BG105803A - Epotylon derivatives, method for their production and pharmaceutical use thereof - Google Patents

Epotylon derivatives, method for their production and pharmaceutical use thereof

Info

Publication number
BG105803A
BG105803A BG105803A BG10580301A BG105803A BG 105803 A BG105803 A BG 105803A BG 105803 A BG105803 A BG 105803A BG 10580301 A BG10580301 A BG 10580301A BG 105803 A BG105803 A BG 105803A
Authority
BG
Bulgaria
Prior art keywords
methyl
pyridyl
oxazolyl
thiazolyl
atom
Prior art date
Application number
BG105803A
Other languages
Bulgarian (bg)
English (en)
Inventor
Ulrich Klar
Werner Skuballa
Bernd Buchmann
Wolfgang Schwede
Michael Schirner
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999107480 external-priority patent/DE19907480A1/de
Priority claimed from DE19954229A external-priority patent/DE19954229A1/de
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of BG105803A publication Critical patent/BG105803A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG105803A 1999-02-11 2001-08-09 Epotylon derivatives, method for their production and pharmaceutical use thereof BG105803A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999107480 DE19907480A1 (de) 1999-02-11 1999-02-11 Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
DE19954229A DE19954229A1 (de) 1999-11-04 1999-11-04 Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
PCT/EP2000/001104 WO2000047584A2 (fr) 1999-02-11 2000-02-11 Derives d'epothilone, leur procede de production et leur utilisation pharmaceutique

Publications (1)

Publication Number Publication Date
BG105803A true BG105803A (en) 2002-03-29

Family

ID=26051977

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105803A BG105803A (en) 1999-02-11 2001-08-09 Epotylon derivatives, method for their production and pharmaceutical use thereof

Country Status (21)

Country Link
US (2) US7001916B1 (fr)
EP (1) EP1161430A2 (fr)
JP (1) JP2002536450A (fr)
KR (1) KR20010094763A (fr)
CN (1) CN1340053A (fr)
AU (1) AU4101800A (fr)
BG (1) BG105803A (fr)
BR (1) BR0008206A (fr)
CA (1) CA2360952A1 (fr)
CZ (1) CZ20012886A3 (fr)
EA (1) EA200100833A1 (fr)
EE (1) EE200100422A (fr)
HK (1) HK1044946A1 (fr)
HU (1) HUP0105330A2 (fr)
IL (1) IL144370A0 (fr)
MX (1) MXPA01008148A (fr)
NO (1) NO20013900L (fr)
PL (1) PL350190A1 (fr)
SK (1) SK11452001A3 (fr)
WO (1) WO2000047584A2 (fr)
YU (1) YU57601A (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1386922B1 (fr) 1996-12-03 2012-04-11 Sloan-Kettering Institute For Cancer Research Synthèse d'épitholones, intermédiaires, analogues et leur utilisation
US6660758B1 (en) * 1996-12-13 2003-12-09 The Scripps Research Institute Epothilone analogs
US7125893B1 (en) * 1999-04-30 2006-10-24 Schering Ag 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
US7723339B2 (en) * 2001-02-27 2010-05-25 Novartis Ag Combination comprising a signal transduction inhibitor and an epothilone derivative
EP2070534A3 (fr) * 2001-08-23 2009-08-26 Novartis Ag Cyclopropyl et analogues d'épothilone de cyclopropyl
WO2003078411A1 (fr) 2002-03-12 2003-09-25 Bristol-Myers Squibb Company Derives de c3-cyano epothilone
MXPA04012444A (es) * 2002-06-10 2005-04-19 Novartis Ag Combinaciones que comprenden epotilonas y sus usos farmaceuticos.
RU2338741C2 (ru) * 2002-07-31 2008-11-20 Мершан Корпорейшн Новые физиологически активные вещества
US20050215604A1 (en) * 2004-03-26 2005-09-29 Kosan Biosciences, Inc. Combination therapies with epothilones and carboplatin
EP1589011A1 (fr) * 2004-04-22 2005-10-26 Schering Aktiengesellschaft Nouveaux dérivés chiraux d'heptyne pour la préparation des epothilones et procédés pour leur préparation
JP2008536479A (ja) 2005-02-11 2008-09-11 ユニバーシティ オブ サザン カリフォルニア ジスルフィド架橋を有するタンパク質の発現法
US8008256B2 (en) * 2006-05-01 2011-08-30 University Of Southern California Combination therapy for treatment of cancer
US20100113128A1 (en) * 2008-11-05 2010-05-06 Snow Richard N Methods and apparatus for determining a reel strip position
WO2010056901A2 (fr) 2008-11-13 2010-05-20 University Of Southern California Procédé d'expression de protéines avec ponts disulfure avec des rendements et une activité améliorés
US20100125146A1 (en) * 2008-11-19 2010-05-20 Johnson Matthey Public Limited Company Method for making pharmaceutical compounds
AU2011255647A1 (en) 2010-05-18 2012-11-15 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
BR112018007673A2 (pt) * 2015-10-16 2018-11-06 Univ Rice William M ?análogos de epotilona, métodos de síntese, métodos de tratamento e conjugados de fármaco dos mesmos?
WO2017096559A1 (fr) * 2015-12-09 2017-06-15 Rhodia Operations Production de dérivés de xylène

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
US5469145A (en) 1992-05-29 1995-11-21 Johnson; Lonnie Wet diaper detector
ES2218328T5 (es) 1995-11-17 2011-11-11 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Derivados de epotilón, su preparación y utilización.
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
DE19636343C1 (de) 1996-08-30 1997-10-23 Schering Ag Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B
US5969145A (en) 1996-08-30 1999-10-19 Novartis Ag Process for the production of epothilones and intermediate products within the process
EP0923583A1 (fr) 1996-08-30 1999-06-23 Novartis AG Procede de fabrication d'epothilones, et composes intermediaires obtenus au cours de ce procede
US6867305B2 (en) * 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP1386922B1 (fr) 1996-12-03 2012-04-11 Sloan-Kettering Institute For Cancer Research Synthèse d'épitholones, intermédiaires, analogues et leur utilisation
US6441186B1 (en) 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
DE19701758A1 (de) 1997-01-20 1998-07-23 Wessjohann Ludgar A Dr Epothilone-Synthesebausteine
US6605599B1 (en) * 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
EP1005465B1 (fr) * 1997-08-09 2007-07-25 Bayer Schering Pharma Aktiengesellschaft Nouveaux derives d'epothilone, leur procede de fabrication et leur utilisation pharmaceutique
AU4775299A (en) * 1998-06-22 2000-01-10 Nicolaou, Kyriacos Costa Desmethyl epothilones
AU6208701A (en) 2000-03-09 2001-09-17 Schering Aktiengesellschaft Radioactively labeled epothilone derivatives, method for the production thereof, and their biochemical and pharmaceutical use
CA2359267A1 (fr) 2000-10-19 2002-04-19 Manabu Takami Module et appareil de selection d'une longueur d'onde
EP1340498A1 (fr) * 2002-03-01 2003-09-03 Schering Aktiengesellschaft Utilisation d'épothilones dans le traitement de maladies du cerveau associées aux processus de prolifération
AU2003253365A1 (en) * 2002-07-31 2004-02-23 Schering Ag New effector conjugates, process for their production and their pharmaceutical use
US7138279B2 (en) 2002-08-13 2006-11-21 Kosan Biosciences, Inc. Transposon-based transformation system

Also Published As

Publication number Publication date
AU4101800A (en) 2000-08-29
JP2002536450A (ja) 2002-10-29
IL144370A0 (en) 2002-05-23
CZ20012886A3 (cs) 2001-11-14
EP1161430A2 (fr) 2001-12-12
HK1044946A1 (zh) 2002-11-08
MXPA01008148A (es) 2003-07-21
CN1340053A (zh) 2002-03-13
WO2000047584A2 (fr) 2000-08-17
HUP0105330A2 (hu) 2002-05-29
WO2000047584A3 (fr) 2000-12-28
YU57601A (sh) 2005-06-10
US7001916B1 (en) 2006-02-21
NO20013900D0 (no) 2001-08-10
BR0008206A (pt) 2002-02-19
KR20010094763A (ko) 2001-11-01
EE200100422A (et) 2002-12-16
PL350190A1 (en) 2002-11-18
NO20013900L (no) 2001-10-11
EA200100833A1 (ru) 2002-02-28
CA2360952A1 (fr) 2000-08-17
US20060040990A1 (en) 2006-02-23
SK11452001A3 (sk) 2002-04-04

Similar Documents

Publication Publication Date Title
BG105803A (en) Epotylon derivatives, method for their production and pharmaceutical use thereof
HUP0302380A2 (hu) Cisztein-proteázok reverzibilis inhibitoraiként alkalmazható új spiroheterociklusos vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0302274A2 (hu) 2,4,8-Triszubsztituált-8H-pirido[2,3-d]pirimidin-7-on-vegyületek és felhasználásuk CSBP/p38 kináz által mediált betegségek kezelésére, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0300527A2 (hu) Pirrolopirimidinon-származékok, a vegyületek előállítása és alkalmazása
HUP0302167A2 (hu) Metabotropikus glutamát receptor antagonista hatású kinolinszármazékok, a vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
HUP0400837A2 (hu) 2-feniltiazol-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
HUP0300148A2 (en) Dipeptide nitrile cathepsin k inhibitors, process for their preparation and pharmaceutical compositions containing them
HUP0303037A2 (hu) Alzheimer-kór kezelésére alkalmas vegyületek és ezeket tartalmazó gyógyszerkészítmények
HUP9901652A2 (hu) Piperidin-karbonsav-származékok alkalmazása vérglükózkoncentráció csökkentésére alkalmas gyógyszerkészítmények előállítására
HUP0102084A2 (hu) Kinolinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
HUP0303283A2 (hu) Új piridinilcsoporttal szubsztituált pirazolopiridin-származékok, előállításuk és alkalmazásuk szív- és keringési betegségek kezelésére alkalmas gyógyszerkészítmény előállítására
HUP0301389A2 (hu) Purinszármazékok
AR047557A1 (es) Compuestos derivados de piridazina y su uso como agentes terapeuticos
HUP0300693A2 (hu) Eljárás epotilon-analógok és -intermedierek előállítására
HUP0204431A1 (hu) 1,5-Diszubsztituált-3,4-dihidro-1H-pirimido[4,5-d]pirimidin-2-on-vegyületek és falhasználásuk, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
NZ336302A (en) Quinoline and quinazoline compounds useful in therapy, particularly in the treatment of benign prostatic hyperplasia
ATE139233T1 (de) Annelierte thiophen-derivate, ihre herstellung und verwendung
ATE302778T1 (de) N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
HUP0302193A2 (hu) 1,4-Diazabiciklo[3.2.2]nonán-benzoxazol,-benzotiazol és -benzimidazol-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények
DE60011889D1 (en) 2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitoren
HUP0400238A2 (hu) Pirrolidin-oxadiazol- és tiadiazolszármazékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények
HUP0204394A2 (en) Novel tetrahydropyridines, preparation method and pharmaceutical compositions containing same
ATE211137T1 (de) Substituierte benzylthienylpiperazine, ihre anwendung als arzneimittel und verfahren für ihre herstellung
TR200002831A2 (tr) Kinolin-4-İl türevleri I
DE69315363T2 (de) Amphotere tricyclische Verbindungen als antihistaminische und antiallergische Mittel