SK282398B6 - Použitie mikročastíc obsahujúcich na sebe adsorbovaný proteín a protilátku na prípravu farmaceutického prostriedku na intranazálne podanie - Google Patents
Použitie mikročastíc obsahujúcich na sebe adsorbovaný proteín a protilátku na prípravu farmaceutického prostriedku na intranazálne podanie Download PDFInfo
- Publication number
- SK282398B6 SK282398B6 SK1422-99A SK142299A SK282398B6 SK 282398 B6 SK282398 B6 SK 282398B6 SK 142299 A SK142299 A SK 142299A SK 282398 B6 SK282398 B6 SK 282398B6
- Authority
- SK
- Slovakia
- Prior art keywords
- microparticles
- protein
- antibody
- pharmaceutical composition
- insulin
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title claims abstract description 75
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 46
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 46
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 12
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract description 32
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 19
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- URLZCHNOLZSCCA-VABKMULXSA-N Leu-enkephalin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 URLZCHNOLZSCCA-VABKMULXSA-N 0.000 claims abstract description 6
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- 230000003204 osmotic effect Effects 0.000 description 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 1
- 229960001723 oxytocin Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI000856A IT1291559B1 (it) | 1997-04-14 | 1997-04-14 | Uso di microparticelle su cui sono stati adsorbiti una proteina ed un anticorpo per preparare una composizione farmaceutica somministrabile |
| PCT/EP1998/002214 WO1998046209A1 (en) | 1997-04-14 | 1998-04-08 | Use of microparticles having a protein and an antibody adsorbed thereon for preparing a pharmaceutical composition for intranasal administration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK142299A3 SK142299A3 (en) | 2000-09-12 |
| SK282398B6 true SK282398B6 (sk) | 2002-01-07 |
Family
ID=11376872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1422-99A SK282398B6 (sk) | 1997-04-14 | 1998-04-08 | Použitie mikročastíc obsahujúcich na sebe adsorbovaný proteín a protilátku na prípravu farmaceutického prostriedku na intranazálne podanie |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7235522B2 (zh) |
| EP (1) | EP0971703B9 (zh) |
| JP (1) | JP2002503222A (zh) |
| KR (1) | KR100507449B1 (zh) |
| CN (1) | CN1135970C (zh) |
| AT (1) | ATE243502T1 (zh) |
| AU (1) | AU742079B2 (zh) |
| BG (1) | BG64269B1 (zh) |
| CA (1) | CA2288970C (zh) |
| CZ (1) | CZ298935B6 (zh) |
| DE (1) | DE69815828T2 (zh) |
| DK (1) | DK0971703T3 (zh) |
| EA (1) | EA002324B1 (zh) |
| ES (1) | ES2201492T3 (zh) |
| GE (1) | GEP20022646B (zh) |
| HU (1) | HU225523B1 (zh) |
| IL (1) | IL132114A (zh) |
| IT (1) | IT1291559B1 (zh) |
| PL (1) | PL189918B1 (zh) |
| PT (1) | PT971703E (zh) |
| SK (1) | SK282398B6 (zh) |
| TR (1) | TR199902536T2 (zh) |
| UA (1) | UA62961C2 (zh) |
| WO (1) | WO1998046209A1 (zh) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2050425A1 (en) * | 1990-09-03 | 1992-03-04 | Yoshiaki Uda | Pharmaceutical composition and its mucous use |
| RU2022562C1 (ru) * | 1992-05-06 | 1994-11-15 | Рубальский Олег Васильевич | Способ лечения вирусной инфекции кожи и слизистых оболочек |
| GB9311454D0 (en) * | 1993-06-03 | 1993-07-21 | Agricultural & Food Res | Pharmaceutical compositions |
| JP3414539B2 (ja) * | 1994-05-11 | 2003-06-09 | 有限会社ドット | 経鼻吸収用組成物 |
| US5879712A (en) * | 1995-06-07 | 1999-03-09 | Sri International | Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced |
-
1997
- 1997-04-14 IT IT97MI000856A patent/IT1291559B1/it active IP Right Grant
-
1998
- 1998-04-08 CZ CZ0362499A patent/CZ298935B6/cs not_active IP Right Cessation
- 1998-04-08 SK SK1422-99A patent/SK282398B6/sk not_active IP Right Cessation
- 1998-04-08 DK DK98922720T patent/DK0971703T3/da active
- 1998-04-08 GE GEAP19985071A patent/GEP20022646B/en unknown
- 1998-04-08 TR TR1999/02536T patent/TR199902536T2/xx unknown
- 1998-04-08 HU HU0001752A patent/HU225523B1/hu not_active IP Right Cessation
- 1998-04-08 AU AU75260/98A patent/AU742079B2/en not_active Ceased
- 1998-04-08 EP EP98922720A patent/EP0971703B9/en not_active Expired - Lifetime
- 1998-04-08 EA EA199900934A patent/EA002324B1/ru not_active IP Right Cessation
- 1998-04-08 KR KR10-1999-7009351A patent/KR100507449B1/ko not_active IP Right Cessation
- 1998-04-08 AT AT98922720T patent/ATE243502T1/de not_active IP Right Cessation
- 1998-04-08 IL IL13211498A patent/IL132114A/en not_active IP Right Cessation
- 1998-04-08 CN CNB988041731A patent/CN1135970C/zh not_active Expired - Fee Related
- 1998-04-08 JP JP54350598A patent/JP2002503222A/ja not_active Withdrawn
- 1998-04-08 WO PCT/EP1998/002214 patent/WO1998046209A1/en active IP Right Grant
- 1998-04-08 ES ES98922720T patent/ES2201492T3/es not_active Expired - Lifetime
- 1998-04-08 CA CA002288970A patent/CA2288970C/en not_active Expired - Fee Related
- 1998-04-08 DE DE69815828T patent/DE69815828T2/de not_active Expired - Fee Related
- 1998-04-08 PL PL98336207A patent/PL189918B1/pl not_active IP Right Cessation
- 1998-04-08 PT PT98922720T patent/PT971703E/pt unknown
- 1998-08-04 UA UA99116188A patent/UA62961C2/uk unknown
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1999
- 1999-11-10 BG BG103873A patent/BG64269B1/bg unknown
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2001
- 2001-11-19 US US09/988,150 patent/US7235522B2/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
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| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20100408 |