SI9300461B - Beads having a core coated with an antifugal and a polymer - Google Patents
Beads having a core coated with an antifugal and a polymer Download PDFInfo
- Publication number
- SI9300461B SI9300461B SI9300461A SI9300461A SI9300461B SI 9300461 B SI9300461 B SI 9300461B SI 9300461 A SI9300461 A SI 9300461A SI 9300461 A SI9300461 A SI 9300461A SI 9300461 B SI9300461 B SI 9300461B
- Authority
- SI
- Slovenia
- Prior art keywords
- antifungal agent
- polymer
- core
- hydrophilic polymer
- microspheres
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title claims 2
- 239000011324 bead Substances 0.000 title abstract 4
- 230000001716 anti-fugal effect Effects 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 claims abstract 8
- 239000003429 antifungal agent Substances 0.000 claims abstract 7
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract 6
- 239000002552 dosage form Substances 0.000 claims abstract 4
- 239000011248 coating agent Substances 0.000 claims abstract 2
- 238000000576 coating method Methods 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims abstract 2
- 239000004005 microsphere Substances 0.000 claims 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 6
- 239000011162 core material Substances 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 3
- HUADITLKOCMHSB-AVQIMAJZSA-N 2-butan-2-yl-4-[4-[4-[4-[[(2s,4r)-2-(2,4-difluorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3O[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 HUADITLKOCMHSB-AVQIMAJZSA-N 0.000 claims 3
- 229920001688 coating polymer Polymers 0.000 claims 3
- 229960004130 itraconazole Drugs 0.000 claims 3
- 229950005137 saperconazole Drugs 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 238000007789 sealing Methods 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229940031705 hydroxypropyl methylcellulose 2910 Drugs 0.000 claims 1
- 239000000565 sealant Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 238000004544 sputter deposition Methods 0.000 claims 1
- 238000001291 vacuum drying Methods 0.000 claims 1
- 239000011247 coating layer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92202664 | 1992-09-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
SI9300461A SI9300461A (en) | 1994-03-31 |
SI9300461B true SI9300461B (en) | 2001-12-31 |
Family
ID=8210890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9300461A SI9300461B (en) | 1992-09-03 | 1993-09-03 | Beads having a core coated with an antifugal and a polymer |
Country Status (33)
Country | Link |
---|---|
US (1) | US5633015A (cs) |
EP (1) | EP0658103B1 (cs) |
JP (1) | JP2865869B2 (cs) |
KR (1) | KR0151893B1 (cs) |
CN (1) | CN1034714C (cs) |
AP (1) | AP444A (cs) |
AT (1) | ATE145327T1 (cs) |
AU (1) | AU665867B2 (cs) |
CA (1) | CA2142848C (cs) |
CY (1) | CY2105B1 (cs) |
CZ (1) | CZ283403B6 (cs) |
DE (1) | DE69306119T2 (cs) |
DK (1) | DK0658103T3 (cs) |
ES (1) | ES2097536T3 (cs) |
FI (1) | FI112437B (cs) |
GR (1) | GR3022198T3 (cs) |
HK (1) | HK1006000A1 (cs) |
HR (1) | HRP931158B1 (cs) |
HU (1) | HU220614B1 (cs) |
IL (1) | IL106871A (cs) |
MX (1) | MX9305438A (cs) |
MY (1) | MY109369A (cs) |
NO (1) | NO307953B1 (cs) |
NZ (1) | NZ255379A (cs) |
OA (1) | OA10130A (cs) |
PH (1) | PH30929A (cs) |
PL (2) | PL172676B1 (cs) |
RU (1) | RU2125445C1 (cs) |
SG (1) | SG48801A1 (cs) |
SI (1) | SI9300461B (cs) |
TW (1) | TW376322B (cs) |
WO (1) | WO1994005263A1 (cs) |
ZA (1) | ZA936493B (cs) |
Families Citing this family (106)
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US5846971A (en) * | 1996-06-28 | 1998-12-08 | Schering Corporation | Oral antifungal composition |
CA2258683C (en) * | 1996-06-28 | 2007-07-31 | Schering Corporation | Oral composition comprising a triazole antifungal compound |
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FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
AU734248B2 (en) * | 1997-03-26 | 2001-06-07 | Janssen Pharmaceutica N.V. | Pellets having a core coated with an antifungal and a polymer |
KR19990001564A (ko) * | 1997-06-16 | 1999-01-15 | 유충식 | 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제 |
KR100514330B1 (ko) * | 1997-12-31 | 2006-02-17 | 주식회사 중외제약 | 난용성 약물을 함유하는 코팅정 |
DE69808670T2 (de) * | 1997-12-31 | 2003-07-03 | Choongwae Pharma Corp., Seoul/Soul | Herstellungsverfahren und zusammensetzung einer oralen zubereitung von itraconazol |
DE19808634A1 (de) * | 1998-02-24 | 1999-08-26 | Schering Ag | Mantel für eine pharmazeutische Zusammensetzung |
UA65607C2 (uk) | 1998-03-04 | 2004-04-15 | Орто-Макнейл Фармацевтикал, Інк. | Фармацевтична композиція (варіанти) та спосіб її приготування |
CA2315110C (en) * | 1998-07-17 | 2006-09-12 | Janssen Pharmaceutica N.V. | Pellets having a core coated with an antifungal and a polymer |
ES2157731B1 (es) * | 1998-07-21 | 2002-05-01 | Liconsa Liberacion Controlada | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
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FR2514261B1 (fr) * | 1981-10-08 | 1986-08-22 | Aec Chim Organ Biolog | Nouvelle composition pour l'enrobage des aliments et des medicaments et granules ainsi enrobes |
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1993
- 1993-08-13 PH PH46686A patent/PH30929A/en unknown
- 1993-08-26 TW TW082106900A patent/TW376322B/zh not_active IP Right Cessation
- 1993-08-27 AU AU49546/93A patent/AU665867B2/en not_active Expired
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- 1993-08-27 JP JP6506851A patent/JP2865869B2/ja not_active Expired - Lifetime
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- 1993-08-27 WO PCT/EP1993/002327 patent/WO1994005263A1/en active IP Right Grant
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- 1993-08-27 DE DE69306119T patent/DE69306119T2/de not_active Expired - Lifetime
- 1993-08-27 KR KR1019950700756A patent/KR0151893B1/ko not_active Expired - Lifetime
- 1993-08-27 HK HK98105166A patent/HK1006000A1/en not_active IP Right Cessation
- 1993-08-27 US US08/432,188 patent/US5633015A/en not_active Expired - Lifetime
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- 1993-08-27 CZ CZ95542A patent/CZ283403B6/cs not_active IP Right Cessation
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1995
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