SI3527263T1 - Derivati bipirazola kot zaviralci JAK - Google Patents
Derivati bipirazola kot zaviralci JAKInfo
- Publication number
- SI3527263T1 SI3527263T1 SI201431754T SI201431754T SI3527263T1 SI 3527263 T1 SI3527263 T1 SI 3527263T1 SI 201431754 T SI201431754 T SI 201431754T SI 201431754 T SI201431754 T SI 201431754T SI 3527263 T1 SI3527263 T1 SI 3527263T1
- Authority
- SI
- Slovenia
- Prior art keywords
- jak inhibitors
- bipyrazole derivatives
- bipyrazole
- derivatives
- jak
- Prior art date
Links
- YGAILVDTGIMZAB-UHFFFAOYSA-N 3-pyrazol-3-ylidenepyrazole Chemical class N1=NC=CC1=C1N=NC=C1 YGAILVDTGIMZAB-UHFFFAOYSA-N 0.000 title 1
- 229940122245 Janus kinase inhibitor Drugs 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361824683P | 2013-05-17 | 2013-05-17 | |
| EP18215671.1A EP3527263B1 (en) | 2013-05-17 | 2014-05-16 | Bipyrazole derivatives as jak inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3527263T1 true SI3527263T1 (sl) | 2021-05-31 |
Family
ID=50983151
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201432117T SI4275756T1 (sl) | 2013-05-17 | 2014-05-16 | Bipirazolni derivati kot zaviralci jak |
| SI201431754T SI3527263T1 (sl) | 2013-05-17 | 2014-05-16 | Derivati bipirazola kot zaviralci JAK |
| SI201431118T SI3231801T1 (sl) | 2013-05-17 | 2014-05-16 | Bipirazolna sol kot inhibitor JAK |
| SI201430239A SI2997023T1 (sl) | 2013-05-17 | 2014-05-16 | Bipirazolni derivati kot inhibitorji JAK |
| SI201432046T SI3786162T1 (sl) | 2013-05-17 | 2014-05-16 | Bipirazolni derivati kot zaviralci JAK |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201432117T SI4275756T1 (sl) | 2013-05-17 | 2014-05-16 | Bipirazolni derivati kot zaviralci jak |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201431118T SI3231801T1 (sl) | 2013-05-17 | 2014-05-16 | Bipirazolna sol kot inhibitor JAK |
| SI201430239A SI2997023T1 (sl) | 2013-05-17 | 2014-05-16 | Bipirazolni derivati kot inhibitorji JAK |
| SI201432046T SI3786162T1 (sl) | 2013-05-17 | 2014-05-16 | Bipirazolni derivati kot zaviralci JAK |
Country Status (36)
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1966202T1 (sl) | 2005-12-13 | 2012-01-31 | Incyte Corp | S heteroarilom substituirani pirolo (2,3-b)piridini in pirolo (2,3-b)pirimidini kot zaviralci janus kinaze |
| EP2173752B2 (en) | 2007-06-13 | 2022-07-13 | Incyte Holdings Corporation | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| CA2762174C (en) | 2009-05-22 | 2018-02-20 | Incyte Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| CN106967070A (zh) | 2009-05-22 | 2017-07-21 | å å¡ç¹æ§è¡å ¬åž | äœäžºjakæå¶åçååç© |
| SG177384A1 (en) | 2009-06-29 | 2012-02-28 | Incyte Corp | Pyrimidinones as pi3k inhibitors |
| AR078012A1 (es) | 2009-09-01 | 2011-10-05 | Incyte Corp | Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus |
| EP3715347B1 (en) | 2010-03-10 | 2021-12-22 | Incyte Holdings Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| NZ603686A (en) | 2010-05-21 | 2014-11-28 | Incyte Corp | Topical formulation for a jak inhibitor |
| PE20140146A1 (es) | 2010-11-19 | 2014-02-06 | Incyte Corp | Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak |
| CA2822070C (en) | 2010-12-20 | 2019-09-17 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
| TWI577676B (zh) | 2011-06-20 | 2017-04-11 | è±å¡ç¹æ§è¡å ¬åž | äœçºïœïœïœæå¶åä¹åäžå¶åºè¯åºãå¡å¶åºæå¡î¢åºçŸ§é¯èºè¡çç© |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | äœçºïœïœïœæå¶åä¹ç°å·±åºæ°®éç°äžç·è¡çç© |
| PL3196202T3 (pl) | 2011-09-02 | 2019-09-30 | Incyte Holdings Corporation | Heterocykloaminy jako inhibitory pi3k |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | ÐÐœÑÐ°Ð¹Ñ Ð¥ÐŸÐ»ÐŽÑÐœÐ³Ñ ÐПÑпПÑейÑÐœ | СпПÑПбО Ñ Ð¿ÑПЌÑÐ¶ÐœÑ ÑпПлÑкО ÐŽÐ»Ñ ÐŸÑÑÐžÐŒÐ°ÐœÐœÑ ÑМгÑбÑÑПÑÑв jak |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | åç²ïœïœïœæå¶åä¹åå¶åºç°äžåºå代ä¹å¡å¯å¹¶å¡å¶åå¡å¯å¹¶å§å¶è¡çç© |
| MX2015005428A (es) | 2012-11-01 | 2015-07-21 | Incyte Corp | Derivados triciclicos fusionados de tiofeno como inhibidores de la cinasa janus (jak). |
| SG11201503695XA (en) | 2012-11-15 | 2015-06-29 | Incyte Corp | Sustained-release dosage forms of ruxolitinib |
| JP6397831B2 (ja) | 2013-03-06 | 2018-09-26 | ã€ã³ãµã€ãã»ããŒã«ãã£ã³ã°ã¹ã»ã³ãŒãã¬ã€ã·ã§ã³ïŒ©ïœïœïœïœïœ ïœïœïœïœïœïœïœ ïœïœïœïœïœïœïœïœïœïœ | ïœïœé»å®³å€ã®è£œé æ¹æ³åã³ãã®äžéäœ |
| WO2014186706A1 (en) * | 2013-05-17 | 2014-11-20 | Incyte Corporation | Bipyrazole derivatives as jak inhibitors |
| UA120499C2 (uk) | 2013-08-07 | 2019-12-26 | ÐÐœÑÐ°Ð¹Ñ ÐПÑпПÑейÑÐœ | ÐÑкÑÐ²Ð°ÐœÐœÑ Ð·Ð°Ñ Ð²ÐŸÑÑÐ²Ð°ÐœÑ Ñз заÑÑПÑÑваММÑÐŒ лÑкаÑÑÑÐºÐžÑ ÑПÑÐŒ з ÑпПвÑлÑМеМОЌ вОвÑлÑМеММÑÐŒ ÐŽÐ»Ñ ÑМгÑбÑÑПÑа jak1 |
| PE20161388A1 (es) * | 2014-02-28 | 2016-12-28 | Incyte Corp | Inhibidores de la jak1 para el tratamiento de sindromes mielodisplasicos |
| NZ725778A (en) | 2014-04-08 | 2023-04-28 | Incyte Holdings Corp | Treatment of b-cell malignancies by a combination jak and pi3k inhibitor |
| JP2017514832A (ja) | 2014-04-30 | 2017-06-08 | ã€ã³ãµã€ãã»ã³ãŒãã¬ã€ã·ã§ã³ïŒ©ïœïœïœïœïœ ïœïœïœïœïœïœïœïœïœïœ | ïœïœïŒæå¶å€ã調補ããæ¹æ³åã³ãã®æ°ãã圢æ |
| WO2015184305A1 (en) * | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
| WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| US9586949B2 (en) | 2015-02-09 | 2017-03-07 | Incyte Corporation | Aza-heteroaryl compounds as PI3K-gamma inhibitors |
| MD3831833T2 (ro) | 2015-02-27 | 2023-04-30 | Incyte Holdings Corp | Procedee pentru prepararea unui inhibitor PI3K |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| CN107847432A (zh) | 2015-05-29 | 2018-03-27 | 西執å¥å 西æ¯å ¬åž | D2oçš³å®åçè¯ç©å¶å |
| TWI744256B (zh) | 2015-11-06 | 2021-11-01 | çŸåè±å¡ç¹å ¬åž | äœçºïŒ°ïŒ©ïŒïŒ«-γæå¶åä¹éç°ååç© |
| AR107293A1 (es) | 2016-01-05 | 2018-04-18 | Incyte Corp | COMPUESTOS DE PIRIDINA Y PIRIDIMINA COMO INHIBIDORES DE PI3K-g |
| US10138248B2 (en) | 2016-06-24 | 2018-11-27 | Incyte Corporation | Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-b]pyridazines and substituted imidazo[1,2-a]pyrazines as PI3K-γ inhibitors |
| CN107759623B (zh) * | 2016-08-23 | 2020-08-14 | èå·æºå±±æºæ°Žçç©å»è¯æéå ¬åž | Jakæå¶åçäžéŽäœåå ¶å¶å€æ¹æ³ |
| MX2019002627A (es) * | 2016-09-06 | 2019-10-30 | Hoffmann La Roche | Compuestos de 8-(azetidin-1-il)-[1,2,4]triazolo[1,5-a]piridinilo, composiciones y métodos de uso del mismo. |
| MD3697789T2 (ro) | 2017-10-18 | 2022-02-28 | Incyte Corp | DerivaÈi imidazol condensaÈi substituiÈi cu grupÄri hidroxi terÈiare ca inhibitori PI3K-GAMA |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| MD3746429T2 (ro) | 2018-01-30 | 2022-08-31 | Incyte Corp | Procedee pentru prepararea de (1-(3-fluoro-2-(trifluorometil)izonicotinil)piperidin-4-onÄ) |
| BR112020016628A2 (pt) | 2018-02-16 | 2020-12-15 | Incyte Corporation | Inibidores da via de jak1 para o tratamento de distúrbios relacionados a citocinas |
| HUE067471T2 (hu) * | 2018-03-30 | 2024-10-28 | Incyte Corp | Gennyes verejtékmirigy-gyulladás kezelése jak inhibitorok alkalmazásával |
| WO2019191679A1 (en) | 2018-03-30 | 2019-10-03 | Incyte Corporation | Biomarkers for inflammatory skin disease |
| CN112567247A (zh) | 2018-04-13 | 2021-03-26 | å èµç¹å ¬åž | çšäºç§»æ€ç©æ宿䞻ç ççç©æ å¿ç© |
| CN108484468A (zh) * | 2018-05-11 | 2018-09-04 | åäº¬å€§åŠ | è³åºæ°®æç¯äžç·ç±»ååç©çå¶å€æ¹æ³ |
| CA3101323A1 (en) | 2018-06-01 | 2019-12-05 | Incyte Corporation | Dosing regimen for the treatment of pi3k related disorders |
| CR20250050A (es) | 2018-09-05 | 2025-03-19 | Incyte Corp | Formas cristalinas de un inhibidor de fosfoinositida 3âquinasa (pi3k) (divisional 2021-0165) |
| IL282643B2 (en) | 2018-10-31 | 2025-08-01 | Incyte Corp | A selective jak1 inhibitor for use in a method of treating hematological disease |
| AU2019403304B2 (en) | 2018-12-19 | 2025-09-04 | Incyte Corporation | JAK1 pathway inhibitors for the treatment of gastrointestinal disease |
| JP2022524997A (ja) | 2019-03-05 | 2022-05-11 | ã€ã³ãµã€ãã»ã³ãŒãã¬ã€ã·ã§ã³ | æ ¢æ§èºå皮移æ€çæ©èœäžå šã®æ²»çã®ããã®ïœïœïœïŒçµè·¯é»å®³å€ |
| JP2022526301A (ja) * | 2019-03-19 | 2022-05-24 | ã€ã³ãµã€ãã»ã³ãŒãã¬ã€ã·ã§ã³ | å°åžžæ§çœæã®ãã€ãªããŒã«ãŒ |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| JP2022549506A (ja) | 2019-09-27 | 2022-11-25 | ãã£ã¹ã¯ã»ã¡ãã£ã·ã³ã»ã€ã³ã³ãŒãã¬ã€ããã | 骚é«ç·ç¶çããã³é¢é£ç¶æ ãåŠçœ®ããããã®æ¹æ³ |
| US12203942B2 (en) | 2019-10-10 | 2025-01-21 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| US12360120B2 (en) | 2019-10-10 | 2025-07-15 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| US11992490B2 (en) | 2019-10-16 | 2024-05-28 | Incyte Corporation | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP) |
| JP7518900B2 (ja) * | 2019-10-16 | 2024-07-18 | ã€ã³ãµã€ãã»ã³ãŒãã¬ã€ã·ã§ã³ | ç®èãšãªããããŒãã¹åã³æå¹³èç¬ïŒïœïœïŒã®æ²»çã®ããã®ïœïœïœïŒé»å®³å€ã®äœ¿çš |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN115836089A (zh) | 2020-05-13 | 2023-03-21 | 迪æ¯å å»è¯å ¬åž | çšäºæ²»ç骚é«çº€ç»Žåçæè¡å¹ŒçŽ ïŒhjvïŒæäœ |
| FI4157831T3 (fi) | 2020-06-02 | 2024-12-02 | Incyte Corp | MenetelmiÀ jak1-estÀjÀn valmistamiseksi |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| IL300555A (en) | 2020-08-18 | 2023-04-01 | Incyte Corp | Process and intermediates for preparing a JAK inhibitor |
| AU2021329301A1 (en) | 2020-08-18 | 2023-04-13 | Incyte Corporation | Process and intermediates for preparing a JAK1 inhibitor |
| CN112159394B (zh) * | 2020-10-09 | 2021-10-22 | åå Žç¹ç§çœçç©ç§ææéå ¬åž | äžç§äœäžºjakæ¿é ¶æå¶åçå°ååååç©åå ¶çšé |
| HRP20250528T1 (hr) | 2020-12-04 | 2025-06-20 | Incyte Corporation | Jak inhibitor s analogom vitamina d za lijeÄenje koÅŸnih bolesti |
| US11957661B2 (en) * | 2020-12-08 | 2024-04-16 | Incyte Corporation | JAK1 pathway inhibitors for the treatment of vitiligo |
| CN114099514A (zh) * | 2020-12-29 | 2022-03-01 | äžæµ·å²žéå»è¯ç§ææéå ¬åž | é¢é²ææ²»çegfråèœåŒåžžçžå ³çå¯äœçšçæ¹æ³ |
| EP4274578A1 (en) | 2021-01-11 | 2023-11-15 | Incyte Corporation | Combination therapy comprising jak pathway inhibitor and rock inhibitor |
| LT4333840T (lt) | 2021-05-03 | 2026-01-12 | Incyte Corporation | Jak1 kelio inhibitoriai, skirti mazgelinio nieÅŸulio gydymui |
| US12071439B2 (en) | 2021-07-12 | 2024-08-27 | Incyte Corporation | Process and intermediates for preparing a JAK inhibitor |
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