SK13872001A3 - Trieda enzýmov v biosyntetickej dráhe na produkciu triacylglycerolu a rekombinantné molekuly DNA kódujúce tieto enzýmy - Google Patents
Trieda enzýmov v biosyntetickej dráhe na produkciu triacylglycerolu a rekombinantné molekuly DNA kódujúce tieto enzýmy Download PDFInfo
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- SK13872001A3 SK13872001A3 SK1387-2001A SK13872001A SK13872001A3 SK 13872001 A3 SK13872001 A3 SK 13872001A3 SK 13872001 A SK13872001 A SK 13872001A SK 13872001 A3 SK13872001 A3 SK 13872001A3
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- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 title claims abstract description 68
- 102000004190 Enzymes Human genes 0.000 title claims abstract description 49
- 108090000790 Enzymes Proteins 0.000 title claims abstract description 49
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 14
- 230000006696 biosynthetic metabolic pathway Effects 0.000 title claims abstract description 8
- 108020004511 Recombinant DNA Proteins 0.000 title claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 57
- 239000000194 fatty acid Substances 0.000 claims abstract description 57
- 229930195729 fatty acid Natural products 0.000 claims abstract description 57
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 52
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 34
- 150000001982 diacylglycerols Chemical class 0.000 claims abstract description 34
- 238000012546 transfer Methods 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 14
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 14
- 150000003626 triacylglycerols Chemical class 0.000 claims abstract description 13
- 230000008569 process Effects 0.000 claims abstract description 5
- 108030002650 Phospholipid:diacylglycerol acyltransferases Proteins 0.000 claims description 107
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 62
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 62
- 239000002773 nucleotide Substances 0.000 claims description 62
- 125000003729 nucleotide group Chemical group 0.000 claims description 62
- 210000004027 cell Anatomy 0.000 claims description 56
- 108090000623 proteins and genes Proteins 0.000 claims description 55
- 150000002632 lipids Chemical class 0.000 claims description 48
- 241000196324 Embryophyta Species 0.000 claims description 40
- 241000219195 Arabidopsis thaliana Species 0.000 claims description 36
- 239000002299 complementary DNA Substances 0.000 claims description 32
- 230000009261 transgenic effect Effects 0.000 claims description 29
- 230000000694 effects Effects 0.000 claims description 23
- 108020004414 DNA Proteins 0.000 claims description 21
- 239000012528 membrane Substances 0.000 claims description 19
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 16
- 239000013598 vector Substances 0.000 claims description 16
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- 235000007244 Zea mays Nutrition 0.000 claims description 9
- 150000001413 amino acids Chemical group 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 210000005253 yeast cell Anatomy 0.000 claims description 9
- 108010044467 Isoenzymes Proteins 0.000 claims description 8
- 241000235347 Schizosaccharomyces pombe Species 0.000 claims description 7
- 230000014509 gene expression Effects 0.000 claims description 7
- 230000036961 partial effect Effects 0.000 claims description 7
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims description 5
- 241000221961 Neurospora crassa Species 0.000 claims description 5
- 230000009466 transformation Effects 0.000 claims description 5
- 240000003768 Solanum lycopersicum Species 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 238000009825 accumulation Methods 0.000 claims description 3
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- 239000003795 chemical substances by application Substances 0.000 claims description 2
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- 108010050848 glycylleucine Proteins 0.000 claims 30
- 108010034529 leucyl-lysine Proteins 0.000 claims 20
- 108010055341 glutamyl-glutamic acid Proteins 0.000 claims 19
- 108010047495 alanylglycine Proteins 0.000 claims 18
- KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 claims 18
- 108010015792 glycyllysine Proteins 0.000 claims 16
- 108010051242 phenylalanylserine Proteins 0.000 claims 16
- SCCPDJAQCXWPTF-VKHMYHEASA-N Gly-Asp Chemical compound NCC(=O)N[C@H](C(O)=O)CC(O)=O SCCPDJAQCXWPTF-VKHMYHEASA-N 0.000 claims 14
- XGDCYUQSFDQISZ-BQBZGAKWSA-N Leu-Ser Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CO)C(O)=O XGDCYUQSFDQISZ-BQBZGAKWSA-N 0.000 claims 12
- NSTPXGARCQOSAU-VIFPVBQESA-N N-formyl-L-phenylalanine Chemical compound O=CN[C@H](C(=O)O)CC1=CC=CC=C1 NSTPXGARCQOSAU-VIFPVBQESA-N 0.000 claims 11
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- ISHNZELVUVPCHY-ZETCQYMHSA-N Lys-Gly-Gly Chemical compound NCCCC[C@H](N)C(=O)NCC(=O)NCC(O)=O ISHNZELVUVPCHY-ZETCQYMHSA-N 0.000 claims 10
- 108010038633 aspartylglutamate Proteins 0.000 claims 10
- CXISPYVYMQWFLE-VKHMYHEASA-N Ala-Gly Chemical compound C[C@H]([NH3+])C(=O)NCC([O-])=O CXISPYVYMQWFLE-VKHMYHEASA-N 0.000 claims 9
- RVKIPWVMZANZLI-UHFFFAOYSA-N H-Lys-Trp-OH Natural products C1=CC=C2C(CC(NC(=O)C(N)CCCCN)C(O)=O)=CNC2=C1 RVKIPWVMZANZLI-UHFFFAOYSA-N 0.000 claims 9
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- FSXRLASFHBWESK-UHFFFAOYSA-N dipeptide phenylalanyl-tyrosine Natural products C=1C=C(O)C=CC=1CC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FSXRLASFHBWESK-UHFFFAOYSA-N 0.000 claims 9
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- 108010058119 tryptophyl-glycyl-glycine Proteins 0.000 claims 9
- RLMISHABBKUNFO-WHFBIAKZSA-N Ala-Ala-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O RLMISHABBKUNFO-WHFBIAKZSA-N 0.000 claims 8
- NIZKGBJVCMRDKO-KWQFWETISA-N Ala-Gly-Tyr Chemical compound C[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 NIZKGBJVCMRDKO-KWQFWETISA-N 0.000 claims 8
- OMLWNBVRVJYMBQ-YUMQZZPRSA-N Arg-Arg Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O OMLWNBVRVJYMBQ-YUMQZZPRSA-N 0.000 claims 8
- SBHUBSDEZQFJHJ-CIUDSAMLSA-N Asp-Asp-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CC(O)=O SBHUBSDEZQFJHJ-CIUDSAMLSA-N 0.000 claims 8
- UVTSZKIATYSKIR-RYUDHWBXSA-N Gly-Tyr-Glu Chemical compound [H]NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O UVTSZKIATYSKIR-RYUDHWBXSA-N 0.000 claims 8
- KIAOPHMUNPPGEN-PEXQALLHSA-N Ile-Gly-His Chemical compound CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CC1=CN=CN1)C(=O)O)N KIAOPHMUNPPGEN-PEXQALLHSA-N 0.000 claims 8
- 108010063718 gamma-glutamylaspartic acid Proteins 0.000 claims 8
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- ZBYLEBZCVKLPCY-FXQIFTODSA-N Asp-Ser-Arg Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O ZBYLEBZCVKLPCY-FXQIFTODSA-N 0.000 claims 7
- LKDIBBOKUAASNP-FXQIFTODSA-N Glu-Ala-Glu Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(O)=O LKDIBBOKUAASNP-FXQIFTODSA-N 0.000 claims 7
- HGJREIGJLUQBTJ-SZMVWBNQSA-N Glu-Trp-Leu Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(O)=O HGJREIGJLUQBTJ-SZMVWBNQSA-N 0.000 claims 7
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- 108010049041 glutamylalanine Proteins 0.000 claims 7
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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EP99106656 | 1999-04-01 | ||
EP99111321 | 1999-06-10 | ||
US18068700P | 2000-02-07 | 2000-02-07 | |
PCT/EP2000/002701 WO2000060095A2 (en) | 1999-04-01 | 2000-03-28 | Enzymes of the biosynthetic pathway for the production of triacylglycerol and recombinant dna molecules encoding these enzymes |
Publications (1)
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SK13872001A3 true SK13872001A3 (sk) | 2002-06-04 |
Family
ID=26152952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SK1387-2001A SK13872001A3 (sk) | 1999-04-01 | 2000-03-28 | Trieda enzýmov v biosyntetickej dráhe na produkciu triacylglycerolu a rekombinantné molekuly DNA kódujúce tieto enzýmy |
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US (2) | US7427593B1 (xx) |
EP (1) | EP1165803B1 (xx) |
JP (1) | JP2002541783A (xx) |
CN (1) | CN1230541C (xx) |
AT (1) | ATE356213T1 (xx) |
AU (1) | AU777031B2 (xx) |
BR (1) | BR0009510A (xx) |
CA (1) | CA2366187C (xx) |
CZ (1) | CZ20013529A3 (xx) |
DE (1) | DE60033793T2 (xx) |
ES (1) | ES2283294T3 (xx) |
HU (1) | HUP0200480A3 (xx) |
IL (1) | IL145307A (xx) |
MX (1) | MXPA01009577A (xx) |
NO (1) | NO20014716L (xx) |
PL (1) | PL351260A1 (xx) |
RU (1) | RU2272073C2 (xx) |
SK (1) | SK13872001A3 (xx) |
TR (1) | TR200102859T2 (xx) |
UA (1) | UA75041C2 (xx) |
WO (1) | WO2000060095A2 (xx) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60045117D1 (de) * | 1999-08-30 | 2010-11-25 | Monsanto Technology Llc | Pflanzen-Sterol-Acyltransferasen |
US7045326B2 (en) | 2001-02-23 | 2006-05-16 | The Regents Of The University Of California | Mono- and diacylglycerol acyltransferases and methods of use thereof |
US20020119138A1 (en) | 2001-02-26 | 2002-08-29 | Sylvaine Cases | Diacylglycerol o-acyltransferase 2alpha (DGAT2alpha) |
US7229815B2 (en) * | 2001-08-30 | 2007-06-12 | Indian Institute Of Science | Triacylglycerol biosynthesis in the cytosol of eukaryotes |
AU2002357298B2 (en) | 2001-12-17 | 2008-07-10 | E. I. Du Pont De Nemours And Company | Phospholipid:diacylglycerol acyltransferases |
AU2003223975A1 (en) * | 2002-03-30 | 2003-10-13 | Basf Plant Science Gmbh | Expression of phospholipid:diacylglycerine acyltransferase (pdat) for the production of plant storage lipids with polyunsaturated fatty acids |
SE0201581D0 (sv) * | 2002-05-29 | 2002-05-29 | Scandinavian Biotechnology Res | New improved acyltransferase |
CA2491234A1 (en) | 2002-07-10 | 2004-01-22 | Basf Plant Science Gmbh | Use of a gene for increasing the oil content in plants |
US7267976B2 (en) | 2003-07-02 | 2007-09-11 | E.I. Du Pont De Nemours And Company | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts |
US7479374B2 (en) | 2003-07-09 | 2009-01-20 | National University Of Singapore | Triacylglycerol-deficient fission yeast and its uses |
US7273746B2 (en) | 2004-11-04 | 2007-09-25 | E.I. Dupont De Nemours And Company | Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
JP4803584B2 (ja) * | 2006-02-08 | 2011-10-26 | 独立行政法人産業技術総合研究所 | 脂質生産性の高い形質転換微生物 |
CA2693630C (en) | 2006-07-14 | 2021-08-31 | Commonwealth Scientific And Industrial Research Organisation | Altering the fatty acid composition of rice |
CA2768737A1 (en) | 2008-07-21 | 2010-01-28 | Commonwealth Scientific And Industrial Research Organisation | Improved vegetable oils and uses therefor |
ES2603530T3 (es) | 2008-07-21 | 2017-02-28 | Commonwealth Scientific And Industrial Research Organisation | Aceite de semilla de algodón mejorado y usos |
US8394621B2 (en) | 2008-10-23 | 2013-03-12 | Matrix Genetrics, LLC | Modified photosynthetic microorganisms for producing triglycerides |
US8835137B2 (en) * | 2008-12-23 | 2014-09-16 | Matrix Genetics, Llc | Modified photosynthetic microorganisms with reduced glycogen and their use in producing carbon-based products |
EP2518147B1 (en) | 2009-12-21 | 2017-10-11 | Suntory Holdings Limited | Diacylglycerole acyltransferase gene, and use thereof |
RU2545375C2 (ru) * | 2010-02-03 | 2015-03-27 | Сантори Холдингз Лимитед | Гомолог глицерол-3-фосфат-ацилтрансферазы и его использование |
US8980613B2 (en) | 2010-04-06 | 2015-03-17 | Matrix Genetics, Llc | Modified photosynthetic microorganisms for producing lipids |
FI122886B (fi) | 2010-06-24 | 2012-08-31 | Valtion Teknillinen | Geneettisesti muokattuja sieniä ja niiden käyttö lipidituotannossa |
AU2011274301B2 (en) | 2010-06-28 | 2015-06-11 | Nuseed Global Innovation Ltd | Methods of producing lipids |
JP5800311B2 (ja) * | 2011-01-27 | 2015-10-28 | 国立大学法人東京工業大学 | 植物油脂の製造方法 |
CN102492742A (zh) * | 2011-04-27 | 2012-06-13 | 北京大学 | 促进植物营养组织中异位产三酰甘油的培养基及其应用 |
US8951776B2 (en) * | 2011-10-19 | 2015-02-10 | Massachusetts Institute Of Technology | Engineered microbes and methods for microbial oil production |
US8735111B2 (en) | 2011-12-27 | 2014-05-27 | Commonwealth Scientific And Industrial Research Organisation | Processes for producing hydrocarbon products |
US8809026B2 (en) | 2011-12-27 | 2014-08-19 | Commonwealth Scientific And Industrial Research Organisation | Processes for producing lipids |
US11639507B2 (en) | 2011-12-27 | 2023-05-02 | Commonwealth Scientific And Industrial Research Organisation | Processes for producing lipids |
NZ631696A (en) | 2012-04-25 | 2017-02-24 | Grains Res & Dev Corp | High oleic acid oils |
EP2861728B1 (en) * | 2012-06-19 | 2017-12-27 | E. I. du Pont de Nemours and Company | Improved production of polyunsaturated fatty acids by coexpression of acyl-coa: lysophosphatidylcholine acyltransferases and phospholipid: diacylglycerol acyltransferases |
ES2969618T3 (es) | 2014-07-07 | 2024-05-21 | Nuseed Global Innovation Ltd | Procesos para producir productos industriales de lípidos vegetales |
JP6580912B2 (ja) | 2015-09-11 | 2019-09-25 | 花王株式会社 | 脂質の製造方法 |
US11859193B2 (en) | 2016-09-02 | 2024-01-02 | Nuseed Global Innovation Ltd. | Plants with modified traits |
CN110386966A (zh) * | 2018-04-23 | 2019-10-29 | 中国科学院大连化学物理研究所 | 一种含有叶绿体转运肽的基因序列的应用 |
Family Cites Families (6)
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GB9510927D0 (en) * | 1995-05-31 | 1995-07-26 | Ca Nat Research Council | Plant and seed oil modification |
KR20010013431A (ko) * | 1997-06-05 | 2001-02-26 | 칼진 엘엘시 | 디아실글리세롤 아실 트란스페라제 단백질 |
CA2703147C (en) | 1998-12-02 | 2014-07-29 | Karlene H. Butler | Plant diacylglycerol acyltransferases |
US7157619B1 (en) * | 1999-08-30 | 2007-01-02 | Monsanto Technology, L.L.C. | Plant sterol acyltransferases |
US6791008B1 (en) * | 1999-11-12 | 2004-09-14 | Scandinavian Biotechnology Research (Scanbi) Ab | Use of a class of enzymes and their encoding genes to increase the oil content in transgenic organisms |
CN1294265C (zh) * | 1999-11-12 | 2007-01-10 | 斯堪的纳维亚生物技术研究公司 | 应用一类酶及其编码基因增加转基因生物的含油量 |
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- 2000-03-28 AU AU38147/00A patent/AU777031B2/en not_active Ceased
- 2000-03-28 EP EP00917001A patent/EP1165803B1/en not_active Expired - Lifetime
- 2000-03-28 IL IL145307A patent/IL145307A/en active IP Right Grant
- 2000-03-28 BR BR0009510-9A patent/BR0009510A/pt not_active Application Discontinuation
- 2000-03-28 CA CA2366187A patent/CA2366187C/en not_active Expired - Fee Related
- 2000-03-28 CN CNB008059985A patent/CN1230541C/zh not_active Expired - Fee Related
- 2000-03-28 TR TR2001/02859T patent/TR200102859T2/xx unknown
- 2000-03-28 WO PCT/EP2000/002701 patent/WO2000060095A2/en active IP Right Grant
- 2000-03-28 AT AT00917001T patent/ATE356213T1/de not_active IP Right Cessation
- 2000-03-28 RU RU2001129499/13A patent/RU2272073C2/ru not_active IP Right Cessation
- 2000-03-28 DE DE60033793T patent/DE60033793T2/de not_active Expired - Lifetime
- 2000-03-28 HU HU0200480A patent/HUP0200480A3/hu unknown
- 2000-03-28 SK SK1387-2001A patent/SK13872001A3/sk unknown
- 2000-03-28 PL PL00351260A patent/PL351260A1/xx not_active Application Discontinuation
- 2000-03-28 UA UA2001107429A patent/UA75041C2/uk unknown
- 2000-03-28 CZ CZ20013529A patent/CZ20013529A3/cs unknown
- 2000-03-28 ES ES00917001T patent/ES2283294T3/es not_active Expired - Lifetime
- 2000-03-28 MX MXPA01009577A patent/MXPA01009577A/es active IP Right Grant
- 2000-03-30 US US09/537,710 patent/US7427593B1/en not_active Expired - Fee Related
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2001
- 2001-09-28 NO NO20014716A patent/NO20014716L/no not_active Application Discontinuation
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2007
- 2007-02-27 US US11/679,791 patent/US7635582B2/en not_active Expired - Fee Related
Also Published As
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CA2366187C (en) | 2010-05-25 |
US20080160592A1 (en) | 2008-07-03 |
JP2002541783A (ja) | 2002-12-10 |
WO2000060095A2 (en) | 2000-10-12 |
US7635582B2 (en) | 2009-12-22 |
CN1362994A (zh) | 2002-08-07 |
UA75041C2 (en) | 2006-03-15 |
DE60033793D1 (de) | 2007-04-19 |
NO20014716D0 (no) | 2001-09-28 |
US7427593B1 (en) | 2008-09-23 |
CN1230541C (zh) | 2005-12-07 |
ATE356213T1 (de) | 2007-03-15 |
WO2000060095A3 (en) | 2001-02-01 |
IL145307A0 (en) | 2002-06-30 |
MXPA01009577A (es) | 2003-07-21 |
IL145307A (en) | 2007-12-03 |
AU777031B2 (en) | 2004-09-30 |
HUP0200480A3 (en) | 2009-08-28 |
CZ20013529A3 (cs) | 2002-02-13 |
AU3814700A (en) | 2000-10-23 |
DE60033793T2 (de) | 2007-12-06 |
CA2366187A1 (en) | 2000-10-12 |
TR200102859T2 (tr) | 2002-01-21 |
NO20014716L (no) | 2001-11-28 |
EP1165803B1 (en) | 2007-03-07 |
EP1165803A2 (en) | 2002-01-02 |
HUP0200480A2 (hu) | 2002-07-29 |
ES2283294T3 (es) | 2007-11-01 |
PL351260A1 (en) | 2003-04-07 |
BR0009510A (pt) | 2002-04-23 |
RU2272073C2 (ru) | 2006-03-20 |
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