SK154498A3 - Carboline derivatives, process for the preparation thereof, pharmaceutical compositions containing same and use of mentioned derivatives as drugs - Google Patents
Carboline derivatives, process for the preparation thereof, pharmaceutical compositions containing same and use of mentioned derivatives as drugs Download PDFInfo
- Publication number
- SK154498A3 SK154498A3 SK1544-98A SK154498A SK154498A3 SK 154498 A3 SK154498 A3 SK 154498A3 SK 154498 A SK154498 A SK 154498A SK 154498 A3 SK154498 A3 SK 154498A3
- Authority
- SK
- Slovakia
- Prior art keywords
- tetrahydro
- carbolin
- methylenedioxyphenyl
- propen
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9609820.7A GB9609820D0 (en) | 1996-05-10 | 1996-05-10 | Chemical compounds |
GBGB9609777.9A GB9609777D0 (en) | 1996-05-10 | 1996-05-10 | Chemical compounds |
PCT/EP1997/002277 WO1997043287A1 (fr) | 1996-05-10 | 1997-05-05 | Derives de carboline |
Publications (1)
Publication Number | Publication Date |
---|---|
SK154498A3 true SK154498A3 (en) | 2000-01-18 |
Family
ID=26309303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1544-98A SK154498A3 (en) | 1996-05-10 | 1997-05-05 | Carboline derivatives, process for the preparation thereof, pharmaceutical compositions containing same and use of mentioned derivatives as drugs |
Country Status (26)
Country | Link |
---|---|
US (2) | US6117881A (fr) |
EP (1) | EP0912567B1 (fr) |
JP (1) | JP3418405B2 (fr) |
KR (1) | KR20000010918A (fr) |
CN (1) | CN1067071C (fr) |
AP (1) | AP9801365A0 (fr) |
AT (1) | ATE215950T1 (fr) |
AU (1) | AU711885B2 (fr) |
BG (1) | BG102879A (fr) |
BR (1) | BR9709230A (fr) |
CA (1) | CA2253948C (fr) |
CZ (1) | CZ358598A3 (fr) |
DE (1) | DE69711882T2 (fr) |
EA (1) | EA199800907A1 (fr) |
EE (1) | EE9800390A (fr) |
ES (1) | ES2175404T3 (fr) |
HU (1) | HUP9901478A3 (fr) |
IL (1) | IL126951A0 (fr) |
IS (1) | IS4864A (fr) |
NO (1) | NO985222L (fr) |
OA (1) | OA10920A (fr) |
PL (1) | PL329875A1 (fr) |
SK (1) | SK154498A3 (fr) |
TR (1) | TR199802282T2 (fr) |
WO (1) | WO1997043287A1 (fr) |
YU (1) | YU49898A (fr) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR199802282T2 (xx) * | 1996-05-10 | 1999-03-22 | Icos Corporation | Karbolin t�revleri. |
US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
DE19837069C1 (de) * | 1998-08-17 | 2000-01-05 | Bayer Ag | Substituierte Zimtsäuren und Zimtsäureester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von substituierten Indanoncarbonsäureestern |
JP2002524564A (ja) * | 1998-09-16 | 2002-08-06 | アイコス コーポレイション | cGMPホスホジエステラーゼ阻害剤としてのカルボリン誘導体 |
DE19903087A1 (de) * | 1999-01-27 | 2000-08-10 | Forssmann Wolf Georg | Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern |
ES2213004T3 (es) | 1999-03-24 | 2004-08-16 | Harbor Branch Oceanographic Institution, Inc. | Usos antiinflamatorios de manzaminas. |
NO20002097L (no) | 1999-04-30 | 2001-10-26 | Lilly Icos Llc | Fremstillingsgjenstander |
US6451807B1 (en) | 1999-04-30 | 2002-09-17 | Lilly Icos, Llc. | Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor |
CN1436080A (zh) | 2000-04-19 | 2003-08-13 | 利利艾科斯有限公司 | 环gmp-特异性磷酸二酯酶抑制剂治疗帕金森氏病的用途 |
UA74826C2 (en) | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
MXPA02012470A (es) | 2000-06-23 | 2004-01-26 | Lilly Icos Llc | Inhibidores de fosfodiesterasa especificos para gmp ciclico. |
US6821978B2 (en) | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
WO2002064590A2 (fr) * | 2001-02-12 | 2002-08-22 | Lilly Icos Llc | Composes chimiques |
DE60216233T2 (de) | 2001-02-12 | 2007-09-27 | Lilly Icos Llc, Wilmington | Carbolinderivate |
MXPA03009750A (es) * | 2001-04-25 | 2004-06-30 | Lilly Icos Llc | Compuestos quimicos. |
WO2002098875A1 (fr) * | 2001-06-05 | 2002-12-12 | Lilly Icos Llc | Derives de carboline utilises comme inhibiteurs de pde-5 |
ATE335742T1 (de) | 2001-06-21 | 2006-09-15 | Lilly Icos Llc | Carbolinderivate als pdev inhibitoren |
JP2005509038A (ja) | 2001-11-09 | 2005-04-07 | シェーリング コーポレイション | 多環式グアニン誘導体ホスホジエステラーゼv阻害剤 |
WO2003053923A2 (fr) | 2001-12-20 | 2003-07-03 | Applied Research Systems Ars Holding N.V. | Derives de pyrrolidine utilises en tant que modulateurs de la prostaglandine |
TWI329111B (en) * | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
US7595311B2 (en) | 2002-05-24 | 2009-09-29 | Exelixis, Inc. | Azepinoindole derivatives as pharmaceutical agents |
EP2526958B1 (fr) * | 2003-06-13 | 2017-10-18 | Ironwood Pharmaceuticals, Inc. | Procédé et compositions de traitement des troubles gastro-intestinaux |
WO2004113300A1 (fr) * | 2003-06-23 | 2004-12-29 | Ono Pharmaceutical Co., Ltd. | Nouveau compose heterocyclique tricyclique |
UA92317C2 (ru) * | 2004-03-15 | 2010-10-25 | Пи-Ти-Си ТЕРАПЬЮТИКС, ИНК. | Производные карболина, пригодные для ингибирования развития кровеносных сосудов |
US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
SA05260149B1 (ar) * | 2004-05-26 | 2010-06-16 | إيساي آر آند دي منجمنت كو.، ليمتد | مركب سيناميد |
US7667041B2 (en) * | 2004-05-26 | 2010-02-23 | Eisai R&D Management Co., Ltd. | Cinnamide compound |
US7923563B2 (en) | 2004-10-26 | 2011-04-12 | Eisai R&D Management Co., Ltd. | Amorphous object of cinnamide compound |
EP1829874B1 (fr) | 2004-12-22 | 2014-02-12 | Ono Pharmaceutical Co., Ltd. | Compose tricyclique et son utilisation |
US8506934B2 (en) | 2005-04-29 | 2013-08-13 | Robert I. Henkin | Methods for detection of biological substances |
EP2275095A3 (fr) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenese par modulation des recepteurs muscariniques |
EP2258359A3 (fr) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline |
EP2377530A3 (fr) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation de neurogénèse par inhibition PDE |
EP2314289A1 (fr) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Modulation de la neurogenese dont la médiation est assurée par récepteur gaba |
ZA200804550B (en) | 2005-11-09 | 2009-08-26 | Combinatorx Inc | Methods, compositions, and kits for the treatment of medical conditions |
CA2628047A1 (fr) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | Procede de production d'un derive cinnamide |
EP1953151A4 (fr) * | 2005-11-18 | 2010-06-02 | Eisai R&D Man Co Ltd | Sels de composé cynamide ou solvates de ces derniers |
US20070117839A1 (en) * | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
CA2629745A1 (fr) | 2005-11-24 | 2007-05-31 | Eisai R & D Management Co., Ltd. | Composes cinnamide de type morpholine |
TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
WO2007134077A2 (fr) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenèse induite par le récepteur 5ht |
CA2651813A1 (fr) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenese par modulation de l'angiotensine |
AR062095A1 (es) | 2006-07-28 | 2008-10-15 | Eisai R&D Man Co Ltd | Profarmaco de compuesto cinamida |
AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2008095136A2 (fr) | 2007-01-31 | 2008-08-07 | Henkin Robert I | Procédés de détection de substances biologiques |
CL2008000582A1 (es) * | 2007-02-28 | 2008-06-27 | Eisai R&D Man Co Ltd | Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis. |
JPWO2008140111A1 (ja) * | 2007-05-16 | 2010-08-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シンナミド誘導体のワンポット製造方法 |
TW200916469A (en) | 2007-08-31 | 2009-04-16 | Eisai R & Amp D Man Co Ltd | Multi-cyclic compounds |
US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
JPWO2009096349A1 (ja) * | 2008-01-28 | 2011-05-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 結晶性のシンナミド化合物またはその塩 |
US8580801B2 (en) | 2008-07-23 | 2013-11-12 | Robert I. Henkin | Phosphodiesterase inhibitor treatment |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
EP2804603A1 (fr) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation |
WO2014055801A1 (fr) | 2012-10-05 | 2014-04-10 | Henkin Robert I | Inhibiteurs de la phosphodiestérase destinés à traiter des troubles du goût et de l'odorat |
WO2015126944A1 (fr) | 2014-02-18 | 2015-08-27 | Henkin Robert I | Procédés et compositions permettant de diagnostiquer et de traiter une perte et/ou une distorsion du goût ou de l'odorat |
JP2019515643A (ja) * | 2015-09-23 | 2019-06-13 | ミネルバ バイオテクノロジーズ コーポレーション | 幹細胞分化剤のスクリーニング方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3644384A (en) * | 1969-06-09 | 1972-02-22 | Sterling Drug Inc | Certain 2-(alpha-haloacetyl) - 1 2 3 4-tetrahydro - 9h - pyrido(3 4-b)indole-3-carboxylates and derivatives |
US3717638A (en) * | 1971-03-11 | 1973-02-20 | Sterling Drug Inc | 1,2,3,4,6,7,12,12A-OCTAHYDRO-2-PHENYLPYRAZINO[2',1':6,1]PYRIDO[3,4-b]INDOLES AND INTERMEDIATES THEREFOR |
US3917599A (en) * | 1973-03-30 | 1975-11-04 | Council Scient Ind Res | 2-Substituted-1,2,3,4,6,7,12,12A-octahydropyrazino(2{40 ,1{40 :6,1)pyrido(3,4-B)indoles |
GB1454171A (en) * | 1973-10-19 | 1976-10-27 | Council Scient Ind Res | Tetracyclic compounds |
US4188390A (en) * | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
US4656174A (en) * | 1982-07-24 | 1987-04-07 | Pfizer Inc. | Quinoline therapeutic agents |
IT1217190B (it) * | 1988-04-22 | 1990-03-14 | Recordati Chem Pharm | Composti utili per il trattamento e diagnosi di disfunzioni frettili |
FI892362A (fi) * | 1988-06-01 | 1989-12-02 | Eisai Co Ltd | Buten- eller propensyraderivat. |
EP0357122A3 (fr) * | 1988-08-29 | 1991-10-23 | Duphar International Research B.V | L'application des bêta-carbolines, benzofurane et benzothiophène analogues pour obtenir un médicament à activité cytostatique |
DE3830096A1 (de) * | 1988-09-03 | 1990-03-15 | Hoechst Ag | Piperazindione mit psychotroper wirkung |
FR2649613B1 (fr) * | 1989-07-11 | 1991-09-27 | Virag Ronald | Medicament vaso-actif |
JPH0344324A (ja) * | 1989-07-13 | 1991-02-26 | Kazuoki Tsuchiya | 性機能賦活剤 |
US5270323A (en) * | 1990-05-31 | 1993-12-14 | Pfizer Inc. | Method of treating impotence |
EP0459666B1 (fr) * | 1990-05-31 | 1994-11-09 | Pfizer Inc. | Médicament contre l'impuissance |
GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
GB9218322D0 (en) * | 1992-08-28 | 1992-10-14 | Pfizer Ltd | Therapeutic agents |
GB9311920D0 (en) * | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
TR199802282T2 (xx) * | 1996-05-10 | 1999-03-22 | Icos Corporation | Karbolin t�revleri. |
US5874437A (en) * | 1996-11-01 | 1999-02-23 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
US6043252A (en) * | 1997-05-05 | 2000-03-28 | Icos Corporation | Carboline derivatives |
-
1997
- 1997-05-05 TR TR1998/02282T patent/TR199802282T2/xx unknown
- 1997-05-05 JP JP54045697A patent/JP3418405B2/ja not_active Expired - Fee Related
- 1997-05-05 EP EP97922960A patent/EP0912567B1/fr not_active Expired - Lifetime
- 1997-05-05 AP APAP/P/1998/001365A patent/AP9801365A0/en unknown
- 1997-05-05 DE DE69711882T patent/DE69711882T2/de not_active Expired - Fee Related
- 1997-05-05 CA CA002253948A patent/CA2253948C/fr not_active Expired - Fee Related
- 1997-05-05 CN CN97194508A patent/CN1067071C/zh not_active Expired - Fee Related
- 1997-05-05 HU HU9901478A patent/HUP9901478A3/hu unknown
- 1997-05-05 IL IL12695197A patent/IL126951A0/xx unknown
- 1997-05-05 PL PL97329875A patent/PL329875A1/xx unknown
- 1997-05-05 AU AU28910/97A patent/AU711885B2/en not_active Ceased
- 1997-05-05 CZ CZ983585A patent/CZ358598A3/cs unknown
- 1997-05-05 KR KR1019980709066A patent/KR20000010918A/ko not_active Application Discontinuation
- 1997-05-05 ES ES97922960T patent/ES2175404T3/es not_active Expired - Lifetime
- 1997-05-05 YU YU49898A patent/YU49898A/sh unknown
- 1997-05-05 SK SK1544-98A patent/SK154498A3/sk unknown
- 1997-05-05 BR BR9709230A patent/BR9709230A/pt not_active IP Right Cessation
- 1997-05-05 WO PCT/EP1997/002277 patent/WO1997043287A1/fr not_active Application Discontinuation
- 1997-05-05 EA EA199800907A patent/EA199800907A1/ru unknown
- 1997-05-05 EE EE9800390A patent/EE9800390A/xx unknown
- 1997-05-05 US US09/155,811 patent/US6117881A/en not_active Expired - Fee Related
- 1997-05-05 AT AT97922960T patent/ATE215950T1/de not_active IP Right Cessation
-
1998
- 1998-10-13 IS IS4864A patent/IS4864A/is unknown
- 1998-10-29 BG BG102879A patent/BG102879A/xx unknown
- 1998-11-09 NO NO985222A patent/NO985222L/no not_active Application Discontinuation
- 1998-11-09 OA OA9800218A patent/OA10920A/en unknown
-
2000
- 2000-06-12 US US09/592,514 patent/US6306870B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL126951A0 (en) | 1999-09-22 |
DE69711882T2 (de) | 2002-10-31 |
HUP9901478A3 (en) | 1999-11-29 |
CN1067071C (zh) | 2001-06-13 |
IS4864A (is) | 1998-10-13 |
PL329875A1 (en) | 1999-04-12 |
US6117881A (en) | 2000-09-12 |
JP2000513717A (ja) | 2000-10-17 |
EP0912567B1 (fr) | 2002-04-10 |
HUP9901478A2 (hu) | 1999-08-30 |
NO985222L (no) | 1999-01-11 |
EE9800390A (et) | 1999-06-15 |
TR199802282T2 (xx) | 1999-03-22 |
YU49898A (sh) | 2000-03-21 |
ATE215950T1 (de) | 2002-04-15 |
AU711885B2 (en) | 1999-10-21 |
EA199800907A1 (ru) | 1999-04-29 |
BR9709230A (pt) | 1999-08-10 |
CN1218471A (zh) | 1999-06-02 |
US6306870B1 (en) | 2001-10-23 |
AU2891097A (en) | 1997-12-05 |
NO985222D0 (no) | 1998-11-09 |
AP9801365A0 (en) | 1998-12-31 |
ES2175404T3 (es) | 2002-11-16 |
OA10920A (en) | 2003-02-21 |
DE69711882D1 (en) | 2002-05-16 |
KR20000010918A (ko) | 2000-02-25 |
BG102879A (en) | 1999-09-30 |
EP0912567A1 (fr) | 1999-05-06 |
CZ358598A3 (cs) | 1999-03-17 |
CA2253948A1 (fr) | 1997-11-20 |
WO1997043287A1 (fr) | 1997-11-20 |
CA2253948C (fr) | 2005-07-26 |
JP3418405B2 (ja) | 2003-06-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SK154498A3 (en) | Carboline derivatives, process for the preparation thereof, pharmaceutical compositions containing same and use of mentioned derivatives as drugs | |
US6043252A (en) | Carboline derivatives | |
JP4459807B2 (ja) | テトラヒドロピラニルシクロペンチルテトラヒドロイソキノリン系のケモカイン受容体活性調節剤 | |
AU702324B2 (en) | Cyclic GMP-specific phosphodiesterase inhibitors | |
RU2271358C2 (ru) | Производные бета-карболина, обладающие действием ингибиторов фосфодиэстеразы, фармацевтическая композиция (варианты), способ ее получения, способ ингибирования действия фосфодиэстеразы (варианты) и способ увеличения концентрации цгмф | |
US20070275990A1 (en) | Heterocyclic Spiro Compound | |
EP2224803B1 (fr) | Spiropipéridines utilisables en tant qu'inhibiteurs de la tryptase | |
JP2007519734A (ja) | アミノシクロペンチルピリドピラジノン系ケモカイン受容体活性調節剤 | |
KR20060015294A (ko) | 피라졸로-퀴나졸린 유도체, 그의 제조 방법 및 상기유도체의 키나제 저해제로서의 용도 | |
US7781453B2 (en) | Aminopyridine-derivatives | |
EP1029860B1 (fr) | Derives de benzofuranne | |
US20080139588A1 (en) | Pyrrolo[2,3-d]pyrimidine cytokine inhibitors | |
CZ16896A3 (en) | 9-substituted 2-(2-n-alkoxyphenyl) purin-6-ones, process of their preparation, pharmaceutical composition such compounds and their use | |
US20240239804A1 (en) | Furoindazole derivatives as antagonists or inhibitors of gpr84 | |
JP2007519633A (ja) | アルキルアミノ、アリールアミノおよびスルホンアミドシクロペンチルアミド系のケモカイン受容体活性調節剤 | |
WO2005110409A2 (fr) | Modulateurs tetrahydropyranyle cyclopentyle de tetrahydroisoquinoline 1 substituee et 1,1-disubstituee de l'activite des recepteurs de chimiokine | |
SK1772000A3 (en) | 8-substituted-9h-1,3-dioxolo(4,5-h)(2,3)benzodiazepine derivatives, as ampa/kainate receptor inhibitors | |
KR20030005176A (ko) | 4-피리딜- 및 2,4-피리미디닐-치환된 피롤 유도체 및 그의제약학에서의 용도 | |
US6100246A (en) | Spiro-piperidine derivatives as inhibitors of nitric oxide synthase | |
JP2009511463A (ja) | Hivインテグラーゼ酵素の阻害剤 | |
SK1792000A3 (en) | 1,3-DIOXOLO(4,5-H)(2,3)BENZODIAZEPINE DERIVATIVES, PROCESS FORì (54) THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION CO | |
WO2024194352A1 (fr) | Modulateurs de p2x3 deutérés | |
EA038451B1 (ru) | 7-замещенные 1-арил-нафтиридин-3-амиды карбоновых кислот и их применение | |
JPS62212372A (ja) | ピペラジン誘導体 |