SK281113B6 - 9-amino-7-(subst.)-6-demetyl-6-deoxytetracyklíny, spôsob a medziprodukty na ich výrobu, farmaceutické a veterinárne prípravky na ich báze - Google Patents

9-amino-7-(subst.)-6-demetyl-6-deoxytetracyklíny, spôsob a medziprodukty na ich výrobu, farmaceutické a veterinárne prípravky na ich báze Download PDF

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Publication number
SK281113B6
SK281113B6 SK2972-92A SK297292A SK281113B6 SK 281113 B6 SK281113 B6 SK 281113B6 SK 297292 A SK297292 A SK 297292A SK 281113 B6 SK281113 B6 SK 281113B6
Authority
SK
Slovakia
Prior art keywords
amino
dimethylamino
dioxo
octahydro
tetrahydroxy
Prior art date
Application number
SK2972-92A
Other languages
English (en)
Slovak (sk)
Other versions
SK297292A3 (en
Inventor
Joseph J. Hlavka
Phaik-Eng Sum
Yakov Gluzman
Ving J. Lee
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of SK297292A3 publication Critical patent/SK297292A3/sk
Publication of SK281113B6 publication Critical patent/SK281113B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Tires In General (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Moulding By Coating Moulds (AREA)
  • Luminescent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK2972-92A 1991-10-04 1992-09-29 9-amino-7-(subst.)-6-demetyl-6-deoxytetracyklíny, spôsob a medziprodukty na ich výrobu, farmaceutické a veterinárne prípravky na ich báze SK281113B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines

Publications (2)

Publication Number Publication Date
SK297292A3 SK297292A3 (en) 1994-12-07
SK281113B6 true SK281113B6 (sk) 2000-12-11

Family

ID=25092681

Family Applications (1)

Application Number Title Priority Date Filing Date
SK2972-92A SK281113B6 (sk) 1991-10-04 1992-09-29 9-amino-7-(subst.)-6-demetyl-6-deoxytetracyklíny, spôsob a medziprodukty na ich výrobu, farmaceutické a veterinárne prípravky na ich báze

Country Status (25)

Country Link
US (3) US5281628A (ja)
EP (1) EP0535346B1 (ja)
JP (1) JP3183729B2 (ja)
KR (1) KR100261528B1 (ja)
CN (1) CN1053182C (ja)
AT (1) ATE129697T1 (ja)
AU (1) AU651734B2 (ja)
CA (1) CA2079703C (ja)
CZ (1) CZ285015B6 (ja)
DE (1) DE69205792T2 (ja)
DK (1) DK0535346T3 (ja)
ES (1) ES2081005T3 (ja)
FI (1) FI111716B (ja)
GR (1) GR3017978T3 (ja)
HK (1) HK1000319A1 (ja)
HU (2) HU211214B (ja)
IL (1) IL103319A (ja)
MX (1) MX9205573A (ja)
NO (1) NO300129B1 (ja)
NZ (1) NZ244556A (ja)
PH (1) PH30343A (ja)
PL (2) PL170933B1 (ja)
SK (1) SK281113B6 (ja)
TW (1) TW222616B (ja)
ZA (1) ZA927608B (ja)

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US5981601A (en) * 1992-05-28 1999-11-09 Centre For Molecular Biology And Medicine Method for enhancing cellular bioenergy
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
US5834450A (en) * 1994-02-17 1998-11-10 Pfizer Inc. 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
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ES2260051T3 (es) * 1999-09-14 2006-11-01 Trustees Of Tufts College Metodo para preparar tetraciclinas substituidas con quimicas basadas en metales de transicion.
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6686365B2 (en) * 2000-02-04 2004-02-03 Eli Lilly And Company Pharmaceutical composition
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US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
AU2001271642B2 (en) * 2000-07-07 2006-01-05 Paratek Pharmaceuticals, Inc. 7-substituted tetracycline compounds
ATE544745T1 (de) * 2000-07-07 2012-02-15 Tufts College 9-substituierte minocyclinverbindungen
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
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US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
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EP2332548A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of stroke
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AU2003235759A1 (en) 2002-01-08 2003-07-24 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EA201000491A1 (ru) * 2002-03-08 2010-08-30 Паратек Фармасьютикалс, Инк. Аминометилзамещенные тетрациклиновые соединения
WO2003079984A2 (en) 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
KR101148415B1 (ko) 2002-07-12 2012-05-21 파라테크 파마슈티컬스, 인크. 3, 10, 및 12ａ 치환된 테트라시클린 화합물
JP2006516252A (ja) * 2002-12-27 2006-06-29 アンジオテック インターナショナル アクツィエン ゲゼルシャフト コラーゲンおよびｍｍｐｉを用いる組成物および方法
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2298323A3 (en) 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2332904A3 (en) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
CA2585248A1 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
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US8088755B2 (en) * 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
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US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
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Also Published As

Publication number Publication date
CA2079703A1 (en) 1993-04-05
IL103319A0 (en) 1993-03-15
AU651734B2 (en) 1994-07-28
NO923856D0 (no) 1992-10-02
NO923856L (no) 1993-04-05
HU211214B (en) 1995-11-28
US5281628A (en) 1994-01-25
EP0535346B1 (en) 1995-11-02
EP0535346A1 (en) 1993-04-07
HK1000319A1 (en) 1998-02-27
FI111716B (fi) 2003-09-15
FI924453A (fi) 1993-04-05
JPH05239006A (ja) 1993-09-17
HU211922A9 (en) 1996-01-29
JP3183729B2 (ja) 2001-07-09
NO300129B1 (no) 1997-04-14
IL103319A (en) 1996-07-23
GR3017978T3 (en) 1996-02-29
AU2618292A (en) 1993-04-08
ATE129697T1 (de) 1995-11-15
ZA927608B (en) 1993-04-13
HUT64298A (en) 1993-12-28
PL170939B1 (pl) 1997-02-28
PL170933B1 (pl) 1997-02-28
MX9205573A (es) 1993-05-01
NZ244556A (en) 1994-06-27
CN1053182C (zh) 2000-06-07
KR930007895A (ko) 1993-05-20
PL296140A1 (en) 1993-11-02
CZ297292A3 (en) 1993-04-14
KR100261528B1 (ko) 2000-07-15
CZ285015B6 (cs) 1999-05-12
DE69205792D1 (de) 1995-12-07
TW222616B (ja) 1994-04-21
US5401863A (en) 1995-03-28
FI924453A0 (fi) 1992-10-02
CN1071415A (zh) 1993-04-28
CA2079703C (en) 2004-07-20
HU9203143D0 (en) 1992-12-28
DK0535346T3 (da) 1995-12-04
US5326759A (en) 1994-07-05
DE69205792T2 (de) 1996-06-20
SK297292A3 (en) 1994-12-07
ES2081005T3 (es) 1996-02-16
PH30343A (en) 1997-04-02

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