 (zh)
NZ (1) NZ307946A (zh)
PL (1) PL323796A1 (zh)
SK (1) SK282824B6 (zh)
UA (1) UA46032C2 (zh)
WO (1) WO1996040687A1 (zh)
ZA (1) ZA964764B (zh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
US7544681B2 (en) 2001-09-27 2009-06-09 Ramot At Tel Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
AU2004277464B2 (en) * 2003-10-02 2010-07-08 Pharmacia & Upjohn Company Llc Salts and polymorphs of a pyrrole-substituted indolinone compound
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
JP5284779B2 (ja) * 2005-06-07 2013-09-11 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド コンジュゲート化された向精神薬の新規な塩およびその調製方法
EP2275095A3 (en) * 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651813A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007274583B2 (en) 2006-07-17 2012-11-01 Bar-Ilan University Conjugates comprising a psychotropic drug or a GABA agonist and an organic acid and their use in treating pain and other CNS disorders
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2009101616A1 (en) 2008-02-11 2009-08-20 Ramot At Tel Aviv University Ltd. Novel conjugates for treating neurodegenerative diseases and disorders
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8975251B2 (en) 2009-12-09 2015-03-10 Bar-Ilan University Methods of improving cognitive functions
CN102858345A (zh) 2010-02-24 2013-01-02 雷蒙特亚特特拉维夫大学有限公司 奋乃静-gaba的三甲磺酸盐的晶型及其制备方法
WO2012038963A1 (en) 2010-09-22 2012-03-29 Ramot At Tel-Aviv University Ltd. An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same
JP5997931B2 (ja) * 2011-05-25 2016-09-28 石原産業株式会社 農園芸用殺菌剤組成物及び植物病害の防除方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346911A (en) * 1990-03-06 1994-09-13 Warner-Lambert Company Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment
US5306718A (en) * 1990-03-06 1994-04-26 Warner-Lambert Company Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment

Also Published As

Publication number Publication date
AU5744996A (en) 1996-12-30
HUP9802499A2 (hu) 1999-04-28
EE03971B1 (et) 2003-02-17
UA46032C2 (uk) 2002-05-15
US5534522A (en) 1996-07-09
GEP19991874B (en) 1999-12-06
HK1018055A1 (en) 1999-12-10
NO975704L (no) 1998-01-30
NZ307946A (en) 2001-03-30
ZA964764B (en) 1997-01-08
AU697954B2 (en) 1998-10-22
CN1186493A (zh) 1998-07-01
NO308901B1 (no) 2000-11-13
GR3032772T3 (en) 2000-06-30
ES2142586T3 (es) 2000-04-16
EE9700316A (et) 1998-06-15
SK164497A3 (en) 1998-06-03
EA199800007A1 (ru) 1998-06-25
CZ381797A3 (cs) 1998-05-13
CA2219753A1 (en) 1996-12-19
BG102078A (en) 1998-11-30
ATE187967T1 (de) 2000-01-15
KR19990022572A (ko) 1999-03-25
NO975704D0 (no) 1997-12-05
EP0839148A1 (en) 1998-05-06
DE69605800D1 (de) 2000-01-27
EP0839148B1 (en) 1999-12-22
KR100383031B1 (ko) 2003-10-17
EA000381B1 (ru) 1999-06-24
JPH11506723A (ja) 1999-06-15
WO1996040687A1 (en) 1996-12-19
BG63571B1 (bg) 2002-05-31
PL323796A1 (en) 1998-04-27
CN1063181C (zh) 2001-03-14
CZ286528B6 (cs) 2000-05-17
HUP9802499A3 (en) 1999-06-28
DK0839148T3 (da) 2000-05-22
DE69605800T2 (de) 2000-11-16

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