SK11452001A3 - Deriváty epotilónu, farmaceutický prípravok s ich obsahom a ich použitie - Google Patents
Deriváty epotilónu, farmaceutický prípravok s ich obsahom a ich použitie Download PDFInfo
- Publication number
- SK11452001A3 SK11452001A3 SK1145-2001A SK11452001A SK11452001A3 SK 11452001 A3 SK11452001 A3 SK 11452001A3 SK 11452001 A SK11452001 A SK 11452001A SK 11452001 A3 SK11452001 A3 SK 11452001A3
- Authority
- SK
- Slovakia
- Prior art keywords
- methyl
- group
- ethenyl
- dihydroxy
- dione
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1999107480 DE19907480A1 (de) | 1999-02-11 | 1999-02-11 | Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
DE19954229A DE19954229A1 (de) | 1999-11-04 | 1999-11-04 | Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
PCT/EP2000/001104 WO2000047584A2 (fr) | 1999-02-11 | 2000-02-11 | Derives d'epothilone, leur procede de production et leur utilisation pharmaceutique |
Publications (1)
Publication Number | Publication Date |
---|---|
SK11452001A3 true SK11452001A3 (sk) | 2002-04-04 |
Family
ID=26051977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1145-2001A SK11452001A3 (sk) | 1999-02-11 | 2000-02-11 | Deriváty epotilónu, farmaceutický prípravok s ich obsahom a ich použitie |
Country Status (21)
Country | Link |
---|---|
US (2) | US7001916B1 (fr) |
EP (1) | EP1161430A2 (fr) |
JP (1) | JP2002536450A (fr) |
KR (1) | KR20010094763A (fr) |
CN (1) | CN1340053A (fr) |
AU (1) | AU4101800A (fr) |
BG (1) | BG105803A (fr) |
BR (1) | BR0008206A (fr) |
CA (1) | CA2360952A1 (fr) |
CZ (1) | CZ20012886A3 (fr) |
EA (1) | EA200100833A1 (fr) |
EE (1) | EE200100422A (fr) |
HK (1) | HK1044946A1 (fr) |
HU (1) | HUP0105330A2 (fr) |
IL (1) | IL144370A0 (fr) |
MX (1) | MXPA01008148A (fr) |
NO (1) | NO20013900L (fr) |
PL (1) | PL350190A1 (fr) |
SK (1) | SK11452001A3 (fr) |
WO (1) | WO2000047584A2 (fr) |
YU (1) | YU57601A (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2273083C (fr) | 1996-12-03 | 2012-09-18 | Sloan-Kettering Institute For Cancer Research | Synthese d'epothilones, intermediaires utilises dans leur synthese, analogues et utilisations de celles-ci |
US6660758B1 (en) * | 1996-12-13 | 2003-12-09 | The Scripps Research Institute | Epothilone analogs |
AU772750C (en) * | 1999-04-30 | 2005-02-24 | Schering Aktiengesellschaft | 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations |
US7723339B2 (en) * | 2001-02-27 | 2010-05-25 | Novartis Ag | Combination comprising a signal transduction inhibitor and an epothilone derivative |
AU2002331171A1 (en) * | 2001-08-23 | 2003-03-10 | Novartis Pharma Gmbh | Cyclopropyl and cyclobutyl epothilone analogs |
ES2337134T3 (es) | 2002-03-12 | 2010-04-21 | Bristol-Myers Squibb Company | Derivados de c3-ciano-epotilona. |
CN101816792A (zh) * | 2002-06-10 | 2010-09-01 | 诺瓦提斯公司 | 包含埃坡霉素的组合及其药学用途 |
CN1671856B (zh) * | 2002-07-31 | 2010-05-12 | 卫材R&D管理株式会社 | 生理活性物质 |
US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
EP1589011A1 (fr) * | 2004-04-22 | 2005-10-26 | Schering Aktiengesellschaft | Nouveaux dérivés chiraux d'heptyne pour la préparation des epothilones et procédés pour leur préparation |
EP2634252B1 (fr) | 2005-02-11 | 2018-12-19 | University of Southern California | Procédé d'expression de protéines avec des ponts disulfures |
WO2007130501A2 (fr) * | 2006-05-01 | 2007-11-15 | University Of Southern California | Polythérapie pour traiter le cancer |
US20100113128A1 (en) * | 2008-11-05 | 2010-05-06 | Snow Richard N | Methods and apparatus for determining a reel strip position |
WO2010056901A2 (fr) | 2008-11-13 | 2010-05-20 | University Of Southern California | Procédé d'expression de protéines avec ponts disulfure avec des rendements et une activité améliorés |
US20100125146A1 (en) * | 2008-11-19 | 2010-05-20 | Johnson Matthey Public Limited Company | Method for making pharmaceutical compounds |
EP3566719A1 (fr) | 2010-05-18 | 2019-11-13 | Cerulean Pharma Inc. | Compositions et procédés pour le traitement de maladies auto-immunes et d'autres maladies |
EP3371176A4 (fr) * | 2015-10-16 | 2019-09-04 | William Marsh Rice University | Analogues d'épothilone, procédés de synthèse, procédés de traitement, et conjugués médicamenteux de ceux-ci |
WO2017096559A1 (fr) * | 2015-12-09 | 2017-06-15 | Rhodia Operations | Production de dérivés de xylène |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
US5469145A (en) | 1992-05-29 | 1995-11-21 | Johnson; Lonnie | Wet diaper detector |
PT1186606E (pt) | 1995-11-17 | 2004-08-31 | Biotechnolog Forschung Mbh Gbf | Derivados do epotilone sua preparacao e utilizacao |
US6441025B2 (en) | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
US5969145A (en) | 1996-08-30 | 1999-10-19 | Novartis Ag | Process for the production of epothilones and intermediate products within the process |
NZ334821A (en) | 1996-08-30 | 2000-12-22 | Novartis Ag | Method for producing epothilones |
DE19636343C1 (de) | 1996-08-30 | 1997-10-23 | Schering Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B |
CA2273083C (fr) * | 1996-12-03 | 2012-09-18 | Sloan-Kettering Institute For Cancer Research | Synthese d'epothilones, intermediaires utilises dans leur synthese, analogues et utilisations de celles-ci |
US6867305B2 (en) * | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
DE19701758A1 (de) | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | Epothilone-Synthesebausteine |
US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
US7407975B2 (en) | 1997-08-09 | 2008-08-05 | Bayer Schering Pharma Ag | Epothilone derivatives, method for producing same and their pharmaceutical use |
WO1999067253A2 (fr) | 1998-06-22 | 1999-12-29 | Novartis Ag | Desmethylepothilones |
AU6208701A (en) | 2000-03-09 | 2001-09-17 | Schering Aktiengesellschaft | Radioactively labeled epothilone derivatives, method for the production thereof, and their biochemical and pharmaceutical use |
CA2359267A1 (fr) | 2000-10-19 | 2002-04-19 | Manabu Takami | Module et appareil de selection d'une longueur d'onde |
EP1340498A1 (fr) * | 2002-03-01 | 2003-09-03 | Schering Aktiengesellschaft | Utilisation d'épothilones dans le traitement de maladies du cerveau associées aux processus de prolifération |
JP2006505627A (ja) * | 2002-07-31 | 2006-02-16 | シエーリング アクチエンゲゼルシャフト | 新規エフェクター接合体、それらの生成方法及びそれらの医薬使用 |
US7138279B2 (en) | 2002-08-13 | 2006-11-21 | Kosan Biosciences, Inc. | Transposon-based transformation system |
-
2000
- 2000-02-11 IL IL14437000A patent/IL144370A0/xx unknown
- 2000-02-11 KR KR1020017010109A patent/KR20010094763A/ko not_active Application Discontinuation
- 2000-02-11 CN CN00803717A patent/CN1340053A/zh active Pending
- 2000-02-11 PL PL00350190A patent/PL350190A1/xx not_active Application Discontinuation
- 2000-02-11 CZ CZ20012886A patent/CZ20012886A3/cs unknown
- 2000-02-11 EE EEP200100422A patent/EE200100422A/xx unknown
- 2000-02-11 CA CA002360952A patent/CA2360952A1/fr not_active Abandoned
- 2000-02-11 BR BR0008206-6A patent/BR0008206A/pt not_active IP Right Cessation
- 2000-02-11 EP EP00920433A patent/EP1161430A2/fr not_active Withdrawn
- 2000-02-11 HU HU0105330A patent/HUP0105330A2/hu unknown
- 2000-02-11 WO PCT/EP2000/001104 patent/WO2000047584A2/fr not_active Application Discontinuation
- 2000-02-11 YU YU57601A patent/YU57601A/sh unknown
- 2000-02-11 US US09/913,163 patent/US7001916B1/en not_active Expired - Fee Related
- 2000-02-11 SK SK1145-2001A patent/SK11452001A3/sk unknown
- 2000-02-11 JP JP2000598504A patent/JP2002536450A/ja active Pending
- 2000-02-11 AU AU41018/00A patent/AU4101800A/en not_active Abandoned
- 2000-02-11 MX MXPA01008148A patent/MXPA01008148A/es unknown
- 2000-02-11 EA EA200100833A patent/EA200100833A1/ru unknown
-
2001
- 2001-08-09 BG BG105803A patent/BG105803A/xx unknown
- 2001-08-10 NO NO20013900A patent/NO20013900L/no not_active Application Discontinuation
-
2002
- 2002-09-03 HK HK02106492.8A patent/HK1044946A1/zh unknown
-
2005
- 2005-07-27 US US11/189,787 patent/US20060040990A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL144370A0 (en) | 2002-05-23 |
CN1340053A (zh) | 2002-03-13 |
HUP0105330A2 (hu) | 2002-05-29 |
EA200100833A1 (ru) | 2002-02-28 |
WO2000047584A2 (fr) | 2000-08-17 |
CZ20012886A3 (cs) | 2001-11-14 |
YU57601A (sh) | 2005-06-10 |
US20060040990A1 (en) | 2006-02-23 |
WO2000047584A3 (fr) | 2000-12-28 |
EE200100422A (et) | 2002-12-16 |
BR0008206A (pt) | 2002-02-19 |
EP1161430A2 (fr) | 2001-12-12 |
AU4101800A (en) | 2000-08-29 |
NO20013900D0 (no) | 2001-08-10 |
BG105803A (en) | 2002-03-29 |
KR20010094763A (ko) | 2001-11-01 |
US7001916B1 (en) | 2006-02-21 |
MXPA01008148A (es) | 2003-07-21 |
NO20013900L (no) | 2001-10-11 |
HK1044946A1 (zh) | 2002-11-08 |
CA2360952A1 (fr) | 2000-08-17 |
JP2002536450A (ja) | 2002-10-29 |
PL350190A1 (en) | 2002-11-18 |
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