SK101398A3 - Improved concentrated injection and infusion solutions for intravenous administration - Google Patents
Improved concentrated injection and infusion solutions for intravenous administration Download PDFInfo
- Publication number
- SK101398A3 SK101398A3 SK1013-98A SK101398A SK101398A3 SK 101398 A3 SK101398 A3 SK 101398A3 SK 101398 A SK101398 A SK 101398A SK 101398 A3 SK101398 A3 SK 101398A3
- Authority
- SK
- Slovakia
- Prior art keywords
- solutions
- concentration
- infusion
- additives
- hypersensitivity reactions
- Prior art date
Links
- 238000002347 injection Methods 0.000 title claims abstract description 31
- 239000007924 injection Substances 0.000 title claims abstract description 31
- 239000003978 infusion fluid Substances 0.000 title claims abstract description 15
- 238000001990 intravenous administration Methods 0.000 title description 2
- 239000000654 additive Substances 0.000 claims abstract description 43
- 230000001154 acute effect Effects 0.000 claims abstract description 23
- 239000000243 solution Substances 0.000 claims description 86
- 238000001802 infusion Methods 0.000 claims description 36
- 239000002872 contrast media Substances 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 24
- 208000027930 type IV hypersensitivity disease Diseases 0.000 claims description 23
- 239000000126 substance Substances 0.000 claims description 20
- 229940039231 contrast media Drugs 0.000 claims description 19
- 235000001014 amino acid Nutrition 0.000 claims description 12
- 229940024606 amino acid Drugs 0.000 claims description 12
- 239000011780 sodium chloride Substances 0.000 claims description 12
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 11
- 229960002897 heparin Drugs 0.000 claims description 11
- 229920000669 heparin Polymers 0.000 claims description 11
- 239000007983 Tris buffer Substances 0.000 claims description 10
- 150000001413 amino acids Chemical class 0.000 claims description 10
- 239000000872 buffer Substances 0.000 claims description 10
- 239000003792 electrolyte Substances 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 8
- 230000000996 additive effect Effects 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 6
- 239000004472 Lysine Substances 0.000 claims description 6
- -1 MgCl 2 Chemical compound 0.000 claims description 6
- 229960003646 lysine Drugs 0.000 claims description 6
- 235000018977 lysine Nutrition 0.000 claims description 6
- 206010053567 Coagulopathies Diseases 0.000 claims description 5
- 229960002684 aminocaproic acid Drugs 0.000 claims description 5
- 230000035602 clotting Effects 0.000 claims description 5
- NCAJWYASAWUEBY-UHFFFAOYSA-N 3-[20-(2-carboxyethyl)-9,14-diethyl-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1(21),2,4,6(24),7,9,11,13,15,17,19-undecaen-4-yl]propanoic acid Chemical compound N1C2=C(C)C(CC)=C1C=C(N1)C(C)=C(CC)C1=CC(C(C)=C1CCC(O)=O)=NC1=CC(C(CCC(O)=O)=C1C)=NC1=C2 NCAJWYASAWUEBY-UHFFFAOYSA-N 0.000 claims description 4
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 108010024636 Glutathione Proteins 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 4
- 150000001408 amides Chemical class 0.000 claims description 4
- 230000024203 complement activation Effects 0.000 claims description 4
- 229960003180 glutathione Drugs 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- 239000001632 sodium acetate Substances 0.000 claims description 4
- 235000017281 sodium acetate Nutrition 0.000 claims description 4
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 3
- 239000004471 Glycine Substances 0.000 claims description 3
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 3
- 108010039918 Polylysine Proteins 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 229930182830 galactose Natural products 0.000 claims description 3
- 229960003194 meglumine Drugs 0.000 claims description 3
- 230000007935 neutral effect Effects 0.000 claims description 3
- 229920000656 polylysine Polymers 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 239000001509 sodium citrate Substances 0.000 claims description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
- 235000000346 sugar Nutrition 0.000 claims description 3
- 150000008163 sugars Chemical class 0.000 claims description 3
- VVLAIYIMMFWRFW-UHFFFAOYSA-N 2-hydroxyethylazanium;acetate Chemical compound CC(O)=O.NCCO VVLAIYIMMFWRFW-UHFFFAOYSA-N 0.000 claims description 2
- 239000004475 Arginine Substances 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 2
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- AXDLCFOOGCNDST-UHFFFAOYSA-N N-methyl-DL-tyrosine Natural products CNC(C(O)=O)CC1=CC=C(O)C=C1 AXDLCFOOGCNDST-UHFFFAOYSA-N 0.000 claims description 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims description 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims description 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 229960003121 arginine Drugs 0.000 claims description 2
- 235000009582 asparagine Nutrition 0.000 claims description 2
- 229960001230 asparagine Drugs 0.000 claims description 2
- 235000003704 aspartic acid Nutrition 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 claims description 2
- 229960001076 chlorpromazine Drugs 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- 229960002433 cysteine Drugs 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 235000005772 leucine Nutrition 0.000 claims description 2
- 229960003104 ornithine Drugs 0.000 claims description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 2
- 235000008729 phenylalanine Nutrition 0.000 claims description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 2
- FIAFUQMPZJWCLV-UHFFFAOYSA-N suramin Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(NC(=O)C3=CC=C(C(=C3)NC(=O)C=3C=C(NC(=O)NC=4C=C(C=CC=4)C(=O)NC=4C(=CC=C(C=4)C(=O)NC=4C5=C(C=C(C=C5C(=CC=4)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)C)C=CC=3)C)=CC=C(S(O)(=O)=O)C2=C1 FIAFUQMPZJWCLV-UHFFFAOYSA-N 0.000 claims description 2
- 229960005314 suramin Drugs 0.000 claims description 2
- 239000003623 enhancer Substances 0.000 claims 6
- 239000003189 dimeric nonionic contrast media Substances 0.000 claims 3
- 239000003631 monomeric nonionic contrast media Substances 0.000 claims 3
- 230000002378 acidificating effect Effects 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 239000008139 complexing agent Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- 239000000701 coagulant Substances 0.000 claims 1
- 238000007599 discharging Methods 0.000 claims 1
- 239000002611 ionic contrast media Substances 0.000 claims 1
- 239000003690 nonionic contrast media Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 abstract description 5
- 230000003111 delayed effect Effects 0.000 abstract description 5
- 230000000694 effects Effects 0.000 description 15
- 239000011734 sodium Substances 0.000 description 15
- SHWNNYZBHZIQQV-UHFFFAOYSA-J EDTA monocalcium diisodium salt Chemical compound [Na+].[Na+].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O SHWNNYZBHZIQQV-UHFFFAOYSA-J 0.000 description 14
- 239000012153 distilled water Substances 0.000 description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 13
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 10
- 239000013543 active substance Substances 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 206010020751 Hypersensitivity Diseases 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000004202 carbamide Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 230000000144 pharmacologic effect Effects 0.000 description 5
- 208000026935 allergic disease Diseases 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000003146 anticoagulant agent Substances 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 206010020852 Hypertonia Diseases 0.000 description 2
- 206010042674 Swelling Diseases 0.000 description 2
- 238000002583 angiography Methods 0.000 description 2
- 229940127090 anticoagulant agent Drugs 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- 230000004154 complement system Effects 0.000 description 2
- 238000003113 dilution method Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000815 hypotonic solution Substances 0.000 description 2
- 239000003589 local anesthetic agent Substances 0.000 description 2
- 229960005015 local anesthetics Drugs 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- 150000003815 prostacyclins Chemical class 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- YVPYQUNUQOZFHG-UHFFFAOYSA-N amidotrizoic acid Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I YVPYQUNUQOZFHG-UHFFFAOYSA-N 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 229940125644 antibody drug Drugs 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 229940021013 electrolyte solution Drugs 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000007124 immune defense Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000037189 immune system physiology Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 description 1
- 229960002603 iopromide Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19604095 | 1996-01-25 | ||
| PCT/DE1997/000170 WO1997026862A2 (fr) | 1996-01-25 | 1997-01-27 | Solutions concentrees ameliorees pour injection et perfusion a administrer par voie intraveineuse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK101398A3 true SK101398A3 (en) | 1998-12-02 |
Family
ID=7784538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1013-98A SK101398A3 (en) | 1996-01-25 | 1997-01-27 | Improved concentrated injection and infusion solutions for intravenous administration |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6638913B1 (fr) |
| EP (1) | EP0876140B1 (fr) |
| JP (1) | JP2000505789A (fr) |
| KR (1) | KR100505772B1 (fr) |
| CN (1) | CN1209751A (fr) |
| AT (1) | ATE251893T1 (fr) |
| AU (1) | AU2150497A (fr) |
| BG (1) | BG62913B1 (fr) |
| BR (1) | BR9707081A (fr) |
| CA (1) | CA2244209C (fr) |
| CZ (1) | CZ234898A3 (fr) |
| DE (2) | DE19703816A1 (fr) |
| DK (1) | DK0876140T3 (fr) |
| ES (1) | ES2208884T3 (fr) |
| HU (1) | HUP9901355A3 (fr) |
| IL (1) | IL124676A0 (fr) |
| NO (1) | NO983438L (fr) |
| PL (1) | PL328199A1 (fr) |
| PT (1) | PT876140E (fr) |
| SK (1) | SK101398A3 (fr) |
| WO (1) | WO1997026862A2 (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
| EP0996461B1 (fr) * | 1997-10-31 | 2005-01-12 | Walter Reed Army Institute of Research | Utilisation d'un inhibiteur d'activation de complement pour preparer un medicament pour inhiber les effets secondaires de compositions pharmaceutiques contenant des excipients amphiphiles ou des molecules vecteurs de medicaments |
| ES2217742T3 (es) | 1998-04-01 | 2004-11-01 | Cardiome Pharma Corp. | Compuestos de amino ciclohexil eter y usos del mismo. |
| US7524879B2 (en) | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US6875432B2 (en) | 2000-10-12 | 2005-04-05 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
| US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
| DE10115740A1 (de) | 2001-03-26 | 2002-10-02 | Ulrich Speck | Zubereitung für die Restenoseprophylaxe |
| US20020169112A1 (en) * | 2001-05-08 | 2002-11-14 | Luc Montagnier | Combined treatments and methods for treatment of mycoplasma and mycoplasma-like organism infections |
| DE10244847A1 (de) | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medizinische Vorrichtung zur Arzneimittelabgabe |
| PL227937B1 (pl) | 2003-05-02 | 2018-01-31 | Cardiome Pharma Corp | Sposób wytwarzania związku typu eteru aminocykloheksylowego, związek typu eteru aminocykloheksylowego, jego kompozycja, sposób modulowania aktywności kanałów jonowych, oraz zastosowanie związku typu eteru aminocykloheksylowego do wytwarzania leku |
| US7345087B2 (en) | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| US8058304B2 (en) | 2004-04-01 | 2011-11-15 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| CA2561819A1 (fr) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Promedicaments de composes modulant les canaux ioniques et leurs utilisations |
| JP5583325B2 (ja) | 2004-11-08 | 2014-09-03 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物の投与レジメ |
| US20060270708A1 (en) * | 2005-05-25 | 2006-11-30 | Navinta Llc | Novel process for preparation of isotonic aqueous injection of ropivacaine |
| EP1897535A1 (fr) * | 2006-08-30 | 2008-03-12 | Dirinco AG | Liquide substitue pour haemoflitration |
| US20090239894A1 (en) * | 2008-03-20 | 2009-09-24 | Bjorn Schurad | Stabilized aqueous solutions of ergoline compounds |
| RU2011140498A (ru) | 2009-03-06 | 2013-04-20 | Дженентек, Инк. | Препарат антител |
| US10634741B2 (en) | 2009-12-04 | 2020-04-28 | Endomagnetics Ltd. | Magnetic probe apparatus |
| US9427186B2 (en) * | 2009-12-04 | 2016-08-30 | Endomagnetics Ltd. | Magnetic probe apparatus |
| KR101807894B1 (ko) | 2010-03-01 | 2017-12-12 | 바이엘 헬스케어 엘엘씨 | 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체 |
| CN102319258B (zh) * | 2011-08-04 | 2012-10-31 | 山西诺成制药有限公司 | 一种5%葡萄糖置换液及其制备方法 |
| US8613919B1 (en) | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| JP6351639B2 (ja) | 2013-03-11 | 2018-07-04 | エンドマグネティクス リミテッド | リンパ節検出のための低浸透圧溶液 |
| US9234877B2 (en) | 2013-03-13 | 2016-01-12 | Endomagnetics Ltd. | Magnetic detector |
| US9239314B2 (en) | 2013-03-13 | 2016-01-19 | Endomagnetics Ltd. | Magnetic detector |
| CA2900440A1 (fr) * | 2013-03-27 | 2014-10-02 | Ge Healthcare As | Trousse pour la prestation sur place de milieux de contraste en concentrations definies par l'utilisateur |
| EP3302338B1 (fr) | 2015-06-04 | 2020-09-30 | Endomagnetics Ltd. | Matériaux et formes de marqueur pour localisation à marqueur magnétique |
| AU2019254483A1 (en) * | 2018-04-16 | 2020-12-03 | Merck Patent Gmbh | Viscosity reduction of highly concentrated protein formulations |
| CN110327292A (zh) * | 2019-08-11 | 2019-10-15 | 天津乾丰瑞科技有限公司 | 一种盐酸法舒地尔注射制剂及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE754523A (fr) * | 1969-08-06 | 1971-02-08 | Beecham Group Ltd | Vaccins |
| CA1132901A (fr) * | 1978-07-04 | 1982-10-05 | Fridtjov B. Rakli | Agent de contrastage aux rayons x a base d'aniline et tampon dont le ph s'abaisse avec la temperature |
| EP0077354A4 (fr) * | 1981-04-27 | 1983-09-30 | Baxter Travenol Lab | Solution de dialyse contenant du glucose, des acides amines et de l'insuline. |
| WO1986000227A1 (fr) * | 1984-06-22 | 1986-01-16 | Veech Richard L | Solutions electrolytiques et leur utilisation in vivo |
| IE60901B1 (en) * | 1986-08-21 | 1994-08-24 | Vestar Inc | Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics |
| US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| GB8906130D0 (en) * | 1989-03-17 | 1989-05-04 | Nycomed As | Compositions |
| JPH0341033A (ja) * | 1989-07-07 | 1991-02-21 | Kyowa Hakko Kogyo Co Ltd | 安定なモチリン類含有製剤 |
| ATE111585T1 (de) | 1990-01-18 | 1994-09-15 | Cereria Amos Sgarbi Spa | Grablicht. |
| GB9020091D0 (en) * | 1990-09-14 | 1990-10-24 | Nycomed As | Contrast media |
| DE4135193C1 (fr) * | 1991-10-22 | 1993-03-11 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | |
| IT1256248B (it) * | 1992-12-24 | 1995-11-29 | Bracco Spa | Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x |
| WO1995026331A1 (fr) * | 1994-03-25 | 1995-10-05 | Centro Investigacion Justesa Imagen, S.A. | Nouveaux dimeres iodes non-ioniques, utiles en tant qu'agents de contraste aux rayons x, procede de preparation, et compositions pharmaceutiques les contenant |
| DE4446694A1 (de) * | 1994-12-09 | 1996-06-13 | Schering Ag | Verwendung von Zusätzen zu Kontrastmitteln zur Verbesserung der Bildgebung |
-
1997
- 1997-01-27 PT PT97914098T patent/PT876140E/pt unknown
- 1997-01-27 AU AU21504/97A patent/AU2150497A/en not_active Abandoned
- 1997-01-27 ES ES97914098T patent/ES2208884T3/es not_active Expired - Lifetime
- 1997-01-27 DE DE19703816A patent/DE19703816A1/de not_active Withdrawn
- 1997-01-27 CN CN97191871A patent/CN1209751A/zh active Pending
- 1997-01-27 AT AT97914098T patent/ATE251893T1/de not_active IP Right Cessation
- 1997-01-27 JP JP9526441A patent/JP2000505789A/ja not_active Ceased
- 1997-01-27 BR BR9707081A patent/BR9707081A/pt not_active IP Right Cessation
- 1997-01-27 KR KR10-1998-0705697A patent/KR100505772B1/ko not_active IP Right Cessation
- 1997-01-27 PL PL97328199A patent/PL328199A1/xx unknown
- 1997-01-27 EP EP97914098A patent/EP0876140B1/fr not_active Expired - Lifetime
- 1997-01-27 DE DE59710863T patent/DE59710863D1/de not_active Expired - Fee Related
- 1997-01-27 IL IL12467697A patent/IL124676A0/xx unknown
- 1997-01-27 HU HU9901355A patent/HUP9901355A3/hu unknown
- 1997-01-27 SK SK1013-98A patent/SK101398A3/sk unknown
- 1997-01-27 DK DK97914098T patent/DK0876140T3/da active
- 1997-01-27 WO PCT/DE1997/000170 patent/WO1997026862A2/fr not_active Application Discontinuation
- 1997-01-27 CZ CZ982348A patent/CZ234898A3/cs unknown
- 1997-01-27 CA CA002244209A patent/CA2244209C/fr not_active Expired - Fee Related
-
1998
- 1998-07-21 BG BG102644A patent/BG62913B1/bg unknown
- 1998-07-24 NO NO983438A patent/NO983438L/no not_active Application Discontinuation
-
2000
- 2000-02-14 US US09/504,108 patent/US6638913B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6638913B1 (en) | 2003-10-28 |
| HUP9901355A2 (hu) | 1999-08-30 |
| ES2208884T3 (es) | 2004-06-16 |
| DE19703816A1 (de) | 1997-08-07 |
| EP0876140B1 (fr) | 2003-10-15 |
| KR100505772B1 (ko) | 2005-10-25 |
| DK0876140T3 (da) | 2003-12-15 |
| EP0876140A2 (fr) | 1998-11-11 |
| DE59710863D1 (de) | 2003-11-20 |
| CZ234898A3 (cs) | 1998-11-11 |
| HUP9901355A3 (en) | 2000-06-28 |
| BR9707081A (pt) | 1999-05-25 |
| NO983438D0 (no) | 1998-07-24 |
| NO983438L (no) | 1998-09-18 |
| PT876140E (pt) | 2004-02-27 |
| WO1997026862A3 (fr) | 1997-10-23 |
| BG62913B1 (bg) | 2000-11-30 |
| AU2150497A (en) | 1997-08-20 |
| KR19990081979A (ko) | 1999-11-15 |
| BG102644A (en) | 1999-06-30 |
| CN1209751A (zh) | 1999-03-03 |
| JP2000505789A (ja) | 2000-05-16 |
| WO1997026862A2 (fr) | 1997-07-31 |
| ATE251893T1 (de) | 2003-11-15 |
| CA2244209A1 (fr) | 1997-07-31 |
| PL328199A1 (en) | 1999-01-18 |
| CA2244209C (fr) | 2007-10-23 |
| IL124676A0 (en) | 1998-12-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SK101398A3 (en) | Improved concentrated injection and infusion solutions for intravenous administration | |
| JP4404380B2 (ja) | ＮａＣｌ含有インスリン製剤 | |
| BRPI0208210B1 (pt) | Preparação de insulina pobre em zinco e isenta de zinco com estabilidade aperfeiçoada | |
| US6150331A (en) | Human growth hormone-containing aqueous pharmaceutical composition | |
| KR100546450B1 (ko) | 약학 조성물 | |
| BG65304B1 (bg) | Воден състав, съдържащ моксифлоксацин и натриев хлорид | |
| EP3558344A1 (fr) | Compositions d'agoniste de récepteur du peptide 1 apparenté au glucagon (glp-1) | |
| US20180236079A1 (en) | Stabilized glucagon solutions | |
| US20120225819A1 (en) | Stable formulation of factor viii | |
| US10238717B2 (en) | Parenteral glucagon formulations | |
| JPH06247872A (ja) | 高濃度ｔｃｆ製剤 | |
| CZ194297A3 (en) | Solution of 2-chloro-2-deoxyadenosine in water | |
| CA2995839A1 (fr) | Composition pharmaceutique a administrer par la muqueuse nasale | |
| JPH11302197A (ja) | ヒアルロン酸安定化組成物 | |
| WO2018153506A1 (fr) | Composition d'insuline à action rapide contenant un sel d'acide citrique | |
| KR20190037500A (ko) | 히알루론산과 마그네슘을 포함하는 골관절염 치료를 위한 안정한 액상 조성물 | |
| AU763521B2 (en) | Improved concentrated injection and infusion solutions for intravascular use | |
| JP2946015B2 (ja) | 安定な抗ウィルス点滴用注射剤 | |
| CA2540172A1 (fr) | Formulation liquide de l'hormone de croissance humaine contenant du polyethylene glycol | |
| WO2024011169A1 (fr) | Compositions pharmaceutiques liquides stables comprenant du melphalan | |
| WO2006096079A2 (fr) | Composition pharmaceutique comprenant un analogue biosynthetique d'insuline humaine et son utilisation pour traiter le diabete sucre. | |
| JP2022540862A (ja) | 高濃度インスリン製剤 |