YU57601A - Epotilon derivati, postupak za njihovu izradu i njihova farmaceutska primena - Google Patents
Epotilon derivati, postupak za njihovu izradu i njihova farmaceutska primenaInfo
- Publication number
- YU57601A YU57601A YU57601A YUP57601A YU57601A YU 57601 A YU57601 A YU 57601A YU 57601 A YU57601 A YU 57601A YU P57601 A YUP57601 A YU P57601A YU 57601 A YU57601 A YU 57601A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- methyl
- residue
- pyridyl
- hydrogen
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Ovaj pronalazak opisuje nove epotilon derivate opste formule (I) u kojoj znace R4 vodonik, C1-C10-alkil, aril, C7-C20-aralkil, R5 vodonik, C1-C10-alkil, aril, C7-C10-aralkil, R6 i R7 po vodonik, zajedno dodatnu vezu ili atom kiseonika, R8 metil grupu ili vodonik, kao i da stoje X za 2-piridil, 2-metil-4-tiazolil ili 2-metil-oksazolil ostatak ili jednovremeno R1a i R1b zajedno za trimetilen grupu, R2 za metil, etil ili propil grupu kao i X za 2-piridil, 2-metil-4-tiazolil ili 2-metil-4-oksazolil ostatak ili jednovremeno R1a i R1b uvek za metil grupu, R2 za metil, etil, ili propil i X za 2-piridil, 2-metil-tiazolil ili 2-metil-4-oksazolil ostatak, pri cemu atom azota i/ili sumpora u X moze da se nalazi u oksidovanom obliku i pri cemu, kada R2 i R8 uvek znace metil ostatak, X moze da bude samo u datom slucaju na atomu azota oksidovani 2-piridil ostatak, ukljucujuci sve moguce stereoizomere kao i njihove smese. Nova jedinjenja su podesna za izradu lekova.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1999107480 DE19907480A1 (de) | 1999-02-11 | 1999-02-11 | Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
DE19954229A DE19954229A1 (de) | 1999-11-04 | 1999-11-04 | Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
YU57601A true YU57601A (sh) | 2005-06-10 |
Family
ID=26051977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU57601A YU57601A (sh) | 1999-02-11 | 2000-02-11 | Epotilon derivati, postupak za njihovu izradu i njihova farmaceutska primena |
Country Status (21)
Country | Link |
---|---|
US (2) | US7001916B1 (sh) |
EP (1) | EP1161430A2 (sh) |
JP (1) | JP2002536450A (sh) |
KR (1) | KR20010094763A (sh) |
CN (1) | CN1340053A (sh) |
AU (1) | AU4101800A (sh) |
BG (1) | BG105803A (sh) |
BR (1) | BR0008206A (sh) |
CA (1) | CA2360952A1 (sh) |
CZ (1) | CZ20012886A3 (sh) |
EA (1) | EA200100833A1 (sh) |
EE (1) | EE200100422A (sh) |
HK (1) | HK1044946A1 (sh) |
HU (1) | HUP0105330A2 (sh) |
IL (1) | IL144370A0 (sh) |
MX (1) | MXPA01008148A (sh) |
NO (1) | NO20013900L (sh) |
PL (1) | PL350190A1 (sh) |
SK (1) | SK11452001A3 (sh) |
WO (1) | WO2000047584A2 (sh) |
YU (1) | YU57601A (sh) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0977563B1 (en) | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6660758B1 (en) * | 1996-12-13 | 2003-12-09 | The Scripps Research Institute | Epothilone analogs |
US7125893B1 (en) * | 1999-04-30 | 2006-10-24 | Schering Ag | 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations |
CA2439268C (en) * | 2001-02-27 | 2010-01-19 | Novartis Ag | Combination comprising a signal transduction inhibitor and an epothilone derivative |
AU2002331171A1 (en) * | 2001-08-23 | 2003-03-10 | Novartis Pharma Gmbh | Cyclopropyl and cyclobutyl epothilone analogs |
WO2003078411A1 (en) | 2002-03-12 | 2003-09-25 | Bristol-Myers Squibb Company | C3-cyano epothilone derivatives |
CN101816792A (zh) * | 2002-06-10 | 2010-09-01 | 诺瓦提斯公司 | 包含埃坡霉素的组合及其药学用途 |
JP4328293B2 (ja) * | 2002-07-31 | 2009-09-09 | メルシャン株式会社 | 新規生理活性物質 |
US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
EP1589011A1 (en) * | 2004-04-22 | 2005-10-26 | Schering Aktiengesellschaft | Novel chiral heptyne derivates for the preparation of epothilones and processes for their preparation |
AU2006336468B2 (en) | 2005-02-11 | 2012-04-12 | University Of Southern California | Method of expressing proteins with disulfide bridges |
WO2007130501A2 (en) * | 2006-05-01 | 2007-11-15 | University Of Southern California | Combination therapy for treatment of cancer |
US20100113128A1 (en) * | 2008-11-05 | 2010-05-06 | Snow Richard N | Methods and apparatus for determining a reel strip position |
US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
US20100125146A1 (en) * | 2008-11-19 | 2010-05-20 | Johnson Matthey Public Limited Company | Method for making pharmaceutical compounds |
CN105797168A (zh) | 2010-05-18 | 2016-07-27 | 天蓝制药公司 | 用于治疗自身免疫性疾病或其它疾病的组合物和方法 |
CA3002027A1 (en) * | 2015-10-16 | 2017-04-20 | William Marsh Rice University | Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof |
WO2017096559A1 (en) | 2015-12-09 | 2017-06-15 | Rhodia Operations | Production of xylene derivatives |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
US5469145A (en) | 1992-05-29 | 1995-11-21 | Johnson; Lonnie | Wet diaper detector |
EP0903348B2 (de) | 1995-11-17 | 2008-08-27 | Gesellschaft für Biotechnologische Forschung mbH (GBF) | Epothilon-Derivate und deren Herstellung |
US6441025B2 (en) | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
US5969145A (en) | 1996-08-30 | 1999-10-19 | Novartis Ag | Process for the production of epothilones and intermediate products within the process |
DE19636343C1 (de) | 1996-08-30 | 1997-10-23 | Schering Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B |
EP0923583A1 (de) | 1996-08-30 | 1999-06-23 | Novartis AG | Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens |
EP0977563B1 (en) * | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6867305B2 (en) * | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
DE19701758A1 (de) | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | Epothilone-Synthesebausteine |
US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
PT1005465E (pt) | 1997-08-09 | 2007-10-18 | Bayer Schering Pharma Ag | Novos derivados da epotilona, processo para a sua preparação e sua utilização farmacêutica |
AU4775299A (en) | 1998-06-22 | 2000-01-10 | Nicolaou, Kyriacos Costa | Desmethyl epothilones |
WO2001066154A2 (en) | 2000-03-09 | 2001-09-13 | Klar, Ulrich | Radioactively labeled epothilone derivatives, method for the production thereof, and their biochemical and pharmaceutical use |
CA2359267A1 (en) | 2000-10-19 | 2002-04-19 | Manabu Takami | Wavelength selecting module and wavelength selecting apparatus |
EP1340498A1 (en) * | 2002-03-01 | 2003-09-03 | Schering Aktiengesellschaft | Use of epothilones in the treatment of brain diseases associated with proliferative processes |
KR20050026033A (ko) * | 2002-07-31 | 2005-03-14 | 쉐링 악티엔게젤샤프트 | 신규 효과기 접합체, 그의 제조 방법 및 그의 약학적 용도 |
WO2004015088A2 (en) | 2002-08-13 | 2004-02-19 | Kosan Biosciences, Inc. | Transposon-based transformation system |
-
2000
- 2000-02-11 CZ CZ20012886A patent/CZ20012886A3/cs unknown
- 2000-02-11 EA EA200100833A patent/EA200100833A1/ru unknown
- 2000-02-11 IL IL14437000A patent/IL144370A0/xx unknown
- 2000-02-11 CA CA002360952A patent/CA2360952A1/en not_active Abandoned
- 2000-02-11 HU HU0105330A patent/HUP0105330A2/hu unknown
- 2000-02-11 EP EP00920433A patent/EP1161430A2/de not_active Withdrawn
- 2000-02-11 YU YU57601A patent/YU57601A/sh unknown
- 2000-02-11 BR BR0008206-6A patent/BR0008206A/pt not_active IP Right Cessation
- 2000-02-11 JP JP2000598504A patent/JP2002536450A/ja active Pending
- 2000-02-11 EE EEP200100422A patent/EE200100422A/xx unknown
- 2000-02-11 MX MXPA01008148A patent/MXPA01008148A/es unknown
- 2000-02-11 SK SK1145-2001A patent/SK11452001A3/sk unknown
- 2000-02-11 WO PCT/EP2000/001104 patent/WO2000047584A2/de not_active Application Discontinuation
- 2000-02-11 US US09/913,163 patent/US7001916B1/en not_active Expired - Fee Related
- 2000-02-11 AU AU41018/00A patent/AU4101800A/en not_active Abandoned
- 2000-02-11 KR KR1020017010109A patent/KR20010094763A/ko not_active Application Discontinuation
- 2000-02-11 PL PL00350190A patent/PL350190A1/xx not_active Application Discontinuation
- 2000-02-11 CN CN00803717A patent/CN1340053A/zh active Pending
-
2001
- 2001-08-09 BG BG105803A patent/BG105803A/xx unknown
- 2001-08-10 NO NO20013900A patent/NO20013900L/no not_active Application Discontinuation
-
2002
- 2002-09-03 HK HK02106492.8A patent/HK1044946A1/zh unknown
-
2005
- 2005-07-27 US US11/189,787 patent/US20060040990A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20010094763A (ko) | 2001-11-01 |
CZ20012886A3 (cs) | 2001-11-14 |
EE200100422A (et) | 2002-12-16 |
EA200100833A1 (ru) | 2002-02-28 |
BG105803A (en) | 2002-03-29 |
BR0008206A (pt) | 2002-02-19 |
JP2002536450A (ja) | 2002-10-29 |
IL144370A0 (en) | 2002-05-23 |
CN1340053A (zh) | 2002-03-13 |
NO20013900L (no) | 2001-10-11 |
WO2000047584A3 (de) | 2000-12-28 |
NO20013900D0 (no) | 2001-08-10 |
PL350190A1 (en) | 2002-11-18 |
MXPA01008148A (es) | 2003-07-21 |
US20060040990A1 (en) | 2006-02-23 |
AU4101800A (en) | 2000-08-29 |
WO2000047584A2 (de) | 2000-08-17 |
EP1161430A2 (de) | 2001-12-12 |
SK11452001A3 (sk) | 2002-04-04 |
US7001916B1 (en) | 2006-02-21 |
HK1044946A1 (zh) | 2002-11-08 |
HUP0105330A2 (hu) | 2002-05-29 |
CA2360952A1 (en) | 2000-08-17 |
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