BG62913B1 - Подобрени концентрирани инжекционни и инфузионни разтвори за интравазално прилагане - Google Patents

Подобрени концентрирани инжекционни и инфузионни разтвори за интравазално прилагане Download PDF

Info

Publication number
BG62913B1
BG62913B1 BG102644A BG10264498A BG62913B1 BG 62913 B1 BG62913 B1 BG 62913B1 BG 102644 A BG102644 A BG 102644A BG 10264498 A BG10264498 A BG 10264498A BG 62913 B1 BG62913 B1 BG 62913B1
Authority
BG
Bulgaria
Prior art keywords
infusion
solutions
additives
mmol
hypersensitivity reactions
Prior art date
Application number
BG102644A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG102644A (en
Inventor
Ulrich Speck
Gabriele Schuhmann-Giampieri
Peter Muschick
Werner Krause
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of BG102644A publication Critical patent/BG102644A/xx
Publication of BG62913B1 publication Critical patent/BG62913B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BG102644A 1996-01-25 1998-07-21 Подобрени концентрирани инжекционни и инфузионни разтвори за интравазално прилагане BG62913B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19604095 1996-01-25
PCT/DE1997/000170 WO1997026862A2 (fr) 1996-01-25 1997-01-27 Solutions concentrees ameliorees pour injection et perfusion a administrer par voie intraveineuse

Publications (2)

Publication Number Publication Date
BG102644A BG102644A (en) 1999-06-30
BG62913B1 true BG62913B1 (bg) 2000-11-30

Family

ID=7784538

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102644A BG62913B1 (bg) 1996-01-25 1998-07-21 Подобрени концентрирани инжекционни и инфузионни разтвори за интравазално прилагане

Country Status (21)

Country Link
US (1) US6638913B1 (fr)
EP (1) EP0876140B1 (fr)
JP (1) JP2000505789A (fr)
KR (1) KR100505772B1 (fr)
CN (1) CN1209751A (fr)
AT (1) ATE251893T1 (fr)
AU (1) AU2150497A (fr)
BG (1) BG62913B1 (fr)
BR (1) BR9707081A (fr)
CA (1) CA2244209C (fr)
CZ (1) CZ234898A3 (fr)
DE (2) DE19703816A1 (fr)
DK (1) DK0876140T3 (fr)
ES (1) ES2208884T3 (fr)
HU (1) HUP9901355A3 (fr)
IL (1) IL124676A0 (fr)
NO (1) NO983438L (fr)
PL (1) PL328199A1 (fr)
PT (1) PT876140E (fr)
SK (1) SK101398A3 (fr)
WO (1) WO1997026862A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
CA2298475A1 (fr) 1997-10-31 1999-05-14 Walter Reed Army Institute Of Research Procede permettant d'inhiber les effets secondaires de compositions pharmaceutiques contenant des excipients amphiphiles ou des molecules vecteurs de medicaments
HU229993B1 (en) 1998-04-01 2015-04-28 Cardiome Pharma Corp Aminocyclohexyl ether compounds and uses thereof
US7524879B2 (en) 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US8703126B2 (en) 2000-10-12 2014-04-22 Genentech, Inc. Reduced-viscosity concentrated protein formulations
IL155002A0 (en) 2000-10-12 2003-10-31 Genentech Inc Reduced-viscosity concentrated protein formulations
DE10115740A1 (de) 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
US20020169112A1 (en) * 2001-05-08 2002-11-14 Luc Montagnier Combined treatments and methods for treatment of mycoplasma and mycoplasma-like organism infections
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
ES2264776T3 (es) 2003-05-02 2007-01-16 Cardiome Pharma Corp. Compuestos de aminociclohexil eter y sus usos.
US7345087B2 (en) 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US8058304B2 (en) 2004-04-01 2011-11-15 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
US7977373B2 (en) 2004-04-01 2011-07-12 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
WO2006053037A2 (fr) 2004-11-08 2006-05-18 Cardiome Pharma Corp. Schemas posologiques pour composes de modulation de canaux ioniques
US20060270708A1 (en) * 2005-05-25 2006-11-30 Navinta Llc Novel process for preparation of isotonic aqueous injection of ropivacaine
EP1897535A1 (fr) * 2006-08-30 2008-03-12 Dirinco AG Liquide substitue pour haemoflitration
US20090239894A1 (en) * 2008-03-20 2009-09-24 Bjorn Schurad Stabilized aqueous solutions of ergoline compounds
JP2012519706A (ja) 2009-03-06 2012-08-30 ジェネンテック， インコーポレイテッド 抗体製剤
US10634741B2 (en) * 2009-12-04 2020-04-28 Endomagnetics Ltd. Magnetic probe apparatus
US9427186B2 (en) * 2009-12-04 2016-08-30 Endomagnetics Ltd. Magnetic probe apparatus
NZ602115A (en) 2010-03-01 2014-12-24 Bayer Healthcare Llc Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
CN102319258B (zh) * 2011-08-04 2012-10-31 山西诺成制药有限公司 一种5%葡萄糖置换液及其制备方法
US8613919B1 (en) 2012-08-31 2013-12-24 Bayer Healthcare, Llc High concentration antibody and protein formulations
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
AU2014229811B2 (en) 2013-03-11 2018-02-15 Endomagnetics Ltd. Hypoosmotic solutions for lymph node detection
US9234877B2 (en) 2013-03-13 2016-01-12 Endomagnetics Ltd. Magnetic detector
US9239314B2 (en) 2013-03-13 2016-01-19 Endomagnetics Ltd. Magnetic detector
WO2014158965A1 (fr) * 2013-03-27 2014-10-02 Ge Healthcare As Procédé et réactif pour préparer une composition diagnostique
EP3302338B1 (fr) 2015-06-04 2020-09-30 Endomagnetics Ltd. Matériaux et formes de marqueur pour localisation à marqueur magnétique
CA3097061A1 (fr) * 2018-04-16 2019-10-24 Merck Patent Gmbh Reduction de la viscosite de formulations de proteines hautement concentrees
CN110327292A (zh) * 2019-08-11 2019-10-15 天津乾丰瑞科技有限公司 一种盐酸法舒地尔注射制剂及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754523A (fr) * 1969-08-06 1971-02-08 Beecham Group Ltd Vaccins
DK155714C (da) * 1978-07-04 1989-10-30 Nyegaard & Co As Fremgangsmaade til fremstilling af en steril, injicerbar, fysiologisk acceptabel oploesning af et roentgenkontrastmiddel, samt en oploesning af roentgenkontrastmidlet til brug ved fremgangsmaaden
WO1982003773A1 (fr) * 1981-04-27 1982-11-11 Baxter Travenol Lab Solution de dialyse contenant du glucose, des acides amines et de l'insuline
EP0185759B2 (fr) * 1984-06-22 2004-06-02 Btg International Limited Solutions electrolytiques et leur utilisation (in vivo)
IE60901B1 (en) * 1986-08-21 1994-08-24 Vestar Inc Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
US5096885A (en) * 1988-04-15 1992-03-17 Genentech, Inc. Human growth hormone formulation
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions
JPH0341033A (ja) * 1989-07-07 1991-02-21 Kyowa Hakko Kogyo Co Ltd 安定なモチリン類含有製剤
DE59007142D1 (de) 1990-01-18 1994-10-20 Cereria Amos Sgarbi Spa Grablicht.
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
DE4135193C1 (fr) * 1991-10-22 1993-03-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
WO1995026331A1 (fr) * 1994-03-25 1995-10-05 Centro Investigacion Justesa Imagen, S.A. Nouveaux dimeres iodes non-ioniques, utiles en tant qu'agents de contraste aux rayons x, procede de preparation, et compositions pharmaceutiques les contenant
DE4446694A1 (de) * 1994-12-09 1996-06-13 Schering Ag Verwendung von Zusätzen zu Kontrastmitteln zur Verbesserung der Bildgebung

Also Published As

Publication number Publication date
ES2208884T3 (es) 2004-06-16
IL124676A0 (en) 1998-12-06
KR19990081979A (ko) 1999-11-15
CZ234898A3 (cs) 1998-11-11
PT876140E (pt) 2004-02-27
WO1997026862A2 (fr) 1997-07-31
CN1209751A (zh) 1999-03-03
CA2244209A1 (fr) 1997-07-31
BR9707081A (pt) 1999-05-25
DK0876140T3 (da) 2003-12-15
DE19703816A1 (de) 1997-08-07
BG102644A (en) 1999-06-30
DE59710863D1 (de) 2003-11-20
SK101398A3 (en) 1998-12-02
ATE251893T1 (de) 2003-11-15
WO1997026862A3 (fr) 1997-10-23
KR100505772B1 (ko) 2005-10-25
AU2150497A (en) 1997-08-20
EP0876140B1 (fr) 2003-10-15
NO983438D0 (no) 1998-07-24
HUP9901355A2 (hu) 1999-08-30
EP0876140A2 (fr) 1998-11-11
PL328199A1 (en) 1999-01-18
HUP9901355A3 (en) 2000-06-28
US6638913B1 (en) 2003-10-28
CA2244209C (fr) 2007-10-23
NO983438L (no) 1998-09-18
JP2000505789A (ja) 2000-05-16

Similar Documents

Publication Publication Date Title
BG62913B1 (bg) Подобрени концентрирани инжекционни и инфузионни разтвори за интравазално прилагане
JP7042531B2 (ja) デオキシコール酸を含む医薬組成物
JP2002504908A (ja) 安定なインスリン製剤
EA002776B1 (ru) Фармацевтические композиции, содержащие циклодекстрины и таксоиды
JP3723857B2 (ja) ヒト成長ホルモン含有水性医薬組成物
US6440934B1 (en) Angiogenically effective unit dose of FGF-2 and method of use
IE64080B1 (en) Pharmaceutical for subcutaneous administration containing polypeptides
JPH0714882B2 (ja) 循環器系ショックに対する高浸透圧等塩素性製剤
US20200370025A1 (en) Acute Respiratory Distress Syndrome Therapeutic Agent
JP2005532288A (ja) アロステリックエフェクター化合物を含んだ安定製剤の製造と使用
US6720011B1 (en) Injectable composition for cancer treatment
WO2001041793A1 (fr) Formulation stable d'interferon en solution, son procede de preparation et ses applications
EP0124018B1 (fr) Préparation pharmaceutique contenant de la fibrinonectine purifiée
US10238717B2 (en) Parenteral glucagon formulations
US20220226369A1 (en) Ethanol hardener and use thereof
JPH06247872A (ja) 高濃度ｔｃｆ製剤
EP2106791A1 (fr) Glutamine ou dipeptide contenant de la glutamine avec une posologie spécifique pour le traitement des inflammations
CA2416600A1 (fr) Preparation lyophilisee de tetrahydrate monosodique de n-¬o-(p-pivaloyloxybenzenesulfonylamino)benzoyl|glycine et procede permettant de produire cette preparation
US20030166550A1 (en) Angiogenically effective unit dose of FGF-2 and method of use
JP3022915B2 (ja) 癌転移抑制剤
AU763521B2 (en) Improved concentrated injection and infusion solutions for intravascular use
JP2654518B2 (ja) 肝細胞増殖促進剤
KR20230160261A (ko) 급성 허혈성 뇌졸중을 치료하는 dc009
JP2023553106A (ja) 改善された凍結乾燥製剤
PT85848B (en) Process for the preparation of pharmaceutical compounds with thrombolitic activity containing an urokinase and pro-urokinase synergic mixture