SK20182000A3 - Činidlo regulujúce funkciu receptora súvisiaceho s retinoidmi - Google Patents

Činidlo regulujúce funkciu receptora súvisiaceho s retinoidmi Download PDF

Info

Publication number
SK20182000A3
SK20182000A3 SK2018-2000A SK20182000A SK20182000A3 SK 20182000 A3 SK20182000 A3 SK 20182000A3 SK 20182000 A SK20182000 A SK 20182000A SK 20182000 A3 SK20182000 A3 SK 20182000A3
Authority
SK
Slovakia
Prior art keywords
group
hydrocarbon group
optionally substituted
formula
hydrogen atom
Prior art date
Application number
SK2018-2000A
Other languages
English (en)
Slovak (sk)
Inventor
Yasuo Sugiyama
Yu Momose
Hiroyuki Kimura
Junichi Sakamoto
Hiroyuki Odaka
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of SK20182000A3 publication Critical patent/SK20182000A3/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK2018-2000A 1998-07-01 1999-06-30 Činidlo regulujúce funkciu receptora súvisiaceho s retinoidmi SK20182000A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18669898 1998-07-01
PCT/JP1999/003520 WO2000001679A1 (fr) 1998-07-01 1999-06-30 Regulateurs du recepteur associe aux retinoides

Publications (1)

Publication Number Publication Date
SK20182000A3 true SK20182000A3 (sk) 2001-08-06

Family

ID=16193077

Family Applications (1)

Application Number Title Priority Date Filing Date
SK2018-2000A SK20182000A3 (sk) 1998-07-01 1999-06-30 Činidlo regulujúce funkciu receptora súvisiaceho s retinoidmi

Country Status (16)

Country Link
US (1) US6545009B1 (id)
EP (1) EP1092711A4 (id)
KR (1) KR20010053282A (id)
CN (1) CN1314899A (id)
AU (1) AU4394799A (id)
BR (1) BR9911752A (id)
CA (1) CA2332178A1 (id)
HU (1) HUP0102470A3 (id)
ID (1) ID29247A (id)
IL (1) IL140422A0 (id)
LV (1) LV12633B (id)
NO (1) NO20006667L (id)
PL (1) PL345247A1 (id)
SK (1) SK20182000A3 (id)
WO (1) WO2000001679A1 (id)
ZA (1) ZA200007635B (id)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548529B1 (en) 1999-04-05 2003-04-15 Bristol-Myers Squibb Company Heterocyclic containing biphenyl aP2 inhibitors and method
AR035016A1 (es) 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
US7241785B2 (en) 2001-03-23 2007-07-10 Takeda Pharmaceutical Company Limited Five-membered heterocyclic alkanoic acid derivative
MXPA03009562A (es) * 2001-04-18 2004-02-12 Genzyme Corp METODO PARA TRATAR EL SiNDROME X CON POLIAMINAS ALIFATICAS.
GB0112348D0 (en) * 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
WO2003000301A1 (en) * 2001-06-22 2003-01-03 Merck & Co., Inc. Combination of a ppar-alpha ligand and glucocorticoid for the treatment or prevention of inflammation
JP2003081832A (ja) * 2001-06-26 2003-03-19 Takeda Chem Ind Ltd レチノイド関連受容体機能調節剤
WO2003000249A1 (fr) * 2001-06-26 2003-01-03 Takeda Chemical Industries, Ltd. Regulateur de la fonction du recepteur relatif aux retinoides
DE60217918T2 (de) * 2001-12-29 2007-11-15 Novo Nordisk A/S Kombinierte verwendung einer glp-1-verbindung und eines aldose reduktase inhibitors
AU2003211385A1 (en) 2002-02-28 2003-09-09 Takeda Chemical Industries, Ltd. Azole compounds
ZA200503967B (en) 2002-11-01 2006-11-29 Takeda Pharmaceutical Agent for preventing or treating neuropathy
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
DE10308353A1 (de) * 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2599281C (en) * 2005-02-25 2012-01-17 Heonjoong Kang Thiazole derivatives as ppar delta ligands and their manufacturing process
KR100797798B1 (ko) * 2005-02-25 2008-01-24 재단법인서울대학교산학협력재단 퍼록시솜 증식자 활성화 수용체 델타 리간드 티아졸 유도체및 그의 제조방법
KR20080066938A (ko) * 2005-10-07 2008-07-17 깃세이 야쿠힌 고교 가부시키가이샤 질소 함유 복소환 화합물 및 그것을 함유하는 의약 조성물
WO2008064136A2 (en) * 2006-11-17 2008-05-29 Acadia Pharmaceuticals Inc. Compounds with activity at retinoic acid receptors
US9187485B2 (en) 2007-02-02 2015-11-17 Baylor College Of Medicine Methods and compositions for the treatment of cancer and related hyperproliferative disorders
CN101674730B (zh) 2007-02-02 2014-09-10 贝勒医学院 用于治疗代谢疾病的组合物和方法
US9085566B2 (en) 2007-02-02 2015-07-21 Baylor College Of Medicine Compositions and methods for the treatment of metabolic and related disorders
US9212179B2 (en) 2007-02-02 2015-12-15 Baylor College Of Medicine Compositions and methods for the treatment of metabolic disorders
US9233941B2 (en) 2007-02-02 2016-01-12 Baylor College Of Medicine Methods and compositions for the treatment of body weight related disorders
EP2947080B1 (en) 2007-08-13 2017-10-25 Monsanto Technology LLC Compositions and methods for controlling nematodes
WO2011011105A2 (en) * 2009-05-07 2011-01-27 Baylor College Of Medicine Traceable retinoid acid for imaging, disease prevention and therapy
GB0915196D0 (en) 2009-09-01 2009-10-07 King S College London Therapeutic compounds and their use
WO2012028100A1 (en) * 2010-09-01 2012-03-08 Glaxo Group Limited Novel compounds
JP6797800B2 (ja) * 2014-12-19 2020-12-09 ガルデルマ・リサーチ・アンド・デヴェロップメント 新規化合物、その合成方法、並びに医薬品及び化粧品におけるその使用
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
US10865793B2 (en) 2016-12-06 2020-12-15 Air Squared, Inc. Scroll type device having liquid cooling through idler shafts
US20200025199A1 (en) 2018-07-17 2020-01-23 Air Squared, Inc. Dual drive co-rotating spinning scroll compressor or expander
US11530703B2 (en) 2018-07-18 2022-12-20 Air Squared, Inc. Orbiting scroll device lubrication
US11473572B2 (en) 2019-06-25 2022-10-18 Air Squared, Inc. Aftercooler for cooling compressed working fluid
US11898557B2 (en) 2020-11-30 2024-02-13 Air Squared, Inc. Liquid cooling of a scroll type compressor with liquid supply through the crankshaft
US11885328B2 (en) 2021-07-19 2024-01-30 Air Squared, Inc. Scroll device with an integrated cooling loop

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001420A (en) 1968-12-12 1977-01-04 Science Union Et Cie, Societe Francaise De Recherche Medical Thiazolyl benzoic acid compounds
GB1308028A (en) 1970-06-12 1973-02-21 Science Union & Cie Thiazolylbenzoic acid derivatives and a process for their manufactur
JPS4932853A (id) 1972-07-27 1974-03-26
US4043973A (en) 1974-10-02 1977-08-23 Eastman Kodak Company Multichromophoric ultraviolet stabilizers for organic compositions
US3939115A (en) 1974-10-02 1976-02-17 Eastman Kodak Company Polychromophoric ultraviolet stabilizers and their use in organic compositions
US4164480A (en) 1978-01-09 1979-08-14 Eastman Kodak Company Polychromophoric ultraviolet stabilizers and their use in organic compositions
SU1078859A1 (ru) 1982-03-31 1997-10-20 Б.М. Красовицкий 2-(5-фенилоксазолил-2)-5-(5-арилоксазолил-2)-бензойные кислоты в качестве органических люминофоров сине-зеленого свечения в органических растворителях и водной среде
JPH0725754B2 (ja) 1986-01-30 1995-03-22 富山化学工業株式会社 新規なチアゾール化合物またはその塩
JP2524786B2 (ja) 1987-12-15 1996-08-14 コニカ株式会社 直接ポジハロゲン化銀カラ―写真感光材料
DE3903993A1 (de) 1989-02-10 1990-08-16 Basf Ag Diarylsubstituierte heterocyclische verbindungen, ihre herstellung und arzneimittel daraus
JP2941937B2 (ja) 1990-01-25 1999-08-30 キヤノン株式会社 新規化合物、これを含む液晶組成物及びこれを使用した液晶素子並びに表示装置
JPH04154773A (ja) * 1990-10-15 1992-05-27 Green Cross Corp:The チアゾール誘導体
ES2245660T3 (es) 1990-11-30 2006-01-16 Otsuka Pharmaceutical Co., Ltd. Derivados de azol y su utilizacion como inhibidores de los radicales superoxidos.
US5639770A (en) 1992-05-29 1997-06-17 Otsuka Pharmaceutical Co., Ltd. Thiazole derivatives
JP3385387B2 (ja) 1992-05-29 2003-03-10 大塚製薬株式会社 チアゾール誘導体
US5342851A (en) 1992-10-07 1994-08-30 Mcneil-Ppc, Inc. Substituted thiazole derivatives useful as platelet aggregation inhibitors
DE4302051A1 (de) 1993-01-26 1994-07-28 Thomae Gmbh Dr K 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
KR19980702466A (ko) 1995-02-24 1998-07-15 페라 스타르크, 요헨 카르크 피라졸-4-일-벤조일 유도체 및 제초제로서의 그의 용도
JP3964478B2 (ja) 1995-06-30 2007-08-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬
JP3865829B2 (ja) * 1995-09-21 2007-01-10 株式会社医薬分子設計研究所 レチノイド作用増強性化合物
ES2124167B1 (es) 1996-06-04 1999-09-16 Espanola Prod Quimicos Nuevos derivados del bencimidazol con actividad antihistaminica.
AU4015497A (en) * 1996-08-26 1998-03-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Thiazole derivatives useful as selective inhibitors of pde-iv
JP4300373B2 (ja) 1996-09-30 2009-07-22 大塚製薬株式会社 サイトカイン産生抑制剤及び接着抑制剤
AUPO691897A0 (en) 1997-05-21 1997-06-12 Fujisawa Pharmaceutical Co., Ltd. New compound

Also Published As

Publication number Publication date
EP1092711A4 (en) 2002-07-31
CN1314899A (zh) 2001-09-26
ID29247A (id) 2001-08-16
IL140422A0 (en) 2002-02-10
HUP0102470A3 (en) 2002-05-28
NO20006667L (no) 2001-02-28
LV12633A (lv) 2001-03-20
PL345247A1 (en) 2001-12-03
EP1092711A1 (en) 2001-04-18
LV12633B (en) 2001-07-20
KR20010053282A (ko) 2001-06-25
US6545009B1 (en) 2003-04-08
NO20006667D0 (no) 2000-12-27
CA2332178A1 (en) 2000-01-13
WO2000001679A1 (fr) 2000-01-13
ZA200007635B (en) 2002-01-02
BR9911752A (pt) 2001-04-03
AU4394799A (en) 2000-01-24
HUP0102470A2 (hu) 2002-04-29

Similar Documents

Publication Publication Date Title
SK20182000A3 (sk) Činidlo regulujúce funkciu receptora súvisiaceho s retinoidmi
EP1357115B1 (en) Alkanoic acid derivatives, process for their production and use thereof
DE60012213T2 (de) Fünfgliedrige n-heterocyclen mit hypoglykämischer und hypolipidemischer wirkung
KR100388120B1 (ko) 저혈당 및 저지질혈 활성을 갖는 옥시이미노알칸산 유도체
US20040063775A1 (en) Five-membered heterocyclic alkanoic acid derivative
TW201940471A (zh) 心肌節抑制劑
US20040157881A1 (en) Function regulator for retinoid relative receptor
JP6352415B2 (ja) 新規なヘテロ環化合物
KR20180127644A (ko) 니코틴산 아세틸콜린 수용체의 알로스테릭 조정제
TW201925173A (zh) 鹵代烯丙基胺類ssao/vap-1抑制劑及其用途
JP2000510870A (ja) Npy5受容体アンタゴニストとしてのアミド類
EA016300B1 (ru) НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-κB
EP3814343A1 (en) Cardiac sarcomere inhibitors
CA3129533A1 (en) Substituted bicyclic compounds as farnesoid x receptor modulators
CN112707854A (zh) 吡咯酰胺类化合物及其用途
CN113795254B (zh) 用于ire1抑制的吡唑并吡啶化合物
JP2000080086A (ja) レチノイド関連受容体機能調節剤
EP3924337A1 (en) Substituted bicyclic compounds as farnesoid x receptor modulators
CZ20004879A3 (cs) Činidlo regulující funkci receptoru souvisejícího s retinoidy
JP3074532B2 (ja) オキシイミノアルカン酸誘導体
JP2002348281A (ja) 5員複素環アルカン酸誘導体
MXPA00012925A (en) Retinoid-associated receptor regulators
CZ20004104A3 (cs) Deriváty kyseliny oxyiminoalkanové