SK183999A3 - Il-5 inhibiting 6-azauracil derivatives - Google Patents
Il-5 inhibiting 6-azauracil derivatives Download PDFInfo
- Publication number
- SK183999A3 SK183999A3 SK1839-99A SK183999A SK183999A3 SK 183999 A3 SK183999 A3 SK 183999A3 SK 183999 A SK183999 A SK 183999A SK 183999 A3 SK183999 A3 SK 183999A3
- Authority
- SK
- Slovakia
- Prior art keywords
- alkyl
- formula
- phenyl
- compound
- het
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97202118 | 1997-07-10 | ||
| PCT/EP1998/004191 WO1999002505A1 (en) | 1997-07-10 | 1998-07-07 | Il-5 inhibiting 6-azauracil derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK183999A3 true SK183999A3 (en) | 2000-08-14 |
Family
ID=8228531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1839-99A SK183999A3 (en) | 1997-07-10 | 1998-07-07 | Il-5 inhibiting 6-azauracil derivatives |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1000040B1 (de) |
| JP (1) | JP2002511882A (de) |
| KR (1) | KR20010014049A (de) |
| CN (1) | CN1262679A (de) |
| AR (1) | AR013360A1 (de) |
| AT (1) | ATE364597T1 (de) |
| AU (1) | AU742145B2 (de) |
| BR (1) | BR9811678A (de) |
| CA (1) | CA2294145A1 (de) |
| DE (1) | DE69837922D1 (de) |
| EE (1) | EE200000016A (de) |
| HR (1) | HRP20000003A2 (de) |
| HU (1) | HUP0004687A3 (de) |
| ID (1) | ID24390A (de) |
| IL (1) | IL133916A0 (de) |
| NO (1) | NO20000063L (de) |
| NZ (1) | NZ502180A (de) |
| PL (1) | PL337947A1 (de) |
| SK (1) | SK183999A3 (de) |
| TR (1) | TR200000153T2 (de) |
| TW (1) | TW496865B (de) |
| WO (1) | WO1999002505A1 (de) |
| ZA (1) | ZA986089B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4676061B2 (ja) * | 1998-07-30 | 2011-04-27 | アボット・ラボラトリーズ | グルココルチコイド選択性薬剤 |
| EP0987265A1 (de) * | 1998-09-18 | 2000-03-22 | Janssen Pharmaceutica N.V. | Interleukin-5 hemmende 6-Azauracil Derivate |
| HUP0104641A3 (en) | 1998-12-18 | 2003-01-28 | Janssen Pharmaceutica Nv | Il-5 inhibiting 6-azauracil derivatives process for their preparation and medicaments containing them |
| WO2001010866A1 (en) * | 1999-08-06 | 2001-02-15 | Janssen Pharmaceutica N.V. | Interleukin-5 inhibiting 6-azauracil derivatives |
| WO2002004411A1 (en) | 2000-07-07 | 2002-01-17 | The Administrators Of The Tulane Educational Fund | Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor |
| EP1486490A1 (de) * | 2002-02-28 | 2004-12-15 | Takeda Chemical Industries, Ltd. | Azolverbindungen |
| WO2004071448A2 (en) * | 2003-02-12 | 2004-08-26 | Transtech Pharma Inc. | Substituted azole derivatives as inhibitors of protein tyrosine phosphatases |
| GB0305575D0 (en) | 2003-03-11 | 2003-04-16 | Glaxo Group Ltd | Novel compounds |
| EA200602288A1 (ru) * | 2004-05-29 | 2007-10-26 | 7ТиЭм ФАРМА А/С | Замещённые тиазолуксусные кислоты в качестве лигандов crth2 |
| DE102006049618A1 (de) * | 2006-10-20 | 2008-05-08 | Tschesche, Harald, Prof. Dr. | Triazine und Ihre Verwendung als Metalloproteinase-Inhibitoren |
| CN101265238B (zh) * | 2007-12-12 | 2010-06-16 | 重庆天极旅业有限公司 | 一种三嗪环衍生物的合成方法 |
| CN101265216B (zh) * | 2007-12-18 | 2012-06-27 | 重庆华邦胜凯制药有限公司 | 4-(取代乙氰基)-苯腙衍生物及其合成方法 |
| NZ605690A (en) * | 2010-08-16 | 2014-06-27 | Boehringer Ingelheim Int | Oxadiazole inhibitors of leukotriene production |
| SG11201900215YA (en) * | 2016-07-13 | 2019-02-27 | Univ Paris Descartes | Meclozine derivatives and diclazuril derivatives for use in the prevention and/or the treatment of disorders associated to the inflammation induced by p. acnes |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2149645A1 (de) * | 1970-10-07 | 1972-09-14 | Pfizer | 2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose |
| US3912723A (en) * | 1971-03-29 | 1975-10-14 | Pfizer | 2-Phenyl-as-triazine-3,5(2H,4H)diones |
| US3883528A (en) * | 1974-04-19 | 1975-05-13 | Pfizer | Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats |
| CA1244024A (en) * | 1984-08-01 | 1988-11-01 | Gustaaf M. Boeckx | .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES |
| GB8602342D0 (en) * | 1986-01-30 | 1986-03-05 | Janssen Pharmaceutica Nv | 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones |
| EP0476439A1 (de) * | 1990-09-18 | 1992-03-25 | Bayer Ag | Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung |
| TW403741B (en) * | 1993-10-15 | 2000-09-01 | Takeda Chemical Industries Ltd | Triazine derivative, production and use thereof |
-
1998
- 1998-07-07 EP EP98941299A patent/EP1000040B1/de not_active Expired - Lifetime
- 1998-07-07 HU HU0004687A patent/HUP0004687A3/hu unknown
- 1998-07-07 ID IDW20000034A patent/ID24390A/id unknown
- 1998-07-07 CA CA002294145A patent/CA2294145A1/en not_active Abandoned
- 1998-07-07 WO PCT/EP1998/004191 patent/WO1999002505A1/en active IP Right Grant
- 1998-07-07 KR KR19997012079A patent/KR20010014049A/ko not_active Application Discontinuation
- 1998-07-07 PL PL98337947A patent/PL337947A1/xx unknown
- 1998-07-07 SK SK1839-99A patent/SK183999A3/sk unknown
- 1998-07-07 AT AT98941299T patent/ATE364597T1/de not_active IP Right Cessation
- 1998-07-07 IL IL13391698A patent/IL133916A0/xx unknown
- 1998-07-07 NZ NZ502180A patent/NZ502180A/xx unknown
- 1998-07-07 EE EEP200000016A patent/EE200000016A/xx unknown
- 1998-07-07 TR TR2000/00153T patent/TR200000153T2/xx unknown
- 1998-07-07 DE DE69837922T patent/DE69837922D1/de not_active Expired - Lifetime
- 1998-07-07 BR BR9811678-9A patent/BR9811678A/pt not_active IP Right Cessation
- 1998-07-07 AU AU89738/98A patent/AU742145B2/en not_active Ceased
- 1998-07-07 JP JP50812699A patent/JP2002511882A/ja not_active Withdrawn
- 1998-07-07 CN CN98806978A patent/CN1262679A/zh active Pending
- 1998-07-08 AR ARP980103336A patent/AR013360A1/es not_active Application Discontinuation
- 1998-07-08 TW TW087111014A patent/TW496865B/zh active
- 1998-07-09 ZA ZA9806089A patent/ZA986089B/xx unknown
-
2000
- 2000-01-05 HR HR20000003A patent/HRP20000003A2/xx not_active Application Discontinuation
- 2000-01-06 NO NO20000063A patent/NO20000063L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA986089B (en) | 2000-01-10 |
| NZ502180A (en) | 2000-11-24 |
| EP1000040A1 (de) | 2000-05-17 |
| ID24390A (id) | 2000-07-13 |
| PL337947A1 (en) | 2000-09-11 |
| JP2002511882A (ja) | 2002-04-16 |
| CA2294145A1 (en) | 1999-01-21 |
| BR9811678A (pt) | 2000-09-19 |
| NO20000063D0 (no) | 2000-01-06 |
| ATE364597T1 (de) | 2007-07-15 |
| AU8973898A (en) | 1999-02-08 |
| AU742145B2 (en) | 2001-12-20 |
| NO20000063L (no) | 2000-03-10 |
| IL133916A0 (en) | 2001-04-30 |
| HUP0004687A3 (en) | 2002-03-28 |
| DE69837922D1 (de) | 2007-07-26 |
| WO1999002505A1 (en) | 1999-01-21 |
| HRP20000003A2 (en) | 2000-12-31 |
| KR20010014049A (ko) | 2001-02-26 |
| HUP0004687A2 (hu) | 2002-02-28 |
| CN1262679A (zh) | 2000-08-09 |
| TW496865B (en) | 2002-08-01 |
| TR200000153T2 (tr) | 2000-07-21 |
| EE200000016A (et) | 2000-10-16 |
| EP1000040B1 (de) | 2007-06-13 |
| AR013360A1 (es) | 2000-12-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2988147C (en) | 4-hydroxy-3-(heteroaryl)pyridine-2-one apj agonists for use in the treatment of cardiovascular disorders | |
| ES2202647T3 (es) | Derivados de la piridina-2-il-metilamina, su procedimiento de preparacion y su utilizacion como medicamentos. | |
| US7700591B2 (en) | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors | |
| CA2483159C (en) | Triazole derivatives as tachykinin receptor antagonists | |
| ES2307925T3 (es) | Antagonistas de los receptores de la taquiquinina. | |
| US7247725B2 (en) | Gamma-aminoamide modulators of chemokine receptor activity | |
| US20080188478A1 (en) | Compounds Useful In Therapy | |
| SK183999A3 (en) | Il-5 inhibiting 6-azauracil derivatives | |
| IL179280A (en) | Converted 2-quinolyl-oxazole compounds and pharmaceutical compositions containing them for the treatment of PDE4-related diseases | |
| SK96494A3 (en) | Piperazine and piperidine derivatives, and their use as antipsychotic | |
| RU2172737C2 (ru) | Производное тиофена и фармацевтическая композиция на его основе | |
| WO2005000821A1 (en) | Tachykinin receptor antagonists | |
| CA2755697A1 (en) | Amide derivative | |
| US20190031618A1 (en) | Benzimidazole derivatives useful as cb-1 inverse agonists | |
| CA3001649A1 (en) | Dopamine d3 receptor antagonists having a morpholine moiety | |
| US20020010177A1 (en) | IL-5 inhibiting 6-azauracil derivatives | |
| JP4966193B2 (ja) | Ｄ３受容体に対するアフィニティを有する化合物および医薬におけるその使用 | |
| US6867207B2 (en) | IL-5 inhibiting 6-azauracil derivatives | |
| CZ463999A3 (cs) | Deriváty 6-azauracilu inhibující IL-5 | |
| MXPA00000366A (en) | Il-5 inhibiting 6-azauracil derivatives | |
| MXPA00000362A (en) | 6-azauracil derivatives as il-5 inhibitors | |
| MXPA06009671A (en) | 6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists |