SK11897A3 - 17alpha-dammara compounds, preparation method thereof, pharmaceutical compositions containing them and their use - Google Patents
17alpha-dammara compounds, preparation method thereof, pharmaceutical compositions containing them and their use Download PDFInfo
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- SK11897A3 SK11897A3 SK118-97A SK11897A SK11897A3 SK 11897 A3 SK11897 A3 SK 11897A3 SK 11897 A SK11897 A SK 11897A SK 11897 A3 SK11897 A3 SK 11897A3
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- damar
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- 238000010322 bone marrow transplantation Methods 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
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- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
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- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
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- 238000013375 chromatographic separation Methods 0.000 description 1
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- 229910052802 copper Inorganic materials 0.000 description 1
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- 229960001334 corticosteroids Drugs 0.000 description 1
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- 231100000263 cytotoxicity test Toxicity 0.000 description 1
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- 239000002027 dichloromethane extract Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- IJKVHSBPTUYDLN-UHFFFAOYSA-N dihydroxy(oxo)silane Chemical compound O[Si](O)=O IJKVHSBPTUYDLN-UHFFFAOYSA-N 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
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- 238000002651 drug therapy Methods 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 201000002491 encephalomyelitis Diseases 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 238000007824 enzymatic assay Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- DQYBDCGIPTYXML-UHFFFAOYSA-N ethoxyethane;hydrate Chemical compound O.CCOCC DQYBDCGIPTYXML-UHFFFAOYSA-N 0.000 description 1
- 239000002024 ethyl acetate extract Substances 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
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- 229960002442 glucosamine Drugs 0.000 description 1
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- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
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- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
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- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010829 isocratic elution Methods 0.000 description 1
- 150000002641 lithium Chemical group 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 206010028417 myasthenia gravis Diseases 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 238000013059 nephrectomy Methods 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 229920002113 octoxynol Polymers 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 150000002895 organic esters Chemical class 0.000 description 1
- 229940046781 other immunosuppressants in atc Drugs 0.000 description 1
- KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
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- 239000013641 positive control Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- IUBQJLUDMLPAGT-UHFFFAOYSA-N potassium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([K])[Si](C)(C)C IUBQJLUDMLPAGT-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
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- 210000000278 spinal cord Anatomy 0.000 description 1
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- 238000003756 stirring Methods 0.000 description 1
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- 238000007910 systemic administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
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- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 150000003648 triterpenes Chemical class 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
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- 235000013311 vegetables Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0014—Androstane derivatives substituted in position 17 alfa, not substituted in position 17 beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9415161A GB9415161D0 (en) | 1994-07-27 | 1994-07-27 | Organic compounds |
| PCT/EP1995/002913 WO1996003419A1 (en) | 1994-07-27 | 1995-07-24 | Tetracyclic triterpenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK11897A3 true SK11897A3 (en) | 1997-08-06 |
Family
ID=10758967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK118-97A SK11897A3 (en) | 1994-07-27 | 1995-07-24 | 17alpha-dammara compounds, preparation method thereof, pharmaceutical compositions containing them and their use |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5852005A (tr) |
| EP (1) | EP0801653A2 (tr) |
| JP (1) | JPH10503191A (tr) |
| AU (1) | AU704929B2 (tr) |
| BR (1) | BR9508344A (tr) |
| CA (1) | CA2192789A1 (tr) |
| CZ (1) | CZ23497A3 (tr) |
| FI (1) | FI970320A (tr) |
| GB (1) | GB9415161D0 (tr) |
| HU (1) | HUT76831A (tr) |
| IL (1) | IL114723A0 (tr) |
| MX (1) | MX9700554A (tr) |
| NO (1) | NO970329L (tr) |
| NZ (1) | NZ290430A (tr) |
| PE (1) | PE35596A1 (tr) |
| PL (1) | PL318145A1 (tr) |
| SK (1) | SK11897A3 (tr) |
| TR (1) | TR199500905A2 (tr) |
| WO (1) | WO1996003419A1 (tr) |
| ZA (1) | ZA956279B (tr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6124362A (en) * | 1998-07-17 | 2000-09-26 | The Procter & Gamble Company | Method for regulating hair growth |
| US6450168B1 (en) | 2001-04-17 | 2002-09-17 | Kellie I. Nguyen | Infant sleeping blanket/garment for use with medical devices |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| CN109985052A (zh) * | 2017-12-29 | 2019-07-09 | 上海蓝木化工有限公司 | 三萜类化合物的新用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3644421A (en) * | 1968-12-02 | 1972-02-22 | Syntex Corp | 4-oxa-3-keto-delta**1-pregnene derivatives |
| US3868453A (en) * | 1970-03-04 | 1975-02-25 | Philips Corp | 16-Methylene-9/beta, 10alpha-steroid compounds, pharmaceutical preparations which contain the novel compounds as active ingredients and methods of producing the said compounds and preparations |
| US4057543A (en) * | 1976-07-01 | 1977-11-08 | G. D. Searle & Co. | Process for the preparation of 17β-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone |
| US4636496A (en) * | 1984-03-20 | 1987-01-13 | Wayne State University | Compositions inhibiting murine MXT ductal carcinoma |
| US4755504A (en) * | 1985-10-03 | 1988-07-05 | Yaguang Liu | Pharmaceutical composition from Tienchi |
| JPH04243833A (ja) * | 1991-01-28 | 1992-08-31 | Tsumura & Co | １１β−ヒドロキシステロイドデヒドロゲナーゼ阻害剤 |
-
1994
- 1994-07-27 GB GB9415161A patent/GB9415161D0/en active Pending
-
1995
- 1995-07-17 ZA ZA956279A patent/ZA956279B/xx unknown
- 1995-07-24 CA CA002192789A patent/CA2192789A1/en not_active Abandoned
- 1995-07-24 WO PCT/EP1995/002913 patent/WO1996003419A1/en not_active Application Discontinuation
- 1995-07-24 US US08/776,442 patent/US5852005A/en not_active Expired - Fee Related
- 1995-07-24 PL PL95318145A patent/PL318145A1/xx unknown
- 1995-07-24 EP EP95926974A patent/EP0801653A2/en not_active Withdrawn
- 1995-07-24 NZ NZ290430A patent/NZ290430A/en unknown
- 1995-07-24 CZ CZ97234A patent/CZ23497A3/cs unknown
- 1995-07-24 HU HU9700246A patent/HUT76831A/hu unknown
- 1995-07-24 AU AU31166/95A patent/AU704929B2/en not_active Ceased
- 1995-07-24 MX MX9700554A patent/MX9700554A/es unknown
- 1995-07-24 BR BR9508344A patent/BR9508344A/pt not_active Application Discontinuation
- 1995-07-24 JP JP8505467A patent/JPH10503191A/ja active Pending
- 1995-07-24 SK SK118-97A patent/SK11897A3/sk unknown
- 1995-07-25 IL IL11472395A patent/IL114723A0/xx unknown
- 1995-07-26 PE PE1995274759A patent/PE35596A1/es not_active Application Discontinuation
- 1995-07-27 TR TR95/00905A patent/TR199500905A2/tr unknown
-
1997
- 1997-01-24 NO NO970329A patent/NO970329L/no unknown
- 1997-01-24 FI FI970320A patent/FI970320A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ290430A (en) | 1998-01-26 |
| TR199500905A2 (tr) | 1996-06-21 |
| FI970320A0 (fi) | 1997-01-24 |
| CZ23497A3 (en) | 1997-07-16 |
| EP0801653A2 (en) | 1997-10-22 |
| US5852005A (en) | 1998-12-22 |
| JPH10503191A (ja) | 1998-03-24 |
| WO1996003419A1 (en) | 1996-02-08 |
| EP0801653A3 (tr) | 1997-10-29 |
| NO970329L (no) | 1997-03-25 |
| CA2192789A1 (en) | 1996-02-08 |
| GB9415161D0 (en) | 1994-09-14 |
| PL318145A1 (en) | 1997-05-12 |
| PE35596A1 (es) | 1996-09-04 |
| AU704929B2 (en) | 1999-05-06 |
| AU3116695A (en) | 1996-02-22 |
| IL114723A0 (en) | 1995-11-27 |
| NO970329D0 (no) | 1997-01-24 |
| MX9700554A (es) | 1997-05-31 |
| BR9508344A (pt) | 1998-07-14 |
| FI970320A (fi) | 1997-01-24 |
| ZA956279B (en) | 1997-01-27 |
| HUT76831A (en) | 1997-11-28 |
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